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Pial Collateral Reactivity During Hypertension and Aging
2016
Stroke
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-Lung Chan, Ph.D., Julie G. Sweet, B.S., Nicole Bishop, B.S., and Marilyn J. Cipolla, Ph.D. ...
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Pial Collateral Vasoconstriction during Hypertension and Aging: Understanding the Function of Collaterals for Improved Stroke Therapy Siu
Determination of perivascular innervation ...
doi:10.1161/strokeaha.116.013392
pmid:27103017
pmcid:PMC4878286
fatcat:m7mgvucfhva5nm6whheq2jbpfm
Compressed Indexes for Approximate String Matching
2008
Algorithmica
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And more recently, Chan et al. ...
s also admits a time-space tradeoff; in particular, Chan et al. [6] showed that the tree cross product technique by Buchshaum et al. ...
doi:10.1007/s00453-008-9263-2
fatcat:yhukilfdn5gshdu6rivuwec7ay
Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles
2013
Frontiers in Physiology
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This work was supported by American Heart Association Heartland Affiliate Post-doctoral Fellowship #0725668Z (Siu-Lung Chan); and National Institutes of Health Grants HL-22149, NS-72628, and NS-62461 ( ...
doi:10.3389/fphys.2013.00133
pmid:23805104
pmcid:PMC3693079
fatcat:6hpjdxr6mnce3j7zthi6ezi66q
Compressed Indexes for Approximate String Matching
[chapter]
2006
Lecture Notes in Computer Science
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And more recently, Chan et al. ...
s also admits a time-space tradeoff; in particular, Chan et al. [6] showed that the tree cross product technique by Buchshaum et al. ...
doi:10.1007/11841036_21
fatcat:pag7vro2oretbimngsdszaeiee
Rotavirus vaccine effectiveness in Hong Kong children
2016
Vaccine
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Background: Rotavirus is a common infectious cause of childhood hospitalisation in Hong Kong. Rotavirus vaccines have been used in the private sector since licensure in 2006 but have not been incorporated in the government's universal Childhood Immunisation Programme. This study aimed to evaluate rotavirus vaccine effectiveness against hospitalisation. Methods: This case-control study was conducted in the 2014/2015 rotavirus season in six public hospitals. Hospitalised acute gastroenteritis
doi:10.1016/j.vaccine.2016.08.047
pmid:27595446
fatcat:cwn6zckeujfxzdlx3hgycd5scy
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... ents meeting inclusion criteria were recruited and copies of their immunisation records were collected. Case-patients were defined as enrolled subjects with stool specimens obtained in the first 48 h of hospitalisation that tested positive for rotavirus, whereas control-patients were those with stool specimens obtained in the first 48 h of hospitalisation testing negative for rotavirus. Vaccine effectiveness for administration of at least one dose of either Rotarix Ò (GlaxoSmithKline Biologicals) or RotaTeq Ò (Merck Research Laboratories) was calculated as 1 minus the odds ratio for rotavirus vaccination history for case-patients versus control-patients. Results: Among the 525 eligible subjects recruited, immunisation records were seen in 404 (77%) subjects. 31% (162/525 and 126/404) tested positive for rotavirus. In the 404 subjects assessed for vaccine effectiveness, 2.4% and 24% received at least 1 dose of either rotavirus vaccine in case-and control-patients respectively. The unmatched vaccine effectiveness against hospitalisation for administration of at least one dose of either rotavirus vaccines was 92% (95% confidence interval [CI]: 75%, 98%). The matched analyses by age only and both age and admission date showed 96% (95% CI: 72%, 100%) and 89% (95% CI: 51%, 97%) protection against rotavirus hospitalisation respectively. Conclusions: Rotavirus vaccine is highly effective in preventing hospitalisation from rotavirus disease in young Hong Kong children.
The clinical relevance of vertebral artery hypoplasia
2012
Acta neurologica Taiwanica
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Congenital vertebral artery (VA) hypoplasia is an uncommon embryonic variation of posterior circulation. The frequency of this congenital variation was reported to be 2-6% from autopsy and angiograms. Is it a congenital risk factor of ischemic stroke? In this review, we gave an overview of the literature concerning vertebral artery hypoplasia. VA hypoplasia served as an independent factor of a reduction of the posterior circulation blood flow velocity. VA hypoplasia can play a negative role in
pmid:22879083
fatcat:iiw3jll67rdkjgjbjpzfsxbjlu
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... ases of occlusion of a major brain vessel since it limits the potential of compensatory blood circulation. VA hypoplasia may also lead to regional hypoperfusion and complex neurovascular consequences which correspond to vestibular neuronitis and migraine pathogenesis.
