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Single molecule DNA compaction by purified histones

ShiYong Ran, XiaoLing Wang, WenBo Fu, WeiChi Wang, Ming Li
2008 Science Bulletin  
RAN ShiYong et al. Chinese Science Bulletin | March 2008 | vol. 53 | no. 6 | 836-841  ... 
doi:10.1007/s11434-008-0034-x fatcat:4qjfvu4hqvgjlafeagevcciwbi

Studies on heat-transfer film coefficients inside a horizontal tube in falling film evaporators

Li Xu, Shiyong Wang, Shichang Wang, Yuxin Wang
2004 Desalination  
The effects of liquid load, tube diameter, evaporation boiling point, condensation temperature difference and steam flow velocity on the heat-transfer film coefficients inside horizontal tubes were studied. The experiments were conducted with various operation parameters. In fact, if there is little shear stress on the film surface, it affects film thickness and blocks the condensate flowing inside the tube, but it is not strong enough to make the condensate to be ring flow. We defined the
more » ... ing Reynolds number in order to describe the effect of this small shear on the film of condensate. Using a regression of the experimental data, the models of condensation heat-transfer coefficient were built. According to the literature, some theoretical models cannot be used to explain why condensation heat-transfer coefficients increase gently with steam flow velocity. Our models of condensation heat-transfer coefficient can be used to explain this problem. These results provide a basis for further developing the high efficiency heat-transfer process and novel evaporators.
doi:10.1016/j.desal.2004.06.076 fatcat:4tu3x3vkafb53i2ccov36u56hi

RPCA-Based High Resolution Through-the-Wall Human Motion Detection and Classification [article]

Qiang An, Shuoguang Wang, Wenji Zhang, Hao Lv, Jianqi Wang, Shiyong Li, Ahmad Hoorfar
2020 arXiv   pre-print
Erol in [7] RPCA-Based High Resolution Through-the-Wall Human Motion Detection and Classification Qiang An*, Shuoguang Wang*, Wenji Zhang, Hao Lv, Jianqi Wang, Shiyong Li †, and Ahmad Hoorfar †, IEEE  ...  Shuoguang Wang and TABLE  ... 
arXiv:2001.10902v1 fatcat:4mcnzncjx5chnihv6ylxpcl6o4

Exome sequencing identified new mutations in a Marfan syndrome family

Guangxin Li, Jian Yu, Kun Wang, Bin Wang, Minghai Wang, Shuguang Zhang, Shiyong Qin, Zhenhai Yu
2014 Diagnostic Pathology  
Marfan syndrome is a common autosomal dominant hereditary connective tissue disorder. There is no cure for Marfan syndrome currently. Next-generation sequencing (NGS) technology is efficient to identify genetic lesions at the exome level. Here we carried out exome sequencing of two Marfan syndrome patients. Further Sanger sequencing validation in other five members from the same family was also implemented to confirm new variants which may contribute to the pathogenesis of the disease. Two new
more » ... ariants, including one nonsense SNP in the Marfan syndrome gene FBN1 and one missense mutation in exon 15 of LRP1, which may be related to the phenotype of the patients were identified. The exome sequencing analysis provides us a new insight into the molecular events governing pathogenesis of Marfan syndrome. Virtual slide: http://www.diagnosticpathology.diagnomx.eu/vs/1229110069114125.
doi:10.1186/1746-1596-9-25 pmid:24484584 pmcid:PMC3918099 fatcat:qriqlxqihncjrpfddsvhag5hbe

Near-Field Millimeter-Wave Imaging via Circular-Arc MIMO Arrays [article]

Shiyong Li, Shuoguang Wang, Guoqiang Zhao, Houjun Sun
2021 arXiv   pre-print
Millimeter-wave (MMW) imaging has a wide prospect in application of concealed weapons detection. We propose a circular-arc multiple-input multiple-output (MIMO) array scheme with uniformly spaced transmit and receive antennas along the horizontal-arc direction, while scanning along the vertical direction. The antenna beams of the circular-arc MIMO array can provide more uniform coverage of the imaging scene than those of the linear or planar MIMO arrays. Further, a near-field three-dimensional
more » ... 3-D) imaging algorithm, based on the spatial frequency domain processing, is presented with analysis of sampling criteria and resolutions. Numerical simulations, as well as comparisons with the back-projection (BP) algorithm, are provided to show the efficacy of the proposed approach.
arXiv:2102.13418v1 fatcat:p2lg7o7rvfafdnvsyaryrokro4

Designer spin order in diradical nanographenes [article]

