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A Brief History of Protein Sorting Prediction

Henrik Nielsen, Konstantinos D. Tsirigos, Søren Brunak, Gunnar von Heijne
2019 The Protein Journal  
Because the secretory pathway was the first one to be studied both experimentally and through bioinformatics, our main focus is on the historical development of prediction methods for signal peptides that  ...  Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides has been a focus point of research.  ...  In particular, there is still room for major improvements in signal-based multi-category location methods that can sort proteins between multiple cellular locations with high reliability through modeling  ... 
doi:10.1007/s10930-019-09838-3 pmid:31119599 pmcid:PMC6589146 fatcat:cufi3rynanfjxntr76b77lhfwq

Computational prediction of secreted proteins in gram-negative bacteria

Xinjie Hui, Zewei Chen, Junya Zhang, Moyang Lu, Xuxia Cai, Yuping Deng, Yueming Hu, Yejun Wang
2021 Computational and Structural Biotechnology Journal  
classified the secreted proteins according to the types of secretion systems in Gram-negative bacteria, summarized the known features of these proteins, and reviewed the algorithms and tools for their prediction  ...  -3L 3.0 Attention Deep Learning; Window-Based Scoring Sec/SPI; Cleavage site 3L; Table 4 4 Representative software tools predicting substrates of T1~9SSs  ...  Signal-3L 3.0, a model using a 3-layer hybrid method of integrating deep learning algorithms and window-based scoring, showed better performance in prediction of Sec/SPI SPs of gram-negative bacteria but  ... 
doi:10.1016/j.csbj.2021.03.019 pmid:33897982 pmcid:PMC8047123 fatcat:xvj4vcrnujbpzgzx3ait62s2dy

Yoga and its impact on chronic inflammatory autoimmune arthritis

Surabhi Gautam
2021 Frontiers in Bioscience (Elite Edition)  
Interactions between the T cell receptor (TCR) and MHC class II-peptide antigen with co-stimulation through CD28-CD80/86 pathway leads to the activation of CD4+ T cells via antigenpresenting cells (APCs  ...  Application of the newly revised standards yields a score of 0-10, with a score of ≥6 fulfilling the requirements for definite RA.  ... 
doi:10.2741/873 fatcat:7fj7g3efcna2dlaeirmbqddzq4

Asia Pacific Stroke Conference 2016. Abstracts of the Annual Conference of theAsia Pacific Stroke Organization (APSO) Combined with Stroke Society of Australasia, Brisbane, Qld., Australia, July 14-17, 2016: Abstracts

2016 Cerebrovascular Diseases  
Gastrodin had significantly improved the neurologic functions in rats. The infarct volume of dose group rats was significantly different compared with that of control group (P = 0.044).  ...  The primary outcome measure was Motor Assessment Scale item 6 (upper arm function, MAS-6) at post-intervention, with a score of >1 point change classified as a minimal clinically important difference (  ...  Conclusion: As motor learning and visual attention requires intact cholinergic signaling, we hypothesize that a disruption in cholinergic signaling is contributing to these impairments.  ... 
doi:10.1159/000447732 pmid:27409083 fatcat:npg6lu4kgzherj7oa5aaory3lq

Abstracts from the 26th European Society for Animal Cell Technology Meeting - Cell culture technologies: bridging academia and industry to provide solutions for patients

2020 BMC Proceedings  
Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality.  ...  Acknowledgements MRM was supported by the FCT fellowship PD/BD/128215/2016. iNOVA4Health -UID/Multi/04462/2019, a program financially supported by FCT-MES, through national funds and co-funded by FEDER  ...  Kamen (National Research Council of Canada) for kindly providing the HEK293 cells, which this work was performed with.  ... 
doi:10.1186/s12919-020-00188-y fatcat:6kscifx565appmxq57svl42biy

2021 Midwest Clinical and Translational Research Meeting of CSCTR and MWAFMR

2021 Journal of Investigative Medicine  
Score ROC-Validation Cohort Abstract 20 Figure 1 Tc-99m pyrophosphate scintigraphy Positive and Negative Tc-99m pyrophosphate scans Abstracts 1072  ...  showing a large anterior mediastinal mass Abstract 14 Figure 3 Anterior mediastinal mass CT chest, axial view, showing a large anterior mediastinal mass Abstracts 1070 Abstract 2 Figure 1 Amyloidosis Prediction  ...  The utility of this prediction score for improving the yield of Tc-99m PYP scintigraphy needs to be evaluated prospectively.  ... 
doi:10.1136/jim-2021-mw fatcat:rxy4aexgkrdzljsxfm77lrgvry


2017 Intensive Care Medicine Experimental  
This was defined as either death at 1 year follow-up or sur- risk prediction score based on demographics and blood laboratory values viving with a EuroQoL-5D 3L health related quality of life  ...  Cases were classified as with or without HF through symptom/sign assessment, N-terminal pro-B type natriuretic peptide testing, and echocardiography.  ... 
doi:10.1186/s40635-017-0151-4 pmid:28933044 pmcid:PMC5607052 fatcat:7ci6aalts5bivkoabidoehb2xe

