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Is Somebody Watching Your Facebook Newsfeed?
[article]
2013
arXiv
pre-print
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With the popularity of Social Networking Services (SNS), more and more sensitive information are stored online and associated with SNS accounts. The obvious value of SNS accounts motivates the usage stealing problem -- unauthorized, stealthy use of SNS accounts on the devices owned/used by account owners without any technology hacks. For example, anxious parents may use their kids' SNS accounts to inspect the kids' social status; husbands/wives may use their spouses' SNS accounts to spot
arXiv:1308.5168v1
fatcat:4wnzmnjblbb25mkidlri76rj5e
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... e affairs. Usage stealing could happen anywhere in any form, and seriously invades the privacy of account owners. However, there is no any currently known defense against such usage stealing. To an SNS operator (e.g., Facebook Inc.), usage stealing is hard to detect using traditional methods because such attackers come from the same IP addresses/devices, use the same credentials, and share the same accounts as the owners do. In this paper, we propose a novel continuous authentication approach that analyzes user browsing behavior to detect SNS usage stealing incidents. We use Facebook as a case study and show that it is possible to detect such incidents by analyzing SNS browsing behavior. Our experiment results show that our proposal can achieve higher than 80% detection accuracy within 2 minutes, and higher than 90% detection accuracy after 7 minutes of observation time.
MgCrab
2019
Proceedings of the VLDB Endowment
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Recent deterministic database systems have achieved high scalability and high availability in distributed environments given OLTP workloads. However, modern OLTP applications usually have changing workloads or access patterns, so how to make the resource provisioning elastic to the changing workloads becomes an important design goal for a deterministic database system. Live migration, which moves the specified data from a source machine to a destination node while continuously serving the
doi:10.14778/3303753.3303764
fatcat:l4pqajzqwzgbfcxewlh7gsmth4
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... ng transactions, is a key technique required for the elasticity. In this paper, we present MgCrab, a live migration technique for a deterministic database system, that leverages the determinism to maintain the consistency of data on the source and destination nodes at very low cost during a migration period. We implement MgCrab on an open-source database system. Extensive experiments were conducted and the results demonstrate the effectiveness of MgCrab. PVLDB Reference Format:
Hysteresis of polymer stabilized blue phase liquid crystals
2012
Liquid Crystals XVI
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Hung-Yuan Chen and Ms. Shih-Ya Ni for the technical assistance. ...
doi:10.1117/12.930834
fatcat:42lswg7ua5euhcjsp7pqvztiba
Erdafitinib Resensitizes ABCB1-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs
2020
Cancers
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The development of multidrug resistance (MDR) in cancer patients, which is often associated with the overexpression of ABCB1 (MDR1, P-glycoprotein) in cancer cells, remains a significant problem in cancer chemotherapy. ABCB1 is one of the major adenosine triphosphate (ATP)-binding cassette (ABC) transporters that can actively efflux a range of anticancer drugs out of cancer cells, causing MDR. Given the lack of Food and Drug Administration (FDA)-approved treatment for multidrug-resistant
doi:10.3390/cancers12061366
pmid:32466597
fatcat:sbuy4pouzzaw7kunpdtzi6crdm
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... , we explored the prospect of repurposing erdafitinib, the first fibroblast growth factor receptor (FGFR) kinase inhibitor approved by the FDA, to reverse MDR mediated by ABCB1. We discovered that by reducing the function of ABCB1, erdafitinib significantly resensitized ABCB1-overexpressing multidrug-resistant cancer cells to therapeutic drugs at sub-toxic concentrations. Results of erdafitinib-stimulated ABCB1 ATPase activity and in silico docking analysis of erdafitinib binding to the substrate-binding pocket of ABCB1 further support the interaction between erdafitinib and ABCB1. Moreover, our data suggest that ABCB1 is not a major mechanism of resistance to erdafitinib in cancer cells. In conclusion, we revealed an additional action of erdafitinib as a potential treatment option for multidrug-resistant cancers, which should be evaluated in future drug combination trials.
