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Pial Collateral Reactivity During Hypertension and Aging

Siu-Lung Chan, Julie G. Sweet, Nicole Bishop, Marilyn J. Cipolla
2016 Stroke  
-Lung Chan, Ph.D., Julie G. Sweet, B.S., Nicole Bishop, B.S., and Marilyn J. Cipolla, Ph.D.  ...  ONLINE SUPPLEMENT Pial Collateral Vasoconstriction during Hypertension and Aging: Understanding the Function of Collaterals for Improved Stroke Therapy Siu Determination of perivascular innervation  ... 
doi:10.1161/strokeaha.116.013392 pmid:27103017 pmcid:PMC4878286 fatcat:m7mgvucfhva5nm6whheq2jbpfm

Compressed Indexes for Approximate String Matching

Ho-Leung Chan, Tak-Wah Lam, Wing-Kin Sung, Siu-Lung Tam, Swee-Seong Wong
2008 Algorithmica  
And more recently, Chan et al.  ...  s also admits a time-space tradeoff; in particular, Chan et al. [6] showed that the tree cross product technique by Buchshaum et al.  ... 
doi:10.1007/s00453-008-9263-2 fatcat:yhukilfdn5gshdu6rivuwec7ay

Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles

Siu-Lung Chan, Gary L. Baumbach
2013 Frontiers in Physiology  
This work was supported by American Heart Association Heartland Affiliate Post-doctoral Fellowship #0725668Z (Siu-Lung Chan); and National Institutes of Health Grants HL-22149, NS-72628, and NS-62461 (  ... 
doi:10.3389/fphys.2013.00133 pmid:23805104 pmcid:PMC3693079 fatcat:6hpjdxr6mnce3j7zthi6ezi66q

Compressed Indexes for Approximate String Matching [chapter]

Ho-Leung Chan, Tak-Wah Lam, Wing-Kin Sung, Siu-Lung Tam, Swee-Seong Wong
2006 Lecture Notes in Computer Science  
And more recently, Chan et al.  ...  s also admits a time-space tradeoff; in particular, Chan et al. [6] showed that the tree cross product technique by Buchshaum et al.  ... 
doi:10.1007/11841036_21 fatcat:pag7vro2oretbimngsdszaeiee

Rotavirus vaccine effectiveness in Hong Kong children

Karene Hoi Ting Yeung, Jacqueline E. Tate, Ching Ching Chan, Martin C.W. Chan, Paul K.S. Chan, Kin Hung Poon, Sylvia Luen Yee Siu, Genevieve Po Gee Fung, Kwok Leung Ng, Iris Mei Ching Chan, Pui Tak Yu, Chi Hang Ng (+2 others)
2016 Vaccine  
Background: Rotavirus is a common infectious cause of childhood hospitalisation in Hong Kong. Rotavirus vaccines have been used in the private sector since licensure in 2006 but have not been incorporated in the government's universal Childhood Immunisation Programme. This study aimed to evaluate rotavirus vaccine effectiveness against hospitalisation. Methods: This case-control study was conducted in the 2014/2015 rotavirus season in six public hospitals. Hospitalised acute gastroenteritis
more » ... ents meeting inclusion criteria were recruited and copies of their immunisation records were collected. Case-patients were defined as enrolled subjects with stool specimens obtained in the first 48 h of hospitalisation that tested positive for rotavirus, whereas control-patients were those with stool specimens obtained in the first 48 h of hospitalisation testing negative for rotavirus. Vaccine effectiveness for administration of at least one dose of either Rotarix Ò (GlaxoSmithKline Biologicals) or RotaTeq Ò (Merck Research Laboratories) was calculated as 1 minus the odds ratio for rotavirus vaccination history for case-patients versus control-patients. Results: Among the 525 eligible subjects recruited, immunisation records were seen in 404 (77%) subjects. 31% (162/525 and 126/404) tested positive for rotavirus. In the 404 subjects assessed for vaccine effectiveness, 2.4% and 24% received at least 1 dose of either rotavirus vaccine in case-and control-patients respectively. The unmatched vaccine effectiveness against hospitalisation for administration of at least one dose of either rotavirus vaccines was 92% (95% confidence interval [CI]: 75%, 98%). The matched analyses by age only and both age and admission date showed 96% (95% CI: 72%, 100%) and 89% (95% CI: 51%, 97%) protection against rotavirus hospitalisation respectively. Conclusions: Rotavirus vaccine is highly effective in preventing hospitalisation from rotavirus disease in young Hong Kong children.
doi:10.1016/j.vaccine.2016.08.047 pmid:27595446 fatcat:cwn6zckeujfxzdlx3hgycd5scy

