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In order to clarify the function of fish collagenase in tissues, we investigated substrate specifici ties of its recombinant enzymes. The enzymes were expressed in E. coli with cDNAs of collagenases such as matrix metalloproteinases 2 and 13 (MMPs-2 and -13), which have been isolated from a rainbow trout fibroblast cDNA library. MMPs-2 and -13 were found to have limited activities against rainbow trout type V collagen and to cleave rainbow trout type I collagen and its gelatin together withdoi:10.2331/fishsci.68.sup2_1567 fatcat:tg2j73imuzczdpgyfpcx52nrei
more »... re fragmentation, re spectively, at a low temperature. Moreover, expression analysis has revealed the distribution of these MMPs in several tissues of rainbow trout. Therefore, they appear to play a crucial role in the collagen catabolism of rainbow trout.
Yuji Kadoi, MD Shigeru Saito, MD Department of Anesthesiology and Reanimatology Gunma University School of Medicine 3-39-22, Showa-machi Maebashi, Gunma 371-8511 Japan ...doi:10.1016/s0022-5223(00)70245-5 pmid:10612788 fatcat:zhpnvoohmbgzfnmb2tzvszcsdm
Kadoi, MD Shigeru Saito, MD Department of Anesthesiology and Reanimatology Gunma University, School of Medicine 3-39-22, Showa-machi Maebashi, Gunma 371-8511, Japan 2. Hornick P, Taylor K. ...doi:10.1016/s0022-5223(00)70247-9 pmid:10612790 fatcat:fhsfv6lwevfjda2z35vdgtqrgq
unlikely that the modest IABP-induced pulse pressure of only 24 ± 8 mm Hg would generate a dp/dt of 645 ± 64 mm Hg/s, particularly at the level of small cerebral arteries, and thus be enough to produce sufficient stretch to induce significant production of L-arginine in the small cerebral arteries. If the pulse pressure was not sufficient, then significant cerebral vasodilation would not be obtained to affect the SjvO 2 , and hence the IABP-induced pulsatility would be unable to ameliorate thedoi:10.1016/s0022-5223(00)70031-6 fatcat:5iugdd4ydja6fo5nyvfxaj523a
more »... mpaired SjvO 2 . A similar study using a pulsatile system capable of producing a pulse pressure of 50 to 60 mm Hg 6 to mimic that produced by the natural heart would be needed to be able to definitely exclude or include the role played by pulsatility. The study only demonstrates that the modest IABP-induced pulsatility was not effective but by no means excludes the role pulsatility may have. 3. It is widely known that during CPB the levels of circulating endogenous catecholamines including norepinephrine are increased. During systemic infusion of norepinephrine, increased electrical brain activity (consisting of increased low-voltage high-frequency waves and decreased high-voltage slow-frequency waves) suggestive of promotion of excitatory (N-methyl-D-aspartate?) receptor activation has been noted in nonischemic rabbits (unpublished observations of electroencephalograms concurrent to brain microdialysis studies), which may lead to Na + and Ca ++ influx. To maintain the normal Na + and Ca ++ transmembrane gradient, the demand for mechanisms to extrude them, which are highly oxygen consuming, will be increased. Therefore during late CPB the decreased SjvO 2 might be a manifestation of that increased oxygen extraction not counteracted by the anesthetics, pressures, or pulsatility used by the authors. The exact effect of increased circulating catecholamines during CPB on the cerebral vasculature is not known, but if it was equivalent to increased sympathetic activity, then vasoconstriction of small cerebral vessels would result with consequent decreased flow. 7 If both effects are operating, the development of decreased SjvO 2 over the first 20 minutes of perfusion and the return to normal after CPB, also in 20 or 30 minutes, are easily explainable. Norepinephrine determination with and without blockade in conjunction with metabolic studies across the brain in both groups might shed some light.
Lymphokine activated killer (LAK) activity in normal pregnancy Shigeru Saito, Mami Saito, Tamotsu Ibaragi and Motohiko Ichijo Department of Obstetrics and Gynecology, Nara Medical University, Nara [Summary ...doi:10.2177/jsci.10.286 fatcat:56a47k34indrvowscoitkylmmm
JA Clinical Reports
Background Few cases of asystole or severe bradycardia occurring after the termination of seizure in the third phase with the dominance of parasympathetic nervous system activity during electroconvulsive therapy (ECT) have been reported. We describe a case of severe bradycardia occurring at the termination of seizure. Case presentation The patient had been diagnosed with bipolar disorder more than 9 years earlier. No adverse hemodynamic events had been observed in over 100 sessions of ECTdoi:10.1186/s40981-020-00389-6 pmid:33067732 fatcat:idn3zzj54vcqdoqhjz5en2x3yq
more »... med during a 9-year period. ECT was usually induced by propofol and suxamethonium. On this ECT, the heart rate gradually decreased before seizure termination, and severe bradycardia (5–6 beats/min) was identified lasting 15–20 s. Atropine administration immediately before electrical stimulus prevented any further bradycardia during the next session of ECT. Conclusions This case report indicates that attention should be paid to adverse cardiac events related to autonomic nerve activity even before such events occur during ECT.
Saito and S.Takata: Improvements for measurement of 222Rn in water 393 C=Cow•Eexp•kln(2)•E/z•l(7) where H: lapse of time from sampling to measurement (h) v : half life of 222Rn (=3.8229x ...doi:10.3769/radioisotopes.41.8_391 fatcat:urtlpiwzrfaztchi43azyhp5ue
The temporal profile measurement for ultra-short electron bunches is one of the key issues for accelerator-based coherent light sources. A bunch length measurement system using Cherenkov radiation (CR) is under development at the Research Center for Electron Photon Science, Tohoku University. This system allows for the real-time diagnostics of electron bunches. The system comprises a thin silica aerogel as the Cherenkov radiator, a specially designed optical transport line, and a high-speeddoi:10.3390/particles1010025 fatcat:w54ndmgt3re7dmrvocpdlyfjam
more »... ak camera. The electron bunch length can be obtained by measuring the time spread of the CR from the electrons passing through the radiator medium using the streak camera. In this paper, we describe the novel bunch length measurement system using CR, discuss the expected time resolution of the system, and finally present the measurement results.
Nobuyuki IMOTO and Shigeru SAITO. ...doi:10.11470/oubutsu1932.57.1535 fatcat:dvp2wxbbtzendhizpl3vapatdm
Nippon Laser Igakkaishi
doi:10.3389/fimmu.2021.770242 pmid:34671364 pmcid:PMC8520997 fatcat:hkg5spommzf6hgxfj7mk6qvvmu
Purpose] The purpose of this study was to examine the temporal changes of the modified Gait Efficacy Scale (mGES) of patients admitted to convalescent rehabilitation wards. [Participants and Methods] Eleven patients with lower limb fracture participated in this study. mGES was measured at admission, then monthly, and at discharge, and at the time of walking independence in the ward. [Results] mGES showed significant differences between at admission, at the time of walking independence, and atdoi:10.1589/rika.36.233 fatcat:fmcz2vmwjrcdtgib2se3jrs76a
more »... scharge. The mGES scores at admission, at the time of independence of walking in the ward, and at discharge were higher in the same order. Compared to just before walking independence, mGES had significantly increased at just after walking independence. The change in mGES before walking independence was significantly higher than after walking independence. [Conclusion] The results suggest that gait self-efficacy is more likely to improve before walking independence than after walking independence.
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