Sitravatinib Sensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs
2020
Cancers
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The development of multidrug resistance (MDR) in cancer patients driven by the overexpression of ATP-binding cassette (ABC) transporter ABCB1 or ABCG2 in cancer cells presents one of the most daunting therapeutic complications for clinical scientists to resolve. Despite many novel therapeutic strategies that have been tested over the years, there is still no approved treatment for multidrug-resistant cancers to date. We have recently adopted a drug repurposing approach to identify therapeutic
doi:10.3390/cancers12010195
pmid:31941029
pmcid:PMC7017071
fatcat:264psz4gwnfabknmaz3z7lcrbe
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... ents that are clinically active and at the same time, capable of reversing multidrug resistance mediated by ABCB1 and ABCG2. In the present study, we investigated the effect of sitravatinib, a novel multitargeted receptor tyrosine kinase inhibitor, on human ABCB1 and ABCG2 in multidrug-resistant cancer cell lines. We discovered that at submicromolar concentrations, sitravatinib re-sensitizes ABCB1- and ABCG2-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs. We found that sitravatinib blocks the drug efflux function of ABCB1 and ABCG2 in a concentration-dependent manner but does not significantly alter the protein expression of ABCB1 or ABCG2 in multidrug-resistant cancer cells. In conclusion, we reveal a potential drug repositioning treatment option for multidrug-resistant cancers by targeting ABCB1 and ABCG2 with sitravatinib and should be further investigated in future clinical trials.
Rendezvous for heterogeneous spectrum-agile devices
2014
IEEE INFOCOM 2014 - IEEE Conference on Computer Communications
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Cognitive radio (CR) is intended to meet the exponentially growing demand for spectrum by allowing for opportunistic utilization of idle legacy channels. Rendezvous, where two radios complete handshaking in an idle channel, is a key step for "stranger" (unknown to each other) CRs to start communication. However, none of existing algorithms guarantee rendezvous for heterogeneous or stranger CRs with different spectrum-sensing capabilities, in spite of the fact that (i) a wide variety of mobile
doi:10.1109/infocom.2014.6848168
dblp:conf/infocom/WuWHS14
fatcat:zjeewb6oivcvheghozr72hiffq
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... vices are equipped with heterogeneous radios and (ii) there are numerous applications requiring efficient rendezvous for heterogeneous radios/CRs. In this paper, we propose a new channel hopping algorithm, called Heterogeneous Hopping (HH), that guarantees rendezvous without assuming existence of a universal channel set that can be sensed by all radios. HH is realized with a two-layer design that harmonizes the fixed-short-cycle and parity-alignment techniques we propose here, in order to guide CRs to rendezvous in two complementary situations resulting from the different capabilities of mobile wireless devices. To best of our knowledge, HH is the first channel-hopping scheme that guarantees rendezvous between heterogeneous radios. Our in-depth evaluation has shown HH to be significantly faster than simple extensions of existing schemes. Moreover, the latter cannot guarantee successful rendezvous, either. 978-1-4799-3360-0/14/$31.00 c 2014 IEEE
Hysteresis-free polymer-stabilized blue phase liquid crystals using thermal recycles
2012
Optical Materials Express
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Hung-Yuan Chen for the technical assistance. This research was supported partially by Chimei-Innolux Corp. and partially by the National Science Council (NSC) in Taiwan under the contract no. ...
Wu et al. realized that the hysteresis could be solved by reducing the electric field required to provide enough phase retardation [6] . In 2011, C. Y. ...
doi:10.1364/ome.2.001149
fatcat:lq43bkogjbaxravydgoqr5ooha
Interactive Spoken Content Retrieval by Deep Reinforcement Learning
[article]
2016
arXiv
pre-print
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User-machine interaction is important for spoken content retrieval. For text content retrieval, the user can easily scan through and select on a list of retrieved item. This is impossible for spoken content retrieval, because the retrieved items are difficult to show on screen. Besides, due to the high degree of uncertainty for speech recognition, the retrieval results can be very noisy. One way to counter such difficulties is through user-machine interaction. The machine can take different
arXiv:1609.05234v1
fatcat:67kww7wyvbffhkdwzlfnjrmvna
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... ons to interact with the user to obtain better retrieval results before showing to the user. The suitable actions depend on the retrieval status, for example requesting for extra information from the user, returning a list of topics for user to select, etc. In our previous work, some hand-crafted states estimated from the present retrieval results are used to determine the proper actions. In this paper, we propose to use Deep-Q-Learning techniques instead to determine the machine actions for interactive spoken content retrieval. Deep-Q-Learning bypasses the need for estimation of the hand-crafted states, and directly determine the best action base on the present retrieval status even without any human knowledge. It is shown to achieve significantly better performance compared with the previous hand-crafted states.