Yuqiang Zheng, Can Li, Chengyang Xu, Doreen Beyer, Xinlei Yue, Yan Zhao, Guanyong Wang, Dandan Guan, Yaoyi Li, Hao Zheng, Canhua Liu, Junzhi Liu (+5 others)
2020 arXiv   pre-print
The magnetic properties of carbon materials are at present the focus of an intense research effort in physics, chemistry and materials science due to their potential applications in spintronics and quantum computations. Although the presence of spins in open-shell nanographenes has been recently confirmed, the ability to control magnetic coupling sign has remained elusive, but the most desirable. Here, we demonstrate an effective approach of engineering magnetic ground states in atomically
more » ... se open-shell bipartite/nonbipartite nanographenes using combined scanning probe techniques and mean-field Hubbard model calculations. The magnetic coupling sign between two spins has been controlled via breaking bipartite lattice symmetry of nanographenes. In addition, the exchange-interaction strength between two spins has been widely tuned by finely tailoring their spin density overlap, realizing a large exchange-interaction strength of 42 meV. Our demonstrated method provides ample opportunities for designer above-room-temperature magnetic phases and functionalities in graphene nanomaterials.
arXiv:2011.10224v1 fatcat:z6qbogpspfc2fhq7elvs3suy24

Iron-catalyzed ene-type propargylation of diarylethylenes with propargyl alcohols

Shiyong Peng, Lei Wang, Jian Wang
2012 Organic and biomolecular chemistry  
3-(2-Ethoxyphenyl)pent-1-en-4-yne-1,1-diyl)dibenzene (3c): 74% yield; 1 H NMR (300 MHz, CDCl 3 ): δ = 7.58 (dd, J = 7.6, 1.6 Hz, 1H), 7.44-7.15 (m, 12H), 6.97 (td, J = 7.5, 0.9 Hz, 1H), 6.81 (d, J = 8.1 Hz, 1H), 6.12 (d, J = 9.8 Hz, 1H), 4.88 (dd, J = 9.8, 2.5 Hz, 1H), 3.92 (m, 3H), 2.31 (d, J = 2.6 Hz, 1H), 1.17 (t, J = 7.0 Hz, 2H). 13 C NMR (75 MHz, CDCl 3 ): δ = 155.HRMS (EI) calcd for C 25 H 22 O [M+H] + 338.1671, found 338.1682. (3-(2-(Allyloxy)phenyl)pent-1-en-4-yne-1,1-diyl)dibenzene
more » ... : 84% yield; 1 H NMR (300 MHz, CDCl 3 ): δ = 7.60 (dd, J = 7.6, 1.7 Hz, 1H), 7.46-7.18 (m, 12H), 7.00 (td, J = 7.5, 1.0 Hz, 1H), 6.85-6.78 (m, 1H), 6.16 (d, J = 9.9 Hz, 1H), 5.84 (ddt, J = 17.3, 10.4, 5.1 Hz, 1H), 5.27-5.11 (m, 2H), 4.90 (dd, J = 9.9, 2.5 Hz, 1H), 4.52-4.34 (m, 2H), 2.32 (d, J = 2.6 Hz, 1H); 13 C NMR (75 MHz,
doi:10.1039/c1ob06456h pmid:21968565 fatcat:inn4tfunz5ckriuwqqu3hf7yrm

Emergence of localized in-gap states in conjugated polymers of branched topology

Shiyong Wang, Weihua Wang, Nian Lin
2012 Physical Review B  
Using cryogenic scanning tunneling microscopy and spectroscopy, we investigated cross-linked phenyelenebased polymers with various branched morphology at a single-molecule resolution. We found that localized states that are in the band gap of un-branched polymers emerge at the branch junctions. These in-gap states can be shifted close to the Fermi level through three means: extending the length of branch arms, coupling adjacent branches in hyperbranched structures, or increasing the number of
more » ... anch arms. Single-band tight-binding calculations can reproduce all experimental results and provide quantitative relationships between the energy level shifts and the branching geometry. Our discovery evidences the emergence and development of in-gap states in the band structures of conjugated systems with fractional dimensions.
doi:10.1103/physrevb.86.045428 fatcat:6t2ymmq5fbcmtl2h27a6wnf3pi

Meningioma with ring enhancement on MRI: a rare case report

Miao Wang, Zhongke Wang, Peng Ren, Xiaoqing Zhang, Shiyong Liu
2021 BMC Medical Imaging  
Miao Wang and Zhongke Wang contributed equally to this work Department of Neurosurgery, Xinqiao Hospital, Army Medical University, 400037 Chongqing, China with extensive central degeneration and necrosis  ... 
doi:10.1186/s12880-021-00555-x pmid:33568080 pmcid:PMC7877038 fatcat:53rxyj4hpvc7vlqiwal2sn55yy

Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin

Chunyun Wang, Peilan Qi, Yan Lu, Lei Liu, Yanan Zhang, Qianli Sheng, Tianshun Wang, Mengying Zhang, Rui Wang, Shiyong Song
2020 Drug Delivery  
ORCID Shiyong Song http://orcid.org/0000-0003-2208-608X  ...  ., 2016; Wang et al., 2017; Pan et al., 2019) .  ...  Wang et al. (2015) synthesized a boric acid-functionalized polymer that could be combined with polyphenolic anticancer drug emodin to form a pH-responsive prodrug.  ... 
doi:10.1080/10717544.2020.1726526 pmid:32090637 pmcid:PMC7054969 fatcat:nlojdgacevdffifdvnivsr2xpq

State-dependent cortical unit activity reflects dynamic brain state transitions in anesthesia [article]

Heonsoo Lee, Shiyong Wang, Anthony G Hudetz
2020 bioRxiv   pre-print
How anesthesia affects cortical neuronal spiking and information transfer could help understand the neuronal basis of conscious state. Recent investigations suggest that global state of the anesthetized brain is not stationary but changes spontaneously at a fixed level of anesthetic concentration. How cortical unit activity changes with dynamically transitioning brain states under anesthesia is unclear. We hypothesized that distinct cortical states are characterized by distinct neuronal spike
more » ... tterns. Extracellular unit activity was measured with sixty-four-channel silicon microelectrode arrays in cortical layers 5/6 of primary visual cortex of chronically instrumented, freely moving male rats (N = 7) during stepwise reduction of the anesthetic desflurane (6, 4, 2, and 0%). Unsupervised machine learning applied to multi-unit spike patterns revealed five distinct brain states of which four occurred at various anesthetic concentrations and shifted spontaneously. In deeper anesthesia states, the number of active units and overall spike rate decreased while the remaining active units showed increased bursting (excitatory neurons), spike timing variability, unit-to-population correlation and unit-to-unit transfer entropy, especially among putative excitatory units, despite the overall decrease in transfer entropy. A novel desynchronized brain state with increased spike timing variability, entropy and electromyographic activity that occurred mostly in deep anesthesia was discovered. These results provide evidence for distinct unit activity patterns associated with spontaneous changes in local cortical brain states at stationary anesthetic conditions. The appearance of a paradoxical, desynchronized brain state in deep anesthesia contends the prevailing view of monotonic dose-dependent anesthetic effects on the brain.
doi:10.1101/2020.06.13.150235 fatcat:jo3evle52fbo5g76fhxvfahafe

Ebola interventions: listen to communities

Ruth Kutalek, Shiyong Wang, Mosoka Fallah, Chea Sanford Wesseh, Jeffrey Gilbert
2015 Lancet Global Health  
Furthermore, enhancing community participation and engagement is key since contact tracing has been impeded by communities' lack *Ruth Kutalek, Shiyong Wang, Mosoka Fallah, Chea Sanford Wesseh, Jeff rey  ... 
doi:10.1016/s2214-109x(15)70010-0 pmid:25618243 fatcat:y4onq255unfshiohszcosxgq6e

Nitric oxide in cancer metastasis

Huiwen Cheng, Lei Wang, Molly Mollica, Anthony T. Re, Shiyong Wu, Li Zuo
2014 Cancer Letters  
COX-2, cyclooxygenase; CXCR4, CXC chemokine receptor 4; ECM, extracellular matrix; ELAM-1, endothelial leukocyte adhesion molecule 1; eNOS, endothelial nitric oxide synthase; GC, guanylyl cyclase; HIF-1, hypoxia-inducible factor-1; HUVECs, human umbilical vascular endothelial cells; IL-33, cytokine interleukin-33; iNOS, inducible nitric oxide synthase; MAPK, mitogen-activated protein kinase; MMP, matrix metalloproteinase; nNOS, neuronal nitric oxide synthase; NO • , nitric oxide; NO • -NSAIDs,
more » ... itric oxide-releasing non-steroidal anti-inflammatory drugs; NOS, nitric oxide synthase; PCNA, proliferating cell nuclear antigen; PKC, protein kinase Highlights • This review summarizes the dichotomous effects of NO • in tumor metastasis. • Biological factors influence the pro-and anti-metastatic impact of NO • . • NO • induces cytotoxicity and apoptosis to hinder cancer cell growth. • NO • promotes intravasation and angiogenesis to enhance cancer cell growth. • The bimodal nature of NO • facilitates the anti-cancer potential of NO • -NSAIDs.
doi:10.1016/j.canlet.2014.07.014 pmid:25079686 pmcid:PMC4150837 fatcat:fzovnkhgfnardhrjhh4foegrue

