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Trauma Affecting School-Aged Children in the San Francisco Bay Area

Pollie Bith-Melander, Sharon May, Lemny Perez, Timothy Nguyen, Amber Huynh
2019 Mathews Journal of Psychiatry & Mental Health  
doi:10.30654/mjpmh.10025 fatcat:uc7rvwjz2vgk3bfp3z6jypowye

Protonation of Nickel–Iron Hydrogenase Models Proceeds after Isomerization at Nickel

Mioy T. Huynh, David Schilter, Sharon Hammes-Schiffer, Thomas B. Rauchfuss
2014 Journal of the American Chemical Society  
Theory and experiment indicate that the protonation of reduced NiFe dithiolates proceeds via a previously undetected isomer with enhanced basicity. In particular, it is proposed that protonation of (OC) 3 Fe(pdt)-Ni(dppe) (1; pdt 2− = − S(CH 2 ) 3 S − ; dppe = Ph 2 P(CH 2 ) 2 PPh 2 ) occurs at the Fe site of the two-electron mixed-valence Fe(0)Ni(II) species, not the Fe(I)-Ni(I) bond for the homovalence isomer of 1. The new pathway, which may have implications for protonation of other complexes
more » ... and clusters, was uncovered through studies on the homologous series L(OC) 2 Fe(pdt)M(dppe), where M = Ni, Pd (2), and Pt (3) and L = CO, PCy 3 . Similar to 1, complexes 2 and 3 undergo both protonation and 1e − oxidation to afford well-characterized hydrides ([2H] + and [3H] + ) and mixed-valence derivatives ([2] + and [3] + ), respectively. Whereas the Pd site is tetrahedral in 2, the Pt site is square-planar in 3, indicating that this complex is best described as Fe(0)Pt(II). In view of the results on 2 and 3, the potential energy surface of 1 was reinvestigated with density functional theory. These calculations revealed the existence of an energetically accessible and more basic Fe(0)Ni(II) isomer with a square-planar Ni site.
doi:10.1021/ja505783z pmid:25094041 pmcid:PMC4156870 fatcat:lzrtluyjszgqze7axaack2z344

Interplay between Terminal and Bridging Diiron Hydrides in Neutral and Oxidized States

Xin Yu, Chen-Ho Tung, Wenguang Wang, Mioy T. Huynh, Danielle L. Gray, Sharon Hammes-Schiffer, Thomas B. Rauchfuss
2017 Organometallics  
Experimental details, NMR ( 1 H, 31 P) and IR spectra, comparison of experimentally measured and DFT calculated structures, redox potentials, and ν CO values, calculated reaction free energies and spin densities, coordinates and energies of all optimized structures, and crystallographic data (PDF)
doi:10.1021/acs.organomet.7b00297 pmid:28781408 pmcid:PMC5538148 fatcat:hlh66rbwt5bqzknng2rulaztmy

Computational Investigation of [FeFe]-Hydrogenase Models: Characterization of Singly and Doubly Protonated Intermediates and Mechanistic Insights

Mioy T. Huynh, Wenguang Wang, Thomas B. Rauchfuss, Sharon Hammes-Schiffer
2014 Inorganic Chemistry  
The [FeFe]-hydrogenase enzymes catalyze hydrogen oxidation and production efficiently with binuclear Fe metal centers. Recently the bioinspired H 2 -producing model system Fe 2 (adt)(CO) 2 (dppv) 2 (adt=azadithiolate and dppv=diphosphine) was synthesized and studied experimentally. In this system, the azadithiolate bridge facilitates the formation of a doubly protonated ammonium-hydride species through a proton relay. Herein computational methods are utilized to examine this system in the
more » ... s oxidation states and protonation states along proposed mechanistic pathways for H 2 production. The calculated results agree well with the experimental data for the geometries, CO vibrational stretching frequencies, and reduction potentials. The calculations illustrate that the NH···HFe dihydrogen bonding distance in the doubly protonated species is highly sensitive to the effects of ionpairing between the ammonium and BF 4 − counterions, which are present in the crystal structure, in that the inclusion of BF 4 − counterions leads to a significantly longer dihydrogen bond. The non-hydride Fe center was found to be the site of reduction for terminal hydride species and unsymmetric bridging hydride species, whereas the reduced symmetric bridging hydride species exhibited spin delocalization between the Fe centers. According to both experimental measurements and theoretical calculations of the relative pK a values, the Fe d center of the neutral species is more basic than the amine, and the bridging hydride species is more thermodynamically stable than the terminal hydride species. The calculations implicate a possible pathway for H 2 evolution that involves an intermediate with H 2 weakly bonded to one Fe, a short H 2 distance similar to the molecular bond length, the spin density delocalized over the two Fe centers, and a nearly symmetrically bridged CO ligand. Overall, this study illustrates the mechanistic roles of the ammonium-hydride interaction, flexibility of the bridging CO ligand, and intramolecular electron transfer between the Fe centers in the catalytic cycle. Such insights will assist in the design of more effective bioinspired catalysts for H 2 production.
doi:10.1021/ic5013523 pmid:25207842 pmcid:PMC4186672 fatcat:uzgplb3rcfhtzmu7mp6zdvzsme

