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Systemic immune-inflammation index (SII): A More Promising Inflammation-Based Prognostic Marker for Patients with synchronic colorectal peritoneal carcinomatosis

Qian Yan, Zhai Ertao, Zhang Zhimei, Dai Weigang, Peng Jianjun, Chen Jianhui, Chen Chuangqi
2020 Journal of Cancer  
Conclusions: SII was a better inflammation factor to predict the outcomes of SCRPC patients receiving CRS and systematic CT.  ...  Results: Univariate analysis revealed that elevated NLR, PLR and SII were significantly correlate with worse survival outcome.  ...  Author Contributions Qian Yan and Zhai Ertao contributed equally to this study, including study concept and design,  ... 
doi:10.7150/jca.46446 pmid:32742472 pmcid:PMC7391211 fatcat:sosl4bstird7hlof7qlajhbwja

Late distant recurrence of breast carcinoma and metastasis to the main bronchus and choroid

Zhijie Luo, Qin Cai, Yuanyuan Zhao, Xiaochuan Wang, Siying Fu, Linzhu Zhai
2018 Medicine  
Rationale: Metastases of breast carcinoma to the main bronchus and choroid are rare, but have been reported in relevant literature. Late distant recurrence of breast carcinoma after more than 20 years is extremely rare. Herein, we report a 57-year-old woman with late distant recurrence and metastasis to the main bronchus and choroid almost 28 years after surgery. Patient concerns: At the age of 29, the patient underwent chemotherapy and endocrine treatment after a right side mastectomy to
more » ... breast carcinoma. The patient was hospitalized for a cough with blood-tinged sputum, dysphagia, and blurred vision in the left eye at the age of 57. Diagnoses: On evaluation, laboratory findings detected the elevated serum tumor markers of CA12-5, CA15-3, NSE, and Cyfra21-1. The imaging showed left lung metastase, multiple lymph node metastases, and small suspected metastases in the both sides of parietal lobes. Fundus fluorescein angiography showed choroidal occupying lesion of the left side which indicates secondary metastasis and retinal detachment. Combined with the pathological finding via fiberoptic bronchoscopic biopsy, the patient was clinically diagnosed with a late distant recurrence of breast carcinoma. Interventions: The patient received oral endocrine therapy of letrozole, but she refused chemotherapy, radiotherapy and other topical treatments. Outcomes: At the 3-month follow-up visit, the multiple lesions of the left lung and lymph nodes had partially regressed, and the lesion of right parietal lobe had disappeared. The patient's clinical symptoms, such as blood-tinged sputum and dysphagia, had significantly improved. Lessons: We have described this case and reviewed the relevant literature concerning late distant recurrence of breast carcinoma. Importantly, this case indicates that patients with HR positive breast carcinoma are more likely to develop late distant recurrence and clinicians should not ignore the follow-up examinations even more than 20 years after the surgery. Abbreviations: BC = breast carcinoma, BM = bronchial metastasis, CM = choroidal metastasis, CT =computed tomography, HR = hormone receptor, IHC = immunohistochemistry, MRI = magnetic resonance image. A 57-year-old woman, who underwent a mastectomy 28 years prior, was hospitalized for cough with blood-tinged sputum, dysphagia,
doi:10.1097/md.0000000000010754 pmid:29768356 pmcid:PMC5976331 fatcat:a4k5pk4djfbwjixm7tm5wvn2b4

Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish

Jing Luo, Xiaokang Zhang, Siying He, Qiyong Lou, Gang Zhai, Chuang Shi, Zhan Yin, Fang Zheng
2019 Redox Biology  
Nuclear prelamin A recognition factor-like (NARFL) is a human protein that participates in cytosolic iron-sulfur (Fe-S) protein biogenesis and cellular defense against oxidative stress. Previous studies of Narfl knockout mice did not reveal well the regulatory mechanisms of embryonic development mediated by Narfl because the homozygous mice die in utero. Here, we investigated the function of narfl in an established zebrafish knockout model by taking advantage of zebrafish external fertilization
more » ... and ease of embryonic development examination. Our experiments showed that narfl deletion resulted in larvae lethality, subintestinal vessel (SIV) malformation and digestive organ defects in the early stages of embryonic development. Biochemical analyses and western blot revealed increased oxidative stress and upregulated hypoxia-inducible factor-1α (HIF-1α) expression in narfl-/- fish. The use of HIF-1α inhibitor 2-methoxyestradiol (2ME2) for the treatment of mutants partially rescued the SIV sprouting. These results suggest that narfl deletion causes increased oxidative stress and subintestinal vessel malformation, which further influence the development of digestive organs and might contribute to the lethality of the narfl knockout fish.
doi:10.1016/j.redox.2019.101355 pmid:31677554 pmcid:PMC6920133 fatcat:iydehw5jxjay7l3o3ac4azrmm4

Treatment of the bone marrow stromal stem cell supernatant by nasal administration—a new approach to EAE therapy

