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Single-unit activities during epileptic discharges in the human hippocampal formation
2013
Frontiers in Computational Neuroscience
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Using microelectrodes in the hippocampal formations of 8 patients with drug-resistant temporal lobe epilepsy, we studied ID by simultaneously analyzing action potentials from individual neurons and the ...
We found that ∼30% of the units increased their firing rate during ID and 40% showed a decrease during the post-ID period. ...
This work was supported by funding from the program "Investissements d'avenir" ANR-10-IAIHU-06 and from the ICM and OCIRP. ...
doi:10.3389/fncom.2013.00140
pmid:24151464
pmcid:PMC3799238
fatcat:pdln5sjepbdinkfns6rsdxvniy
Septo-Hippocampal Networks in Chronically Epileptic Rats: Potential Antiepileptic Effects of Theta Rhythm Generation
2006
Journal of Neurophysiology
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hippocampal networks in chronically epileptic rats: potential antiepileptic effects of theta rhythm generation. ...
Theta rhythm inhibits the occurrence of epileptic discharges in the hippocampal formation in pilocarpine treated epileptic rats. A: spontaneous theta rhythm. ...
Theta rhythm inhibits the occurrence of epileptic discharges in the hippocampal formation The presence of theta rhythm in the hippocampal EEG produced a strong reduction in the frequency of hippocampal ...
doi:10.1152/jn.00040.2006
pmid:16554504
fatcat:quhisddvjzd7pj5yoqh4mdxosm
Septo-hippocampal networks in chronic epilepsy
2010
Experimental Neurology
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epileptic activity. ...
interictal spikes, (3) the discharges of those lateral septal neurons were well correlated to the hippocampal interictal spikes, (4) in contrast, the discharges of medial septal neurons were not correlated ...
Mean firing frequency in epileptic unit during theta was 2.6 AP/s. ...
doi:10.1016/j.expneurol.2009.12.010
pmid:20026111
pmcid:PMC3167385
fatcat:owht6w36vrbd7oci5twemts5ee
The Paroxysmal Depolarization Shift: Reconsidering Its Role in Epilepsy, Epileptogenesis and Beyond
2019
International Journal of Molecular Sciences
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Evidence for the roles of PDS has often been obtained from investigations of the multi-unit correlate of PDS, an electrographic spike termed "interictal" because of its occurrence during seizure-free periods ...
In this article, we give an introduction to PDS and review evidence that links PDS to pro- as well as anti-epileptic mechanisms, and to other types of neuronal dysfunction. ...
Spike frequencies were similar to those reported for discharges in lateralized periodic discharges (LPDs), which were described to arise in the terminal phase of SE in humans [127] . ...
doi:10.3390/ijms20030577
pmid:30699993
pmcid:PMC6387313
fatcat:vfg5kns3ubhmppzxbh56krqvta
Hippocampal and Entorhinal Cortex High-Frequency Oscillations (100-500 Hz) in Human Epileptic Brain and in Kainic Acid-Treated Rats with Chronic Seizures
1999
Epilepsia
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Results: Intermittent oscillatory activity ranging from 100 to 200 Hz in frequency and 50-150 ms in duration was recorded ...
Methods: Prolonged in vivo wideband recordings of electrical activity were made in hippocampus and entorhinal cortex (EC) of (a) normal rats, (b) kindled rats, (c) rats having chronic recurrent spontaneous ...
Maria Melendez kindly assisted in manuscript preparation. ...
doi:10.1111/j.1528-1157.1999.tb02065.x
pmid:9952257
fatcat:ozir4khq2fb6tjwkuycgr4tg7a
Single neuron burst firing in the human hippocampus during sleep
2002
Hippocampus
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We recorded human hippocampal single neuron activity in subjects implanted with depth electrodes required for medical diagnosis and quantitatively evaluated discharge activity from each neuron during episodes ...
Although there are numerous non-primate studies of the single neuron correlates of sleep-related hippocampal EEG patterns, very limited hippocampal neuronal data are available for correlation with human ...
Acknowledgments The authors thank A. Bragin, J. Zeitzer, and F. Lopez-Rodriguez for their helpful discussions, and T. Fields and E. Behnke for excellent technical assistance. ...
doi:10.1002/hipo.10026
pmid:12542225
fatcat:sxvicakzq5emtezekigj2mdlfy
Activity of Human Hippocampal Formation and Amygdala Neurons During Sleep
1979
Sleep
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Fine wire microelectrodes were implanted for diagnostic purposes in 17 patients suffering from psychomotor epilepsy, Single-and multiunit activity during waking and natural nocturnal slow wave sleep and ...
The firing rates of hippocampal gyrus units usually decreased during slow wave sleep and then increased to levels equal to or above waking during REM. ...
manuscript, and our patients for their active cooperation. ...
doi:10.1093/sleep/2.2.161
fatcat:q2zvxhw7dbcnzg4li6u3tehd4m
The epileptic human hippocampal cornu ammonis 2 region generates spontaneous interictal-like activity in vitro
2009
Brain
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the generation of interictal-like activity in the human epileptic cornu ammonis 2 region. ...