Metabolic Labeling of Fucosylated Glycans in Developing Zebrafish

Karen W. Dehnert, Brendan J. Beahm, Thinh T. Huynh, Jeremy M. Baskin, Scott T. Laughlin, Wei Wang, Peng Wu, Sharon L. Amacher, Carolyn R. Bertozzi
2011 ACS Chemical Biology  
doi:10.1021/cb100284d pmid:21425872 pmcid:PMC3117394 fatcat:landrkqtnjfnbeolmwczoy4q6y

Models of the Ni-L and Ni-SIa States of the [NiFe]-Hydrogenase Active Site

Geoffrey M. Chambers, Mioy T. Huynh, Yulong Li, Sharon Hammes-Schiffer, Thomas B. Rauchfuss, Edward Reijerse, Wolfgang Lubitz
2015 Inorganic Chemistry  
A new class of synthetic models for the active site of [NiFe]-hydrogenases are described. The Ni I/II (SCys) 2 and Fe II (CN) 2 CO sites are represented with (RC 5 H 4 )Ni I/II and Fe II (diphos)(CO) modules, where diphos = 1,2-C 2 H 4 (PPh 2 ) 2 (dppe) or cis-1,2-C 2 H 2 (PPh 2 ) 2 (dppv). The two bridging thiolate ligands are represented by CH 2 (CH 2 S) 2 2− (pdt 2− ), Me 2 C(CH 2 S) 2 2− (Me 2 pdt 2− ), and (C 6 H 5 S) 2 2− . The reaction of Fe(pdt)(CO) 2 (dppe) and [(C 5 H 5 ) 3 Ni 2 ]BF 4
more » ... affords [(C 5 H 5 )Ni(pdt)Fe(dppe)-(CO)]BF 4 ([1a]BF 4 ). Monocarbonyl [1a]BF 4 features an S = 0 Ni II Fe II center with five-coordinated iron, as proposed for the Ni-SI a state of the enzyme. One-electron reduction of [1a] + affords the S = 1 / 2 derivative [1a] 0 , which, according to density functional theory (DFT) calculations and electron paramagnetic resonance and Mössbauer spectroscopies, is best described as a Ni I Fe II compound. The Ni I Fe II assignment matches that for the Ni-L state in [NiFe]-hydrogenase, unlike recently reported Ni II Fe I -based models. Compound [1a] 0 reacts with strong acids to liberate 0.5 equiv of H 2 and regenerate [1a] + , indicating that H 2 evolution is catalyzed by [1a] 0 . DFT calculations were used to investigate the pathway for H 2 evolution and revealed that the mechanism can proceed through two isomers of [1a] 0 that differ in the stereochemistry of the Fe(dppe)CO center. Calculations suggest that protonation of [1a] 0 (both isomers) affords Ni III -H-Fe II intermediates, which represent mimics of the Ni-C state of the enzyme. Beyond complementing our understanding of the enzyme, synthetic models could underpin the development of new catalysts for the processing of H 2 . 1,2 The possibility of connecting synthetic complexes to enzyme states was established with [(dppe)Ni(pdt)(μ-H)Fe(CO) 3 ] +.14,21 A related nickel-iron hydride [(amine) 2 Ni(SR) 2 (μ-H)FeL 3 ] + catalyzes the reduction of redox dyes by H 2 , a characteristic assay for the hydrogenases. 15 With a Ni II -H-Fe II core, these synthetic complexes represent early models for the Ni-R state of the protein, despite discrepancies (Table 1). 16 Concurrent with the development of these diamagnetic models, 21,22 efforts have been made to replicate the paramagnetic states of the enzyme. The two most prominent paramagnetic states are Ni-C and Ni-L. Invoked in all catalytic mechanisms is Ni-C, 6,7,23-25 which features a hydride bridging the Ni III and Fe II centers. No synthetic analogues of this nickel(III) hydride have been detected, but this paper provides a first glimpse of a synthetic model. With a Ni I Fe II core, Ni-L is typically generated by low-temperature photolysis of Ni-C, and recent evidence points to its role in catalysis. 26,27 These S = 1 / 2 states deviate most strongly from the conventional chemistry of dimetal systems and therefore offer the greatest opportunity for the discovery of fundamentally new reactivity. The first reported S = 1 / 2 NiFe complex was [(diphos)Ni(pdt)Fe-(CO) 2 L] + . Spectroscopic, crystallographic, and computational analyses show, however, that these cations are described as Ni II Fe I Chambers et al.
doi:10.1021/acs.inorgchem.5b01662 pmid:26421729 pmcid:PMC4807737 fatcat:rheqlszlozggji6v2ihghg6hvm

