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Simultaneous estimation of physiological parameters and the input function - in vivo PET data

Koon-Pong Wong, D. Feng, S.R. Meikle, M.J. Fulham
<span title="">2001</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/opxxmwcvy5fnnhqoc4wtvb4etm" style="color: black;">IEEE Transactions on Information Technology in Biomedicine</a> </i> &nbsp;
We found that the input function and parameter estimates obtained with our noninvasive methods agreed well with those estimated from the gold standard method of arterial blood sampling and that rCMRGlc  ...  of the parameter estimates when we deal with data obtained from clinical studies.  ...  ACKNOWLEDGMENT The authors would like to thank the National PET/Cyclotron Center, Taipei Veterans General Hospital, Taiwan, R.O.C., for providing the brain data sets used in this paper. Hong  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/4233.908397">doi:10.1109/4233.908397</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/11300218">pmid:11300218</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4vs5ezzwbrht5b2nudfmg37k6q">fatcat:4vs5ezzwbrht5b2nudfmg37k6q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170705074239/http://ira.lib.polyu.edu.hk/bitstream/10397/1883/1/Wong_et_al_Simultaneous_Estimation_Physiological.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f4/99/f499854dfb1275693af12e2e3427a88e035935f3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/4233.908397"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice

Marco F. Taddio, Linjing Mu, Claudia Keller, Roger Schibli, Stefanie D. Krämer
<span title="2018-06-03">2018</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/r5ecdsgx3bafnpd5wn625laa2i" style="color: black;">Contrast Media &amp; Molecular Imaging</a> </i> &nbsp;
Physiologically based pharmacokinetic modelling (PBPK) is a powerful tool to predict in vivo pharmacokinetics based on physiological parameters and data from in vivo studies and in vitro assays.  ...  We evaluated the feasibility of PBPK modelling with PET data from mice. We used data from two of our PET tracers under development, [11C]AM7 and [11C]MT107.  ...  Conflicts of Interest The authors declare that there are no conflicts of interest regarding the publication of this article.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2018/5849047">doi:10.1155/2018/5849047</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29967572">pmid:29967572</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6008768/">pmcid:PMC6008768</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hvzirlzsrnaalh5whywxkqzpoy">fatcat:hvzirlzsrnaalh5whywxkqzpoy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200305140630/https://www.zora.uzh.ch/id/eprint/158650/1/5849047.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5c/65/5c65e13d2a948fbc20de6577212d267451114f52.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2018/5849047"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008768" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A technique for extracting physiological parameters and the required input function simultaneously from PET image measurements: theory and simulation study

Dagan Feng, Koon-Pong Wong, Chi-Ming Wu, Wan-Chi Siu
<span title="">1997</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/opxxmwcvy5fnnhqoc4wtvb4etm" style="color: black;">IEEE Transactions on Information Technology in Biomedicine</a> </i> &nbsp;
In this paper, a technique is proposed to extract the input function together with the physiological parameters from the brain dynamic images alone.  ...  However, quantitative studies using tracer kinetic modeling require the measurement of the tracer time-activity curve in plasma (PTAC) as the model input function.  ...  INTRODUCTION T HE USE of the tracer kinetic modeling technique in positron emission tomography (PET) enables quantification of physiological and biochemical processes in humans in vivo.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/4233.681168">doi:10.1109/4233.681168</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/11020827">pmid:11020827</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tj2md3huhrfhreuv7gc4q7nili">fatcat:tj2md3huhrfhreuv7gc4q7nili</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810220442/http://ira.lib.polyu.edu.hk/bitstream/10397/1879/1/Feng_et_al_Extracting_Physiological_Parameters.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c9/c2/c9c2559597a9e377999694f1700e3f5885a4cb9e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/4233.681168"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Flexible numerical simulation framework for dynamic PET-MR data

Johannes Mayer, Richard Brown, Kris Thielemans, Evgueni Ovtchinnikov, Edoardo Pasca, David Atkinson, Ashley Gillman, Paul Marsden, Matteo Ippoliti, Marcus Makowski, Tobias Schaeffter, Christoph Kolbitsch
<span title="2020-07-21">2020</span> <i title="IOP Publishing"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zuggg3zvsfaatpw6invuoevl7a" style="color: black;">Physics in Medicine and Biology</a> </i> &nbsp;
To closely emulate medical examination, input and output of the simulation are files in standardised open-source raw data formats.  ...  This enables the use of existing raw data as a template input and ensures seamless integration of the output into existing reconstruction pipelines.  ...  Acknowledgment The authors gratefully acknowledge funding from the German Research Foundation (GRK 2260 BIOQIC and DFGCRC 1340 Matrix in Vision) and the Computational Collaborative Project in Synergistic  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1088/1361-6560/ab7eee">doi:10.1088/1361-6560/ab7eee</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32692725">pmid:32692725</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/si5so36q2na5plub62kqndaejq">fatcat:si5so36q2na5plub62kqndaejq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201107051650/https://discovery.ucl.ac.uk/id/eprint/10106457/1/Mayer_2020_Phys._Med._Biol._65_145003.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/73/17/73170ef9053b8bb5752a99af7694afa0f630c60e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1088/1361-6560/ab7eee"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> iop.org </button> </a>