The clinical relevance of vertebral artery hypoplasia

Yu-Ming Chuang, Lung Chan, Hung-Ming Wu, Siu-Pak Lee, Yiu-Tong Chu
2012 Acta neurologica Taiwanica  
Congenital vertebral artery (VA) hypoplasia is an uncommon embryonic variation of posterior circulation. The frequency of this congenital variation was reported to be 2-6% from autopsy and angiograms. Is it a congenital risk factor of ischemic stroke? In this review, we gave an overview of the literature concerning vertebral artery hypoplasia. VA hypoplasia served as an independent factor of a reduction of the posterior circulation blood flow velocity. VA hypoplasia can play a negative role in
more » ... ases of occlusion of a major brain vessel since it limits the potential of compensatory blood circulation. VA hypoplasia may also lead to regional hypoperfusion and complex neurovascular consequences which correspond to vestibular neuronitis and migraine pathogenesis.
pmid:22879083 fatcat:iiw3jll67rdkjgjbjpzfsxbjlu


Siu-Lung Chan, Marilyn J. Cipolla
2012 Journal of immunoassay & immunochemistry  
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear transcription factor that regulates many genes and is involved in extensive biological functions. Accurately determining PPARγ activity in various tissues is important to understanding mechanisms of human physiology and pathophysiology. Thus, we evaluated a PPARγ DNA binding immunoassay using nuclear extracts of spleen and adipose tissue from rats treated with rosiglitazone (20 mg/kg in food, 7 days, n=6) or vehicle (n=6) and
more » ... compared results to mRNA expression of PPARγ target genes, a well-established method to investigate PPARγ activity. In adipose tissue, the PPARγ immunoassay showed that rosiglitazone did not change PPARγ binding, but qPCR analysis showed that expression of two PPARγ target genes, CD36 and liver X receptor-α, were significantly increased. In spleen, the PPARγ immunoassay showed that rosiglitazone decreased PPARγ binding, but qPCR analysis showed no significant change. The different results obtained between PPARγ binding immunoassay and target gene expression suggest that PPARγ immunoassays may not be suitable when used with fresh homogenates of spleen and adipose tissue. Validation of the assay with each individual tissue is recommended.
doi:10.1080/15321819.2011.647189 pmid:22738654 pmcid:PMC3386555 fatcat:pggr2uahh5asjfhvhxlx5x4ooi

Effect of PPARγ Inhibition during Pregnancy on Posterior Cerebral Artery Function and Structure

Siu-Lung Chan
2010 Frontiers in Physiology  
., 2005) through NADPH oxidase-derived superoxide and not hypertension per se (Chan and Baumbach, 2009 ).  ... 
doi:10.3389/fphys.2010.00130 pmid:21423372 pmcid:PMC3059960 fatcat:lz2btkfhbrgfxgqy6fn7v2lraq

Nosocomial outbreak of COVID-19 by possible airborne transmission leading to a superspreading event