Whole Body Vibration: The Effect of Position and Frequency on Perceived Exertion in Healthy, Active Adults

Annette Karim, Elizabeth Lemos, Huynh Nguyen, Katy Mitchell, Toni Roddey, Sharon Olson
2019 Journal of Health Science  
Whole Body Vibration (WBV) is a new exercise trend in fitness and performance enhancement. WBV platforms oscillate over a range of frequencies and amplitudes; however no study to date has examined the experience of perceived exertion with differences in vibration frequency and static or dynamic body position, nor examined the difference between sexes based on position and frequency during WBV. The purpose of this study was to assess the effects of position and frequency on perceived exertion
more » ... ing WBV in healthy, active adults. A convenience sample of 39 healthy young adults who participated in moderated exercise was blinded and randomly allocated to six WBV conditions composed of different frequency and position combinations. The participants received instruction, provided informed consent, participated in a warm-up session, and then reported rating of perceived exertion for each WBV condition. A 2×3 within-subjects multivariate approach ANOVA was conducted against an alpha of 0.05. A statistically significant main effect of position (p = 0.004) and significant main effect of frequency (p = 0.025) were found. Significant marginal means were found between the frequencies of 0 Hz and 50 Hz (p = 0.007). Statistically significant differences were found between sexes for all combinations.
doi:10.17265/2328-7136/2019.01.001 fatcat:bimyrroggrhsddxrx2uw2qopwe

Estimating the infection fatality risk of COVID-19 in New York City, March 1-May 16, 2020 [article]

Wan Yang, Sasikiran Kandula, Mary Huynh, Sharon K Greene, Gretchen Van Wye, Wenhui Li, Hiu Tai Chan, Emily McGibbon, Alice Yeung, Donald Olson, Anne Fine, Jeffrey Shaman
2020 medRxiv   pre-print
During March 1-May 16, 2020, 191,392 laboratory-confirmed COVID-19 cases were diagnosed and reported and 20,141 confirmed and probable COVID-19 deaths occurred among New York City (NYC) residents. We applied a network model-inference system developed to support the City's pandemic response to estimate underlying SARS-CoV-2 infection rates. Based on these estimates, we further estimated the infection fatality risk (IFR) for 5 age groups (i.e. <25, 25-44, 45-64, 65-74, and 75+ years) and all ages
more » ... overall, during March 1-May 16, 2020. We estimated an overall IFR of 1.45% (95% Credible Interval: 1.09-1.87%) in NYC. In particular, weekly IFR was estimated as high as 6.1% for 65-74 year-olds and 17.0% for 75+ year-olds. These results are based on more complete ascertainment of COVID-19-related deaths in NYC and thus likely more accurately reflect the true, higher burden of death due to COVID-19 than previously reported elsewhere. It is thus crucial that officials account for and closely monitor the infection rate and population health outcomes and enact prompt public health responses accordingly as the pandemic unfolds.
doi:10.1101/2020.06.27.20141689 fatcat:kcaxt32tdrhhtfqjz47iaqf7eq

Relative Validity of the Eat and Track (EaT) Smartphone App for Collection of Dietary Intake Data in 18-to-30-Year Olds

