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Designing and Comparing Optimised Pseudo-Continuous Arterial Spin Labelling Protocols for Measurement of Cerebral Blood Flow [article]

Joseph G Woods, Michael A Chappell, Thomas W Okell
<span title="2020-03-03">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
One of the novel hybrid protocols, HybridT1-adj, was found to produce the most confident, accurate and repeatable CBF estimates of all protocols tested in both simulations and in vivo (24%, 47%, and 28%  ...  and sequential multi-timepoint protocols, were first optimised using a Cram&eacuter-Rao Lower Bound framework and then compared for CBF accuracy and repeatability using Monte Carlo simulations and in  ...  This approach gives a more conservative standard error than would be calculated from 14 the combined voxelwise data across subjects due to the large number of voxels. 15 17 The optimised timings for  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.03.02.973537">doi:10.1101/2020.03.02.973537</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qpkxptf6cbgupheu2pvqv5iv74">fatcat:qpkxptf6cbgupheu2pvqv5iv74</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200314232250/https://www.biorxiv.org/content/biorxiv/early/2020/03/03/2020.03.02.973537.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.03.02.973537"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia

Richard G. Wise, Ashley D. Harris, Alan J. Stone, Kevin Murphy
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
The combined approach to oxygen and carbon dioxide modulation, as well as taking less time to acquire data, yielded whole brain grey matter estimates of CMRO 2 and OEF of 184±45 μmol/100g/min and 0.42±  ...  The interleaved approach to hypercapnia and hyperoxia, as well as yielding estimates of CMRO 2 and OEF demonstrated a significant increase in regional CBF, venous oxygen saturation (SvO 2 ) (a decrease  ...  For global grey matter our OEF estimates lay in the range 0.37-0.50 for the interleaved protocol and 0.36-0.42 for the combined protocol, these ranges being closer to those reported in PET studies ( (Leenders  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2013.06.008">doi:10.1016/j.neuroimage.2013.06.008</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23769703">pmid:23769703</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4151288/">pmcid:PMC4151288</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/m6u2exkmnvgnxfk2o325f4xi5m">fatcat:m6u2exkmnvgnxfk2o325f4xi5m</a> </span>
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Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity

M. Germuska, H.L. Chandler, R.C. Stickland, C. Foster, F. Fasano, T.W. Okell, J. Steventon, V. Tomassini, K. Murphy, R.G. Wise
<span title="2018-09-29">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen consumption (CMRO2  ...  The effective oxygen diffusivity was found to be highly correlated with CMRO2 during rest and activation, consistent with previous PET observations of a strong correlation between metabolic oxygen demand  ...  Acknowledgements We would like to thank Wellcome for supporting this work: Wellcome Strategic Award, 'Multi-scale and multi-modal assessment of coupling in the healthy and diseased brain', grant reference  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2018.09.035">doi:10.1016/j.neuroimage.2018.09.035</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30278214">pmid:30278214</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6264385/">pmcid:PMC6264385</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tv6vrusuhvgkbgz6sirnglkzci">fatcat:tv6vrusuhvgkbgz6sirnglkzci</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190427081718/http://orca.cf.ac.uk/115997/1/1-s2.0-S1053811918308206-main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/58/6b/586b2e28cf77fa29f50ca9b7f964b71fae0e91c8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2018.09.035"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264385" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Clinical radionuclide therapy dosimetry: the quest for the "Holy Gray"

B. Brans, L. Bodei, F. Giammarile, O. Linden, M. Luster, W. J. G. Oyen, J. Tennvall
<span title="2007-02-01">2007</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5i3tlebejzfxfoahy2rzxggcz4" style="color: black;">European Journal of Nuclear Medicine and Molecular Imaging</a> </i> &nbsp;
The recent developments in PET and PET/CT imaging, including micro-devices for animal research, and molecular medicine provide major challenges for innovative therapy and dosimetry techniques.  ...  Data in the literature which underscore the potential of dosimetry to avoid under-and overdosing and to standardise radionuclide therapy methods internationally are very scarce.  ...  The advantage is that there is no need for planning/simulation in this high-dose protocol, which may increase in importance if multiple centres participate.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00259-006-0338-5">doi:10.1007/s00259-006-0338-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17268773">pmid:17268773</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1914264/">pmcid:PMC1914264</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/t6lo2ymmlbetvazafz4j6mtxqa">fatcat:t6lo2ymmlbetvazafz4j6mtxqa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171010190207/http://publisher-connector.core.ac.uk/resourcesync/data/Springer-OA/pdf/305/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjEwMDcvczAwMjU5LTAwNi0wMzM4LTUucGRm.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0b/8f/0b8fb79f595e79852ad4cf155b5e7e40426de69a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00259-006-0338-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914264" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging

Roberto Sciagrà, Cardiovascular Committee of the European Association of Nuclear Medicine (EANM), Mark Lubberink, Fabien Hyafil, Antti Saraste, Riemer H. J. A. Slart, Denis Agostini, Carmela Nappi, Panagiotis Georgoulias, Jan Bucerius, Christoph Rischpler, Hein J. Verberne
<span title="2020-11-02">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5i3tlebejzfxfoahy2rzxggcz4" style="color: black;">European Journal of Nuclear Medicine and Molecular Imaging</a> </i> &nbsp;
Together with the many steps necessary for the correct execution of quantitative measurements, the importance of a multiparametric approach and of a comprehensive and clinically useful report have been  ...  convincingly demonstrated the advantages of this imaging approach.  ...  Polar maps are based on the same simulated MBF scans for both cases.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00259-020-05046-9">doi:10.1007/s00259-020-05046-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33135093">pmid:33135093</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jcxaeshrqbd6vil72pfqgzyfgm">fatcat:jcxaeshrqbd6vil72pfqgzyfgm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210428212258/https://link.springer.com/content/pdf/10.1007/s00259-020-05046-9.pdf?error=cookies_not_supported&amp;code=37545a61-b268-4294-9ee1-a1ee95e1caa1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d5/28/d528ff6c7d0335b4743590826acb5d33d163af4f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00259-020-05046-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Hierarchical Bayesian myocardial perfusion quantification

Cian M. Scannell, Amedeo Chiribiri, Adriana D.M. Villaa, Marcel Breeuwer, Jack Lee
<span title="2019-11-09">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kpkfymbkufcnzjfc5ydyokby4y" style="color: black;">Medical Image Analysis</a> </i> &nbsp;
This is due to the complexity of the models relative to the observed data which is limited by the low signal-to-noise ratio, the temporal resolution, the length of the acquisitions and other complex imaging  ...  In this work, a Bayesian inference scheme is proposed which allows the reliable estimation of the parameters of the two-compartment exchange model from myocardial perfusion MR data.  ...  Acknowledgements Conflict of Interest None  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.media.2019.101611">doi:10.1016/j.media.2019.101611</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31760191">pmid:31760191</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uohszesulfbobelljjqs7vmm4m">fatcat:uohszesulfbobelljjqs7vmm4m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427212637/https://kclpure.kcl.ac.uk/ws/files/118821886/Hierarchical_Bayesian_myocardial_perfusion_SCANNELL_Accepted8November2019Publishedonline9November2019_GREEN_AAM_CC_BY_NC_ND_.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/61/a1/61a1154a8adf2d49f498e1a65c34fac0f010229d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.media.2019.101611"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

In SilicoModelling of Treatment-Induced Tumour Cell Kill: Developments and Advances

Loredana G. Marcu, Wendy M. Harriss-Phillips
<span title="">2012</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xytabl7eh5a5lle2ofnetovd7u" style="color: black;">Computational and Mathematical Methods in Medicine</a> </i> &nbsp;
Fractionated radiotherapy, chemotherapy, and combined therapies are reviewed, providing a comprehensive overview of the modelling literature for current modellers and radiobiologists to ignite the interest  ...  parameters used to describe the tumour system, and treatment modality applied, as well as reported outcomes from simulations.  ...  This direct input is used in some model as an alternative to simulating the tumour growth process, and rather the tumour is created at full size based on clinical data, ready for treatment simulation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2012/960256">doi:10.1155/2012/960256</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22852024">pmid:22852024</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3407630/">pmcid:PMC3407630</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zkcstoml6jdw5poflatfdg2upe">fatcat:zkcstoml6jdw5poflatfdg2upe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190502081311/http://downloads.hindawi.com/journals/cmmm/2012/960256.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/db/d4/dbd489dd97f8e36bd1fefabb0c641c8fe3d02364.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2012/960256"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407630" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A streamlined acquisition for mapping baseline brain oxygenation using quantitative BOLD