39th International Symposium on Intensive Care and Emergency Medicine

2019 Critical Care  
Conclusions: Our work demonstrates the applicability of deep learning models to diagnose hemorrhage based on raw, waveform vital signs.  ...  levels at ICU admission to predict mortality in patients with sepsis, to test the hypothesis that using a combination of biomarkers of multiple systems would improve predictive value.  ...  Conclusions: A high agreement between Nu-DESC and CAM-ICU was found however the comparison was based on predominately patients with negative delirium score.  ... 
doi:10.1186/s13054-019-2358-0 fatcat:pcva4dngjzfo5ekzkvzj5fcwge

Oral Abstracts

2017 European Stroke Journal  
Conclusion: The parsimonious, biomarker-based CoRisk-Score for the combined prediction of disability and death was well calibrated, could be externally validated, and performed better than a risk-score  ...  The net reclassification improvement between the calibrated CoRisk-Score with and without copeptin was 54%, indicating that copeptin improved prediction in more than half of patients when added to a score  ...  The primary analysis was based on the intention-to-treat-groups (ITT).  ... 
doi:10.1177/2396987317705236 fatcat:6qiln7zdcfdmbfj5obl7a57ga4

Typical patterns of expiratory flow and carbon dioxide in mechanically ventilated patients with spontaneous breathing

S. E. Rees, S. Larraza, N. Dey, S. Spadaro, J. B. Brohus, R. W. Winding, C. A. Volta, D. S. Karbing
2016 Journal of clinical monitoring and computing  
Typical patterns of expiratory flow and carbon dioxide in mechanically ventilated patients with spontaneous breathing Rees, Stephen Edward; Larraza Rico, Sebastián; Dey, N.; Spadaro, S.; Brohus, J.  ...  We observed that those respondents with high MDS score (>100 points) were more likely to suffer from Burnout (28.9 % x 14.4 %, p = 0.010).  ...  The combination of malnutrition and heavy caloric deficit were relevant nutritional QI associated with ICU mortality regardless of sex, age and Apache II.  ... 
doi:10.1007/s10877-016-9903-z pmid:27344663 fatcat:znxs3iq6vnawdn6se6h7fborja


2012 Journal of clinical rheumatology  
Frozen sections of the brain stem were obtained with a cryostat and processed for the immunohistochemical detection of hypocretin peptides, as previously described (Pose et al., 2000).  ...  The fact that hypocretin elicits an increase in input resistance suggests that this peptide suppresses a potassium conductance in these cells.  ...  Scoring of hypopneas, perhaps more than RERAs, may improve outcome-based assessment for SDB.  ... 
doi:10.1097/rhu.0b013e3182557a66 fatcat:wtmtrd3kpfbyjoysmb6qrgxcua

38th International Symposium on Intensive Care and Emergency Medicine

2018 Critical Care  
Methods: Peripheral blood mononuclear cells (PBMC) were isolated from healthy volunteers (n=4) and incubated with 62.5 ng/mL LPS.  ...  The increase in cell death was associated with an increase in oxidative stress (total and mitochondria) (Fig. 2) , suggesting that the adverse effect of LPS on cellular metabolism may be mediated by an  ...  We identified areas that need improvement and with the support of hospital management we will initiate HSEMS-validated measures to reduce stress.  ... 
doi:10.1186/s13054-018-1973-5 pmid:32831123 fatcat:4iyogy3eazcrrm7zpb4pgauuwm

19th IPA International Congress, 31 August - 3 September 2019 Santiago de Compostela, Spain

2019 International Psychogeriatrics  
Deep brain stimulation as a treatment for neurodegenerative disease Gwenn Smith Can we aspire to live to 150?  ...  Conclusion: We concluded that there is room for improvement in the research of dementia and vehicle mortalities.  ...  the WHELD based e-learning programme with and without skype supervision to treatment as usual in nursing homes.  ... 
doi:10.1017/s1041610219001339 fatcat:sdbelhaz6rh6zajpn6dmvjxeie

ESICM LIVES 2016: part two

S. Sivakumar, F. S. Taccone, K. A. Desai, C. Lazaridis, M. Skarzynski, M. Sekhon, W. Henderson, D. Griesdale, L. Chapple, A. Deane, L. Williams, R. Strickland (+2488 others)
2016 Intensive Care Medicine Experimental  
A sample size of 370 was calculated based on a population of 10,000 physician members, a 5 % margin error, and 95 % confidence interval.  ...  Methods Electronic survey of 22 items including two case-based scenarios; endorsed by SCCM (9,000 recipients) and ESICM (on-line newsletter) in 2013.  ...  We observed that those respondents with high MDS score (>100 points) were more likely to suffer from Burnout (28.9 % x 14.4 %, p = 0.010).  ... 
doi:10.1186/s40635-016-0099-9 fatcat:rry7hn5zvrgp3o4ukdsslsmd3q

Thirteenth meeting of the European Neurological Society 14–18June 2003,Istanbul, Turkey

2003 Journal of Neurology  
All 3 inhibitors bind NgR with similar mechanisms involved in the onset of migraine attacks and the interaction with migraine trigger factors.  ...  Surprisingly, all 3 of these inhibitors interact with the same receptor complex to exert their effects.  ...  mean pain and sleep scores and SF-MPQ scores, and efficacy was maintained through study end.  ... 
doi:10.1007/bf03160427 fatcat:dra3sin345hullyy7lbyrzyjsa
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