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Zhang Shaocheng M.D, the operator. Table 4 . 4 1 shows different types of donor-receptor nerve fiber anastomosis and their potential resultant benefits. Fig. 17. ...doi:10.5772/28700 fatcat:fc3dyei2crg77aijdbdnvky2sq
Osteoporosis is a disease that significantly influences life expectancy and quality in humans. Oxidative stress may stimulate bone marrow osteoclast differentiation and inhibit osteoblast (OB) differentiation. OB proliferation and differentiation are affected by the forkhead box O (FoxO)1/ β-catenin signaling pathway. The osteogenic differentiation of mesenchymal stem cells (MSCs) may be promoted by silent information regulator type-1 [sirtuin (SIRT)1]. However, the molecular mechanism of SIRT1doi:10.3892/mmr.2018.8657 pmid:29512706 fatcat:hvvicv6gzbhj5mbzcgwre6e25e
more »... regulation of osteogenic differentiation of MSCs remains unclear, and further elucidation is needed. The present study investigated the role of SIRT1 in the FoxO1/β-catenin signaling pathway in oxidative stress and its mechanism in the osteoblastic progenitor cell line (MC3T3-E1). The results demonstrated that OB apoptosis and elevated oxidative stress in cells were simulated by H 2 O 2 , which was inhibited by moderate SIRT1 overexpression through reducing the oxidative stress. Further studies revealed that FOXO1 and β-catenin pathway activity was downregulated by SIRT1 and eventually resulted in inhibition of target genes, including the proapoptotic gene B cell lymphoma-2 interacting mediator of cell death, DNA repair gene growth arrest and DNA damage inducible protein 45 and the OB differentiation suppressor gene peroxisome proliferator activated receptor (PPAR)-γ. Furthermore, β-catenin and PPAR-γ were inhibited by SIRT1. Overall, the results of the present study suggest that moderate overexpression of SIRT1 (~3-fold of normal level) may directly or indirectly inhibit apoptosis of OBs via the FOXO1 and β-catenin signaling pathway.
Zhang et al. cut off some or all of the reserve nerve fibers and anastomosed them by selectively cutting some of the receptor nerve fibers [42, 55] . ... Later, Zhang et al. used the side-to-side suture interfascicular of peripheral nerves for partial sensory function reconstruction for paraplegia or tetraplegia  . ...doi:10.26599/jnr.2021.9040019 fatcat:ehgfyknzvnbylhfzueuww2qx6a
Electronic devices which mimic the functionality of biological synapses are a large step to replicate the human brain for neuromorphic computing and for numerous medical research investigations. One of the representative synaptic behaviors is paired-pulse facilitation (PPF). It has been widely investigated because it is regarded to be related to biological memory. However, plasticity behavior is only part of the human brain memory behavior. Here, we present a phenomenon which is opposite todoi:10.2147/ijn.s207852 pmid:32231432 pmcid:PMC7085341 fatcat:cp7dlwkjqbgarno5ha4ivwgdxu
more »... i.e., paired-pulse inhibition (PPI), in nano oxide devices for the first time. The research here suggests that rather than being enhanced, the phenomena of memory loss would also be possessed by such electronic devices. The device physics mechanism behind memory loss behavior was investigated. This mechanism is sustained by historical memory and degradation manufactured by device trauma to regulate characteristically stimulated origins of artificial transmission behaviors. Under the trauma of a memory device, both the signal amplitude and signal time stimulated by a pulse are lower than the first signal stimulated by a previous pulse in the PPF, representing a new scenario in the struggle for memory. In this way, more typical human brain behaviors could be simulated, including the effect of age on latency and error generation, cerebellar infarct, trauma and memory loss pharmacological actions (such as those caused by hyoscines and nitrazepam). Thus, this study developed a new approach for implementing the manner in which the brain works in semiconductor devices for improving medical research.
The requirements of device under the multi-mission of monitoring, protecting, controlling and communicating is discussed in this paper to bring forward a design of dual CPU structure with ARM & DSP for microprocessor protection. Via the comparative analysis of several common algorithms, the algorithm of FFT, which can make the controlling of calculation accuracy easier and has a filter feature inherently, is selected to analyze the sampling data of protector and calculates relative electricaldoi:10.1016/j.egypro.2012.01.250 fatcat:orohaza6ezblrp757d3ufhcgpm
more »... rameters. Relevant program is written for distance protection in 110 kV transmissions, then debugging on software and hardware is made. The results show that the design of DSP & ARM based-microprocessor protection presented in this paper is feasible; such a device has simple and reliable circuit structure and is expandable in both software and hardware. The major designing principles The fault information mainly consists of two parts, the digital part and the analogue one, when the power grid is malfunctioning. The design of dual CPU structure with ARM & DSP for microprocessor protection achieves functions separately. ARM controls the data acquisition, data conversion, logic operation, man-machine interaction and DSP completes in the system the signal processing, the data processing, communication with the computer and the printout and so on. This system adopted modular design ideals to realize accurate fault positioning. At the same time developers can add new functions expediently. Fig.1 shows the framework of the system.
