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Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure

Claudia Metzler-Baddeley, Jilu P. Mole, Erika Leonaviciute, Rebecca Sims, Emma J. Kidd, Benyamin Ertefai, Aurora Kelso-Mitchell, Florence Gidney, Fabrizio Fasano, John Evans, Derek K. Jones, Roland J. Baddeley
2019 NeuroImage  
dispersion and density imaging (NODDI) to investigate the effects of central adiposity on the fornix, parahippocampal cingulum, uncinate fasciculus (compared with whole brain white matter and corticospinal  ...  Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38-71 years old).  ...  collection and scoring of the cognitive and health data, and Rhodri Thomas for his assistance with the APOE genotyping of the saliva samples.  ... 
doi:10.1016/j.neuroimage.2019.02.007 pmid:30735826 pmcid:PMC6435101 fatcat:2k5ezzz76nhedhjdby6gi7hqgy

Adipokines contribute to central-obesity related reductions in myelin-sensitive MRI indices in the fornix [article]

Claudia Metzler-Baddeley, Jilu P. Mole, Erika Leonaviciute, Rebecca Sims, Emma J. Kidd, Benjamin Ertefai, Aurora Kelso-Mitchell, Florence Gidney, Fabrizio Fasano, John Evans, Derek K Jones, Roland J. Baddeley
2018 bioRxiv   pre-print
Obesity-related effects on myelin-sensitive markers were contrasted with differences in apparent axon density from dual-shell diffusion Neurite Orientation Dispersion and Density Imaging (NODDI).  ...  to the correlations between central obesity and myelin-sensitive metrics in the fornix.  ...  In the present study, we did not observe specific effects on hippocampal microstructure.  ... 
doi:10.1101/440990 fatcat:2kb7tb7ffvhpndgkqu344zmpzy

Chronic stress and body composition disorders: implications for health and disease

Charikleia Stefanaki, Panagiota Pervanidou, Dario Boschiero, George P. Chrousos
First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses  ...  This review aims to provide new insights into the newly developed concept of stress-related osteosarcopenic obesity and its prevention.  ...  inflammatory stress on the adipose tissue [52] .  ... 
doi:10.1007/s42000-018-0023-7 pmid:29858868 fatcat:dn4va7ho3rcrvd2rxl6zr5eahq

Genetic risk of dementia modifies the impact of obesity on limbic white matter and spatial navigation behavior in cognitively healthy adults [article]

Jilu P Mole, Fabrizio Fasano, John Evans, Rebecca Sims, Derek A Hamilton, Emma Kidd, Claudia Metzler-Baddeley
2019 bioRxiv   pre-print
A family history (FH) of dementia, APOE4 genotype, and obesity are major risk factors for developing Alzheimer's disease but their combined effects on the brain and cognition remain elusive.  ...  In summary, an individual's genetic dementia risk influenced the impact of obesity on WM myelin and cognition.  ...  Here, we explored the potential moderating effects of systolic and diastolic BP, of plasma markers of inflammation with CRP and IL8, and of adipose tissue dysfunction with the Leptin/Adiponectin Ratio,  ... 
doi:10.1101/871160 fatcat:xw45mq4hzba23a5is3gbodd2iy

Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation

Qin Zhang, Kangyu Jin, Bing Chen, Ripeng Liu, Ripeng Liu, Shangping Cheng, Yuyan Zhang, Jing Lu, Jing Lu
2022 Frontiers in Neuroscience  
In this study, we reviewed the clinical and preclinical literature about the detrimental effects of obesity or high-nutrition diets on cognitive performance and cerebral structure.  ...  We concluded that before the onset of obesity, short-term exposure to high-nutrition diets already blunted central responses to insulin, altered gut microbiome composition, and activated inflammatory mediators  ...  To be more specific, the influence of visceral adiposity (or intraabdominal adiposity) rather than abdominal subcutaneous fat on CNS has been underscored in recent years, but experts' opinions and experimental  ... 
doi:10.3389/fnins.2022.884579 pmid:35873818 pmcid:PMC9298971 doaj:7673f54cd1d148a8abd64f7ddd3604a7 fatcat:jiy3v7iox5cmbelhhadqkqooji

