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A Brief History of Protein Sorting Prediction
2019
The Protein Journal
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Because the secretory pathway was the first one to be studied both experimentally and through bioinformatics, our main focus is on the historical development of prediction methods for signal peptides that ...
Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides has been a focus point of research. ...
In particular, there is still room for major improvements in signal-based multi-category location methods that can sort proteins between multiple cellular locations with high reliability through modeling ...
doi:10.1007/s10930-019-09838-3
pmid:31119599
pmcid:PMC6589146
fatcat:cufi3rynanfjxntr76b77lhfwq
Computational prediction of secreted proteins in gram-negative bacteria
2021
Computational and Structural Biotechnology Journal
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classified the secreted proteins according to the types of secretion systems in Gram-negative bacteria, summarized the known features of these proteins, and reviewed the algorithms and tools for their prediction ...
-3L 3.0
Attention Deep Learning; Window-Based Scoring
Sec/SPI; Cleavage site
http://www.csbio.sjtu.edu.cn/bioinf/Signal-
3L;
Table 4 4 Representative software tools predicting substrates of T1~9SSs ...
Signal-3L 3.0, a model using a 3-layer hybrid method of integrating deep learning algorithms and window-based scoring, showed better performance in prediction of Sec/SPI SPs of gram-negative bacteria but ...
doi:10.1016/j.csbj.2021.03.019
pmid:33897982
pmcid:PMC8047123
fatcat:xvj4vcrnujbpzgzx3ait62s2dy
Yoga and its impact on chronic inflammatory autoimmune arthritis
2021
Frontiers in Bioscience (Elite Edition)
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Interactions between the T cell receptor (TCR) and MHC class II-peptide antigen with co-stimulation through CD28-CD80/86 pathway leads to the activation of CD4+ T cells via antigenpresenting cells (APCs ...
Application of the newly revised standards yields a score of 0-10, with a score of ≥6 fulfilling the requirements for definite RA. ...
doi:10.2741/873
fatcat:7fj7g3efcna2dlaeirmbqddzq4
Asia Pacific Stroke Conference 2016. Abstracts of the Annual Conference of theAsia Pacific Stroke Organization (APSO) Combined with Stroke Society of Australasia, Brisbane, Qld., Australia, July 14-17, 2016: Abstracts
2016
Cerebrovascular Diseases
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Gastrodin had significantly improved the neurologic functions in rats. The infarct volume of dose group rats was significantly different compared with that of control group (P = 0.044). ...
The primary outcome measure was Motor Assessment Scale item 6 (upper arm function, MAS-6) at post-intervention, with a score of >1 point change classified as a minimal clinically important difference ( ...
Conclusion: As motor learning and visual attention requires intact cholinergic signaling, we hypothesize that a disruption in cholinergic signaling is contributing to these impairments. ...
doi:10.1159/000447732
pmid:27409083
fatcat:npg6lu4kgzherj7oa5aaory3lq
Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients
2020
BMC Proceedings
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Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality. ...
Acknowledgements MRM was supported by the FCT fellowship PD/BD/128215/2016. iNOVA4Health -UID/Multi/04462/2019, a program financially supported by FCT-MES, through national funds and co-funded by FEDER ...
Kamen (National Research Council of Canada) for kindly providing the HEK293 cells, which this work was performed with. ...
doi:10.1186/s12919-020-00188-y
fatcat:6kscifx565appmxq57svl42biy
2021 Midwest Clinical and Translational Research Meeting of CSCTR and MWAFMR
2021
Journal of Investigative Medicine
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Score ROC-Validation Cohort Abstract 20 Figure 1 Tc-99m pyrophosphate scintigraphy Positive and Negative Tc-99m pyrophosphate scans Abstracts 1072 ...
showing a large anterior mediastinal mass Abstract 14 Figure 3 Anterior mediastinal mass CT chest, axial view, showing a large anterior mediastinal mass Abstracts 1070 Abstract 2 Figure 1 Amyloidosis Prediction ...
The utility of this prediction score for improving the yield of Tc-99m PYP scintigraphy needs to be evaluated prospectively. ...
doi:10.1136/jim-2021-mw
fatcat:rxy4aexgkrdzljsxfm77lrgvry
ESICM LIVES 2017
2017
Intensive Care Medicine Experimental
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This was defined as either death at 1 year follow-up or sur-
risk prediction score based on demographics and blood laboratory values viving with a EuroQoL-5D 3L health related quality of life ...
Cases were classified as with or without HF
through symptom/sign assessment, N-terminal pro-B type natriuretic
peptide testing, and echocardiography. ...
doi:10.1186/s40635-017-0151-4
pmid:28933044
pmcid:PMC5607052
fatcat:7ci6aalts5bivkoabidoehb2xe
39th International Symposium on Intensive Care and Emergency Medicine
2019
Critical Care
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Conclusions: Our work demonstrates the applicability of deep learning models to diagnose hemorrhage based on raw, waveform vital signs. ...
levels at ICU admission to predict mortality in patients with sepsis, to test the hypothesis that using a combination of biomarkers of multiple systems would improve predictive value. ...
