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Shape-Based Alignment of Hippocampal Subfields: Evaluation in Postmortem MRI [chapter]

Paul A. Yushkevich, Brian B. Avants, John Pluta, David Minkoff, John A. Detre, Murray Grossman, James C. Gee
2008 Lecture Notes in Computer Science  
This paper estimates the accuracy of hippocampal subfield alignment via shape-based normalization.  ...  Evaluation takes place in postmortem MRI dataset acquired at 9.4 Tesla with many averages and approximately 0.01 mm 3 voxel resolution.  ...  Evaluation of Subfield Alignment Quantitative evaluation of the alignment of hippocampal subfields via shape-based and image-based normalization is performed in the leave-one-out framework.  ... 
doi:10.1007/978-3-540-85988-8_61 fatcat:qvqwrbnux5fbnmlps4yxfhteui

Multimodal Hippocampal Subfield Grading For Alzheimer's Disease Classification

Kilian Hett, Alzheimer's Disease Neuroimaging Initiative, Vinh-Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé
2019 Scientific Reports  
Moreover, we propose to study the efficiency of this new framework applied to the hippocampal subfields.  ...  Former in-vivo imaging studies mainly investigated structural alterations of these subfields using volumetric measurements and microstructural modifications with mean diffusivity measurements.  ...  -18-CE45-0013) and in the frame of the Investments for the future Program IdEx Bordeaux, Cluster of excellence CPU and labex TRAIL (BigDataBrain ANR-10-LABX-57).  ... 
doi:10.1038/s41598-019-49970-9 pmid:31554909 pmcid:PMC6761169 fatcat:u7ueph2uaza7rpgdmohbotjokq

In Vivo Hippocampal Subfield Volumes in Schizophrenia and Bipolar Disorder

Unn K. Haukvik, Lars T. Westlye, Lynn Mørch-Johnsen, Kjetil N. Jørgensen, Elisabeth H. Lange, Anders M. Dale, Ingrid Melle, Ole A. Andreassen, Ingrid Agartz
2015 Biological Psychiatry  
The hippocampal subfield segmentation is based on a Bayesian modeling approach and manual delineations of each hippocampal subfield.  ...  Advances in computational MRI postprocessing methods allow automated segmentation of the hippocampal subfields ( Figure 1 ) (23) .  ... 
doi:10.1016/j.biopsych.2014.06.020 pmid:25127742 fatcat:chdtpmuljfaoxhcvzcvkyhpu3e

Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI

Paul A. Yushkevich, Hongzhi Wang, John Pluta, Sandhitsu R. Das, Caryne Craige, Brian B. Avants, Michael W. Weiner, Susanne Mueller
2010 NeuroImage  
We present and evaluate a new method for automatically labeling the subfields of the hippocampal formation in focal 0.4×0.5×2.0mm 3 resolution T2-weighted magnetic resonance images that can be acquired  ...  These results support the feasibility of subfield-specific hippocampal morphometry in clinical studies of memory and neurodegenerative disease.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.  ... 
doi:10.1016/j.neuroimage.2010.06.040 pmid:20600984 pmcid:PMC2939190 fatcat:ysgohcbxajdapm75tt2p5xq6lm

Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease

Robin de Flores, Renaud La Joie, Gaël Chételat
2015 Neuroscience  
Highlights: -Hippocampal subfield structure can be assessed in vivo with (high-resolution) MRI -AD-related atrophy is initially focal (in CA1) before spreading to other subfields -This pattern of atrophy  ...  Overall, hippocampal subfield analysis has proven to be a promising technique in the study of AD.  ...  The aging subfields The association between hippocampal subfield integrity and age was initially evaluated in postmortem studies.  ... 
doi:10.1016/j.neuroscience.2015.08.033 pmid:26306871 fatcat:mo2oypyj4vhyhgow7nznti3wx4

Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment

Paul A. Yushkevich, John B. Pluta, Hongzhi Wang, Long Xie, Song-Lin Ding, Eske C. Gertje, Lauren Mancuso, Daria Kliot, Sandhitsu R. Das, David A. Wolk
2014 Human Brain Mapping  
We evaluate a fully automatic technique for labeling hippocampal subfields and cortical subregions in the medial temporal lobe (MTL) in in vivo 3 Tesla MRI.  ...  A larger cohort of 83 subjects is used to examine the effects of aMCI in the hippocampal region using both subfield volume and regional subfield thickness maps.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.  ... 
doi:10.1002/hbm.22627 pmid:25181316 pmcid:PMC4313574 fatcat:wgfda2e5bfd6doh2pqlszlkrq4

