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Objectives This study compared everolimus-eluting stents (EES) and sirolimus-eluting stents (SES) for long coronary lesions. Background Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. Methods This randomized, multicenter, prospective trial compared the use of long EES with SES in 450 patients with long (Ն25 mm) native coronary lesions. The primary endpoint of the trial was insegment late luminal loss at 9-month angiographicdoi:10.1016/j.jcin.2011.05.024 pmid:22017935 fatcat:km4gaarehjgoxlshwiqjzl3xf4
more »... low-up. : 1 0 . 1 0 1 6 / j . j c i n . 2 0 1 1 . 0 5 . 0 2 4 BMS ؍ bare-metal stent(s) DES ؍ drug-eluting stent(s) EES ؍ everolimus-eluting stent(s) MACE ؍ major adverse cardiac events MI ؍ myocardial infarction PCI ؍ percutaneous coronary intervention SES ؍ sirolimus-eluting stent(s) TLR ؍ target lesion revascularization J A C C : C A R D
Acute Cervical Myelopathy Following Laughing Gas Abuse Hak-Loh Lee 1, † , Seung-Jin Lee 2, † , Tai-Seung Nam 1, * , Seung Hyun Min 1 , Jae-Myung Kim 1 , and Kyung-Wook Kang 1 Departments of 1 Neurology ...doi:10.4068/cmj.2019.55.2.118 pmid:31161125 pmcid:PMC6536437 fatcat:viostvbnt5bhxk6uhzcoopkqke
AbstractWe aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53doi:10.1038/s41598-021-85845-8 pmid:33737711 fatcat:dmg7opb5cjaj7il46avksyxgxe
more »... were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes.
Number of patients enrolled in final analysis 1,625 patients 1,076 patients Follow-up duration after randomization in months, median (interquartile range) 19.6 (12.3-25.5) 18.6 (14.2-21.9)doi:10.1097/01.sa.0000391589.20506.f0 fatcat:4q2ewgfnzjbtdif5uooxi5jb6y
Seung-Jung Park, Department of Cardiology, University of Ulsan College of Medicine, Cardiac Center, Asan Medical Center, 388-1 Poongnap-dong, Songpagu, Seoul 138-736, Korea. ...doi:10.1016/j.jacc.2011.11.047 pmid:22421303 fatcat:qlw5gg2mnngntodkjr4wyjo7x4
Traumatic diaphragmatic rupture is uncommon, but requires a prompt diagnosis and repair. Diaphragmatic injury is most commonly associated with automobile accidents. The diagnosis is difficult and may be delayed because there are no specific symptoms, signs, or radiographic studies that are pathognomic for diaphragmatic injury. The most important factor in the diagnosis is a high suspicion and the use of proper diagnostic studies. We report a case involving the delayed presentation ofdoi:10.4046/trd.2009.66.3.241 fatcat:mqjmduvtijdujiziqgkchubsfe
more »... ic rupture in a 54 year old man, requiring surgical repair 12 days following multiple blunt trauma. It should be noted that early recognition for diaphragmatic injury is important in patients with multiple trauma to avoid the potential fatal complications.
Conceptualization: Seung Wook Lee, Min Hee Lee. Data curation: Seung Wook Lee, Jung Min Jung. Formal analysis: Jung Min Jung. Investigation: Seung Wook Lee, Seo Youn Choi, Jung Min Jung. ... Seung Wook Lee, Ji Eun Lee, Seo Youn Choi, Boem Ha Yi, and Jung Min Jung declare that they have no conflict of interest. ...doi:10.1097/md.0000000000016001 pmid:31192941 pmcid:PMC6587601 fatcat:qsv4s5ipmzgjrmgfx3cx4ew76a
Suppressor of cytokine signaling genes (SOCS) are regarded as pivotal negative feedback regulators of cytokine signals, including the interferon-gamma (IFN-γ), granulocyte-colony stimulating factor, and interleukin families, released by T cells. A detailed understanding of the involvement of SOCS genes in graft-versus-host disease (GVHD) is critical to effectively manage GVHD, yet their expression patterns among recipients remain largely unexplored. Methods Expression levels of SOCS1 and SOCS3doi:10.5045/br.2013.48.1.16 pmid:23589790 pmcid:PMC3625005 fatcat:jyjqfxjgmjbzpjzbl3ig2pwzkm
more »... ere determined by real-time quantitative reverse transcription PCR (qRT-PCR) in patients with acute GVHD (aGVHD) and chronic GVHD (cGVHD), in a severity-dependent manner, after allogeneic hematopoietic stem cell transplantation (HSCT). A total of 71 recipients with AML (N=40), ALL (N=12), myelodysplastic syndromes (MDS; N=10), chronic myelogenous leukemia (CML; N=2), severe aplastic anemia (SAA; N=5), or others (N=2), who received allogeneic HSCT from human leukocyte antigen-identical siblings or unrelated donors between 2009 and 2011, were included in the present study. Results Overall, the expression levels of SOCS1 decreased in recipients with grade II to IV aGVHD and cGVHD when compared to normal donors and non-GVHD recipients. Interestingly, the expressions of SOCS1 decreased significantly more in cGVHD than in aGVHD recipients (P=0.0091). In contrast, SOCS3 expressions were similarly reduced in all the recipients. Conclusion This is the first study to show that SOCS1 and SOCS3 are differentially expressed in recipients following allogeneic HSCT, suggesting a prognostic correlation between SOCS genes and the development of GVHD. This result provides a new platform to study GVHD immunobiology and potential diagnostic and therapeutic targets for GVHD.
