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Conflicts of Interest: Sheryl Flynn is the CEO of Blue Marble Health and could benefit financially from the sale of products developed by Blue Marble Health. ... Sheryl Flynn is the PI of an NIH grant (R44HL137502) that is evaluating the feasibility of a digital pulmonary rehabilitation platform developed by her company. ...doi:10.3390/life11111270 pmid:34833145 pmcid:PMC8625237 fatcat:rodktpwcdfcozdmjqy63oxdbfu
Lecture Notes in Computer Science
In this paper a novel augmented-reality environment is presented for enhancing locomotor training. The main goal of this environment is to excite kids for walking and hence facilitate their locomotor therapy and at the same time provide the therapist with a quantitative framework for monitoring and evaluating the progress of the therapy. This paper focuses on the quantitative part of our framework, which uses a depth camera to capture the patient's body motion. More specifically, we present adoi:10.1007/978-3-319-10437-9_12 fatcat:qegy42zirnb7le5zcjp7wlifxy
more »... del-free graph-based segmentation algorithm that detects the regions of the arms and legs in the depth frames. Then, we analyze their motion patterns in real-time by extracting various features such as the pace, length of stride, symmetry of walking pattern, and arm-leg synchronization. Several experimental results are presented that demonstrate the efficacy and robustness of the proposed methods.
Sheryl Flynn is the co-founder and CEO of Blue Marble Health Company and could benefit financially from the sale of the product described in this paper. ...doi:10.4236/aar.2018.73004 fatcat:gxfhz57brfexzeitzmblpwhpk4
Amino acids induce indicators of response to injury in glomerular mesangial cells. .-High-protein diets exacerbate glomerular hyperfiltration and the progression of diabetic nephropathy. The purpose of this study was to determine whether amino acids also produce nonhemodynamic injury in the glomerulus. When rat mesangial cells were cultured with an amino acid mixture designed to replicate the composition in plasma after protein feeding, production of mRNA (Northern blot analysis) and/or proteindoi:10.1152/ajprenal.00419.2002 pmid:12644443 fatcat:wdh3xm24crgotgfwdehtrg3szu
more »... (ELISA or Western blot analysis) for transforming growth factor-␤1 (TGF-␤1), fibronectin, thrombospondin-1 (TSP-1), and collagen IV were enhanced in a manner comparable to a culture with high glucose (30.5 mM). The bioactive portion of total TGF-␤ (NRK assay) increased in response to amino acids. The TSP-1 antagonist LSKL peptide reduced bioactive TGF-␤ and fibronectin, indicating the dependence of TGF-␤1 activation on TSP-1. DNA synthesis ([ 3 H]thymidine incorporation), an index of cellular proliferation, increased in response to amino acids and was further enhanced by culture with increased levels of both amino acids and glucose. TGF-␤1 and matrix proteins increased when mesangial cells were cultured with excess L-arginine (2.08 mM) alone. Although L-arginine is the precursor of nitric oxide (NO), such responses to amino acids do not appear to be mediated through increased NO production. NO metabolites decreased in the media, and these responses to mixed amino acids or L-arginine were not prevented by NO synthase inhibition. In conclusion, amino acids induce indicators of response to injury in mesangial cells, even when hemodynamic stress is absent. In conditions associated with increased circulating amino acids, such as diabetes and/or a high-protein diet, direct cellular effects could contribute to glomerular injury.
Stroke is a leading cause of long-term disability, and virtual reality- (VR-) based stroke rehabilitation is effective in increasing motivation and the functional performance. Although much of the functional reach and grasp capabilities of the upper extremities were regained, the pinch movement remains impaired following stroke. In this study, we developed a haptic-enhanced VR system to simulate haptic pinch tasks to assist the recovery of upper-extremity fine motor function. We recruited 16doi:10.1155/2017/9840273 pmid:29230275 pmcid:PMC5694569 fatcat:cxklseoo5fdivifcrc4xkgkjse
more »... lts with stroke to verify the efficacy of this new VR system. Each patient received 30 min VR training sessions 3 times per week for 8 weeks. Outcome measures, Fugl-Meyer assessment (FMA), Test Evaluant les Membres superieurs des Personnes Agees (TEMPA), Wolf motor function test (WMFT), Box and Block test (BBT), and Jamar grip dynamometer, showed statistically significant progress from pretest to posttest and follow-up, indicating that the proposed system effectively promoted fine motor recovery of function. Additionally, our evidence suggests that this system was also effective under certain challenging conditions such as being in the chronic stroke phase or a coside of lesion and dominant hand (nondominant hand impaired). System usability assessment indicated that the participants strongly intended to continue using this VR-based system in rehabilitation.
More than one-third of people over the age of 65 experience falls each year, and those who fall once are two to three times more likely to fall again. A fall can significantly limit a person's ability to remain self-sufficient. Fall injuries are responsible for significant disability, reduced physical function, and loss of independence. However, falls are not an inevitable result of aging. Systematic reviews of fall intervention studies have established that prevention programs can reducedoi:10.1515/ijdhd.2011.056 fatcat:iaw7mpb2vbdylb4pcvsn5v43va
more »... Physical activities, including strengthening exercises, tai chi, dancing and walking have been demonstrated to improve balance and decrease risk of falls in older adults. Modified dance-based exercises that include step-based movements have been demonstrated to improve endurance and balance in older adults. Dance video games, using a dance mat with areas that the player must step on in time with cues on the screen, have been demonstrated to improve activity and mood and reduce weight in children and youth. However, these dance games often include fast paced music, frequent jumping and an overload of visual information, movement and colors on the screen. This paper outlines the development of a prototype rhythm game that leverages the benefits of step-based exercise and dance video games to improve balance and reduce falls in older adults.