Conclusions: A high agreement between Nu-DESC and CAM-ICU was found however the comparison was based on predominately patients with negative delirium score. ...
doi:10.1186/s13054-019-2358-0
fatcat:pcva4dngjzfo5ekzkvzj5fcwge
Oral Abstracts
2017
European Stroke Journal
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Conclusion: The parsimonious, biomarker-based CoRisk-Score for the combined prediction of disability and death was well calibrated, could be externally validated, and performed better than a risk-score ...
The net reclassification improvement between the calibrated CoRisk-Score with and without copeptin was 54%, indicating that copeptin improved prediction in more than half of patients when added to a score ...
The primary analysis was based on the intention-to-treat-groups (ITT). ...
doi:10.1177/2396987317705236
fatcat:6qiln7zdcfdmbfj5obl7a57ga4
Typical patterns of expiratory flow and carbon dioxide in mechanically ventilated patients with spontaneous breathing
2016
Journal of clinical monitoring and computing
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Typical patterns of expiratory flow and carbon dioxide in mechanically ventilated patients with spontaneous breathing Rees, Stephen Edward; Larraza Rico, Sebastián; Dey, N.; Spadaro, S.; Brohus, J. ...
We observed that those respondents with high MDS score (>100 points) were more likely to suffer from Burnout (28.9 % x 14.4 %, p = 0.010). ...
The combination of malnutrition and heavy caloric deficit were relevant nutritional QI associated with ICU mortality regardless of sex, age and Apache II. ...
doi:10.1007/s10877-016-9903-z
pmid:27344663
fatcat:znxs3iq6vnawdn6se6h7fborja
ABSTRACT SUPPLEMENT
2012
Journal of clinical rheumatology
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Frozen sections of the brain stem were obtained with a cryostat and processed for the immunohistochemical detection of hypocretin peptides, as previously described (Pose et al., 2000). ...
The fact that hypocretin elicits an increase in input resistance suggests that this peptide suppresses a potassium conductance in these cells. ...
Scoring of hypopneas, perhaps more than RERAs, may improve outcome-based assessment for SDB. ...
doi:10.1097/rhu.0b013e3182557a66
fatcat:wtmtrd3kpfbyjoysmb6qrgxcua
38th International Symposium on Intensive Care and Emergency Medicine
2018
Critical Care
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Methods: Peripheral blood mononuclear cells (PBMC) were isolated from healthy volunteers (n=4) and incubated with 62.5 ng/mL LPS. ...
The increase in cell death was associated with an increase in oxidative stress (total and mitochondria) (Fig. 2) , suggesting that the adverse effect of LPS on cellular metabolism may be mediated by an ...
We identified areas that need improvement and with the support of hospital management we will initiate HSEMS-validated measures to reduce stress. ...
doi:10.1186/s13054-018-1973-5
pmid:32831123
fatcat:4iyogy3eazcrrm7zpb4pgauuwm
19th IPA International Congress, 31 August - 3 September 2019 Santiago de Compostela, Spain
2019
International Psychogeriatrics
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Deep brain stimulation as a treatment for neurodegenerative disease Gwenn Smith Can we aspire to live to 150? ...
Conclusion: We concluded that there is room for improvement in the research of dementia and vehicle mortalities. ...
the WHELD based e-learning programme with and without skype supervision to treatment as usual in nursing homes. ...
doi:10.1017/s1041610219001339
fatcat:sdbelhaz6rh6zajpn6dmvjxeie
ESICM LIVES 2016: part two
2016
Intensive Care Medicine Experimental
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A sample size of 370 was calculated based on a population of 10,000 physician members, a 5 % margin error, and 95 % confidence interval. ...
Methods Electronic survey of 22 items including two case-based scenarios; endorsed by SCCM (9,000 recipients) and ESICM (on-line newsletter) in 2013. ...
We observed that those respondents with high MDS score (>100 points) were more likely to suffer from Burnout (28.9 % x 14.4 %, p = 0.010). ...
doi:10.1186/s40635-016-0099-9
fatcat:rry7hn5zvrgp3o4ukdsslsmd3q
Thirteenth meeting of the European Neurological Society 14–18June 2003,Istanbul, Turkey
2003
Journal of Neurology
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All 3 inhibitors bind NgR with similar mechanisms involved in the onset of migraine attacks and the interaction with migraine trigger factors. ...
Surprisingly, all 3 of these inhibitors interact with the same receptor complex to exert their effects. ...
mean pain and sleep scores and SF-MPQ scores, and efficacy was maintained through study end. ...
doi:10.1007/bf03160427
fatcat:dra3sin345hullyy7lbyrzyjsa
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