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Signal source localization with tetrodes: Experimental verification

Chang Won Lee, Christine E. King, Shun Chi Wu, A. Lee Swindlehurst, Zoran Nenadic
2011 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society  
This study introduces the multiple signal classification (MUSIC) algorithm to the problem of neuron localization and presents the first experimental demonstration of signal source localization using commercially  ...  available 4-sensor electrodes (tetrodes).  ...  Based on the experimental results, we conclude that the localization of neuronal sources with tetrodes is feasible, although the estimated source location may be biased due to the heterogeneity and anisotropy  ... 
doi:10.1109/iembs.2011.6089898 pmid:22254252 dblp:conf/embc/LeeKWSN11 fatcat:omhtftbmpnho7o7ayqkypn6vxq

The accuracy and precision of signal source localization with tetrodes

Chang Won Lee, Agnieszka A. Szymanska, Yuji Ikegaya, Zoran Nenadic
2013 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)  
The location of the source was estimated using the multiple signal classification algorithm, with an accuracy and precision of ∼4 µm and ∼7 µm, respectively.  ...  They also provide spatio-temporal information about extracellular action potentials (EAP) which may be used to localize and resolve individual neuronal signal sources.  ...  Source localization with a tetrode has been experimentally validated in our recent study [5] .  ... 
doi:10.1109/embc.2013.6609554 pmid:24109741 dblp:conf/embc/LeeSIN13 fatcat:y3gmfikhtfbkpcmn5ntbvzqeke

Tetrode technology: advances in implantable hardware, neuroimaging, and data analysis techniques

M.S Jog, C.I Connolly, Y Kubota, D.R Iyengar, L Garrido, R Harlan, A.M Graybiel
2002 Journal of Neuroscience Methods  
This paper discusses several such advances in implantable hardware, magnetic resonance imaging of electrodes in situ, and data analysis software for multiple simultaneous signals. #  ...  The four-dimensional data acquired by tetrodes not only allow superior signal source separation, but also permit localization of putative signal generators in the tissue surrounding the tetrode (Harris  ...  Our analysis has not dealt with sources of misclassification of data such as spike overlap and signal drift.  ... 
doi:10.1016/s0165-0270(02)00092-4 pmid:12100979 fatcat:tbo74lnp4rdkhg4rj2f3vzdo3a

Oscillatory Entrainment of Thalamic Neurons by Theta Rhythm in Freely Moving Rats

Marian Tsanov, Ehsan Chah, Nick Wright, Seralynne D. Vann, Richard Reilly, Jonathan T. Erichsen, John P. Aggleton, Shane M. O'Mara
2011 Journal of Neurophysiology  
We found that theta and spindle oscillations differ in their spatial distribution within AV, suggesting separate cellular sources for these oscillations.  ...  This feature together with their firing properties and spike shape suggests they be classified as "theta" units.  ...  A point source is a single identifiable localized source of certain signal and neurons are accepted point sources for the extracellularly recorded currents ).  ... 
doi:10.1152/jn.00771.2010 pmid:20962067 pmcid:PMC3023377 fatcat:so5tie5f4rgejctdcrdootahdi

Bio-inspired benchmark generator for extracellular multi-unit recordings

Sirenia Lizbeth Mondragón-González, Eric Burguière
2017 Scientific Reports  
We present three application examples. (1) We reproduced in-vivo extracellular hippocampal multi-unit recordings from either tetrode or polytrode designs. (2) We simulated recordings in two different experimental  ...  Currently, the evaluation and optimisation of these tools are hampered by the lack of ground-truth databases of neural signals.  ...  As a starting point, we created the contribution of the local spike activity to the signal.  ... 
doi:10.1038/srep43253 pmid:28233819 pmcid:PMC5324125 fatcat:7rwf2j4ekzc65llqfxqkcuivdi

Wireless logging of extracellular neuronal activity in the telencephalon of free-swimming salmonids