Immune targets for therapeutic development in depression: towards precision medicine

Wayne C. Drevets, Gayle M. Wittenberg, Edward T. Bullmore, Husseini K. Manji
2022 Nature reviews. Drug discovery  
For example, patients with MDD and elevated pro-inflammatory biomarkers are less likely to respond to conventional antidepressant drugs, but novel immune-based therapeutics could potentially address their  ...  This article outlines a framework for developing drugs targeting a novel patient subtype within MDD and reviews the current state of neuroimmune drug development for mood disorders.  ...  Derecki for assistance with early versions of this manuscript and artwork in Fig. 1 .  ... 
doi:10.1038/s41573-021-00368-1 pmid:35039676 pmcid:PMC8763135 fatcat:y76eosbrpzbmbbrdt4ltt52owy

Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging

Amjad Samara, Tatianna Murphy, Jeremy Strain, Jerrel Rutlin, Peng Sun, Olga Neyman, Nitya Sreevalsan, Joshua S. Shimony, Beau M. Ances, Sheng-Kwei Song, Tamara Hershey, Sarah A. Eisenstein
2020 Frontiers in Human Neuroscience  
To determine if similar effects exist in humans with obesity, we applied Diffusion Basis Spectrum Imaging (DBSI) to evaluate neuroinflammation and axonal integrity.  ...  Moreover, using region of interest analyses, average DBSI-RF and DBSI-FF values in the hippocampus were significantly greater and lower, respectively, in obese relative to non-obese individuals (Cohort  ...  Interestingly, a recent study has also shown sex-specific effects of central adiposity and systemic inflammatory markers on limbic system microstructure (Metzler-Baddeley et al., 2019) .  ... 
doi:10.3389/fnhum.2019.00464 pmid:31992978 pmcid:PMC6971102 fatcat:6roax4hyqjhjbdznmalsvpmtta

Biological Alterations in Depression [chapter]

C. Benton, T. Wiltshire
2011 Psychiatric Disorders - Trends and Developments  
antidepressive effects likely through innervations of the limbic brain circuitry (X.  ...  Insulin exerts dosedependent effects on food intake and energy regulation.  ...  Psychiatric Disorders -Trends and Developments Due to their prevalence, pervasiveness and burden inflicted on men and women of today, psychiatric disorders are considered as one of the most important,  ... 
doi:10.5772/27658 fatcat:gxu2sdquu5fuvi7gvbma6rmcre

Is obesity a brain disease?

Gabi Shefer, Yonit Marcus, Naftali Stern
2013 Neuroscience and Biobehavioral Reviews  
That the brain is involved in the pathogenesis and perpetuation of obesity is broadly self-intuitive, but traditional evaluation of this relationship has focused on psychological and environment-dependent  ...  Such induced changes collectively translate into a vicious cycle of deranged metabolic control and cognitive deficits, some of which can be traced back even to childhood or adolescence.  ...  effects on adipose and brain tissues.  ... 
doi:10.1016/j.neubiorev.2013.07.015 pmid:23911925 fatcat:xzttrjvpkbcqnbkycvhsi2kmx4

Cardiovascular risks impact human brain N-acetylaspartate in regionally specific patterns

Joshua Chiappelli, Laura M. Rowland, S. Andrea Wijtenburg, Hongji Chen, Andrew A. Maudsley, Sulaiman Sheriff, Shuo Chen, Anya Savransky, Wyatt Marshall, Meghann C. Ryan, Heather A. Bruce, Alan R. Shuldiner (+3 others)
2019 Proceedings of the National Academy of Sciences of the United States of America  
NAA was strongly and negatively correlated with FCVRS across the brain, but, after accounting for age and sex, the association was found primarily in white matter regions, with additional effects found  ...  NAA mapping of the brain may provide early surveillance for the potential subclinical impact of cardiovascular and metabolic risk factors on the brain.  ...  Based on empirical data from the Framingham Heart Study, the FCVRS is a sex-specific multivariable algorithm based on common laboratory measures and risk factors used to predict an individual's risk for  ... 
doi:10.1073/pnas.1907730116 pmid:31754041 pmcid:PMC6911181 fatcat:nqvv2bv2qvh65jkmtfdwjgoxpy

