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An update on adolescent sleep: New evidence informing the perfect storm model

Stephanie J. Crowley, Amy R. Wolfson, Leila Tarokh, Mary A. Carskadon
2018 Journal of Adolescence  
The maturation of sleep regulatory systems during adolescence in combination with psychosocial and societal pressures culminate in a "Perfect Storm" of short and ill-timed sleep and the associated consequences  ...  A 2011 review paper (Carskadon, 2011) proposed that maturation of bioregulatory mechanisms in concert with psychosocial factors resulted in a "perfect storm" of short, illtimed, and inadequate sleep in  ...  We are also grateful to Michael Gradisar, PhD for his thoughtful feedback on and editing of this manuscript.  ... 
doi:10.1016/j.adolescence.2018.06.001 pmid:29908393 pmcid:PMC6054480 fatcat:smthsxu2njbytjxgywkswa5oze

Sleep and maternal behavior in the postpartum rat after haloperidol and midazolam treatments

Florencia Peña, Mayda Rivas, Joaquín Gonzalez, Natalia Schwarzkopf, Pablo Torterolo, Annabel Ferreira, Luciana Benedetto
2020 Sleep Science  
Methods: 24-hours of continuous polysomnographic recordings were performed on seven male rats, using neocortical superficial electrodes in a 12h light/12h dark condition.  ...  Boys of different pubertal development did not have differences on any sleep parameter. Girls had a longer sleep duration compared to boys on weekends, but not on weekdays.  ...  The authors wish to thank the organization of the XV Latin American Symposium on Chronobiology for including this work in the Symposium's special issue ACKNOWLEDGEMENTS This work was only possible because  ... 
doi:10.5935/1984-0063.20200019 fatcat:veyj7cygarc2phqlxv7f244pty

Sensing risk, fearing uncertainty: systems science approach to change

Ivo P. Janecka
2014 Frontiers in Computational Neuroscience  
to control genetic processes; economic reversals-bursting of bubbles in technology, housing, finance; foreign wars; relentless rise in obesity, neurodegenerative diseases.  ...  There are two attributes of systems science that are especially relevant to this research: One-it offers a method for creating a structural context with a guiding path to pragmatic knowledge; and, two-it  ...  sensory input of data, processed information, and the created knowledge.  ... 
doi:10.3389/fncom.2014.00030 pmid:24744723 pmcid:PMC3978314 fatcat:s3vn6yvojra3bkprjuptsd4zp4

Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products

Mariano Del Toro-Barbosa, Alejandra Hurtado-Romero, Luis Eduardo Garcia-Amezquita, Tomás García-Cayuela
2020 Nutrients  
Gut bacteria influence behavior, and both depression and anxiety symptoms are directly associated with alterations in the microbiota.  ...  The gut-brain-microbiota axis consists of a bilateral communication system that enables gut microbes to interact with the brain, and the latter with the gut.  ...  In a recent study, Leclercq et al. (2017) investigated the long-term effect that antibiotics administration has on rodents at an early-life stage on both brain neurochemistry and behavior.  ... 
doi:10.3390/nu12123896 pmid:33352789 fatcat:355kbpykpngnhoze3drsyajf5u

Eco-HAB as a fully automated and ecologically relevant assessment of social impairments in mouse models of autism

Alicja Puścian, Szymon Łęski, Grzegorz Kasprowicz, Maciej Winiarski, Joanna Borowska, Tomasz Nikolaev, Paweł M Boguszewski, Hans-Peter Lipp, Ewelina Knapska
2016 eLife  
Eco-HAB allows for assessment of the tendency of mice to voluntarily spend time together in ethologically relevant mouse group sizes.  ...  Eco-HAB is an open source, RFID-based system for automated measurement and analysis of social preference and in-cohort sociability in mice. The system closely follows murine ethology.  ...  (c) In contrast, C57BL/6 mice 759 including statistical testing, were performed on raw data.  ... 
doi:10.7554/elife.19532 pmid:27731798 pmcid:PMC5092044 fatcat:eg7vcj4jqbd4jjztom3m2ajbmq

How (and why) the immune system makes us sleep

Luca Imeri, Mark R. Opp
2009 Nature Reviews Neuroscience  
We propose that the alterations in sleep architecture during infection are exquisitely tailored to support the generation of fever, which in turn imparts survival value.  ...  Immune signalling molecules are present in the healthy brain, where they interact with neurochemical systems to contribute to the regulation of normal sleep.  ...  Acknowledgements The authors were supported by US National Institutes of Health Grants MH64843 and HL080972, the Department of Anesthesiology of the University of Michigan Medical School, and the Ministero  ... 
doi:10.1038/nrn2576 pmid:19209176 pmcid:PMC2839418 fatcat:lfy6tsrxlvfy7eyw5xlo4v2h3i

Machine Learning Approach for Vigilance State Classification in Mice

Anik Muhury
In this study, the performance of these models is documented on an independent dataset.  ...  On the other hand, automatic sleep stage categorization can enhance consistency and reliability, aiding professionals in identifying sleep related health problems.  ...  In this case video data can be used for the scoring process as well which can help track the movement of mice as well as eye movement.  ... 
doi:10.13023/etd.2021.442 fatcat:rciqrzaelbdorfnbfptdj2grai