The Impact of Broadcasters on Consumer's Intention to Follow Livestream Brand Community

Wei Wang, Minxue Huang, Shiyong Zheng, Liangtong Lin, Lei Wang
2022 Frontiers in Psychology  
., 2014; Martini, 2018; Wang et al., 2021) . Other relevant literature is summarized in Table 1 .  ... 
doi:10.3389/fpsyg.2021.810883 pmid:35185706 pmcid:PMC8850974 fatcat:mf2o63zfi5gn7f2ja36uv6akem

Palladium-catalyzed cascade reactions of coumarins with alkynes: synthesis of highly substituted cyclopentadiene fused chromones

Lei Wang, Shiyong Peng, Jian Wang
2011 Chemical Communications  
Chemicals and solvents were purchased from commercial suppliers and used as received. 1 H and 13 C NMR spectra were recorded on a Bruker ACF300 (300 MHz) or a AMX500 (500 MHz) spectrometer. Chemical shifts were reported in parts per million (ppm), and the residual solvent peak was used as an internal reference: proton (chloroform δ 7.26), carbon (chloroform δ 77.0) or tetramethylsilane (TMS δ 0.00) was used as a reference. Multiplicity was indicated as follows: s (singlet), d (doublet), t
more » ... et), q (quartet), m (multiplet), dd (doublet of doublet), bs (broad singlet). Coupling constants were reported in Hertz (Hz). Low resolution mass spectra were obtained on a Finnigan/MAT LCQ spectrometer in ESI mode and API 3000™ in APCI (Heated Nebulizer) mode. All high resolution mass spectra were obtained on a Finnigan/MAT 95XL-T spectrometer. For thin layer chromatography (TLC), Merck pre-coated TLC plates (Merck 60 F254) were used, and compounds were visualized with a UV light at 254 nm. Further visualization was achieved by staining with iodine. Flash chromatography separations were performed on Merck 60 (0.040-0.063 mm) mesh silica gel. Starting materials Compounds 1 and 2, 2c, 2d were commercially available. Compounds 1b 1 , 1c 1 , 1e 1 , 1f 1 , 1h 1 , 1i 1 , , 1l 1 , 1m 1 , 1n 1 ; 1a 2 , 1g 2 ,1j 2 , 1k 2 ; 2a 3 , 2b 3 , 2e 3 , 2f 3 , 2g 3 , 2h 3 , 2i 3 , 2j 3 , 2k 3 ,2l 3 were prepared according to literature, respectively. Supplementary Material (ESI) for Chemical Communications This journal is (c) The Royal Society of Chemistry 2011 S3 Representative Procedure for Palladium-catalyzed Reaction Typical procedure for the Palladium-catalyzed Reaction: To a solution of diphenylacetylene 2a ( 178 mg, 1 mmol) and 4-hydroxycoumarin 1a (32.4 mg, 0.2 mmol) in 2 ml of dimethylacetamide, then Copper (II) bromide (89.2 mg, 0.4 mmol) as an oxidant and cesium carbonate (130.3 mg, 0.4 mmol) as an additive were added. The reaction mixture was stirred at 130 o C for 24h. The crude product was purified by column chromatography on silica gel, eluted by hexane/EtOAc = 25:1 then 10:1 to afford 70.0 mg (79% yield) of the desired product 3a as pale white powder. 4. Analytical Data of Palladium-catalyzed Reaction 1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3a). 