Estimation of input function and kinetic parameters using simulated annealing: application in a flow model

Koon-Pong Wong, S.R. Meikle, Dagan Feng, M.J. Fulham
<span title="">2002</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/irkebyewo5dzlfovel4fhqmk34" style="color: black;">IEEE Transactions on Nuclear Science</a> </i> &nbsp;
We conclude that simulated annealing reduces bias in the estimation of physiological parameters and determination of the input function.  ...  A nonlinear least squares method estimated all the parameters in the impulse response functions and the input function but failed occasionally due to high noise levels in the data, causing an ill-conditioned  ...  The simultaneous estimation (SIME) method estimates parameters in the tissue's impulse response functions (IRFs) and the input function simultaneously and requires one or two blood samples for scaling  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tns.2002.1039552">doi:10.1109/tns.2002.1039552</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zl2fhfn2jjdj7dqaqvtimwvatq">fatcat:zl2fhfn2jjdj7dqaqvtimwvatq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170705074225/http://ira.lib.polyu.edu.hk/bitstream/10397/1877/1/Wong_et_al_Estimation_Function_Parameters.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/54/60/546048d85028d45421f61cb2d569151459deec4c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tns.2002.1039552"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Kinetic modelling in small animal imaging with PET

Patrick Dupont, James Warwick
<span title="">2009</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3jmevtg2ajcdnpgyntimblv7iu" style="color: black;">Methods</a> </i> &nbsp;
At the moment there are still several issues which need further research and evaluation before we can fully employ the possibilities of PET as an in-vivo measurement of underlying molecular biology.  ...  The focus has shifted from detection of tracer uptake and visualization of the tracer distribution towards the quantification of the physiological parameters necessary to use this technique for kinetic  ...  Effect of noise, reconstruction, . . . on the parameter estimates Robustness and accuracy of the model Comparison with ex-vivo data, in-vivo data and histology Interpretation of the parameters Quality  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ymeth.2009.03.008">doi:10.1016/j.ymeth.2009.03.008</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19318124">pmid:19318124</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/y5py6kyxcjdtxnebv7bse3wueu">fatcat:y5py6kyxcjdtxnebv7bse3wueu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170812010309/http://gbiomed.kuleuven.be/english/research/50000666/50488664/pdf/2009-dupont-methods.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4c/b4/4cb4e7974c72410639b2201608e5106df07cdfc7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ymeth.2009.03.008"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Bringing Physiology into PET of the Liver

S. Keiding
<span title="2012-02-09">2012</span> <i title="Society of Nuclear Medicine"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/es34xtfdxrgybg2kmdq2n5xqry" style="color: black;">Journal of Nuclear Medicine</a> </i> &nbsp;
The portal vein is inaccessible in humans, and methods of estimating the dual-input time-activity curve without portal vein measurements are being developed.  ...  The use of a flow-weighted dual-input time-activity curve is of importance for the estimation of hepatic blood perfusion through initial dynamic PET recording.  ...  ACKNOWLEDGMENTS This study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK074419).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.111.100214">doi:10.2967/jnumed.111.100214</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22323781">pmid:22323781</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3387357/">pmcid:PMC3387357</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/prwaepsprnfyzgqybk2j4smaua">fatcat:prwaepsprnfyzgqybk2j4smaua</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190218063215/http://pdfs.semanticscholar.org/09bb/9de1b2b4d9f1c9362fc2b8aa54cd43284a46.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/09/bb/09bb9de1b2b4d9f1c9362fc2b8aa54cd43284a46.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.111.100214"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387357" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Model-based receptor quantization analysis for PET parametric imaging