Susumu Takahashi, Takumi Hombe, Riku Takahashi, Kaoru Ide, Shinichiro Okamoto, Ken Yoda, Takashi Kitagawa, Yuya Makiguchi
2021 Animal Biotelemetry  
The results of our study suggest that the recorded signals originate from neurons.  ...  Furthermore, since our system cannot synchronize external event signals in deeper water and only record neuronal activity for a few hours, neuronal recordings need to be operated automatically and locally  ...  Methods Biotelemetry system experimental setup We developed a wireless biologging system that enables the monitoring of extracellular neuronal signals from the brains of free-swimming trout.  ... 
doi:10.1186/s40317-021-00232-4 fatcat:fmy6i5yeurhavb7p3tdgy4vvda

In vivo localization of chronically implanted electrodes and optic fibers in mice

Bálint Király, Diána Balázsfi, Ildikó Horváth, Nicola Solari, Katalin Sviatkó, Katalin Lengyel, Eszter Birtalan, Magor Babos, Gergő Bagaméry, Domokos Máthé, Krisztián Szigeti, Balázs Hangya
2020 Nature Communications  
Here, we propose a method combining the high-resolution information about bone landmarks provided by micro-CT scanning with the soft tissue contrast of the MRI, which allowed us to precisely localize electrodes  ...  This enables arbitrating the success of implantation directly after surgery with a precision comparable to gold standard histology.  ...  Acknowledgements We thank Gabriella Taba for the TLD detectors and help with the radiation dose measurements; Dr. Andor Domonkos for providing a Buzsaki-type silicon probe; Drs.  ... 
doi:10.1038/s41467-020-18472-y pmid:32943633 pmcid:PMC7499215 fatcat:yto5fyal7vckrp5x3wfeaayvcy

RatHat: A self-targeting printable brain implant system

Leila M. Allen, Maanasa Jayachandran, Tatiana D. Viena, Meifung Su, Bruce L. McNaughton, Timothy A. Allen
2020 eNeuro  
Rodent neurosurgery is a complex skill that requires expensive equipment for head stabilization and micromanipulators for localization.  ...  The RatHat can be used in conjunction with the traditional u-frame stereotaxic device, but does not require the use of a micromanipulator for successful implantations.  ...  We`show sample data in which optogenetic stimulation of RE in experimental rats yielded a 4-Hz frequency rhythm in the mPFC (strong) and dHC (weak) LFP signal, but not in controls, demonstrating efficacy  ... 
doi:10.1523/eneuro.0538-19.2020 pmid:32144143 pmcid:PMC7156922 fatcat:kjggtmbimjg75n5n6a5fu7cmoe

Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing

Chen Chen, Francisco C. Rodriguez, Heather L. Read, Monty A. Escabí
2012 Frontiers in Neural Circuits  
Furthermore, correlated firing was stronger for neighboring neuron pairs and increased with proximity and decreasing BF difference.  ...  How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information?  ...  We assume that the measured action potential voltage decays as a powerlaw with distance from the source and that the rate of decay depends on the tetrode geometry, impedance and the electrical characteristics  ... 
doi:10.3389/fncir.2012.00062 pmid:23060750 pmcid:PMC3461703 fatcat:7spyx5e7anaohgrvrwtzgy4vxm

Automated long-term recording and analysis of neural activity in behaving animals

Ashesh K Dhawale, Rajesh Poddar, Steffen BE Wolff, Valentin A Normand, Evi Kopelowitz, Bence P Ölveczky
2017 eLife  
Addressing how neural circuits underlie behavior is routinely done by measuring electrical activity from single neurons in experimental sessions.  ...  Months-long recordings from motor cortex and striatum made and analyzed with our system revealed remarkable stability in basic neuronal properties, such as firing rates and inter-spike interval distributions  ...  Shad for help benchmarking the speed of the FAST algorithm, and Aliaksandr Iuleu for help with figures.  ... 
doi:10.7554/elife.27702 pmid:28885141 pmcid:PMC5619984 fatcat:4hrcszltazfkzivvxdkkjiywby

The hemodynamic initial-dip consists of both volumetric and oxymetric changes correlated to localized spiking activity [article]

