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Protein & Cell
Furthermore, our results revealed that precipitation increased significantly in the Tibetan Plateau and surrounding regions, and Huang et al. ...doi:10.3390/w12082097 fatcat:ptte3i2hwzendkz2wepqwp6nba
Shock and Vibration
The vibration level of a cab affects the passenger's ride comfort and safety significantly. It is of great importance to control the vibration level of cabs under various driving conditions. The associated vibration transfer paths of cabs are studied by using a hierarchical analysis method of a parameter index. The multiobjective design analysis is carried out by using the multiparameter joint optimisation design. Further, the optimal control of the cab vibration level is obtained from adoi:10.1155/2020/8841598 fatcat:36xmkigixvarvken6voye2nofi
more »... ndition simulation environment. Additionally, a multibody vehicle model is established. The simulation analysis under multiple working conditions is conducted. The optimal parameter distribution of the cab mounting structure was established by analysing the influence of the design parameters and experimental verification. This greatly improves the comfort of the cab.
In antitumor immunity, dendritic cells (DCs) capture, process, and present tumor antigens to T cells, initiating a tumoricidal response. However, DCs are often dysfunctional due to their exposure to the tumor microenvironment (TME), leading to tumor escape from immune surveillance. Here, a vital role of microRNA-155 (miR-155) in regulating the function of DCs in breast cancer is reported. Host miR-155 deficiency enhanced breast cancer growth in mice, accompanied by reduced DCs in the tumors anddoi:10.1080/2162402x.2016.1232223 pmid:27999745 pmcid:PMC5139631 fatcat:g2ool2dudjfwblxekzriymovoa
more »... draining lymph nodes. miR-155 deficiency in DCs impaired their maturation, migration ability, cytokine production, and the ability to activate T cells. We demonstrate that miR-155 regulates DC migration through epigenetic modulation of CCR7 expression. Moreover, IL-6 and IL-10, two cytokines abundant in the TME, are found to impair DC maturation by suppressing miR-155 expression. Furthermore, animal studies show that a lack of miR-155 diminishes the effectiveness of DC-based immunotherapy for breast cancer. In conclusion, these findings suggest that miR-155 is a master regulator of DC function in breast cancer, including maturation, cytokine secretion, migration toward lymph nodes, and activation of T-cells. These results suggest that boosting the expression of a single microRNA, miR-155, may significantly improve the efficacy of DC-based immunotherapies for breast cancer.
A set of behavioral voltage-domain verilogA/verilog models allowing a systematic design of the Σ∆ fractional-N frequency synthesizer is discussed in the paper. The approach allows the designer to accurately predict the dynamic or stable characteristic of the closed loop by including nonlinear effects of building blocks in the models. The proposed models are implemented in a three-order Σ∆ fractional-N PLL based frequency synthesizer with a 60MHz frequency tuning range. Cadence SpectreVerilogdoi:10.1109/date.2007.364606 dblp:conf/date/HuangMW07 fatcat:2tusu5hrebc47fojq2v7ax3sp4
more »... ulation results show that behavioral modeling can provide a great speed-up over circuit-level simulation. Synchronously, the phase noise, spurs and settling time can also be accurately predicted, so it is helpful to a grasp of the fundamentals at the early stage of the design and optimization design at the system level. The key simulation results have been compared against measured results obtained from an actual prototype validating the effectiveness of the proposed models. 978-3-9810801-2-4/DATE07 © 2007 EDAA
An inverter-based class AB amplifier is proposed to design the 11b pipelined analogue-to-digital converter (ADC) in 28 nm CMOS technology. The structure of the proposed amplifier is more concise compared with conventional amplifiers. The amplifier occupies small area, and its quiescent dissipation is only 1.4 mA. This structure is suitable for design in scaled process. The operation of the amplifier is carefully elaborated. The simulation results show: the ADC can achieve 75.3 dB SFDR and 66.8doi:10.1587/elex.14.20170047 fatcat:ussfxxklxrha3elxt64kjqu5au
more »... B SNDR, while it occupies an area of 0.4 mm 2 and consumes a power of 17 mW with 1.05 V supply. These results yield a FOMS of 159.3 dB.
