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Emotional intelligence has become a fashionable topic in the popular press, and has been heralded as an eective predictor of successful performance. However, little empirical evidence has borne out these claims. The present study was conducted in order to determine the relationship of emotional intelligence, cognitive ability, and personality with academic achievement. Emotional intelligence was assessed using the EQ-i (total EQ-i score and ®ve EQ-i composite factor scores). Both cognitivedoi:10.1016/s0191-8869(99)00250-0 fatcat:eb6xzhs4o5enbdbneqcbuvqece
more »... ty and personality (in terms of extraversion and self control) were signi®cantly associated with academic achievement. None of the EQ-i factor scores, nor the total EQ-i score, was signi®cantly related to academic achievement. 7
Victor J. Forouhar Moreno et al. MNRAS 000,1-13 (2021) MNRAS 000, 1-13 (2021)4 Victor J. Forouhar Moreno et al. ...arXiv:2107.14245v2 fatcat:vshgjhoycvbxji4g5waore35mm
Objective The purpose of this study was to determine the prevalence and prognostic significance of exercise-induced ventricular arrhythmias (EIVAs) in patients referred for exercise testing, considering the arrhythmic substrate and exerciseinduced ischemia. Background EIVAs are frequently observed during exercise testing, but their prognostic significance is uncertain. The design of this study was a retrospective analysis of prospectively collected data, and it took place in 2doi:10.1067/mhj.2003.60 pmid:12514666 fatcat:q2ecvzqgtzbmncjiicmfpczmwa
more »... ted Veterans Affairs Medical Centers. Patients comprised 6213 consecutive males referred for exercise tests. We measured clinical exercise test responses and all-cause mortality after a mean follow-up of 6 Ϯ 4 years. EIVAs were defined as frequent premature ventricular contractions (PVCs) constituting Ͼ10% of all ventricular depolarizations during any 30 second electrocardiogram recording, or a run of Ն3 consecutive PVCs during exercise or recovery. Results A total of 1256 patients (20%) died during follow-up. EIVAs occurred in 503 patients (8%); the prevalence of EIVAs increased in older patients and in those with cardiopulmonary disease, resting PVCs, and ischemia during exercise. EIVAs were associated with mortality irrespective of the presence of cardiopulmonary disease or exercise-induced ischemia. In those without cardiopulmonary disease, mortality differed more so later in follow up than earlier. In those without resting PVCs, EIVAs were also predictive of mortality, but in those with resting PVCs, poorer prognosis was not worsened by the presence of EIVAs. From
This project starteda sw hat we thought would be aq uick effort for first-author Shaun Kelsey,b ut to our delight, and thanks to crystallographers Victor Day and Allen Oliver,t he structural results demanded ... The photo above shows co-authors Amit Kumar, Victor Day,S haun Kelsey,a nd James Blakemore in the back row.C o-author Allen Oliver is not pictured, but undergraduate Claire Dopp is also shown in the photo-sher ...doi:10.1002/celc.202100848 fatcat:b5sd6qkwkfhsbpy5g3gf6a46ha
Most patients attending cancer clinics have hypovitaminosis D. Correcting or preventing this abnormal condition could mitigate the emotional and physical complications of their disease, but clinical trials of vitamin D therapy in this setting are hindered by the unavailability of safe, effective and practical loading dose regimens. Methods: In this single arm open-label pharmacokinetic trial, outpatients with advanced lung cancer consumed 20,000 IU vitamin D daily with the largest meal of thedoi:10.1186/s12937-016-0203-8 pmid:27716304 pmcid:PMC5053167 fatcat:ibwikcvvxngmhitujrjxl6smly
more »... y for 14 days followed by 10,000 IU per day for a further 7 days. Plasma concentrations of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone, calcium, vitamin C and C-reactive protein were measured on protocol days 0, 14 and 21, and serum vitamin D binding protein (VDBP) concentrations on days 0 and 21. As a secondary objective, preliminary information was obtained regarding clinical effects of rapid vitamin D loading on mood and symptoms by administering appropriate questionnaires two times at baseline and after 14 and 21 days of vitamin D therapy. Results: Of the 91 patients enrolled in the study, 85 % had hypovitaminosis D and 41 % had hypovitaminosis C. Plasma VDBP concentrations were in the normal range. The vitamin D load increased the average plasma 25(OH)D concentration to 116 ± 34 nmol/L (mean ± SD); the median concentration was 122 nmol/L (interquartile range 103-134); VDBP concentrations did not change. Final plasma 25(OH)D concentrations were subnormal (<75 nmol/L) for 13 % of the patients and sub-target (<120 nmol/L) for 44 % of them. In most cases, subnormal and sub-target 25(OH)D concentrations were attributable to obesity and/or a low baseline 25(OH)D concentration. Mood and symptom scores did not change significantly throughout the 3-week protocol. Conclusion: Hypovitaminosis D and C are very common in outpatients with advanced lung cancer. A vitamin D load of 20,000 IU per day for 14 days failed to achieve the target concentration in 44 % of the participants in this trial. These results suggest that a loading dose of 30,000 IU per day for 14 days would be safe and effective for patients who are obese or at risk of severe hypovitaminosis D. The preliminary nature of the study design, and the failure to achieve target 25(OH)D concentrations for a large proportion of the patients, do not allow any firm conclusion about the clinical effects of correcting hypovitaminosis D in this patient population. Nevertheless, no evidence was obtained that partial correction of hypovitaminosis D greatly improved mood, reduced distress or relieved cancer-related symptoms. This trial was registered at clinicaltrials.gov as NCT01631526.