Vincent Chi-Chung Cheng, Kitty Sau-Chun Fung, Gilman Kit-Hang Siu, Shuk-Ching Wong, Lily Shui-Kuen Cheng, Man-Sing Wong, Lam-Kwong Lee, Wan-Mui Chan, Ka-Yee Chau, Jake Siu-Lun Leung, Allen Wing-Ho Chu, Wai-Shan Chan (+8 others)
2021 Clinical Infectious Diseases  
24.1) g Fever, 1 d post-dx Death / 119 d [7 d] P4 F/83 h Nil (suspected DVT) / 0 d [cubicle F corridor, 1 d] i Dec 24, 2020 / DTS (13.4) j Cough, 3 d pre-dx Recovered / 45 d [39 d] P5 F/74 d CA lung  ... 
doi:10.1093/cid/ciab313 pmid:33851214 fatcat:n34edl7dv5hupaebqgg2rawoqa

Oncological outcome after free jejunal flap reconstruction for carcinoma of the hypopharynx

Jimmy Yu Wai Chan, Velda Ling Yu Chow, Richie Chiu Lung Chan, Gregory Ian Siu Kee Lau
2011 European Archives of Oto-Rhino-Laryngology  
Majority of the patients died of regional (n = 12) and systemic metastasis (n = 23), while the rest of them died from metachronous tumor (carcinoma of the lung, n = 6; carcinoma of the oral cavity, n =  ... 
doi:10.1007/s00405-011-1836-z pmid:22094906 pmcid:PMC3365236 fatcat:anwuo44v6nb2nkd7v5ndkut7ha

Endocytic Adaptors in Cardiovascular Disease

Kui Cui, Yunzhou Dong, Beibei Wang, Douglas B. Cowan, Siu-Lung Chan, John Shyy, Hong Chen
2020 Frontiers in Cell and Developmental Biology  
Endocytosis is the process of actively transporting materials into a cell by membrane engulfment. Traditionally, endocytosis was divided into three forms: phagocytosis (cell eating), pinocytosis (cell drinking), and the more selective receptor-mediated endocytosis (clathrin-mediated endocytosis); however, other important endocytic pathways (e.g., caveolin-dependent endocytosis) contribute to the uptake of extracellular substances. In each, the plasma membrane changes shape to allow the
more » ... and internalization of materials, resulting in the formation of an intracellular vesicle. While receptor-mediated endocytosis remains the best understood pathway, mammalian cells utilize each form of endocytosis to respond to their environment. Receptor-mediated endocytosis permits the internalization of cell surface receptors and their ligands through a complex membrane invagination process that is facilitated by clathrin and adaptor proteins. Internalized vesicles containing these receptor-ligand cargoes fuse with early endosomes, which can then be recycled back to the plasma membrane, delivered to other cellular compartments, or destined for degradation by fusing with lysosomes. These intracellular fates are largely determined by the interaction of specific cargoes with adaptor proteins, such as the epsins, disabled-homolog 2 (Dab2), the stonin proteins, epidermal growth factor receptor substrate 15, and adaptor protein 2 (AP-2). In this review, we focus on the role of epsins and Dab2 in controlling these sorting processes in the context of cardiovascular disease. In particular, we will focus on the function of epsins and Dab2 in inflammation, cholesterol metabolism, and their fundamental contribution to atherogenicity.
doi:10.3389/fcell.2020.624159 pmid:33363178 pmcid:PMC7759532 fatcat:z5qhy7ve6fd33fyaqpus5j3shi

A Linear Size Index for Approximate Pattern Matching [chapter]