Xi Wang, Wantong Zhai, Jiahui Zhu, Wei Zhao, Xiaoyi Zou, Siying Qu, Shenyue Wang, Zhongze He, Zhaoying Li, Lingyang Wang, Bo Sun, Hulun Li
2019 Stem Cell Research & Therapy  
Multiple sclerosis (MS) is one of the most common autoimmune diseases of the central nervous system (CNS). CNS has its own unique structural and functional features, while the lack of precision regulatory element with high specificity as therapeutic targets makes the development of disease treatment in the bottleneck. Recently, the immunomodulation and neuroprotection capabilities of bone marrow stromal stem cells (BMSCs) were shown in experimental autoimmune encephalomyelitis (EAE). However,
more » ... e administration route and the safety evaluation limit the application of BMSC. In this study, we investigated the therapeutic effect of BMSC supernatant by nasal administration.
doi:10.1186/s13287-019-1423-6 pmid:31730485 pmcid:PMC6858701 fatcat:5l2lhfhxmzdw7e6dgtzenqhez4

Prognostic value of inflammation-based prognostic index in patients with nasopharyngeal carcinoma: a propensity score matching study

Oei RW, Ye L, Kong F, Du C, Zhai R, Xu T, Shen C, Wang X, He X, Kong L, Hu C, Ying H
2018 Cancer Management and Research  
Ronald Wihal Oei,1,2,* Lulu Ye,1,2,* Fangfang Kong,1,2 Chengrun Du,1,2 Ruiping Zhai,1,2 Tingting Xu,1,2 Chunying Shen,1,2 Xiaoshen Wang,1,2 Xiayun He,1,2 Lin Kong,1,2 Chaosu Hu,1,2 Hongmei Ying1,2 1Department  ...  Results: The optimal cutoff point of 53.0 for PNI and 527.20 for SII were selected. Pearson correlation coefficient showed an inverse correlation between PNI and SII (r = –0.232, P < 0.001).  ...  Management and Research » Volume 10 Prognostic value of inflammation-based prognostic index in patients with nasopharyngeal carcinoma: a propensity score matching study Authors Oei RW, Ye L, Kong F, Du C, Zhai  ... 
doaj:e9d50f730a25458badbb1df4b4c05ed6 fatcat:ruuw2vex7vavpovc2qlzngg3ku

Page 689 of Mathematical Reviews Vol. , Issue 98A [page]

1998 Mathematical Reviews  
See *01025a Zevin, Aleksandr Aronovich . 58131 Zevin, Alexandr A. ........ miinine See Zevin, Aleksandr Aronovich Zhai, Wen Guang ................... 11108 Eee 57026 Zhan, Mei-Qin .....  ...  J. .......... ... 58171 ME GD. ciscccsses paaaven . 73WS2 SII eiiscnictinecatecesceas 49057 Zecchina, Riccardo , .. 82013 SEY se Dinecarhiniaanwcies 93057 ES ee rr Zelidovich, Ya. B. . .esseee.  ... 

Clinical Implication of Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Skull Base Chordoma Patients

Mingxuan Li, Jiwei Bai, Shuai Wang, Yixuan Zhai, Shuheng Zhang, Chuzhong Li, Jiang Du, Yazhuo Zhang
2021 Frontiers in Oncology  
More importantly, patients with high SII and PNI had the worst outcomes and combined use of SII and PNI increased the predictive ability for patients' survival in skull base chordoma.  ...  SII was positively correlated with NLR and PLR, but negatively correlated with PNI.  ...  FIGURE 3 | 3 Comparison the predictive values of NLR, PLR, SII, PNI, and SII+PNI for OS in skull base chordoma. (A) ROC curves of NLR, PLR, SII, PNI, and SII+PNI for 3-year OS.  ... 
doi:10.3389/fonc.2021.548325 pmid:33718126 pmcid:PMC7947628 fatcat:pec56x2s5nboxja4s4d3mekb4e

Prognostic value of systemic immune-inflammation index in patients with gastric cancer

Kang Wang, Feiyu Diao, Zhijun Ye, Xinhua Zhang, Ertao Zhai, Hui Ren, Tong Li, Hui Wu, Yulong He, Shirong Cai, Jianhui Chen
2017 Chinese Journal of Cancer  
High SII was significantly associated with unfavorable prognosis (P < 0.001) and SII was an independent predictor for OS (P = 0.015).  ...  Preoperative SII was calculated. The Chi square test or Fisher's exact test was used to determine the relationship between preoperative SII and clinicopathologic characteristics.  ...  Association of SII with OS Patients were divided into two groups according to SII values.  ... 
doi:10.1186/s40880-017-0243-2 pmid:28899420 pmcid:PMC5596912 fatcat:vinm2qu6bjg4tabhzg7rzwhebu