Z.J. Wang, Peng Qiu, K.J. Ray Liu, Z. Szabo
<span title="">2005</span> <i title="IEEE"> 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference </i> &nbsp;
To obviate the need for the input function or a reference region, in this paper, we propose to estimate the input function and the kinetic parameters simultaneously.  ...  Dynamic PET (positron emission tomography) imaging technique allows image-wide quantification of physiologic and biochemical parameters.  ...  AA11653 and NIH grant No. AG14400.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/iembs.2005.1615835">doi:10.1109/iembs.2005.1615835</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17281605">pmid:17281605</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2045696/">pmcid:PMC2045696</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3vjbnon4w5ehrinvgpyhmrrjyy">fatcat:3vjbnon4w5ehrinvgpyhmrrjyy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810154445/http://pengqiu.gatech.edu/pdf/EMBS05_PET.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ab/68/ab680b053cc7c924162e0c8fd66e1c501d1fac56.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/iembs.2005.1615835"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045696" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

PET/MRI for Neurologic Applications

C. Catana, A. Drzezga, W.-D. Heiss, B. R. Rosen
<span title="2012-11-09">2012</span> <i title="Society of Nuclear Medicine"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/es34xtfdxrgybg2kmdq2n5xqry" style="color: black;">Journal of Nuclear Medicine</a> </i> &nbsp;
PET and MRI provide complementary information in the study of the human brain.  ...  On the PET side, we discuss methods that use the simultaneously acquired MRI data to improve the PET data quantification.  ...  In the study of physiologic brain function, simultaneous acquisition may allow improved in vivo assessment and cross-correlation of several neuropsychologic events, such as changes in hemodynamics, including  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.112.105346">doi:10.2967/jnumed.112.105346</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23143086">pmid:23143086</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3806202/">pmcid:PMC3806202</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rkgav3fkpfg45k7bx4ftaayahy">fatcat:rkgav3fkpfg45k7bx4ftaayahy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190222221551/http://pdfs.semanticscholar.org/3d73/759d806534c3b725ce1e747b9dbf71ba1c02.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3d/73/3d73759d806534c3b725ce1e747b9dbf71ba1c02.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2967/jnumed.112.105346"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806202" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

PET kinetic analysis—compartmental model

Hiroshi Watabe, Yoko Ikoma, Yuichi Kimura, Mika Naganawa, Miho Shidahara
<span title="">2006</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ui2z37jirnhjrpnshuudq6ju4m" style="color: black;">Annals of Nuclear Medicine</a> </i> &nbsp;
PET enables not only visualization of the distribution of radiotracer, but also has ability to quantify several biomedical functions. Compartmental model is a basic idea to analyze dynamic PET data.  ...  We also discussed advanced applications of the compartmental analysis with PET.  ...  in vivo using PET.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/bf02984655">doi:10.1007/bf02984655</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17294668">pmid:17294668</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6frmjdhocjb6dirgutyeouq6je">fatcat:6frmjdhocjb6dirgutyeouq6je</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170809112348/http://www7a.biglobe.ne.jp/~ukimura/Software/Watabe-Survey-ANM06.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2b/bd/2bbdb65928e6d73c975b1e2a7ac85c08397cb552.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/bf02984655"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Noninvasive quantitation of cerebral blood flow using oxygen-15-water and a dual-PET system

H Iida, S Miura, Y Shoji, T Ogawa, H Kado, Y Narita, J Hatazawa, S Eberl, I Kanno, K Uemura
<span title="">1998</span> <i title="Society of Nuclear Medicine"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/es34xtfdxrgybg2kmdq2n5xqry" style="color: black;">Journal of Nuclear Medicine</a> </i> &nbsp;
Measurement of the arterial input function is essential for quantitative assessment of physiological function in vivo using PET.  ...  Recently, a PET system has been developed that consists of two independent PET tomographs for simultaneously scanning the brain and heart, which should avoid the need for arterial blood sampling.  ...  physiological function in vivo using PET.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/9776289">pmid:9776289</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gjmsfeo4ergwtbfy6bxp5azwsi">fatcat:gjmsfeo4ergwtbfy6bxp5azwsi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200318130711/http://jnm.snmjournals.org/content/39/10/1789.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/53/34/53346b69767eb2850f5f5e3e22dc88d075fb8a1e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a>