Alan J. Stone, Nicholas P. Blockley
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
In a healthy subject group (n = 7) apparent elevations in R 2 ′ caused by partial volumes of CSF were shown to be reduced with the application of CSF nulling.  ...  Here we propose a refinement of the qBOLD methodology, dubbed streamlined-qBOLD, in order to provide a clinically feasible method for mapping baseline brain oxygenation.  ...  Here we adapt this approach to optimise the acquisition of multi-τ-weighted ASE data for the measurement of R 2 ′.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2016.11.057">doi:10.1016/j.neuroimage.2016.11.057</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27915118">pmid:27915118</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2vxvknxuzrc27cqnpg4n7pgfhi">fatcat:2vxvknxuzrc27cqnpg4n7pgfhi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201108072119/https://ora.ox.ac.uk/objects/uuid:b12bd419-58a0-4de5-9d31-7843671abfdf/download_file?safe_filename=Stone_Blockley_2017.pdf&amp;file_format=application%2Fpdf&amp;type_of_work=Journal+article" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7c/a8/7ca86ec4ee4bd850e6744f132c2b095651af5561.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2016.11.057"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a>

A review of 3D first-pass, whole-heart, myocardial perfusion cardiovascular magnetic resonance

Merlin J. Fair, Peter D. Gatehouse, Edward V. R. DiBella, David N. Firmin
<span title="2015-08-01">2015</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jflzecjifjfnzmksqbreqnmoo4" style="color: black;">Journal of Cardiovascular Magnetic Resonance</a> </i> &nbsp;
An attempt is made to explain, rather than simply state, the varying methods with the hope that it will give an appreciation of the different components making up a 3D FPP protocol.  ...  Following a summary of the parameters typically desired of 3D FPP methods, the review explains the mechanisms of key acceleration techniques and their potential use in FPP for attaining 3D acquisitions  ...  "Self consistency" is one such approach; optimising together ("joint estimation") the reconstruction of the image and estimation of the coil calibration data, called SPIRiT [82] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12968-015-0162-9">doi:10.1186/s12968-015-0162-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26231784">pmid:26231784</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4522116/">pmcid:PMC4522116</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/46jfox2n4bgvvgzcwenlsn5iou">fatcat:46jfox2n4bgvvgzcwenlsn5iou</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170825215302/https://link.springer.com/content/pdf/10.1186%2Fs12968-015-0162-9.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/67/6d/676d5b454da872d48dc9b29821841d2a0f023434.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12968-015-0162-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522116" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

ECR 2014, Part D

<span title="2014-02-27">2014</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5pgrqns2fjcohbjg75bidocc3y" style="color: black;">Insights into Imaging</a> </i> &nbsp;
Stöblen; Essen/DE Purpose: Visualisation of suspicious lesions in breast MRT for the MR-steered biopsy utilising an optimised contrasting protocol.  ...  The present study seeks to establish a protocol that provides the best possible diagnostic value in interventional contrast MRT-based breast lesion biopsy evaluation.  ...  However the potential for dose reduction when using statistically based iterative reconstruction on already dose optimised protocols is limited and the resulting images are still noisy.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s13244-014-0319-3">doi:10.1007/s13244-014-0319-3</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24573561">pmid:24573561</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3948180/">pmcid:PMC3948180</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hkued6wv2zduxpkzzlslgjr3nq">fatcat:hkued6wv2zduxpkzzlslgjr3nq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170922060704/https://link.springer.com/content/pdf/10.1007%2Fs13244-014-0319-3.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3c/5a/3c5a9c79b1c9a8a68edb26553e6413a4f295217d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s13244-014-0319-3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948180" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Detectors in Medicine and Biology [chapter]

P. Lecoq
<span title="">2020</span> <i title="Springer International Publishing"> Particle Physics Reference Library </i> &nbsp;
Such algorithms iterate a process aiming at optimising an objective function, for instance the verisimilitude function coming from the Poissonian nature of the data recorded by the tomograph.  ...  Monte Carlo simulation is often a key element to study and optimise these algorithms.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-3-030-35318-6_20">doi:10.1007/978-3-030-35318-6_20</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bdn4xmlq6fgztkuomy7jbtcwzm">fatcat:bdn4xmlq6fgztkuomy7jbtcwzm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201108135712/https://link.springer.com/content/pdf/10.1007%2F978-3-030-35318-6_20.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d0/30/d030be21242533421440ef0126010359c2f8bf65.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-3-030-35318-6_20"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

How rapid advances in imaging are defining the future of precision radiation oncology