Ho-Leung Chan, Tak-Wah Lam, Wing-Kin Sung, Siu-Lung Tam, Swee-Seong Wong
2006 Lecture Notes in Computer Science  
This paper revisits the problem of indexing a text S[1..n] to support searching substrings in S that match a given pattern P [1..m] with at most k errors. A naive solution either has a worst-case matching time complexity of Ω(m k ) or requires Ω(n k ) space. Devising a solution with better performance has been a challenge until Cole et al. [5] showed an O(n log k n)-space index that can support k-error matching in O(m+occ+log k n log log n) time, where occ is the number of occurrences.
more » ... by the indexing of DNA, we investigate in this paper the feasibility of devising a linear-size index that still has a time complexity linear in m. In particular, we give an O(n)-space index that supports k-error matching in O(m + occ + (log n) k(k+1) log log n) worst-case time. Furthermore, the index can be compressed from O(n) words into O(n) bits with a slight increase in the time complexity.
doi:10.1007/11780441_6 fatcat:ul5b4ruafjcbfmr3ul6a4skoly

Nox2 Deficiency Prevents Hypertension-Induced Vascular Dysfunction and Hypertrophy in Cerebral Arterioles

Siu-Lung Chan, Gary L. Baumbach
2013 International Journal of Hypertension  
Oxidative stress is involved in many hypertension-related vascular diseases in the brain, including stroke and dementia. Thus, we examined the role of genetic deficiency of NADPH oxidase subunit Nox2 in the function and structure of cerebral arterioles during hypertension. Arterial pressure was increased in right-sided cerebral arterioles with transverse aortic banding for 4 weeks in 8-week-old wild-type (WT) and Nox2-deficient (-/y) mice. Mice were givenNG-nitro-L-arginine methyl ester
more » ... 10 mg/kg) or vehicle to drink. We measured the reactivity in cerebral arterioles through open cranial window in anesthetized mice and wall cross-sectional area and superoxide levelsex vivo. Aortic constriction increased systolic and pulse pressures in right-sided carotid arteries in all groups of mice. Ethidium fluorescence showed increased superoxide in right-sided cerebral arterioles in WT, but not in Nox2-/y mice. Dilation to acetylcholine, but not sodium nitroprusside, was reduced, and cross-sectional areas were increased in the right-sided arterioles in WT, but were unchanged in Nox2-/y mice. L-NAME reduced dilation to acetylcholine but did not result in hypertrophy in right-sided arterioles of Nox2-/y mice. In conclusion, hypertension-induced superoxide production derived from Nox2-containing NADPH oxidase promotes hypertrophy and causes endothelial dysfunction in cerebral arterioles, possibly involving interaction with nitric oxide.
doi:10.1155/2013/793630 pmid:23573415 pmcid:PMC3612447 fatcat:ddj5orgrarcp3axmutdynfwp7i

Protective roles of Cordyceps on lung fibrosis in cellular and rat models

Mengli Chen, Florence W.K. Cheung, Ming Hung Chan, Pak Kwan Hui, Siu-Po Ip, Yick Hin Ling, Chun-Tao Che, Wing Keung Liu
2012 Journal of Ethnopharmacology  
We hypothesize that Cordyceps has beneficial effects on lung fibrosis and the objective of this study is to explore the target(s) of Cordyceps in the relief of lung fibrosis in animal and cell models and  ...  The findings provide an insight into the preventive and therapeutic potentials of Cordyceps for the treatment of lung fibrosis.  ...  12 weeks (Hui and Chan, 2006) .  ... 
doi:10.1016/j.jep.2012.06.033 pmid:22796203 pmcid:PMC7125542 fatcat:jzkpurovunfktopzmfzcfrjgpq

Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer

Thomas Sin, Fengfeng Wang, Fei Meng, S. Wong, William Cho, Parco Siu, Lawrence Chan, Benjamin Yung
2016 International Journal of Molecular Sciences  
Non-small cell lung cancer (NSCLC) represents about 85% of the reported cases of lung cancer.  ...  Introduction Non-small cell lung cancer (NSCLC) makes up about 85% of the reported cases of lung cancer.  ...  This observation concurs with the inverse correlation between miR-21 expression in lung cancer tissues and response to gefitinib treatment [26] .  ... 
doi:10.3390/ijms17020237 pmid:26891293 pmcid:PMC4783968 fatcat:67yepbshgje5xithif4uhzjrcm
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