Synthesis of (E)-5-(2-Radioiodovinyl)arabinosyl Uridine Analog for Probing HSV-1 Thymidine Kinase Gene
2005
Chemistry Letters
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The genetic probe labeled with positron emitter for monitoring tumor cells transfacted by herpes simplex virus thymidine kinase gene has been intensively studied. A useful synthetic methodology was developed to synthesize (E)-5-[2-(tributylstannyl)vinyl]arabinosyl uridine (TSVAU) and to radiolabel (E)-5-{2-[ 125 I]iodovinyl}arabinosyl uridine (IVAU) substrate for herpes simplex virus type-1 thymidine kinase gene. The synthesis started from arabinosyl uridine via six steps to provide TSVAU in
doi:10.1246/cl.2005.1390
fatcat:xn4x4tfpmrbefdcqv3ln5g5sbe
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... yield. The subsequent radiolabeling with Na-[ 125 I]I under oxidation provided [ 125 I]IVAU in 80% radiochemical yield. Gene therapy has become one of the most promising approaches for cancer treatment. The mechanism underlying the therapy starts by delivering the suicide gene into the target cells, followed by administering the prodrugs. The presence of the suicide gene in the target cells activates the prodrugs, such as nucleoside analogs, to form toxic metabolites, which then initiate the subsequent suicidal mechanism. The most intensively studied suicide gene, HSV-1 TK (herpes simplex virus thymidine kinase), can serve bi-functionally as both therapeutic and reporter genes in this system. 2 Moreover, in vivo gene expression of HSV-1 TK can be successfully monitored by imaging its substrate analog, usually a nucleoside analog. After being phosphorylated by viral TK, the metabolite can be randomly incorporated into elongating DNA chains by cellular enzymes. 3 The localization of this event could be traced down by using a tagged nucleoside analog. Of the most excellent candidates for in vivo studies are which radiolabeled with positron emitters owing to their higher imaging quality and quantification capacity. For example, [ 124 I]FIAU (pyrimidine nucleoside) and [ 18 F]FHBG (purine nucleoside) have been coupled with PET (positron emission tomography) to provide invaluable images (Scheme 1). 4, 5 Recently, an investigation on bioactivity-guided screening of nucleosides as substrates for HSV-1 TK by Degrève et al. discovered two potential compounds: IaraU (5-iodoarabinosyl uridine) and IVAU {(E)-5-(2-iodovinyl)arabinosyl uridine} 1 (Scheme 2). 6 As part of our systematic syntheses of radiolabeled thymidine analogs, 7 we have developed a facile synthesis of the former compound [ 125 I]IaraU. 8 Though the syntheses of [ 123 I] IVAU and its precursor TSVAU {(E)-5-[2-(tributylstannyl)vinyl]arabinosyl uridine} 2 have been reported by Dougan et al., the use of acetylene during production of trans-1,2-distannyl ethene was a formidable procedure for the most medicinal chemistry laboratories. 9 Consequently, an alternative precursor bearing trimethylsilyl vinyl group was developed by Morin et al. and [ 125 I]IVAU 1 could be prepared in fair yield. 10
P-glycoprotein Mediates Resistance to the Anaplastic Lymphoma Kinase Inhiitor Ensartinib in Cancer Cells
2022
Cancers
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Ensartinib (X-396) is a promising second-generation small-molecule inhibitor of anaplastic lymphoma kinase (ALK) that was developed for the treatment of ALK-positive non-small-cell lung cancer. Preclinical and clinical trial results for ensartinib showed superior efficacy and a favorable safety profile compared to the first-generation ALK inhibitors that have been approved by the U.S. Food and Drug Administration. Although the potential mechanisms of acquired resistance to ensartinib have not
doi:10.3390/cancers14092341
pmid:35565470
pmcid:PMC9104801
fatcat:miaxsmzvajc37ns4kjdfaya27m
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... en reported, the inevitable emergence of resistance to ensartinib may limit its therapeutic application in cancer. In this work, we investigated the interaction of ensartinib with P-glycoprotein (P-gp) and ABCG2, two ATP-binding cassette (ABC) multidrug efflux transporters that are commonly associated with the development of multidrug resistance in cancer cells. Our results revealed that P-gp overexpression, but not expression of ABCG2, was associated with reduced cancer cell susceptibility to ensartinib. P-gp directly decreased the intracellular accumulation of ensartinib, and consequently reduced apoptosis and cytotoxicity induced by this drug. The cytotoxicity of ensartinib could be significantly reversed by treatment with the P-gp inhibitor tariquidar. In conclusion, we report that ensartinib is a substrate of P-gp, and provide evidence that this transporter plays a role in the development of ensartinib resistance. Further investigation is needed.
