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Sex differences in network controllability as a predictor of executive function in youth

Eli J. Cornblath, Evelyn Tang, Graham L. Baum, Tyler M. Moore, Azeez Adebimpe, David R. Roalf, Ruben C. Gur, Raquel E. Gur, Fabio Pasqualetti, Theodore D. Satterthwaite, Danielle S. Bassett
2019 NeuroImage  
Sex differences in executive function in youth have been linked to vulnerability to psychopathology as well as to behaviors that impinge on health, wellbeing, and longevity.  ...  Here we test the hypothesis that sex differences in impulsivity in youth stem from sex differences in the controllability of structural brain networks as they rewire over development.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies.  ... 
doi:10.1016/j.neuroimage.2018.11.048 pmid:30508681 pmcid:PMC6401302 fatcat:u5e3eb3wdnfvjapaj2axqgvll4

Sex differences in network controllability as a predictor of executive function in youth [article]

Eli J. Cornblath, Evelyn Tang, Graham L. Baum, Tyler M. Moore, David R. Roalf, Ruben C. Gur, Raquel E. Gur, Fabio Pasqualetti, Theodore D. Satterthwaite, Danielle S. Bassett
2018 arXiv   pre-print
Here we test the hypothesis that sex differences in executive function in youth stem from sex differences in the controllability of structural brain networks as they rewire over development.  ...  Sex differences in executive function in youth have been linked to vulnerability to psychopathology as well as to behaviors that impinge on health.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. *** *** 0.95 *** *** *** *** *** *** *** *** *** *** *** **  ... 
arXiv:1801.04623v1 fatcat:t6aq647oj5ax3nmlfqwila37ai

Flexible Traversal Through Diverse Brain States Underlies Executive Function in Normative Neurodevelopment [article]

John D. Medaglia, Theodore D. Satterthwaite, Tyler M. Moore, Kosha Ruparel, Ruben C. Gur, Raquel E. Gur, Danielle S. Bassett
2015 arXiv   pre-print
Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes.  ...  Using a novel dynamic graph approach in which each moment in time is a node and the similarity in brain states at two different times is an edge, we identify two primary brain states reminiscent of intrinsic  ...  ) networks as a predictor of individual differences in adaptive behaviors (12) .  ... 
arXiv:1510.08780v1 fatcat:zzhefmbdxfgt5dwsyzf5fgia7i

Neurocognitive and Functional Heterogeneity in Depressed Youth [article]

Erica B. Baller, Antonia N. Kaczkurkin, Aristeidis Sotiras, Azeez Adebimpe, Danielle S. Bassett, Monica E. Calkins, Zaixu Cui, Raquel E. Gur, Ruben C. Gur, Kristin A Linn, Tyler Moore, David R. Roalf (+5 others)
2019 bioRxiv   pre-print
While subtypes did not differ in clinical psychopathology, they diverged in their activation profiles in regions critical for executive function, which mirrored differences in cognition.  ...  This study sought to identify neurocognitive subtypes in a large sample of depressed youth, and evaluated the neural signatures of these subtypes.  ...  Given known developmental and sex differences in cognition, both age and sex were included as covariates in HYDRA.  ... 
doi:10.1101/778878 fatcat:xqg5c63dxraldj6h4vekvuxueu

Neural predictors of alcohol use and psychopathology symptoms in adolescents

TY Brumback, Matthew Worley, Tam T. Nguyen-Louie, Lindsay M. Squeglia, Joanna Jacobus, Susan F. Tapert
2016 Development and Psychopathology  
This study emphasizes the temporal association between maturation of the salience, inhibition, and executive control networks in early adolescence and late adolescent behavior outcomes.  ...  Cross-sectional studies have identified several functional brain networks that may contribute to risk for substance use and psychopathology in adolescents.  ...  .); Grant T32 AA013525 (Riley, Principal Investigator; Nguyen, Fellow); and a fellowship provided by the Office of Academic Affiliations, Department of Veterans Affairs (to T.B.).  ... 
doi:10.1017/s0954579416000766 pmid:27739397 pmcid:PMC5094063 fatcat:uf2jif6gz5apzlmncd2ese3g2u