MicroRNAs (miRNAs/miRs) negatively regulate the expression of numerous genes and therefore contribute to the occurrence and development of papillary thyroid carcinoma (PTC). Hence, further investigation into the specific roles of miRNAs in PTC is valuable for developing effective therapeutic methods for patients with this disease. MiRNA‑509 is dysregulated and serves pivotal roles in several types of human cancer; however, the expression and roles of miR‑509 in PTC and its underlying mechanismdoi:10.3892/mmr.2018.9750 pmid:30569166 fatcat:j54sth3mjfeehkkmsckgjryrtm
more »... equire further investigation. In the present study, the expression of miR‑509 in PTC tissues and cell lines was detected and the specific functions of miR‑509 in the progression of PTC were investigated. Additionally, the molecular mechanisms underlying the action of miR‑509 in PTC were determined. The present study demonstrated that miR‑509 was significantly downregulated in PTC tissues and cell lines. MiR‑509 upregulation inhibited the PTC cell proliferation and invasion. Mechanistically, paired box 6 (PAX6) was identified as a novel target of miR‑509 in PTC cells. In clinical PTC samples, miR‑509 was significantly overexpressed and inversely correlated with PAX6 expression. PAX6 restoration effectively reversed the inhibitory effects of miR‑509 overexpression on PTC cell proliferation and invasion. These results demonstrated that miR‑509 may act as a tumor suppressor in PTC by directly targeting PAX6. Thus, miR‑509 may be a potential therapeutic target for the treatment of patients with PTC.
Cell Death Discovery
Targeting endoplasmic reticulum (ER) stress is being investigated for its anticancer effect in various cancers, including cervical cancer. However, the molecular pathways whereby ER stress mediates cell death remain to be fully elucidated. In this study, we confirmed that ER stress triggered by compounds such as brefeldin A (BFA), tunicamycin (TM), and thapsigargin (TG) leads to the induction of the unfolded protein response (UPR) in cervical cancer cell lines, which is characterized bydoi:10.1038/cddiscovery.2017.59 pmid:28904818 pmcid:PMC5592653 fatcat:xyf7olm7xncylax6jslua4uzra
more »... levels of inositolrequiring kinase 1α, glucose-regulated protein-78, and C/EBP homologous protein, and swelling of the ER observed by transmission electron microscope (TEM). We found that BFA significantly increased autophagy in tumor cells and induced TC-1 tumor cell death in a dose-dependent manner. BFA increased punctate staining of LC3 and the number of autophagosomes observed by TEM in TC-1 and HeLa cells. The autophagic flux was also assessed. Bafilomycin, which blocked degradation of LC3 in lysosomes, caused both LC3I and LC3II accumulation. BFA initiated apoptosis of TC-1 tumor cells through activation of the caspase-12/caspase-3 pathway. At the same time, BFA enhanced the phosphorylation of IκBα protein and translocation into the nucleus of NF-κB p65. Quinazolinediamine, an NF-κB inhibitor, attenuated both autophagy and apoptosis induced by BFA; meanwhile, it partly enhances survival of cervical cancer cells following BFA treatment. In conclusion, our results indicate that the cross-talk between ER stress, autophagy, apoptosis, and the NF-κB pathways controls the fate of cervical cancer cells. Careful evaluation should be given to the addition of an NF-κB pathway inhibitor to treat cervical cancer in combination with drugs that induce ER stress-mediated cell death.
CHD5 is an essential factor for neuronal differentiation and neurodegenerative diseases. Here, the targeted next generation sequencing and TaqMan genotyping technologies were carried out for CHD5 gene in a two-staged case-control study in Chinese population. The genetic statistics and gene-environment interactions were analyzed to find certain risk factors of Alzheimer's disease. We found intronic rs11121295 was associated with the risk of Alzheimer's disease at both stages including combineddoi:10.18632/oncotarget.23791 pmid:29861839 pmcid:PMC5982770 fatcat:huyslhbiincpbl6cimfbn23dym
more »... horts. This risk effect presented consistently significant associations with the alcoholic subgroups at both all stages in the stratified analysis. The gene-environment interactions further supported the above findings. Our study highlighted the potential role of CHD5 variants in conferring susceptibility to sporadic Alzheimer's disease, especially modified its risk by alcoholic intake.
Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, and cases have been rising steadily worldwide in the past few decades. Despite great progress having been made in surgery and chemotherapy for PTC, the survival rate of PTC patients has not increased significantly. Therefore, there is an urgent need to explore novel treatment strategies. The levels of circRNA_103598, miR-23a-3p and IL-6 mRNA in PTC tissues and cells were examined by qRT-PCR assay. Celldoi:10.2147/cmar.s273072 pmid:33116893 pmcid:PMC7585822 fatcat:4pmtramhqvbhvm7n2wlnz4wcwa
more »... and IC50 values of oncolytic vaccinia virus (OVV) were detected by CCK-8 assay. A dual-luciferase reporter assay was performed to detect the relationships among circRNA_103598, miR-23a-3p and IL-6. ELISA was carried out to detect the expression of IL-6. We found that circRNA_103598 was increased in PTC tissues and cell lines and acted as a sponge for miR-23a-3p. Moreover, knockdown of miR-23a-3p suppressed the OVV-mediated antitumor effect and cell proliferation in PTC. In addition, we revealed that circRNA_103598 bound to miR-23a-3p as a sponge to promote IL-6 expression. Our study first revealed the high expression and oncogenic function of circRNA_103598 in PTC cells. Then, circRNA_103598 sponged miR-23a-3p to upregulate IL-6 expression, with the resulted that cell proliferation was promoted and the OVV-mediated antitumor effect was enhanced by strengthening the viral replication, providing new insights into future therapy for PTC.
Eurographics Workshop on 3D Object Retrieval, EG 3DOR
ZFCE-BoF and ZFCE-MVM submitted by Haisheng Li, Shuilong Dong, Huanpu Yin, Chaoli Zhang from Beijing Technology and Business University, China. ... Table 1 : 1 ECR, CAS-ECKM and CAS-ECSR submitted by Xin Zhao, Yanhua Cheng, Kaiqi Huang and Tieniu Tan from Center for Research on Intelligent Perception and Computing, China. 5. ...doi:10.2312/3dor.20151066 fatcat:hq74conw3ra2fhtg4hbgmdhbcy
Wu Shuilong and He Wenwen (2018) concluded that the increase of consumers' purchase intention to social anthropomorphic products is caused by the mediating effect of enhanced cognitive fluency and weakened ... Huang Xin (2018) conceptualized the definition of "personal anthropomorphism" and "relational anthropomorphism" based on practical cases of corporate anthropomorphism and the definition of personal identity ...doi:10.54691/bcpbm.v14i.69 fatcat:eph6yqxaznbdpi65ivyyfnwnfa
Whole-Mount In situ Hybridization The procedure for whole-mount in situ hybridization was carried out as described previously (Huang et al., 2013) . ... arising reverse genetic tools, such the antisense morpholino oligonucleotide (MO)-based gene knockdown strategies (Nasevicius and Ekker, 2000; Eisen and Smith, 2008) and genomic editing techniques (Huang ...doi:10.3389/fphys.2017.00214 pmid:28443032 pmcid:PMC5387095 fatcat:fc24hjexsjawddvyh6lxe3bury
Shuang, Lu Shikha, Shrestha Shuanghao, Zheng Shikinaka, Kazuhiro Shuanglong, Liu Shikuan, Sun Shu-Chuan, Liao Shiladitya, Paul Shu-feng, Ye Shilun, Feng Shuhei, Takahashi Shima, Pilehvar Shuilong ... Yury, Ivanovich Václav, Ranc Tze-Bin, Song Vaclav, Sebera Tz-Feng, Lin Vadim P., Boyarskiy Tzong-shi, Liu Vadim V., Potapov Tzu-En, Lin Vadim, Khlestkin Tzu-Sen, Yang Vadim, Mizonov Tzu-Yen, Huang ...doi:10.3390/ma14030514 pmid:33494496 fatcat:tu3xitdifjfp5fzrsvhw47mgpm
Shock and Vibration
Flandrin  applied the Huang data-driven technique of empirical mode decomposition to the versatile and broadband model of fractional Gaussian noise. e experimental spectral analysis and statistical ...doi:10.1155/2020/3218564 fatcat:chphs3vzqfellmpr2i4lcak7wm
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