Resilience and immunity

Robert Dantzer, Sheldon Cohen, Scott J. Russo, Timothy G. Dinan
2018 Brain, behavior, and immunity  
These data build on the knowledge that has accumulated on the influence of immune factors on brain and behavior in both animal and human studies.  ...  Most of the data supporting this relationship comes from animal studies on individual differences in the ability to resist situations of chronic stress.  ...  However, the opinions they express in this review have not been influenced by the sponsor and none of the authors' research work presented in the review has been funded by the sponsor.  ... 
doi:10.1016/j.bbi.2018.08.010 pmid:30102966 pmcid:PMC6545920 fatcat:gov53lngxndyhlyslmogsa4nsq

The Sleep-Immune Crosstalk in Health and Disease

Luciana Besedovsky, Tanja Lange, Monika Haack
2019 Physiological Reviews  
Mullington for helpful scientific advice and Richard Flynn for editorial work on this manuscript.  ...  In contrast to the plethora of data on the impact of sleep on isolated immune parameters, only a few studies have investigated the direct effect of sleep on the immune response to vaccination.  ...  In the 1990s, Pollmächer and colleagues performed a series of experiments on the effects of low-dose endotoxin challenge on sleep in humans (e.g., Refs. 224, 396, 442) .  ... 
doi:10.1152/physrev.00010.2018 fatcat:dcojmmxljrbcvhluswahihojfe

Poster Session II

2014 Neuropsychopharmacology  
during the pre-screening process, or both.  ...  Methods: Initial evaluations of the SERT M172 model were performed with mice on a 129S6/S4 background.  ...  its impact on PCC function and connectivity, coupled with pre-existing differences in risk processing.  ... 
doi:10.1038/npp.2014.281 fatcat:al6onvo7vzhofpmlzfblnbaxha

Synaptic Pruning in Alzheimer's Disease: Role of the Complement System

Frederic H. Brucato, Daniel E. Benjamin
2020 Global Journal of Medical Research  
Despite this, there is currently only symptomatic treatment for AD and this treatment is limited to only a handful of FDA approved AD drugs.  ...  Alz heimer's disease (AD) continues to threaten aged individuals and health care systems around the world.  ...  targets • The role of neuroinflammation in AD • Factors and systems that influence inflammation including the complement system • Complement system's direct involvement in AD including a role in Beta-Amyloid  ... 
doi:10.34257/gjmrfvol20is6pg1 pmid:32982106 pmcid:PMC7518506 fatcat:kjejczrwsrb4rcxk5frsisxrv4

Imaging the Perivascular Space as a Potential Biomarker of Neurovascular and Neurodegenerative Diseases

Joel Ramirez, Courtney Berezuk, Alicia A. McNeely, Fuqiang Gao, JoAnne McLaurin, Sandra E. Black
2016 Cellular and molecular neurobiology  
Although the brain lacks conventional lymphatic vessels found in peripheral tissue, evidence suggests that the space surrounding the vasculature serves a similar role in the clearance of fluid and metabolic  ...  The purpose of this review is to: (i) describe some of the recent pre-clinical findings from basic science that shed light on the potential neurophysiological mechanisms driving glymphatic and perivascular  ...  To date, most pre-clinical studies have been performed on mouse models of aging and AD; however, the small brain size and limited white matter make translation into the clinical evolution of ePVS challenging  ... 
doi:10.1007/s10571-016-0343-6 pmid:26993511 fatcat:xbxzoauukze6jicxd62qyxfxfu

Cross Talks in Swiss Psychiatry. 26th Annual Meeting of the Swiss Society of Biological Psychiatry

2006 Neuropsychobiology  
Measuring the 'dimensionality' of the behavior of a complex system can assess the degree of non-cooperativity or functional dissociation of the processes that generate the system's behavior.  ...  Abstracts 6 Identification of a Genetic Cluster Influencing Memory Performance and Hippocampal Activity in Humans D.J.-F. de Quervain, A.  ...  Results: No differences were found between the abstainers, the moderately, and the daily cannabis using schizophrenia patients on the PANSS scores.  ... 
doi:10.1159/000095170 fatcat:hrw3d2e36zatfap7nuctpvddp4

The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)

Laura N. Verboon, Hiren C. Patel, Andrew D. Greenhalgh
2021 Frontiers in Immunology  
A history of mild TBI increases the risk of developing emotional and neurocognitive disorders later in life that can impact on day to day living.  ...  Here, we will assess the impact of mild TBI on brain and patient health, and evaluate the recent evidence for immune cell involvement in its pathogenesis.  ...  The same former players had varied performance on a test of verbal learning and memory (145) .  ... 
doi:10.3389/fimmu.2021.620698 pmid:33679762 pmcid:PMC7928307 fatcat:csbk7zvhovbpbpy4v7cu4hw7jm

Poster Session III

2011 Neuropsychopharmacology  
In sum, our findings reveal a novel role for FMRP in the processes underlying alterations in the brain and behavior that occur in response to repeated cocaine exposure.  ...  Decreased drinking in BK b1 deficient mice suggests a key role of BK channels in the initial neuroadaptations to ethanol within the reward system.  ...  Another twenty-one (10 Active, 11 Sham) non-sleep deprived subjects were run as controls for WM performance.  ... 
doi:10.1038/npp.2011.293 fatcat:o4t4mbgxcbax7fgl5vb2dzbep4
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