Cheirobuccal sensory syndrome
2008
Acta neurologica Taiwanica
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Two patients presented with sensory impairments confined to their right intraoral cheek and right first three fingers. An objective decrease of pinprick pain was detected at these sites. Neuroimaging illustrated recent infarcts in the contralateral ventral thalamus of both patients. The intraoral and cheiral sensory impairments resolved within two months after onset. We coined the term "cheirobuccal sensory syndrome" to describe these cases. The clinical significance and pathogenesis of this peculiar syndrome are discussed.
pmid:18564829
fatcat:wua6m4noibefnesvnaq2ph4ai4
Nonisothermal Crystallization Kinetics of Acetylated Bamboo Fiber-Reinforced Polypropylene Composites
2019
Polymers
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Hung et al. [17] also studied the effect of wood acetylation on the mechanical properties and creep resistance of WPCs. ...
Hung et al. [16] investigated the influence of acetylated BFs with different weight percentage gains (WPGs) on the natural weathering properties of bamboo plastic composites. ...
doi:10.3390/polym11061078
pmid:31234540
pmcid:PMC6631590
fatcat:4ngvmuqso5bkvkocowrdqyuvpu
Interrupted and cascaded permutation invariant training for speech separation
[article]
2019
arXiv
pre-print
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Permutation Invariant Training (PIT) has long been a stepping stone method for training speech separation model in handling the label ambiguity problem. With PIT selecting the minimum cost label assignments dynamically, very few studies considered the separation problem to be optimizing both the model parameters and the label assignments, but focused on searching for good model architecture and parameters. In this paper, we investigate instead for a given model architecture the various flexible
arXiv:1910.12706v1
fatcat:q65xm4s4grhodlx5dg34io5i64
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... label assignment strategies for training the model, rather than directly using PIT. Surprisingly, we discover a significant performance boost compared to PIT is possible if the model is trained with fixed label assignments and a good set of labels is chosen. With fixed label training cascaded between two sections of PIT, we achieved the state-of-the-art performance on WSJ0-2mix without changing the model architecture at all.
8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells
2020
Biomedicines
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8-Hydroxydaidzein (8-OHD, 7,8,4′-trihydoxyisoflavone) is a hydroxylated derivative of daidzein isolated from fermented soybean products. The aim of this study is to investigate the anti-proliferative effects and the underlying mechanisms of 8-OHD in K562 human chronic myeloid leukemia (CML) cells. We found that 8-OHD induced reactive oxygen species (ROS) overproduction and cell cycle arrest at the S phase by upregulating p21Cip1 and downregulating cyclin D2 (CCND2) and cyclin-dependent kinase 6
doi:10.3390/biomedicines8110506
pmid:33207739
pmcid:PMC7696406
fatcat:wrgo2mfaqfdlfeev4dzxtteabe
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... (CDK6) expression. 8-OHD also induced autophagy, caspase-7-dependent apoptosis, and the degradation of BCR-ABL oncoprotein. 8-OHD promoted Early Growth Response 1 (EGR1)-mediated megakaryocytic differentiation as an increased expression of marker genes, CD61 and CD42b, and the formation of multi-lobulated nuclei in enlarged K562 cells. A microarray-based transcriptome analysis revealed a total of 3174 differentially expressed genes (DEGs) after 8-OHD (100 μM) treatment for 48 h. Bioinformatics analysis of DEGs showed that hemopoiesis, cell cycle regulation, nuclear factor-κB (NF-κB), and mitogen-activated protein kinase (MAPK) and Janus kinase/signal transducers and activators of transcription (JAK-STAT)-mediated apoptosis/anti-apoptosis networks were significantly regulated by 8-OHD. Western blot analysis confirmed that 8-OHD significantly induced the activation of MAPK and NF-κB signaling pathways, both of which may be responsible, at least in part, for the stimulation of apoptosis, autophagy, and differentiation in K562 cells. This is the first report on the anti-CML effects of 8-OHD and the combination of experimental and in silico analyses could provide a better understanding for the development of 8-OHD on CML therapy.
Consolidated and Undrained Ring Shear Tests on the Sliding Surface of the Hsien-du-shan Landslide in Taiwan
2018
Geofluids
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A new consolidated undrained ring shear test capable of measuring the pore pressures is presented to investigate the initiation mechanism of the Hsien-du-shan rock avalanche, triggered by Typhoon Morakot ...
Ching Hung for his valuable comments. ...
(2018) ; Hung et al. (2018); [5] ). ...
doi:10.1155/2018/9410890
fatcat:36b4b5vc6bffdim4hvhiwnolgq
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