Systemic immune-inflammation index for predicting prognosis of colorectal cancer

Jian-Hui Chen, Er-Tao Zhai, Yu-Jie Yuan, Kai-Ming Wu, Jian-Bo Xu, Jian-Jun Peng, Chuang-Qi Chen, Yu-Long He, Shi-Rong Cai
2017 World Journal of Gastroenterology  
SII was calculated with the formula SII = (P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively.  ...  RESULTS The optimal cut-off point for SII was defined as 340. The overall survival (OS) and disease-free survival (DFS) were better in patients with low NLR, PLR, and SII (P < 0.05).  ...  SII was calculated with the formula SII = (P × N)/L, where P, N, and L refer to peripheral platelet, neutrophil, and lymphocyte counts, respectively.  ... 
doi:10.3748/wjg.v23.i34.6261 pmid:28974892 pmcid:PMC5603492 fatcat:6bwxkqbmtjaujenrle2yefznte

Prognostic value of inflammation-based prognostic index in patients with nasopharyngeal carcinoma: a propensity score matching study

Ronald Wihal Oei, Lulu Ye, Fangfang Kong, Chengrun Du, Ruiping Zhai, Tingting Xu, Chunying Shen, Xiaoshen Wang, Xiayun He, Lin Kong, Chao-Su Hu, Hongmei Ying
2018 Cancer Management and Research  
balance between low PNI/SII and high PNI/SII groups.  ...  Group 1: PNI ≥53.0 sii <527.20, group 2: Pni <53.0 sii <527.20 or Pni ≥53.0 sii ≥527.20, group 3: Pni <53.0 sii ≥527.20. Log-rank test, P < 0.05.  ... 
doi:10.2147/cmar.s171239 pmid:30147375 pmcid:PMC6103307 fatcat:wbpxycxj6fdu7iv7atbkvuidoa

Global phosphorylation analysis of -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)

K. Xiao, J. Sun, J. Kim, S. Rajagopal, B. Zhai, J. Villen, W. Haas, J. J. Kovacs, A. K. Shukla, M. R. Hara, M. Hernandez, A. Lachmann (+7 others)
2010 Proceedings of the National Academy of Sciences of the United States of America  
(+)] and without [SII (−)] SII treatment.  ...  SII stimulation.  ... 
doi:10.1073/pnas.1008461107 pmid:20686112 pmcid:PMC2930550 fatcat:fywqn4jeibeircscmng2ta4dny

Page 34 of Acta Physiologica Vol. 190, Issue 1 [page]

2007 Acta Physiologica  
which is incapable of signalling via G proteins but activates f-arrestin-dependent pathways, showed that angioten- sin-mediated f-arrestin signalling has a specific role in cardiovascular regulation (Zhai  ...  Lefkowitz in this issue, agonists at the angiotensin AT) receptor are capable of activating both G protein and f-arrestin-dependent pathways (angiotensin) or of restricted signalling (mutant angiotensin SII  ... 

Prognostic Value of the Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Patients With Medulloblastoma Undergoing Surgical Resection

Sihan Zhu, Zhuqing Cheng, Yuanjun Hu, Zhenghe Chen, Ji Zhang, Chao Ke, Qunying Yang, Fuhua Lin, Yinsheng Chen, Jian Wang
2021 Frontiers in Nutrition  
Comparative survival analysis exhibited that the high-SII cohort had significantly shorter OS (p = 0.0048) than the low-SII cohort.  ...  Clinical characteristics and SII, NLR, MLR, and PNI were tested with the Pearson's chi-squared test.  ...  Li M, Bai J, Wang S, Zhai Y, Zhang S, Li C, et al.  ... 
doi:10.3389/fnut.2021.754958 pmid:34977115 pmcid:PMC8718683 fatcat:jry5na5mfbcmdiqy7m2wahv7hm

Page 295 of American Ceramic Society Bulletin Vol. 73, Issue 3 [page]

1994 American Ceramic Society Bulletin  
(SXIII-26-94) Zhai, H. (SHIP-20-94) Zhang, C. (SX VIlc-184-94) Zhang, G.B. (E-51-94) Zhang, L. (SX VIIb-55-94) (G-23-94) Zhang, L.T. (SX VIP-7-94) (SIII-21-94) Zhang, M. (SIII-92-94) Zhang, S.C.  ...  (SII-17-94) Wheaton, B.R. (JI-5-94) Wheeler, M.J. (SIII-26-94) Wheeler, P.M. (SXIII-8-94) Wheeler, R. (SIII-11-94) White, D.P. (SX-5-94) White, G.S.  ... 

Sound-induced perturbations of the brain network in non-REM sleep, and network oscillations in wake

Weiwei Wu, Bhavin R. Sheth
2013 Psychophysiology  
We recorded cortical activity in stage 2 (SII) sleep and wake using EEG while a tone was intermittently played.  ...  Freeman and colleagues (Freeman, Holmes, West, & Vanhatalo, 2006; Freeman & Zhai, 2009 ) also studied EcoG data from a preoperative patient undergoing preoperative monitoring for epilepsy surgery and  ...  Furthermore, it is known that SII (N2) sleep is a transitional state and 50 consecutive trials in SII sleep ensures a certain degree of stability of the SII state.  ... 
doi:10.1111/psyp.12011 pmid:23316945 fatcat:4lpebgpclzh2vpfdsf4jrzojae
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