The causal structure of age-dependent limbic decline: fornix white matter glia damage causes hippocampal grey matter damage, not vice versa [article]

Claudia Metzler-Baddeley, Jilu P. Mole, Rebecca Sims, Fabrizio Fasano, John Evans, Derek K. Jones, John P. Aggleton, Roland J. Baddeley
2018 bioRxiv   pre-print
limbic structures implicated in age-related memory decline: the hippocampus and the fornix in 166 asymptomatic individuals (aged 38 - 71 years).  ...  The implications of these findings for neuroglia and neurodegenerative models of aging and late onset dementia are discussed.  ...  Author contributions: CM-B is the PI of the study and is responsible for the conceptualization and data acquisition and analyses of the study. CM-B has also  ... 
doi:10.1101/440917 fatcat:rmqtdg2vajgdtjcqxg4p7xc44e

The brain's role in human obesity

A. Horstmann, A. Villringer
2013 e-Neuroforum  
This warrants the investigation of the brain's role in the devel­opment and maintenance of obesity that in­deed has become a growing field in the neu­rosciences.  ...  The rise in obesity rates cannot be explained on the basis of our obesogenic environment alone, because large interindividual differences in weight status exist between people.  ...  This work of was supported by the IFB Adiposity Diseases, Federal Ministry of Education and Research (BMBF), Germany, FKZ: 01E01001 ( and the German Research Foundation (DFG) (http:/  ... 
doi:10.1007/s13295-013-0048-y fatcat:fwwp6hskwfcblkg6z6cnrc2xkq

Potential diagnostic biomarkers for schizophrenia

Weihua Yue, Hailiang Huang, Jubao Duan
2022 Medical Review  
a profound impact on the individual and society.  ...  In recent years, some exciting discoveries have been made in the research on objective biomarkers of SCH, mainly focusing on genetic susceptibility genes, metabolic indicators, immune indices, brain imaging  ...  Dysfunction of the autonomic nervous system has adverse effects on physical health, which reflects changes in the function of several regions of the central nervous system, and the dysfunction of autonomic  ... 
doi:10.1515/mr-2022-0009 fatcat:wpykz3rjm5cg7d2n2qogdyfkeu

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

Stephanie Kullmann, Martin Heni, Manfred Hallschmid, Andreas Fritsche, Hubert Preissl, Hans-Ulrich Häring
2016 Physiological Reviews  
We also describe the beneficial effects of enhanced brain insulin signaling on human eating behavior and cognition and discuss potential applications in the treatment of metabolic and cognitive disorders  ...  Decreases in insulin sensitivity of central nervous pathways, i.e., brain insulin resistance, may therefore constitute a joint pathological feature of metabolic and cognitive dysfunctions.  ...  Studies on eating behavior show that central insulin administration inhibits food intake and reduces body weight particularly in men, which suggests a sex-specific component to insulin effects on eating  ... 
doi:10.1152/physrev.00032.2015 pmid:27489306 fatcat:ov3peng3ybevjjbqii4gfrnt7m

Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease

Melinda Barkhuizen, Raul Abella, J. S. Hans Vles, Luc J. I. Zimmermann, Diego Gazzolo, Antonio W. D. Gavilanes
2020 Pediatric Cardiology  
The heart develops early during gestation, and CHD has a profound effect on fetal brain development for the remainder of gestation.  ...  AbstractCongenital heart defects (CHD) is one of the most common types of birth defects.  ...  Infants with CHD have a preoperative increase in neuron-specific marker phosphorylated neurofilament heavy and the calcium-binding protein S100B, and detectable levels of neuron-specific enolase (NSE)  ... 
doi:10.1007/s00246-020-02440-w pmid:33373013 fatcat:227zvbcvvra7plrdtsnm4ipo24
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