To leverage massive distributed data and computation resources, machine learning in the network edge is considered to be a promising technique especially for large-scale model training. Federated learning (FL), as a paradigm of collaborative learning techniques, has obtained increasing research attention with the benefits of communication efficiency and improved data privacy. Due to the lossy communication channels and limited communication resources (e.g., bandwidth and power), it is ofarXiv:2110.11775v1 fatcat:22ii7wz3nva4fb53got3nglf3e
more »... t to investigate fast responding and accurate FL schemes over wireless systems. Hence, we investigate the problem of jointly optimized communication efficiency and resources for FL over wireless Internet of things (IoT) networks. To reduce complexity, we divide the overall optimization problem into two sub-problems, i.e., the client scheduling problem and the resource allocation problem. To reduce the communication costs for FL in wireless IoT networks, a new client scheduling policy is proposed by reusing stale local model parameters. To maximize successful information exchange over networks, a Lagrange multiplier method is first leveraged by decoupling variables including power variables, bandwidth variables and transmission indicators. Then a linear-search based power and bandwidth allocation method is developed. Given appropriate hyper-parameters, we show that the proposed communication-efficient federated learning (CEFL) framework converges at a strong linear rate. Through extensive experiments, it is revealed that the proposed CEFL framework substantially boosts both the communication efficiency and learning performance of both training loss and test accuracy for FL over wireless IoT networks compared to a basic FL approach with uniform resource allocation.
Zhang, Vogelmann, et al., 2019) . ... Zhang, Liu, et al., 2019) . ... Data Availability Statement The model data used in this study can be downloaded online (http://portal.nersc.gov/project/m2136/ E3SMv1/Zhang-SLF). ...doi:10.1029/2020ea001125 fatcat:q73icbptgjdezajttmo7tufbu4
Zhang) in 1994. Laboratory studies suggest that this method effectively prevents muscle atrophy [7, 17, 24] . ...doi:10.1007/s00701-011-1264-2 pmid:22231778 pmcid:PMC3284681 fatcat:a3iwaahgpned5gxy7q63f7sjr4
The surface protein SdrE, a microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family protein expressed on the surface of Staphylococcus aureus (S. aureus), can recognize human complement regulator Factor H and C4BP, thus making it a potentially promising vaccine candidate. In this study, SdrE 278-591 was found to directly affect S. aureus host cell invasion. Additionally, the crystal structure of SdrE 278-591 at a resolution of 1.25 Å was established, with thedoi:10.1371/journal.pone.0168814 pmid:28125581 pmcid:PMC5268492 fatcat:7nmkvuxknfdiznc5v5v76otc44
more »... ensional structure revealing N2-N3 domains which fold in a manner similar to an IgG fold. Furthermore, a putative ligand binding site located at a conserved charged groove formed by the interface between N2 and N3 domains was identified, with β2 suspected to occupy the ligand recognizing site and undergo a structural rearrangement to allow ligand binding. Overall, these findings have further contributed to the understanding of SdrE as a key factor for S. aureus invasivity and will enable a better understanding of bacterial infection processes.
Texture-based methods: Zhang et al.  used local binary pattern (LBP) to obtain texture features of shadow regions. ...doi:10.1109/access.2020.2984680 fatcat:5ejat5z7k5cgxgtbozoglpwyfu
Amorphous nano oxides (AO) are intriguing advanced materials for a wide variety of nanosystem medical applications including serving as biosensors devices with p-n junctions, nanomaterial-enabled wearable sensors, artificial synaptic devices for AI neurocomputers and medical mimicking research. However, p-type AO with reliable electrical properties are very difficult to obtain according to the literature. Based on the oxide thin film transistor, a phenomenon that could change an n-type materialdoi:10.2147/ijn.s215244 pmid:31920307 pmcid:PMC6938175 fatcat:zxixtewzjjh5hagix67f55wkty
more »... into a p-type semiconductor is proposed and explained here. The typical In-Ga-Zn-O material has been reported to be an n-type semiconductor, which can be changed by physical conditions, such as in processing or bias. In this way, here, we have identified a manner to change nano material electrical properties among n-type and p-type semiconductors very easily for medical application like biosensors in artificial skin.
Based on  and  , Zhang et al.  presented three improved zero-watermarking schemes respectively named by DC-RE, CU-SVD and CU-SVD-RE. ... YUJIN ZHANG (Member, IEEE) received the Ph.D. degree in communication and information system from Shanghai Jiao Tong University, Shanghai, China, in 2014. ...doi:10.1109/access.2020.3004841 fatcat:6xpyrs6fdfcwlfosar6qzcrzca
These types of controllers are investigated by Zhang N. and Feng G. in [19, 21] with different models and design approaches. ...doi:10.1002/asjc.40 fatcat:q25dxfb5pjdo3pdbcybw2a2inm
A prescribed performance fuzzy adaptive output-feedback control approach is proposed for a class of single-input and single-output nonlinear stochastic systems with unmeasured states. Fuzzy logic systems are used to identify the unknown nonlinear system, and a fuzzy state observer is designed for estimating the unmeasured states. Based on the backstepping recursive design technique and the predefined performance technique, a new fuzzy adaptive output-feedback control method is developed. It isdoi:10.1155/2014/836378 fatcat:gmg2vkhnpbgdne7frzevhvc3qu
more »... hown that all the signals of the resulting closed-loop system are bounded in probability and the tracking error remains an adjustable neighborhood of the origin with the prescribed performance bounds. A simulation example is provided to show the effectiveness of the proposed approach.
The dynamical behaviors of an Euler discretized sliding mode control (SMC) systems based on equivalent control strategy are studied. A periodic-2 orbit in steady state is found for the switching function of the Euler discretized SMC systems. The time steps for the switching function to converge toward the periodic-2 orbit are obtained. When the discretized SMC system is stable, it further shows that the system states of the SMC systems will also enter into some periodic-2 orbits, and thesedoi:10.1109/tac.2014.2308620 fatcat:nde4hcqmpbatpndhzwgsp4fzfi
more »... dic-2 orbits are characterized by explicit analytic expressions. Finally, simulation examples are given to illustrate the theoretical results.
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