79% yield; 1 H NMR (500 MHz, CDCl 3 ): δ = 8.31 -8.19 (m, 1H), 7.55 (dd, J = 11.3, 4.2, 1H), 7.43 -7.33 (m, 8H), 7.25 (ddd, J = 14.1, 7.1, 2.2, 9H), 7.01 (t, J = 7.3, 1H), 6.94 (t, J = 7.5, 2H), 6.83 -6.75 (m, 2H).; 13 C NMR (125 MHz, CDCl 3 ): δ = O O 7-methyl-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3b). 81% yield; 1 HNMR (500 MHz, CDCl 3 ) δ = 7.96 (s, 1H), 7.32 (ddd, J = 9.6, 7.7, 3.3 Hz, 7H), 7.25 -7.16 (m, 10H), 6.95 (t, J =7.4 Hz, 1H), 6.88 (t, J =7.6 Hz, 2H), 6.75-6.67 (m, 2H), 2.35 (s, 3H).; 13 C NMR (125 MHz, CDCl 3 ): δ = HRMS (ESI) calcd for C 37 H 27 O 2 [M+H] + 503.2006, found 503.2011. 7-isopropyl-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3c). 79% yield; 1 HNMR (500 MHz, CDCl 3 ) δ = 8.34 -7.99 (m, 1H), 7.50 (dd, J =8.6, 2.2 Hz, 1H), 7.47 -7.40 (m, 6H), 7.40 -7.35 (m, 1H), 7.35 (s, 9H), 7.06 (t, J =7.3 Hz, 1H), 6.99 (t, J=7.6, 2H), 6.86 (dd, J =19.2, 8.0 Hz, 2H), 3.04 (hept, J = 6.8 Hz, 1H), 1.30 (d, J = 6.9 Hz, 6H).; 13 C NMR (126 MHz, S5 7-ethyl-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3d). 84% yield; 1 H NMR (500 MHz, CDCl 3 ) δ = 8.10 (s, 1H), 7.47-7.38 (m, 6H), 7.36-7.28 (m, 11H), 7.05 (t, J = 7.4 Hz, 1H), 6.98 (t, J = 7.6 Hz, 2H), 6.81 (d, J = 7.3, 2H), 2.75 (q, J = 7.6 Hz, 2H), 1.27 (t, J = 7.6 Hz, 3H).; 13 C NMR (125 MHz, 15.98.; HRMS (ESI) calcd for C 38 H 29 O 2 [M+H] + 517.2162, found 5172173. O O 6,7-dimethyl-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3e). 50% yield; 1 H NMR (500 MHz, CDCl 3 ) δ = 8.01 (s, 1H), 7.45 -7.38 (m, 6H), 7.34 -7.27 (m, 9H), 7.22 (s, 1H), 7.09 -7.02 (m, 1H), 6.98 (dd, J = 10.4, 4.7, 2H), 6.85 -6.78 (m, 2H), 2.35 (s, 6H).; 13 C (125 MHz, S7 6-methoxy-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3h). 62% yield; 1 H NMR (500 MHz, CDCl 3 ) δ = 8.15 (d, J = 8.9 Hz, 1H), 7.39 (td, J =7.6, 2.7 Hz, 6H), 7.33 -7.24 (m, 9H), 7.02 (t, J =7.3 Hz, 1H), 6.94 (dd, J =13.5, 5.9 Hz, 3H), 6.82 -6.77 (m, 3H), 3.82 (s, 3H).; 13 C NMR (125 MHz, HRMS (EI) calcd for [M+H] + C 37 H 27 O 2 519.1955, found 519.1967. 7-fluoro-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3i). 66% yield; 1 H NMR (500 MHz, CDCl 3 ) δ = 7.88 (dd, J =8.4, 3.1 Hz, 1H), 7.40-7.36 (m, 7H), 7.31-7.25 (m, 10H), 7.03 (t, J = 7.4 Hz, 1H), 6.95 (t, J = 7.6 Hz, 2H), 6.79 -6.76 (m, 2H).; 13 C NMR (125 MHz, S8 6-chloro-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3g). 68% yield; 1 H NMR (500 MHz, CDCl 3 ): δ = 8.21 (d, J = 8.6, 1H), 7.48-7.35 (m, 8H), 7.35-7.26 (m, 9H), 7.06 (t, J = 7.3 Hz, 1H), 6.98 (t, J = 7.6 Hz, 2H), 6.81 (d, J = 7.7 Hz, 2H).; 13 C NMR (125 MHz, HRMS (ESI) calcd for C 36 H 24 O 2 Cl [M+H] + 523.1459, found 523.1474. 7-chloro-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one (3h). 74% yield; 1 H NMR (500 MHz, CDCl 3 ): δ = 8.19 (t, J = 4.7 Hz, 1H), 7.51 (dd, J = 8.9, 2.6 Hz, 1H), 7.39 -7.33 (m, 7H), 7.31 -7.24 (m, 9H), 7.05 -7.00 (m, 1H), 6.95 (dd, J = 10.5, 4.8 Hz, 2H), 6.77 (t, J = 1.5 Hz, 2H).; 13 C NMR (125 MHzHRESIMS (complex as standard) calcd for C 44 H 39 O 2 Cl 2 [M+H] + 669.2337, found 669.2322.
doi:10.1039/c1cc10939a pmid:21416093 fatcat:7z7gyetinrcsnmsui6ptuugtsm
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