Ali Danish Zaidi, Niels Birbaumer, Eberhard Fetz, Nikos Logothetis, Ranganatha SItaram
2018 bioRxiv   pre-print
by local neural activity.  ...  Moreover, the HbT-dip and HbR-rebound were strongly coupled to highly localized spiking activity.  ...  Since neuronal processes such as multi-unit spiking are fast, dynamic and spatially 25 localized, a feature in the BOLD signal with similar properties, which also correlates strongly with local neuronal  ... 
doi:10.1101/259895 fatcat:trf6f6r34zenlm7w65ndtcqbtq

Miniature Neurologgers for Flying Pigeons: Multichannel EEG and Action and Field Potentials in Combination With GPS Recording

Alexei L. Vyssotski, Andrei N. Serkov, Pavel M. Itskov, Giacomo Dell'Omo, Alexander V. Latanov, David P. Wolfer, Hans-Peter Lipp
2006 Journal of Neurophysiology  
Abramchuk for help with neurologgers development and manufacturing. We are particularly grateful to N. Bologova, S. Pazhetnova, N. Ben Abdallah, and C. and M. Calderoni for expert care of pigeons.  ...  Operating and testing procedures have been approved by the local animal experimentation committees of the Veterinary Office of the Canton of Zurich, in compliance with Swiss, Italian, and Russian legislation  ...  A unity gain source follower was used for the buffering of the signal from the reference electrode ( Fig. 2A, amp 1) .  ... 
doi:10.1152/jn.00879.2005 pmid:16236777 fatcat:afq273bakzg2bchcpi2q3hvzi4

Carbon nanotube composite coating of neural microelectrodes preferentially improves the multiunit signal-to-noise ratio

Gytis Baranauskas, Emma Maggiolini, Elisa Castagnola, Alberto Ansaldo, Alberto Mazzoni, Gian Nicola Angotzi, Alessandro Vato, Davide Ricci, Stefano Panzeri, Luciano Fadiga
2011 Journal of Neural Engineering  
Neuronal signals were recorded in vivo from rat cortex by employing tetrodes with two recording sites coated with polypyrrole-CNT and the remaining two left untreated.  ...  However, their signal-to-noise ratio (SNR) is often far from optimal due to their high impedance value.  ...  Three tracks were made with each of the two tetrodes. Each tetrode had two recording sites coated with MWCNT-PPy while the remaining two recording sites were left uncoated.  ... 
doi:10.1088/1741-2560/8/6/066013 pmid:22064890 fatcat:7g6zeqcujrg4lpn2f3tg4nq2ci

Slow gamma rhythms in CA3 are entrained by slow gamma activity in the dentate gyrus

Yi-Tse Hsiao, Chenguang Zheng, Laura Lee Colgin
2016 Journal of Neurophysiology  
In hippocampal area CA1, slow (ϳ25-55 Hz) and fast (ϳ60 -100 Hz) gamma rhythms are coupled with different CA1 afferents.  ...  Hippocampal place cells, neurons with receptive fields for particular locations in space (O'Keefe 1976) , have been shown to code  ...  Gereke for assistance with WPLI analyses, Sean G. Trettel for assistance with parallelization of MATLAB analyses, and Kevin Wood Bieri for providing recordings from one rat.  ... 
doi:10.1152/jn.00499.2016 pmid:27628206 pmcid:PMC5133296 fatcat:nhjtx56oaja4xabm2rvum2fyna

Intracranial neuronal ensemble recordings and analysis in epilepsy

Emília Tóth, Dániel Fabó, László Entz, István Ulbert, Loránd Erőss
2016 Journal of Neuroscience Methods  
Since then, microelectrodes remained only experimental tools in humans to detect unitary neuronal activity to reveal physiological and pathological brain functions.  ...  Pathological neuronal firing was demonstrated 50 years ago as the hallmark of epileptically transformed cortex with the use of implanted microelectrodes.  ...  signal quality.  ... 
doi:10.1016/j.jneumeth.2015.09.028 pmid:26453987 fatcat:zn5gezpevrcytdhh3gm3jttx7i
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