A.N.E. 2007;12(2):1-9 premature ventricular contractions; heart rate; electrocardiogram Address for reprints : Victor F. Froelicher, M.D., VA Palo Alto Health Care System, ...doi:10.1111/j.1542-474x.2007.00150.x pmid:17593180 fatcat:4xxg5hdtjngmnhnl5kwetsbfxa
Energy Expenditure (EE) (kcal/day), a key element to guide obesity treatment, is measured from CO2 production, VCO2 (mL/min), and/or O2 consumption, VO2 (mL/min). Current technologies are limited due to the requirement of wearable facial accessories. A novel system, the Smart Pad, which measures EE via VCO2 from a room's ambient CO2 concentration transients was evaluated. Resting EE (REE) and exercise VCO2 measurements were recorded using Smart Pad and a reference instrument to studydoi:10.3390/s22041355 pmid:35214262 pmcid:PMC8963031 fatcat:q4c4i3oa6vbszdoryuletlfhum
more »... duration's influence on accuracy. The Smart Pad displayed 90% accuracy (±1 SD) for 14–19 min of REE measurement and for 4.8–7.0 min of exercise, using known room's air exchange rate. Additionally, the Smart Pad was validated measuring subjects with a wide range of body mass indexes (BMI = 18.8 to 31.4 kg/m2), successfully validating the system accuracy across REE's measures of ~1200 to ~3000 kcal/day. Furthermore, high correlation between subjects' VCO2 and λ for CO2 accumulation was observed (p < 0.00001, R = 0.785) in a 14.0 m3 sized room. This finding led to development of a new model for REE measurement from ambient CO2 without λ calibration using a reference instrument. The model correlated in nearly 100% agreement with reference instrument measures (y = 1.06x, R = 0.937) using an independent dataset (N = 56).
In this patient population, the variables of age and hyperlipidemia did not significantly predict the presence of CAD; however, an ABI at rest of Յ0.90 versus other cardiovascular risk factors was an independent predictor of the presence of CAD and 3-vessel and left main CAD, but not of 1-or 2-vessel CAD. Cardiovascular risk factors were not predictive of CAD in this population, and this may be explained by the small sample size of the population in our study. 1,2 An abnormal ABI predicts thedoi:10.1016/j.amjcard.2003.10.051 pmid:14969631 fatcat:a6pjifmzwbeq3dur6wjj7v6d7q
more »... erall presence of CAD; however, the results of the logistic regression and receiver-operating characteristic curve analysis suggest that this is driven largely by the identification of patients with severe CAD, including 3-vessel and left main disease. Limitations of our study included the small sample size and possibility of bias due to selection of a high-risk group, because all patients were referred for coronary angiography. However, this should apply to all groups of patients in the study. The results of this study also cannot be extrapolated to the general population, because we enrolled only African-Americans with risk factors; our hypothesis was that the ABI would be of value in screening selected intermediate-risk patients who may benefit from coronary angiography for risk stratification. Our population thereby meets these criteria and provides useful information to physicians treating these patients.
Hannah Faye Chua and Victor J. Strecher. ...doi:10.1038/nn.2761 pmid:21358641 pmcid:PMC3109081 fatcat:vvcr36pbpzccnjilbjyzqrhob4
T o succeed in evidence-based diagnosis and treatment at the point of care, health-care personnel need access to trustworthy clinical practice guidelines. 1 The last decade has seen major advances in the science of creating clinical practice guidelines, including rigorous standards for development and tools to assess their methodologic rigor and transparency.    Advances in approaches to summarize evidence, rate its quality, and move in a transparent manner from evidence todoi:10.1378/chest.13-0746 pmid:23918106 fatcat:v22hgnz2iffa3avfylykkvcuai
more »... ons include the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. 4,5 GRADE has become an international standard, adopted by . 70 organiza-Standards and guidance for developing trustworthy clinical practice guidelines are now available, and a number of leading guidelines adhere to the key standards. Even current trustworthy guidelines, however, generally suffer from a cumbersome development process, suboptimal presentation formats, ineffi cient dissemination to clinicians at the point of care, high risk of becoming quickly outdated, and suboptimal facilitation of shared decision-making with patients. To address these limitations, we have-in our innovative research program and nonprofi t organization, MAGIC (Making GRADE the Irresistible Choice)-constructed a conceptual framework and tools to facilitate the creation, dissemination, and dynamic updating of trustworthy guidelines. We have developed an online application that constitutes an authoring and publication platform that allows guideline content to be written and structured in a database, published directly on our web platform or exported in a computer-interpretable language (eg, XML) enabling dissemination through a wide range of outputs that include electronic medical record systems, web portals, and applications for smartphones/tablets. Modifi cations in guidelines, such as recommendation updates, will lead to automatic alterations in these outputs with minimal additional labor for guideline authors and publishers, greatly facilitating dynamic updating of guidelines. Semiautomated creation of a new generation of decision aids linked to guideline recommendations should facilitate face-to-face shared decision-making in the clinical encounter. We invite guideline organizations to partner with us (www.magicproject.org) to apply and further improve the tools for their purposes. This work will result in clinical practice guidelines that we cannot only trust, but also easily share and use. CHEST 2013; 144(2):381-389