RACIAL DIFFERENCES IN INFLAMMATION, WHITE MATTER MICROSTRUCTURE, AND MYELIN INTEGRITY

Elizabeth A. Boots, Karla J. Castellanos, Sean C.L. Deoni, Lisa L. Barnes, Lisa M. Tussing-Humphreys, Melissa Lamar
2019 Alzheimer's & Dementia  
First we ran a linear model predicting attentional control using both thickness and Ab as predictors.  ...  P2-414 PRESERVED FUNCTIONAL BRAIN NETWORK AMONG THE ELDERLY WITH YOUTHFUL MEMORY IN SUPERAGING Geon Ha Kim 1 , Bori R.  ... 
doi:10.1016/j.jalz.2019.06.2820 fatcat:5ynwydu5dfbr7gtk6dypejypoy

Cognitive functions in schizophrenia: a comparative study in an Indian population

Kaberi Bhattacharyya, Prathama Guha, Malay Ghosal, Prabir Barman
2012 Sri Lanka Journal of Psychiatry  
Family history of schizophrenia in first degree relatives is a predictor of poor verbal working memory.  ...  The study failed to show any impairment in the area of concentration and executive function, though patients needed more time and intermittent verbal prompts to reach a level of performance equivalent  ...  Acknowledgement The assistance of Dr Utpal Dutta and Dr Dilip Mondal in conducting this study is gratefully acknowledged.  ... 
doi:10.4038/sljpsyc.v3i1.3836 fatcat:2cq3zrdfsngc3idtnz5hdh6dxy

Moderators of Neuropsychological Mechanism in Attention-Deficit Hyperactivity Disorder

Molly A. Nikolas, Joel T. Nigg
2014 Journal of Abnormal Child Psychology  
However, substantial evidence supporting heterogeneity in neuropsychological performance among youth with ADHD as well as apparent effect differences by sex, age, and comorbidity have slowed progress.  ...  siblings, and 103 non-ADHD controls) completed diagnostic interviews and a theoretically informed battery of neuropsychological functioning.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health.  ... 
doi:10.1007/s10802-014-9904-7 pmid:25037459 pmcid:PMC4300292 fatcat:ahb2wvvdyjhdpafp6j46li6zky

Functional connectivity in central executive network protects youth against cardiometabolic risks linked with neighborhood violence

Gregory E. Miller, Edith Chen, Casey C. Armstrong, Ann L. Carroll, Sekine Ozturk, Kelsey J. Rydland, Gene H. Brody, Todd B. Parrish, Robin Nusslock
2018 Proceedings of the National Academy of Sciences of the United States of America  
Consistent with predictions, resting-state connectivity within the central executive network (CEN) emerged as a moderator of adaptation.  ...  Drawing on knowledge of the brain's intrinsic functional architecture, we predicted that individual differences in resting-state connectivity would explain variability in the strength of the association  ...  Consistent with predictions, resting-state connectivity within the central executive network (CEN) emerged as a moderator of adaptation.  ... 
doi:10.1073/pnas.1810067115 pmid:30397136 pmcid:PMC6255151 fatcat:7buyjgpm7zgylczamasqbv5fba

Neural and Endocrine Correlates of Early Life Abuse in Youth With Depression and Obesity

Kevin L. Sun, Kathleen T. Watson, Sarthak Angal, Baylee F. Bakkila, Aaron J. Gorelik, Sara M. Leslie, Natalie L. Rasgon, Manpreet K. Singh
2018 Frontiers in Psychiatry  
Results of an oral glucose tolerance test (OGTT) and resting state functional connectivity (RSFC), using the amygdala, insula, and nucleus accumbens (NAcc) as seed-based reward network regions of interest  ...  The origin and consequence of insulin resistance in depressed youth may, in part, be rooted in exposure to environmental stressors, such as early life abuse, that may lead to aberrant brain motivational  ...  ACKNOWLEDGMENTS We would like to express appreciation to our research participants and families, as well as members of our Pediatric Emotion And Resilience Lab (PEARL) for their contributions to this work  ... 
doi:10.3389/fpsyt.2018.00721 pmid:30622489 pmcid:PMC6308296 fatcat:jdljfsujp5hs5juppavvlzal4e

Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents

Josiane Bourque, Philip A. Spechler, Stéphane Potvin, Robert Whelan, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin (+16 others)
2017 American Journal of Psychiatry  
This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing.  ...  A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later.  ...  A Predictors  ... 
doi:10.1176/appi.ajp.2017.16080897 pmid:28320226 pmcid:PMC5951182 fatcat:fqlwdtrn4bf2xhxh5plf7jku2a

Parental family history of alcohol use disorder and neural correlates of response inhibition in children from the Adolescent Brain Cognitive Development (ABCD) Study

Briana Lees, Laika Aguinaldo, Lindsay M. Squeglia, M. Alejandra Infante, Natasha E. Wade, Margie Hernandez Mejia, Joanna Jacobus
2020 Alcoholism: Clinical and Experimental Research  
inhibit a response as compared to children with no such family history.  ...  Substance-naïve children with a parental family history of AUD exhibit greater neural activation in some regions of the fronto-basal ganglia and cerebellar networks when they successfully or unsuccessfully  ...  Inhibitory control is one component of higher-order executive functions (Giedd et al., 1999; Gogtay et al., 2004) .  ... 
doi:10.1111/acer.14343 pmid:32333792 pmcid:PMC7323844 fatcat:olkuvc7lardjphusihfdovayau

Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

Monique Ernst, Brenda Benson, Eric Artiges, Adam X. Gorka, Herve Lemaitre, Tiffany Lago, Ruben Miranda, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Rüdiger Brühl, Christian Büchel (+26 others)
2019 Translational Psychiatry  
The main question concerns how the DMN evolves with puberty as a function of sex.  ...  This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN).  ...  This work received support from the following funding sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcementrelated behavior in normal brain function and psychopathology) (LSHM-CT  ... 
doi:10.1038/s41398-019-0433-6 pmid:30804326 pmcid:PMC6389927 fatcat:3maagssrmjhu5mo5xrn6zlbwke

Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosis

Fred W. Sabb, Theo G.M. van Erp, Molly E. Hardt, Mirella Dapretto, Rochelle Caplan, Tyrone D. Cannon, Carrie E. Bearden
2010 Schizophrenia Research  
Methods-Forty CHR youth and 24 demographically comparable healthy controls underwent functional magnetic resonance imaging while performing a naturalistic discourse processing paradigm.  ...  Results-Relative to controls, CHR participants showed increased neural activity in a network of language-associated brain regions, including the medial prefrontal cortex bilaterally, left inferior frontal  ...  .), NIMH MH65079 and NIMH P50 MH066286, as well as donations from the Rutherford Charitable Foundation and Staglin Music Festival for Mental Health to the UCLA Foundation.  ... 
doi:10.1016/j.schres.2009.09.042 pmid:19861234 pmcid:PMC2818263 fatcat:dvsrpiiwcrai3lth2k4wz2mxuq

Prediction of Antidepressant Efficacy by Cognitive Function in First-Episode Late-Life Depression: A Pilot Study

Weigang Pan, Chaomeng Liu, Dandi Zhu, Yi Liu, Peixian Mao, Yanping Ren, Xin Ma
2022 Frontiers in Psychiatry  
The preliminary findings suggested that working memory, attention, visuospatial, language function, and delayed memory should be examined further as a means of providing the useful objective biomarkers  ...  Thirty-eight matched healthy controls (HC) were assessed using RBANS and TMT. There was significant decrease of score of RBANS and increase of score of TMT in patients with LLD compared with HC.  ...  Increased cognitive control network functional connectivity and decreased default mode network functional connectivity were observed in LLD with remission, but not in patients with ineffective treatment  ... 
doi:10.3389/fpsyt.2022.916041 pmid:35669268 pmcid:PMC9163406 fatcat:2xcbfrszdjbk7oyhkmgxmbplge
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