Lyndal Wellard-Cole, Juliana Chen, Alyse Davies, Adele Wong, Sharon Huynh, Anna Rangan, Margaret Allman-Farinelli
2019 Nutrients  
(1) Background: Smartphone dietary assessment apps can be acceptable and valid data collection methods but have predominantly been validated in highly educated women, and none specifically measured eating-out habits in young adults. (2) Methods: Participants recorded their food and beverage consumption for three days using the Eat and Track (EaT) app, and intakes were compared with three dietitian-administered 24-h recall interviews matched to the same days as the reference method. Wilcoxon
more » ... ed-rank or t-tests, correlation coefficients and Bland–Altman plots assessed agreement between the two methods for energy and percentage energy from nutrients (%E). (3) Results: One hundred and eighty nine of 216 participants (54% females, 60% resided in higher socioeconomic areas, 49% university-educated) completed the study. There were significant differences in median energy intake between methods (p < 0.001), but the EaT app had acceptable agreement for most nutrient densities at the group level. Correlation coefficients ranged from r = 0.56 (%E fat) to 0.82 (%E sugars), and between 85% and 94% of participants were cross-classified into the same or adjacent quartiles. Bland–Altman plots showed wide limits of agreement but no obvious biases for nutrient densities except carbohydrate in males. (4) Conclusions: The EaT app can be used to assess group nutrient densities in a general population of 18-to-30-year olds.
doi:10.3390/nu11030621 fatcat:duxpoaedivbutfl53qaefbipg4

Mechanism of H2 Production by Models for the [NiFe]-Hydrogenases: Role of Reduced Hydrides

Olbelina A. Ulloa, Mioy T. Huynh, Casseday P. Richers, Jeffery A. Bertke, Mark J. Nilges, Sharon Hammes-Schiffer, Thomas B. Rauchfuss
2016 Journal of the American Chemical Society  
The intermediacy of a reduced nickel-iron hydride in hydrogen evolution catalyzed by Ni-Fe complexes was verified experimentally and computationally. In addition to catalyzing hydrogen evolution, the highly basic and bulky (dppv)Ni(μ-pdt)Fe(CO)(dppv) ([1] 0 ; dppv = cis-C 2 H 2 (PPh 2 ) 2 ) and its hydride derivatives have yielded to detailed characterization in terms of spectroscopy, bonding, and reactivity. The protonation of [1] 0 initially produces unsym-[H1] + , which converts by a
more » ... der pathway to sym-[H1] + . These species have C 1 (unsym) and C s (sym) symmetries, respectively, depending on the stereochemistry of the octahedral Fe site. Both experimental and computational studies show that [H1] + protonates at sulfur. The S = 1/2 hydride [H1] 0 was generated by reduction of [H1] + with Cp* 2 Co. Density functional theory (DFT) calculations indicate that [H1] 0 is best described as a Ni(I)-Fe(II) derivative with significant spin density on Ni and some delocalization on S and Fe. EPR spectroscopy reveals both kinetic and thermodynamic isomers of [H1] 0 . Whereas [H1] + does not evolve H 2 upon protonation, treatment of [H1] 0 with acids gives H 2 . The redox state of the "remote" metal (Ni) modulates the hydridic character of the Fe(II)-H center. As supported by DFT calculations, H 2 evolution proceeds either directly from [H1] 0 and external acid or from protonation of the Fe-H bond in [H1] 0 to give a labile dihydrogen complex. Stoichiometric tests indicate that protonation-induced hydrogen evolution from [H1] 0 initially produces [1] + , which is reduced by [H1] 0 . Our results reconcile the required reductive activation of a metal hydride and the resistance of metal hydrides toward reduction. This dichotomy is resolved by reduction of the remote (non-hydride) metal of the bimetallic unit. should reflect on the mechanism since oxidation of [H1] 0 predominantly gives significant sym, and protonation of [1] 0 generates exclusively unsym (see above). Indeed, treatment of Ulloa et al. Comparisons of these NiFe models with the [NiFe]-hydrogenases are instructive. Overall, the biological system operates at one oxidation state higher than these models (Table 7) . This difference reflects the effects of charge, since the model complexes are almost always 7 Ulloa et al.
doi:10.1021/jacs.6b04579 pmid:27328053 pmcid:PMC5029088 fatcat:ohu6or55ifezvg3b2w7ofbtafm