DETERMINATION OF PPARγ ACTIVITY IN ADIPOSE TISSUE AND SPLEEN
2012
Journal of immunoassay & immunochemistry
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Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear transcription factor that regulates many genes and is involved in extensive biological functions. Accurately determining PPARγ activity in various tissues is important to understanding mechanisms of human physiology and pathophysiology. Thus, we evaluated a PPARγ DNA binding immunoassay using nuclear extracts of spleen and adipose tissue from rats treated with rosiglitazone (20 mg/kg in food, 7 days, n=6) or vehicle (n=6) and
doi:10.1080/15321819.2011.647189
pmid:22738654
pmcid:PMC3386555
fatcat:pggr2uahh5asjfhvhxlx5x4ooi
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... compared results to mRNA expression of PPARγ target genes, a well-established method to investigate PPARγ activity. In adipose tissue, the PPARγ immunoassay showed that rosiglitazone did not change PPARγ binding, but qPCR analysis showed that expression of two PPARγ target genes, CD36 and liver X receptor-α, were significantly increased. In spleen, the PPARγ immunoassay showed that rosiglitazone decreased PPARγ binding, but qPCR analysis showed no significant change. The different results obtained between PPARγ binding immunoassay and target gene expression suggest that PPARγ immunoassays may not be suitable when used with fresh homogenates of spleen and adipose tissue. Validation of the assay with each individual tissue is recommended.
Effect of PPARγ Inhibition during Pregnancy on Posterior Cerebral Artery Function and Structure
2010
Frontiers in Physiology
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., 2005) through NADPH oxidase-derived superoxide and not hypertension per se (Chan and Baumbach, 2009 ). ...
doi:10.3389/fphys.2010.00130
pmid:21423372
pmcid:PMC3059960
fatcat:lz2btkfhbrgfxgqy6fn7v2lraq
Nosocomial outbreak of COVID-19 by possible airborne transmission leading to a superspreading event
2021
Clinical Infectious Diseases
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24.1) g
Fever, 1 d post-dx Death / 119 d [7 d]
P4
F/83 h
Nil (suspected DVT) / 0 d [cubicle F corridor, 1 d] i
Dec 24, 2020 / DTS (13.4) j
Cough, 3 d pre-dx Recovered / 45 d [39 d]
P5
F/74 d
CA lung ...
doi:10.1093/cid/ciab313
pmid:33851214
fatcat:n34edl7dv5hupaebqgg2rawoqa
Oncological outcome after free jejunal flap reconstruction for carcinoma of the hypopharynx
2011
European Archives of Oto-Rhino-Laryngology
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Majority of the patients died of regional (n = 12) and systemic metastasis (n = 23), while the rest of them died from metachronous tumor (carcinoma of the lung, n = 6; carcinoma of the oral cavity, n = ...
doi:10.1007/s00405-011-1836-z
pmid:22094906
pmcid:PMC3365236
fatcat:anwuo44v6nb2nkd7v5ndkut7ha
Endocytic Adaptors in Cardiovascular Disease
2020
Frontiers in Cell and Developmental Biology
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Endocytosis is the process of actively transporting materials into a cell by membrane engulfment. Traditionally, endocytosis was divided into three forms: phagocytosis (cell eating), pinocytosis (cell drinking), and the more selective receptor-mediated endocytosis (clathrin-mediated endocytosis); however, other important endocytic pathways (e.g., caveolin-dependent endocytosis) contribute to the uptake of extracellular substances. In each, the plasma membrane changes shape to allow the
doi:10.3389/fcell.2020.624159
pmid:33363178
pmcid:PMC7759532
fatcat:z5qhy7ve6fd33fyaqpus5j3shi
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... and internalization of materials, resulting in the formation of an intracellular vesicle. While receptor-mediated endocytosis remains the best understood pathway, mammalian cells utilize each form of endocytosis to respond to their environment. Receptor-mediated endocytosis permits the internalization of cell surface receptors and their ligands through a complex membrane invagination process that is facilitated by clathrin and adaptor proteins. Internalized vesicles containing these receptor-ligand cargoes fuse with early endosomes, which can then be recycled back to the plasma membrane, delivered to other cellular compartments, or destined for degradation by fusing with lysosomes. These intracellular fates are largely determined by the interaction of specific cargoes with adaptor proteins, such as the epsins, disabled-homolog 2 (Dab2), the stonin proteins, epidermal growth factor receptor substrate 15, and adaptor protein 2 (AP-2). In this review, we focus on the role of epsins and Dab2 in controlling these sorting processes in the context of cardiovascular disease. In particular, we will focus on the function of epsins and Dab2 in inflammation, cholesterol metabolism, and their fundamental contribution to atherogenicity.