Simultaneous multiagent hyperpolarized13C perfusion imaging

Cornelius von Morze, Robert A. Bok, Galen D. Reed, Jan Henrik Ardenkjaer-Larsen, John Kurhanewicz, Daniel B. Vigneron
<span title="2013-12-31">2013</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/34p2n5u2vjfgrf7j2rmkmfhogu" style="color: black;">Magnetic Resonance in Medicine</a> </i> &nbsp;
We exploited the varying bilayer permeability of these tracers to quantify vascular permeability and perfusion parameters simultaneously, using perfusion modeling methods that were investigated in simulations  ...  , and [ 13 C]t-butanol) and correspondingly variable chemical shifts and physiological characteristics, and to exploit their varying diffusibility for simultaneous measurement of vascular permeability  ...  Acknowledgments We gratefully acknowledge the assistance of Mark Van Criekinge, Christine Leon Swisher, and Ilwoo Park with experiments in this study.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/mrm.25071">doi:10.1002/mrm.25071</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24382698">pmid:24382698</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4077988/">pmcid:PMC4077988</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/oh3fmpdt2vfejj2zi6wff7reky">fatcat:oh3fmpdt2vfejj2zi6wff7reky</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200206072450/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4077988&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4a/ef/4aef9dd49f49fca3bc3f612e9e17849284bc7fd3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/mrm.25071"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077988" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Mixture principal component analysis for distribution volume parametric imaging in brain PET studies

Peng Qiu, Z.Jane Wang, K.J. Ray Liu
<span title="">2006</span> <i title="IEEE"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qcepwfkflvg5toaa6fh2alj3b4" style="color: black;">3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 2006.</a> </i> &nbsp;
Second, the proposed mPCA-based classification approach is incorporated as the clustering preprocessing into our earlier work [4] to simultaneously estimate the DV parametric image and the input function  ...  The efficiency and superiority of the proposed scheme is demonstrated by real brain PET data.  ...  ACKNOWLEDGEMENT The authors are grateful to Dr. Zsolt Szabo and his group members for providing us with the data, and helpful discussions and support.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/isbi.2006.1625071">doi:10.1109/isbi.2006.1625071</a> <a target="_blank" rel="external noopener" href="https://dblp.org/rec/conf/isbi/QiuWL06.html">dblp:conf/isbi/QiuWL06</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3kud5v7xrvhc3pbk2a3nj3dei4">fatcat:3kud5v7xrvhc3pbk2a3nj3dei4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20100605121547/http://www.cspl.umd.edu/sig/publications/Qiu_ISBI_200604.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7f/b9/7fb9b23940e913417ec6061cc919c0a1393ea992.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/isbi.2006.1625071"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Noninvasive Quantification of the Differential Portal and Arterial Contribution to the Liver Blood Supply From PET Measurements Using the$^11$C-Acetate Kinetic Model

S. Chen, D. Feng
<span title="">2004</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nrcoa2vuhjcvfctty6zgus57um" style="color: black;">IEEE Transactions on Biomedical Engineering</a> </i> &nbsp;
An extra parameter was included in the model input function to describe the contribution of PV to the liver.  ...  Index Terms-Dual-input function, noninvasive measurement, parameter estimation, positron emission tomography (PET), tracer kinetic modeling.  ...  Ho, Director of the Department of Nuclear Medicine & Positron Emission Tomography, Hong Kong Sanatorium and Hospital, for his kindly support.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tbme.2004.828032">doi:10.1109/tbme.2004.828032</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15376506">pmid:15376506</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4aidghrbr5etlendl6fv3haf4u">fatcat:4aidghrbr5etlendl6fv3haf4u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200319153821/http://ira.lib.polyu.edu.hk/bitstream/10397/1876/1/Chen_Feng_Portal_Arterial_Contribution.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1a/3f/1a3fb995ece5fd3fa14bf78dd92f157306dd45b8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tbme.2004.828032"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

A factor-image framework to quantification of brain receptor dynamic PET studies

Z.J. Wang, Z. Szabo, Peng Lei, J. Varga, K.J. Ray Liu
<span title="">2005</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gkn2pu46ozb4tmkxczacnmtvkq" style="color: black;">IEEE Transactions on Signal Processing</a> </i> &nbsp;
Radioligand kinetic parameters are estimated together with the input function.  ...  Real brain PET data are also examined, and good performance is observed in determining the TACs and the underlying factor images.  ...  Estimated factor TACs in brain PET study in the case of known (i.e., measured) (top) input function and (bottom) the case of input function estimated simultaneously with the kinetic parameters.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tsp.2005.853149">doi:10.1109/tsp.2005.853149</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18769527">pmid:18769527</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2185066/">pmcid:PMC2185066</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j5btkf25p5fvlcw5nuv3i2tjja">fatcat:j5btkf25p5fvlcw5nuv3i2tjja</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20110708111351/http://www.ece.ubc.ca:80/~zjanew/journal/ZJW_TSP_PET_16.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/12/b3/12b3a8a5dc86608e0a77762eb9fb5dcdf01890b4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/tsp.2005.853149"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185066" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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