A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation

Guowei Yin, Samantha Kistler, Samuel D. George, Nora Kuhlmann, Leslie Garvey, Minh Huynh, Rachel K. Bagni, Michael Lammers, Channing J. Der, Sharon L. Campbell
2017 Journal of Biological Chemistry  
Edited by Norma Allewell The KRAS GTPase plays a critical role in the control of cellular growth. The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also post-translational modification. Lysine 104 in KRAS can be modified by ubiquitylation and acetylation, but the role of this residue in intrinsic KRAS function has not been well characterized. We find that lysine 104 is important for GEF recognition, because mutations at this
more » ... osition impaired GEF-mediated nucleotide exchange. Because the KRAS K104Q mutant has recently been employed as an acetylation mimetic, we conducted a series of studies to evaluate its in vitro and cellbased properties. Herein, we found that KRAS K104Q exhibited defects in both GEF-mediated exchange and GAP-mediated GTP hydrolysis, consistent with NMR-detected structural perturbations in localized regions of KRAS important for recognition of these regulatory proteins. Despite the partial defect in both GEF and GAP regulation, KRAS K104Q did not alter steady-state GTP-bound levels or the ability of the oncogenic KRAS G12V mutant to cause morphologic transformation of NIH 3T3 mouse fibroblasts and of WT KRAS to rescue the growth defect of mouse embryonic fibroblasts deficient in all Ras genes. We conclude that the KRAS K104Q mutant retains both WT and mutant KRAS function, probably due to offsetting defects in recognition of factors that up-regulate (GEF) and down-regulate (GAP) RAS activity.
doi:10.1074/jbc.m116.762435 pmid:28154176 pmcid:PMC5377764 fatcat:rgp4j4oqzzbwhdp7yjy4kwvkye

Comparison of Objective Image Quality Metrics to Expert Radiologists' Scoring of Diagnostic Quality of MR Images

Allister Mason, James Rioux, Sharon E. Clarke, Andreu Costa, Matthias Schmidt, Valerie Keough, Thien Huynh, Steven Beyea
2019 IEEE Transactions on Medical Imaging  
Image quality metrics (IQMs) such as root mean square error (RMSE) and structural similarity index (SSIM) are commonly used in the evaluation and optimization of accelerated magnetic resonance imaging (MRI) acquisition and reconstruction strategies. However, it is unknown how well these indices relate to a radiologist's perception of diagnostic image quality. In this study, we compare the image quality scores of five radiologists with the RMSE, SSIM, and other potentially useful IQMs: peak
more » ... l to noise ratio (PSNR) multi-scale SSIM (MSSSIM), information-weighted SSIM (IWSSIM), gradient magnitude similarity deviation (GMSD), feature similarity index (FSIM), high dynamic range visible difference predictor (HDRVDP), noise quality metric (NQM), and visual information fidelity (VIF). The comparison uses a database of MR images of the brain and abdomen that have been retrospectively degraded by noise, blurring, undersampling, motion, and wavelet compression for a total of 414 degraded images. A total of 1017 subjective scores were assigned by five radiologists. IQM performance was measured via the Spearman rank order correlation coefficient (SROCC) and statistically significant differences in the residuals of the IQM scores and radiologists' scores were tested. When considering SROCC calculated from combining scores from all radiologists across all image types, RMSE and SSIM had lower SROCC than six of the other IQMs included in the study (VIF, FSIM, NQM, GMSD, IWSSIM, and HDRVDP). In no case did SSIM have a higher SROCC or significantly smaller residuals than RMSE. These results should be considered when choosing an IQM in future imaging studies.
doi:10.1109/tmi.2019.2930338 pmid:31535985 fatcat:obswcwzli5g3fjczr6zic36nwe

Characterization of the Recombinant IKK1/IKK2 Heterodimer

Q. Khai Huynh, Hymavathi Boddupalli, Sharon A. Rouw, Carol M. Koboldt, Troii Hall, Cindy Sommers, Scott D. Hauser, Jennifer L. Pierce, Rodney G. Combs, Beverly A. Reitz, Judy A. Diaz-Collier, Robin A. Weinberg (+3 others)
2000 Journal of Biological Chemistry  
Huynh, H. Boddupalli, C. M. Koboldt, B. L. Hood, B. F. Kilpatrick, and C. S. Tripp, unpublished data.  ... 
doi:10.1074/jbc.m000296200 pmid:10823818 fatcat:yomqpg2quzevbkzrvpgcziawoi

Genome–Wide Hypomethylation and Specific Tumor-Related Gene Hypermethylation are Associated with Esophageal Squamous Cell Carcinoma Outcome