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Texdoi:10.1016/j.neuroimage.2011.12.064 pmid:22245645 pmcid:PMC3288964 fatcat:vohmo4b4kbchnbgnaaoohpvo3i
more »... rm) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: The amygdala is critically involved in detecting emotionally salient stimuli and in enhancing memory for emotional information. Growing evidence also suggests that the amygdala plays a crucial role in addiction, perhaps by strengthening associations between emotionally-charged drug cues and drug-seeking behavior. In the current study, by integrating functional MRI (fMRI), genetics, and outcome data from a large group of smokers who completed a smoking-cessation intervention and attempted to quit, we show that the amygdala also plays a role in quitting. Specifically, we demonstrate that the amygdala response to smokingcessation messages in smokers trying to quit is a predictor of their post-intervention quitting outcome. We further show that the amygdala response is modulated by genetic variation in the serotonin transporter and mediates the impact of this genetic variation on quitting. These results point to a gene-brain-behavior pathway relevant to smoking cessation, and add to our understanding of the role of the amygdala in nicotine addiction.
Limm 3 , Victor Nizet 5,6 , Jack E. ... Mitchell 1-3 , Shaun W. Lee 1-3 , Morgan A. Pence 4 , Andrew L. Markley 3 , Joyce D. Mitchell et al.SupplementalFigure S1. Mitchell et al.SupplementalFigure S2. ...doi:10.1074/jbc.m900802200 pmid:19286651 pmcid:PMC2676033 fatcat:bhdavtitrfawbesrdgv2xgybxu
Ho-Cing Victor Yau: Writingoriginal draft. Shaun Samuelson: Methodology; validation; writingreview and editing. ...doi:10.1111/ans.17414 pmid:34874098 fatcat:kgiglnpcpvertm5437vc3kd35e
Through elaboration of its botulinum toxins, Clostridium botulinum produces clinical syndromes of infant botulism, wound botulism, and other invasive infections. Using comparative genomic analysis, an orphan nine-gene cluster was identified in C. botulinum and the related foodborne pathogen Clostridium sporogenes that resembled the biosynthetic machinery for streptolysin S, a key virulence factor from group A Streptococcus responsible for its hallmark ␤-hemolytic phenotype. Geneticdoi:10.1074/jbc.m110.118554 pmid:20581111 pmcid:PMC2934687 fatcat:gszofy5jrvhmbhkca4gsn6f2ru
more »... on, in vitro reconstitution, mass spectral analysis, and plasmid intergrational mutagenesis demonstrate that the streptolysin S-like gene cluster from Clostridium sp. is responsible for the biogenesis of a novel post-translationally modified hemolytic toxin, clostridiolysin S.
Staphylococcus aureus subverts innate defenses during infection in part by killing host immune cells to exacerbate disease. This human pathogen intercepts host cues and activates a transcriptional response via the S. aureus exoprotein expression (SaeR/SaeS [SaeR/S]) two-component system to secrete virulence factors critical for pathogenesis. We recently showed that the transcriptional repressor CodY adjusts nuclease ( nuc ) gene expression via SaeR/S, but the mechanism remained unknown. Here,doi:10.1128/jb.00012-18 pmid:29378891 fatcat:kwce6p6y7bhltmk3l2qjgzvssq
more »... identified two CodY binding motifs upstream of the sae P1 promoter, which suggested direct regulation by this global regulator. We show that CodY shares a binding site with the positive activator SaeR and that alleviating direct CodY repression at this site is sufficient to abrogate stochastic expression, suggesting that CodY represses sae expression by blocking SaeR binding. Epistasis experiments support a model that CodY also controls sae indirectly through Agr and Rot-mediated repression of the sae P1 promoter. We also demonstrate that CodY repression of sae restrains production of secreted cytotoxins that kill human neutrophils. We conclude that CodY plays a previously unrecognized role in controlling virulence gene expression via SaeR/S and suggest a mechanism by which CodY acts as a master regulator of pathogenesis by tying nutrient availability to virulence gene expression. IMPORTANCE Bacterial mechanisms that mediate the switch from a commensal to pathogenic lifestyle are among the biggest unanswered questions in infectious disease research. Since the expression of most virulence genes is often correlated with nutrient depletion, this implies that virulence is a response to the lack of nourishment in host tissues and that pathogens like S. aureus produce virulence factors in order to gain access to nutrients in the host. Here, we show that specific nutrient depletion signals appear to be funneled to the SaeR/S system through the global regulator CodY. Our findings reveal a strategy by which S. aureus delays the production of immune evasion and immune-cell-killing proteins until key nutrients are depleted.
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