In vivo Analysis of Hippocampal Subfield Atrophy in Mild Cognitive Impairment via Semi-Automatic Segmentation of T2-Weighted MRI

John Pluta, Paul Yushkevich, Sandhitsu Das, David Wolk
2012 Journal of Alzheimer's Disease  
This pattern of atrophy in a-MCI is consistent with the topography of AD pathology observed in postmortem studies, and corrected left CA1 provided stronger discrimination than whole hippocampal volume  ...  The measurement of hippocampal volumes using MRI is a useful in-vivo biomarker for detection and monitoring of early Alzheimer's Disease (AD), including during the amnestic Mild Cognitive Impairment (a-MCI  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or National Institutes of Health.  ... 
doi:10.3233/jad-2012-111931 pmid:22504319 pmcid:PMC3391337 fatcat:o4cq66sqqnfudg23g6qemouqke

Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence

Renaud La Joie, Marine Fouquet, Florence Mézenge, Brigitte Landeau, Nicolas Villain, Katell Mevel, Alice Pélerin, Francis Eustache, Béatrice Desgranges, Gaël Chételat
2010 NeuroImage  
Recent advances in neuroimaging have highlighted the interest to differentiate hippocampal subfields for cognitive neurosciences and more notably in assessing the effects of normal and pathological aging  ...  This contrasts with the predominant vulnerability of the CA1 subfield to Alzheimer's Disease (AD) reported in several previous studies, suggesting that the assessment of hippocampal subfields may improve  ...  ; and iv) the validity of a more criticable but less timeconsuming automatic voxel-based approach to detect age effects on the hippocampal subfields is evaluated.  ... 
doi:10.1016/j.neuroimage.2010.06.024 pmid:20600996 fatcat:gv4ymtpom5hrdltv7z35rijjfe

Illness Progression, Recent Stress, and Morphometry of Hippocampal Subfields and Medial Prefrontal Cortex in Major Depression

Michael T. Treadway, Michael L. Waskom, Daniel G. Dillon, Avram J. Holmes, Min Tae M. Park, M. Mallar Chakravarty, Sunny J. Dutra, Frida E. Polli, Dan V. Iosifescu, Maurizio Fava, John D.E. Gabrieli, Diego A. Pizzagalli
2015 Biological Psychiatry  
Volumetric analyses of the hippocampus were performed using a recently-validated subfield segmentation approach, while cortical thickness estimates were obtained using Vertex-Based Cortical Thickness (  ...  Background-Longitudinal studies of illness progression in Major Depressive Disorder (MDD) indicate that the onset of subsequent depressive episodes becomes increasingly decoupled from external stressors  ...  Garfield Weston Foundation to MMC and the National Institute of Mental Health (NIMH) grant R01 MH068376 awarded to DAP as well as National Center for Complementary & Alternative Medicine (NCCAM) grant  ... 
doi:10.1016/j.biopsych.2014.06.018 pmid:25109665 pmcid:PMC4277904 fatcat:r65re4smhbh53kbazure3zc3ue

Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates [article]

Aurelie Bussy, Eric Plitman, Raihaan Patel, Stephanie Tullo, Alyssa Salaciak, Saashi Bedford, Sarah Farzin, Marie-Lise Beland, Vanessa Valiquette, Christina Kazazian, Christine Tardif, Gabriel Devenyi (+1 others)
2020 bioRxiv   pre-print
The current work suggests that although T1w, T2w and slab derived subfield volumetric outputs are largely homologous, modality choice plays a meaningful role in the volumetric estimation of the hippocampal  ...  The MAGeT Brain algorithm was used for segmentation of the hippocampal grey matter (GM) subfields and peri-hippocampal white matter (WM) subregions.  ...  , and to establish guidelines for subfield boundaries based on reference atlases and neuroanatomical landmarks visible postmortem and on MRI (Yushkevich et al. 2015; Olsen et al. 2019) .  ... 
doi:10.1101/2020.05.28.121343 fatcat:yyl3xafgtvgmnnqk3whofm3mse