The dentate gyrus, the cornu ammonis 2 region and the subiculum of the human hippocampal formation are resistant to the cell loss associated with temporal lobe epilepsy. ...
Magony for the data analysis program SpikeSolution. ...
doi:10.1093/brain/awp238
pmid:19767413
fatcat:flpw6zyo7zhn3b3imzh4wr3qxq
Interaction between Seizure and Theta Rhythm
2020
Journal of Behavioral and Brain Science
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hippocampal interictal epileptiform dischargers increased with the transition from the awake state to drowsiness and a slow-wave sleep phase. ...
It is expected, that augmentation of inhibitory processes in hippocampal neurons in the course of dorsomedial hypothalamus stimulation can trigger mechanisms preventing the development of epileptiform ...
Ninelli Skhirtladze for her help in the preparation of the manuscript.
Conflicts of Interest The authors declare no conflicts of interest regarding the publication of this paper. ...
doi:10.4236/jbbs.2020.101002
fatcat:neiws7disvekpa3rn72kfyo7z4
Hippocampal Place Cells in Epileptic Rats Show Alterations in Activity: A Possible Clue to Decreased Memory Performance
2004
Epilepsy Currents
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Hippocampal place cell activity was compared with changes in learning and memory and the neuropathologic changes that occur in these animals. ...
To address the cellular concomitants of spatial memory impairment directly, we recorded the activity of place cells from CA1 in freely moving rats subjected to SE during early development and compared ...
Hippocampal place cell activity was compared with changes in learning and memory and the neuropathologic changes that occur in these animals. ...
doi:10.1111/j.1535-7597.2004.44013.x
pmid:16059484
pmcid:PMC1176356
fatcat:n7fwghchqbhx7ecrtwdtm3gmmy
Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats
1999
Neuroscience
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These findings indicate the presence of an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced afterdischarges in susceptible animals. ...
Long-term analysis of interneuronal activity in intact, drug-free rats also revealed periodic excitability changes in the hippocampal network at 0.025 Hz. ...
Acknowledgements-This work was supported by the Academy of Finland (32391) and the NIH (NS34994, MH54671). ...
doi:10.1016/s0306-4522(99)00367-x
pmid:10579564
fatcat:sohkukalyzaarbodfr3sspc33y
Hippocampus and epilepsy: Findings from human tissues
2015
Revue neurologique (Paris)
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This surgery offers the opportunity to study pathological activity in living human tissue for pharmacoresistant partial epilepsy syndromes including temporal lobe epilepsies with hippocampal sclerosis, ...
This activity is initiated, not in the hippocampus but in the subiculum an output region which projects to the entorhinal cortex. ...
Almost all work, on temporal neocortex, rather than the hippocampal formation, has concerned pharmacologically induced epileptic activities 'Epileptiform' activities in human tissue have frequently been ...
doi:10.1016/j.neurol.2015.01.563
pmid:25724711
pmcid:PMC4409112
fatcat:keilneu3ejcirpuuhgn3vewmj4
Stereotypical activation of hippocampal ensembles during seizures
2017
Brain
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Stereotypical activation of hippocampal ensembles during seizures. Brain ...
Neumann and colleagues performed extracellular local field potential (LFP) and single unit recordings in the dorsal CA1 region of the hippocampus in chronically epileptic rats. ...
Stereotypical activation of hippocampal ensembles during seizures This scientific commentary refers to 'Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic ...
doi:10.1093/brain/awx205
pmid:29050401
fatcat:usrig7qs2vekpfspkxruqb5p5y
Position- and Time-Dependent Arc Expression Links Neuronal Activity to Synaptic Plasticity During Epileptogenesis
2018
Frontiers in Cellular Neuroscience
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We conclude that during epileptogenesis epileptic activity emerges early and persists in the whole hippocampus, however, only the sclerotic part shows modulation of discharge amplitudes accompanied by ...
However, the power of these discharges steadily increased during epileptogenesis. ...
parts of the hippocampal formation. ...
doi:10.3389/fncel.2018.00244
pmid:30154698
fatcat:fic7yr7ipzdpbpp532fc3wskoq
Large-Scale Microelectrode Recordings of High-Frequency Gamma Oscillations in Human Cortex during Sleep
2010
Journal of Neuroscience
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Furthermore, it is not known whether oscillations with similar characteristics are also present in the human brain. ...
In this study, we examined the existence of gamma oscillations during polysomnographically defined sleep-wake states using large-scale microelectrode recordings (up to 56 channels), with single-cell and ...
epileptic hippocampal formations and spreading to lateral or contralateral brain regions (Fig. 1) . ...
doi:10.1523/jneurosci.5049-09.2010
pmid:20534826
pmcid:PMC3842470
fatcat:j3j5wataqrc2nnfkjvx3e4lgki
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