A Linear Size Index for Approximate Pattern Matching
[chapter]
2006
Lecture Notes in Computer Science
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This paper revisits the problem of indexing a text S[1..n] to support searching substrings in S that match a given pattern P [1..m] with at most k errors. A naive solution either has a worst-case matching time complexity of Ω(m k ) or requires Ω(n k ) space. Devising a solution with better performance has been a challenge until Cole et al. [5] showed an O(n log k n)-space index that can support k-error matching in O(m+occ+log k n log log n) time, where occ is the number of occurrences.
doi:10.1007/11780441_6
fatcat:ul5b4ruafjcbfmr3ul6a4skoly
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... by the indexing of DNA, we investigate in this paper the feasibility of devising a linear-size index that still has a time complexity linear in m. In particular, we give an O(n)-space index that supports k-error matching in O(m + occ + (log n) k(k+1) log log n) worst-case time. Furthermore, the index can be compressed from O(n) words into O(n) bits with a slight increase in the time complexity.
Nox2 Deficiency Prevents Hypertension-Induced Vascular Dysfunction and Hypertrophy in Cerebral Arterioles
2013
International Journal of Hypertension
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Oxidative stress is involved in many hypertension-related vascular diseases in the brain, including stroke and dementia. Thus, we examined the role of genetic deficiency of NADPH oxidase subunit Nox2 in the function and structure of cerebral arterioles during hypertension. Arterial pressure was increased in right-sided cerebral arterioles with transverse aortic banding for 4 weeks in 8-week-old wild-type (WT) and Nox2-deficient (-/y) mice. Mice were givenNG-nitro-L-arginine methyl ester
doi:10.1155/2013/793630
pmid:23573415
pmcid:PMC3612447
fatcat:ddj5orgrarcp3axmutdynfwp7i
more »
... 10 mg/kg) or vehicle to drink. We measured the reactivity in cerebral arterioles through open cranial window in anesthetized mice and wall cross-sectional area and superoxide levelsex vivo. Aortic constriction increased systolic and pulse pressures in right-sided carotid arteries in all groups of mice. Ethidium fluorescence showed increased superoxide in right-sided cerebral arterioles in WT, but not in Nox2-/y mice. Dilation to acetylcholine, but not sodium nitroprusside, was reduced, and cross-sectional areas were increased in the right-sided arterioles in WT, but were unchanged in Nox2-/y mice. L-NAME reduced dilation to acetylcholine but did not result in hypertrophy in right-sided arterioles of Nox2-/y mice. In conclusion, hypertension-induced superoxide production derived from Nox2-containing NADPH oxidase promotes hypertrophy and causes endothelial dysfunction in cerebral arterioles, possibly involving interaction with nitric oxide.
Protective roles of Cordyceps on lung fibrosis in cellular and rat models
2012
Journal of Ethnopharmacology
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We hypothesize that Cordyceps has beneficial effects on lung fibrosis and the objective of this study is to explore the target(s) of Cordyceps in the relief of lung fibrosis in animal and cell models and ...
The findings provide an insight into the preventive and therapeutic potentials of Cordyceps for the treatment of lung fibrosis. ...
12 weeks (Hui and Chan, 2006) . ...
doi:10.1016/j.jep.2012.06.033
pmid:22796203
pmcid:PMC7125542
fatcat:jzkpurovunfktopzmfzcfrjgpq
Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer
2016
International Journal of Molecular Sciences
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Non-small cell lung cancer (NSCLC) represents about 85% of the reported cases of lung cancer. ...
Introduction Non-small cell lung cancer (NSCLC) makes up about 85% of the reported cases of lung cancer. ...
This observation concurs with the inverse correlation between miR-21 expression in lung cancer tissues and response to gefitinib treatment [26] . ...
doi:10.3390/ijms17020237
pmid:26891293
pmcid:PMC4783968
fatcat:67yepbshgje5xithif4uhzjrcm
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