Behrman AL, Light KE, Flynn SM, Thigpen MT. Is the Functional Reach Test useful for identifying falls risk among individuals with Parkinson's disease? Arch Phys Med Rehabil 2002;83:538-42. ...doi:10.1053/apmr.2002.30934 pmid:11932858 fatcat:v5rfwtddkvgtvoniaoexx7flgy
Objective: To compare phase-and task-dependent H-reflex modulation in standing and walking in 2 spinal cord injury (SCI) groups with and without a walker. Methods: Fourteen subjects with American Spinal Injury Association Impairment Scale D SCI (40±10 years) participated. Tibial nerve was stimulated to evoke 15 H-reflexes (at M-wave 7%-13% of maximum-M). Results: H-reflex was greater in the walker group during stance (but not standing/swing). Conclusion: Differences in H-reflex modulationdoi:10.1310/sci2016-0007 pmid:29339857 pmcid:PMC4896323 fatcat:7baiozyhrrdqnd6u4xwnudbduq
more »... n groups walking with and without a walker may be explained by sensory mechanism that enhances central excitation, difference in motor activation levels between groups, and other complex mechanisms that influence balance or stability.
Phadke CP, Flynn SM, Thompson FJ, Behrman AL, Trimble MH, Kukulka CG. ... From the Departments of Physical Therapy (Phadke, Behrman, Trimble) and Neuroscience (Thompson), University of Florida, Gainesville, FL; Division of Biokinesiology and Physical Therapy (Flynn), University ...doi:10.1016/j.apmr.2009.01.022 pmid:19577036 fatcat:27hxq6wzd5aq5bmsbk4jglt6b4
Lecture Notes in Computer Science
We describe a pilot clinical trial with a flexible telerehabilitation platform that allows a therapist to remotely monitor the exercise regimen and progress of a patient who previously suffered from a stroke. We developed virtual game environments which were host to a progressive set of training tasks from precise fine motor movements to reaching movements that involve full arm and shoulder activity. Concurrently, the therapist monitored the progress of the patient through a video channel.doi:10.1007/978-3-642-22024-1_14 fatcat:sio5xjesinaqlfz5rcppb6cxaa
more »... sment of psychosocial variables show that negative feelings (confusion, t(13)=2.54, p<.05, depression t(13)=2.58, p<.05, and tension, t(13)=2, p<.1) were significantly lessened after the game play. Patients' overall satisfaction with the telerehabilitation system was positively correlated with the feeling of co-presence of the therapist, r(8)=.770, p<.005. Patients felt less efficacious in continuing therapy after participating in the telerehabilitation game compared to their reported perseverance self-efficacy before the game, t(5)=2.71, p<.05 and showed decreased willingness to persist in therapy regardless of fatigue after the game play, t(5)=2.67, p<.05. However, when patients' pretest mood scores were taken into account, this trend was reversed. Patients' active mood before the game was positively correlated with their willingness to persist in the therapy after the game, r(14)=.699, p<.005. Telerehabilitation significantly enhanced stroke patients' psychological states.
In 2019, heterosexual sex accounted for 23% of new HIV diagnoses in the United States and six dependent areas (1). Although preexposure prophylaxis (PrEP) can safely reduce the risk for HIV infection among heterosexual persons, this group is underrepresented in PrEP research (2). CDC analyzed National HIV Behavioral Surveillance (NHBS) data to describe PrEP awareness among heterosexually active adults in cities with high HIV prevalence. Overall, although 32.3% of heterosexually active adultsdoi:10.15585/mmwr.mm7047a3 pmid:34818317 pmcid:PMC8612510 fatcat:5ybxxkevufazphxdpcpmgkbps4
more »... were eligible were aware of PrEP, <1% used PrEP. Racial, ethnic, and gender disparities were identified, with the lowest awareness of PrEP among residents of Puerto Rico (5.8%) and Hispanic or Latino (Hispanic) men (19.5%) and women (17.6%). Previous studies have found that heterosexual adults are interested in taking PrEP when they are aware of it (3); tailoring PrEP messaging, including Spanish-language messaging, to heterosexual adults, might increase PrEP awareness and mitigate disparities in use.
., 41009, 41572 Florit, Reyes, 40908 ~ d, Kory, 40344 , Margo, 41512 Flynn. ... ., 41779 Flynn, John P., 41985 Flynn, Patrick M., 39350 Foehrenbach, Leonore M.. 41227 Fopel, Barry 8, 4 _ aia, es as 41547 Dene, 41156 Foley: Robert, 39754 Folkard, Simon, 39853 AUTHOR INDEX Follette, ...
Florida Bar Journal
Nathan . 552-2900 Sheryl Javits, Research Assistant Judge Philip A. Hubbart . 552-2900 Bonnie Lano, Research Assistant Louis J. Spallone, Clerk . 552-2900 Rufus E. ... Scheb . 686-5552 Robert Lee Donald, Research Assistant Judge T.TruettOtt . . . 687-0616 William Flynn, Research Assistant Judge Herboth S. Ryder (Information unavailable at presstime. ...
Florida Bar Journal
Truett Ott . 686-8171 William Flynn, Research Assistant Judge Herboth S. Ryder . 686-8171 Lewis M. Petzold, Research Assistant Judge Paul W. Danahy, Jr . 686-8171 Doris A. ... Nathan . 552-2900 Sheryl Javits, Research Assistant Judge Phillip A. Hubbart . 552-2900 Bonnie Lano. Research Assistant Judge James W. Kehoe . 552-2900 Tom Boyd, Research Assistant Louis J. ...
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