Sojun Hoshimoto, Hiroya Takeuchi, Shigeshi Ono, Myung Shin Sim, Jamie L. Huynh, Sharon K. Huang, Diego M. Marzese, Yuko Kitagawa, Dave S.B. Hoon
2015 Journal of Thoracic Oncology  
Esophageal squamous cell carcinoma (ESCC) is a cancer of variable outcomes with limited effective treatments resulting in poor overall survival (OS). Epigenetic alterations contributing to this deadly cancer type that can be used as novel therapeutic or diagnostic targets are still poorly understood. Methods: We explored genome-wide DNA methylation data from The Cancer Genome Atlas project and identified a panel of tumor-related genes hypermethylated in ESCC. The methylation statuses of RASSF1,
more » ... RARB, CDKN2A (p16INK4a, p14ARF), APC, and RUNX3 genes and long interspersed nucleotide element-1 (LINE-1) were validated in a large cohort (n = 140) of clinically well-annotated ESCC specimens and esophageal normal mucosa (n = 28) using a quantitative methylation-specific polymerase chain reaction. Results: Hypermethylation of RARB, p16INK4a, RASSF1, APC, RUNX3, and p14ARF were observed in 55%, 24%, 20%, 19%, 14%, and 8% of specimens, respectively. Hypermethylation of APC was significantly associated with tumor depth (p = 0.02) and American Joint Committee on Cancer stage (p = 0.03). Global DNA methylation level, assessed by LINE-1, was significantly lower in ESCC than in normal mucosa (p < 0.0001), and lower in greater than or equal to T2 (n = 69) than T1 tumors (n = 45; p = 0.03). There was a significant inverse correlation between LINE-1 and RARB methylation (p = 0.008). Importantly, hypermethylation of RASSF1 and APC genes was significantly associated with overall survival (OS; p = 0.006 and p = 0.007, respectively). In addition, patients with tumors containing a higher number of methylated genes (greater than two genes) presented worse OS (p = 0.003). Conclusions: This study demonstrates that epigenetic alterations of a panel of tumor-related genes and the noncoding region LINE-1 can be used as prognostic indicators and help in clinical management of ESCC patients.
doi:10.1097/jto.0000000000000441 pmid:25514805 fatcat:hywd2hk5fjgnna4w5gbj3epequ

Tumor Necrosis Factor Inhibitor Exposure and Radiographic Outcomes in Veterans with Rheumatoid Arthritis: A Longitudinal Cohort Study

Grant W Cannon, Alan R Erickson, Chia-Chen Teng, Tina Huynh, Sharon Austin, Sally W Wade, Bradley S Stolshek, David H Collier, Alex Mutebi, Brian C Sauer
2019 Rheumatology Advances in Practice  
The aim was to estimate the impact of TNF inhibitor (TNFi) exposure on radiographic disease progression in US Veterans with RA during the first year after initiating therapy. This historical longitudinal cohort design used clinical and claims data to evaluate radiographic progression after initiation of TNFi. US Veterans with RA initiating TNFi treatment (index date), ≥ 6 months pre-index and ≥ 12 months post-index VA enrolment/activity, and initial (6 months pre-index to 30 days post-index)
more » ... follow-up (10-18 months post-index) bilateral hand radiographs were eligible. The cumulative TNFi exposure and change in modified Sharp score (MSS) between initial and follow-up radiographs were calculated. The percentage of patients with clinically meaningful change in MSS (≥ 5) for each month of exposure was assessed using a longitudinal marginal structural model with inverse probability of treatment weights. Mean values and CIs were generated using 1000 bootstrapped samples. For 246 eligible patients, the mean (s.d.) age was 58 (11) years; 81% were male. The mean (s.d.) initial MSS was 19.6 (33.4) (range 0-214). The mean change (s.d.) in MSS was 0.3 (3.6) (median 0, range -19 to 22). Patients with the greatest exposure had the least radiographic progression for both crude and adjusted model analyses. Adjusted rates of MSS change ≥ 5 points (95% CI) were 10.6% (9.8%, 11.4%) for patients with 3 months of exposure compared with 5.4% (5.1%, 5.7%) for patients with 12 months of exposure. One-year changes in radiographic progression were small. Patients with the greatest cumulative TNFi exposure experienced the least progression.
doi:10.1093/rap/rkz015 pmid:31763619 pmcid:PMC6649949 fatcat:fnjardip3nbqzfbsksmk5byuci
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