A high-resolution computational atlas of the human hippocampus from postmortem magnetic resonance imaging at 9.4 T

2009 NeuroImage  
An example application examining subfield-level hippocampal atrophy in temporal lobe epilepsy demonstrates the application of the atlas to in vivo studies.  ...  A synthetic average image is derived from the MRI of the samples using shape and intensity averaging in the diffeomorphic non-linear registration framework, and a consensus labeling of the template is  ...  Postmortem MR studies described in this manuscript were performed in the Small Animal Imaging Facility in the Department of Radiology at the University of Pennsylvania.  ... 
doi:10.1016/j.neuroimage.2008.08.042 pmid:18840532 pmcid:PMC2650508 fatcat:ee5iccsorjhtpijjlqfsew4lle

Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol

Paul A. Yushkevich, Robert S.C. Amaral, Jean C. Augustinack, Andrew R. Bender, Jeffrey D. Bernstein, Marina Boccardi, Martina Bocchetta, Alison C. Burggren, Valerie A. Carr, M. Mallar Chakravarty, Gaël Chételat, Ana M. Daugherty (+35 others)
2015 NeuroImage  
Objective: An increasing number of human in vivo magnetic resonance imaging (MRI) studies have focused on examining the structure and function of the subfields of the hippocampal formation (the dentate  ...  This paper characterizes, both qualitatively and quantitatively, the variability in the existing manual segmentation protocols for labeling hippocampal and parahippocampal substructures in MRI, with the  ...  to include most of the published protocols for hippocampal/parahippocampal subfield segmentation in MRI.  ... 
doi:10.1016/j.neuroimage.2015.01.004 pmid:25596463 pmcid:PMC4387011 fatcat:4uafowbhanhwrepmnylzodchjy

Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology

Daniel H. Adler, Laura E. M. Wisse, Ranjit Ittyerah, John B. Pluta, Song-Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John L. Robinson, Theresa Schuck, John Q. Trojanowski, Murray Grossman (+9 others)
2018 Proceedings of the National Academy of Sciences of the United States of America  
Serial histological imaging in 9 of the 31 specimens was used to label hippocampal subfields in the atlas based on cytoarchitecture.  ...  Recently, a growing number of in vivo human MRI studies have focused their attention on hippocampal subfields (6-8).  ...  We acknowledge the donors of Alzheimer's Disease Research, a program of the BrightFocus Foundation (to L.E.M.W.) for support of this research.  ... 
doi:10.1073/pnas.1801093115 pmid:29592955 fatcat:fflsicw7hfdqdmk3fo5xu5hgcu

Measurement of the Stratum Radiatum/Lacunosum-Moleculare (SRLM) [chapter]

Steffen Oeltze, Hartmut Schütze, Anne Maaß, Emrah Düzel, Bernhard Preim
2014 Informatik aktuell  
We evaluate our approach based on coronal T 2 * -weighted 7-Tesla MR images of 27 subjects.  ...  It was shown in vivo that patients with mild AD exhibit a reduced thickness of the SRLM. We propose a new approach to measure SRLM thickness in coronal brain sections.  ...  Only the SRLM part in the hippocampal body is used in the thickness evaluation. SRLM Measurement Our measurement of the SRLM is based on its medial axis.  ... 
doi:10.1007/978-3-642-54111-7_50 dblp:conf/bildmed/OeltzeSMDP14 fatcat:obl57it56nchdcpp3i4rku3km4

Disentangling Hippocampal Shape Anomalies in Epilepsy

Hosung Kim, Tommaso Mansi, Neda Bernasconi
2013 Frontiers in Neurology  
Surface-based analysis of volume in TLE revealed severe ipsilateral atrophy mainly along the rostro-caudal extent of the hippocampal CA1 subfield.  ...  The contribution of volume and position to the overall hippocampal shape in these conditions has not been studied.  ...  ACKNOWLEDGMENTS This work was supported by the Canadian Institutes of Health Research (MOP-57840 and MOP-93815).  ... 
doi:10.3389/fneur.2013.00131 pmid:24062718 pmcid:PMC3769634 fatcat:gyrdjndbqbgzhfjgfzpswwbotm
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