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ShapePheno: unsupervised extraction of shape phenotypes from biological image collections

Theofanis Karaletsos, Oliver Stegle, Christine Dreyer, John Winn, Karsten M. Borgwardt
2012 Computer applications in the biosciences : CABIOS  
Results: We propose a probabilistic machine learning model that allows for the extraction of deformation phenotypes from biological images, making them available as quantitative traits for downstream analysis  ...  However, more subtle, but biologically informative phenotypes, such as the local deformation of the shape of an individual with respect to the population mean cannot be automatically extracted and quantified  ...  Conflict of Interest: none declared.  ... 
doi:10.1093/bioinformatics/bts081 pmid:22333244 fatcat:qez3qktxuvg67b5xacn2plplgu