Laura Beaton, Steve Bandula, Mark N. Gaze, Ricky A. Sharma
<span title="2019-03-26">2019</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/k7cos7qqgzazliffoxrrx3awka" style="color: black;">British Journal of Cancer</a> </i> &nbsp;
radiotherapy planning process, and how these advances have the potential to allow a more individualised approach to the cancer therapy.  ...  Recent data suggest that imaging biomarkers that assess underlying tumour heterogeneity can identify areas within a tumour that are at higher risk of radio-resistance, and therefore potentially allow for  ...  An alternative approach is to create a library of plans for each treatment course, and to then select the 'optimal' plan based on the current imaging.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41416-019-0412-y">doi:10.1038/s41416-019-0412-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30911090">pmid:30911090</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6474267/">pmcid:PMC6474267</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/msz3bql245addmy6e77afzmrwa">fatcat:msz3bql245addmy6e77afzmrwa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200510065317/https://www.nature.com/articles/s41416-019-0412-y.pdf?error=cookies_not_supported&amp;code=0ec1072d-d871-4c36-9443-31bfc2f0fa66" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/07/b1/07b16a17bb0340629b3ccbf199dd5636d4927851.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41416-019-0412-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474267" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Simultaneous photoradiochemical labelling of antibodies for immuno-PET

Malay Patra, Simon Klingler, Larissa S. Eichenberger, Jason P. Holland
<span title="2019-03-07">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5u6jlpnlzndwrequnssxehzurq" style="color: black;">iScience</a> </i> &nbsp;
A standard two-step approach gave a measured conjugation efficiency of 3.5% ± 0.4%. In contrast, the one-step process gave a higher photoradiolabeling efficiency of ∼76%.  ...  Experimental data support the conclusion that the combination of photochemistry and radiochemistry is a viable strategy for producing radiolabeled proteins for imaging and therapy.  ...  Data presented are based on quantification of the PET images in units of SUVmean.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.isci.2019.03.004">doi:10.1016/j.isci.2019.03.004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30903963">pmid:30903963</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6430723/">pmcid:PMC6430723</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hovdsz54kvekxnwj4ewsllau7y">fatcat:hovdsz54kvekxnwj4ewsllau7y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200207191822/https://www.zora.uzh.ch/id/eprint/170478/1/iscience_2019.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8e/7d/8e7d4bedf6467317da542b57112961eaad2232d2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.isci.2019.03.004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430723" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Rational Protein Engineering to Increase the Activity and Stability of IsPETase Using the PROSS Algorithm

Andrew Rennison, Jakob R. Winther, Cristiano Varrone
<span title="2021-11-10">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ma7srn4ogzduvotoi5tuhzgngu" style="color: black;">Polymers</a> </i> &nbsp;
Currently, re-moulding is the main path for PET recycling, but this eventually leads to an unsustainable loss of quality; thus, other means of recycling are required.  ...  In the present study, we have used sequence and structure-based bioinformatic tools to identify mutations to increase the thermal stability of the enzyme so as to increase PET degradation activity during  ...  students at the Linderstrøm-Lang Centre for Protein Science, Section for Biomolecular Sciences, Department of Biology, University of Copenhagen.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/polym13223884">doi:10.3390/polym13223884</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34833182">pmid:34833182</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8621346/">pmcid:PMC8621346</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mvnvgpsj3jhzvcocm5pvtgvh6m">fatcat:mvnvgpsj3jhzvcocm5pvtgvh6m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220502112722/https://mdpi-res.com/d_attachment/polymers/polymers-13-03884/article_deploy/polymers-13-03884.pdf?version=1636547415" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3f/cc/3fcc6449735060dabac93c81f0f8a7d8d2c38c01.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/polym13223884"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621346" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Ion and Neutron Beams Discover New Facts from History

Anna Macková, Jan Kučera, Jan Kameník, Vladimír Havránek, Karel Kranda
<span title="2017-10-02">2017</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/owfts7oirngkddk3b7kqhywdae" style="color: black;">Nuclear Physics News</a> </i> &nbsp;
Simulated data are also cardinal to test and optimise new techniques for data correction, image reconstruction, reconstruction of the interaction position within a detector, etc.  ...  For passively scattered beams, treatment plan optimisation is mostly based on human intelligence and a manual trial and error process.  ...  This has made PET a very important tool in the discovery, development and approval process of modern pharmaceuticals.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/10619127.2017.1388686">doi:10.1080/10619127.2017.1388686</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nxj4nqnfvfc4vbslelb67hauhe">fatcat:nxj4nqnfvfc4vbslelb67hauhe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722042337/http://www.nupecc.org/npmed/npmed2014_hires.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2f/77/2f77a42a345f6d2f7b9ba3d4e0e5dc8176492aa8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/10619127.2017.1388686"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> tandfonline.com </button> </a>
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