Wan-Seop Kim, Hye Seung Han, Seung Eun Lee. Validation: Jae-Wook Lee, Ji Hyun Park. Writing -original draft: Hye Seung Lee. Writing -review & editing: Ji Hyun Park, Seung Eun Lee. ... Eun Lee.Data curation: Hye Seung Lee. ...doi:10.1371/journal.pone.0218046 pmid:31276506 pmcid:PMC6611592 fatcat:r6hklyhhazcu5ltphxwwr7quzy
It is well known that diabetic patients have a high risk of cardiovascular events, and although there has been a tremendous effort to reduce these cardiovascular risks, the incidence of cardiovascular morbidity and mortality in diabetic patients remains high. Therefore, the early detection of coronary artery disease (CAD) is necessary in those diabetic patients who are at risk of cardiovascular events. Significant medical and radiological advancements, including coronary computed tomographydoi:10.4093/dmj.2018.0041 fatcat:kp375ygsb5h3ja5svkv2qphy6u
more »... ography (CCTA), mean that it is now possible to investigate the characteristics of plaques, instead of solely evaluating the calcium level of the coronary artery. Recently, several studies reported that the prevalence of subclinical coronary atherosclerosis (SCA) is higher than expected, and this could impact on CAD progression in asymptomatic diabetic patients. In addition, several reports suggest the potential benefit of using CCTA for screening for SCA in asymptomatic diabetic patients, which might dramatically decrease the incidence of cardiovascular events. For these reasons, the medical interest in SCA in diabetic patients is increasing. In this article, we sought to review the results of studies on CAD in asymptomatic diabetic patients and discuss the clinical significance and possibility of using CCTA to screen for SCA.
Background Anti-tumor necrosis factor (TNF) treatment for inflammatory bowel disease (IBD) increases the risk of tuberculosis (TB) infection. In the present study, we analyzed the clinical characteristics and risks of TB in Korean patients with IBD who received anti-TNF treatment. Methods The study included patients with IBD who were treated using anti-TNF agents between January 2001 and June 2018 at the Asan Medical Center. Overall, 1434 patients with ulcerative colitis or Crohn's disease weredoi:10.1186/s12876-021-01973-5 pmid:34670529 fatcat:x7mh5xbr3bf75e2n2l3dqpacyu
more »... enrolled. We calculated the incidence of active TB infection after anti-TNF treatment and compared the clinical characteristics of the TB group with those of the non-TB group. Results Twenty-one patients (1.46%) developed active TB infection, and the incidence rate of active TB was 366.73 per 100,000 person-years. In total, 198 patients (14.9%) were positive for latent tuberculosis infection (LTBI), of whom only eight (4%) did not complete LTBI treatment. The age at which the anti-TNF therapy was started was significantly higher in the TB group than in the non-TB group (HR 1.041, 95% CI 1.014–1.069, p = 0.002), and as age increased, so did the incidence rate of active TB infection (linearity p < 0.001). There was no significant difference in the incidence rate of LTBI between the TB and non-TB groups (HR 0.896, 95% CI 0.262–3.066, p = 0.862). Conclusions In patients with IBD, the incidence rate of TB increased with age at anti-TNF therapy initiation. Active treatment of LTBI may lower the incidence of TB in patients with IBD who are to undergo anti-TNF therapy.
Coronary artery calcium score (CACS) is associated with increased risk of atrial fibrillation (AF). However, the relationship between the burden of CACS and extra-coronary calcium and the AF is unclear. This cross-sectional study retrospectively analyzed the data of 143,529 participants (74.9% men; mean age, 41.7 ± 8.6 years) who underwent health examination including non-contrast cardiac CT and electrocardiography, from 2010 to 2018 to evaluate the association between cardiac calcium and AF.doi:10.3390/jcm11020371 pmid:35054065 pmcid:PMC8782034 fatcat:nabqnxlfwnex5d5jleqje5qj3e
more »... was diagnosed in 679 participants. The prevalence of AF was significantly increased as the CACS increased (p < 0.01). Multivariable analysis adjusted for age, sex, body mass index, hypertension, diabetes, hyperlipidemia, smoking, alcohol, and history of coronary artery disease showed a significant association between a high CACS ≥1000 and AF (OR 2.26, 95% CI 1.07–4.77, p = 0.032). In a subgroup analysis of participants with a CACS ≥100, aortic valve and thoracic aorta calcium were significantly associated with AF (OR 3.49, 95% CI 1.57–7.77, p = 0.002 and OR 2.19, 95% CI 1.14–4.21, p = 0.01, respectively). High CACS was associated with AF, and extra-coronary atherosclerosis was associated with AF in participants with a moderate to very high CACS.
Sporadic Creutzfeldt-Jakob disease (CJD) is clinically characterized by rapidly progressive dementia combined with other cardinal symptoms, such as myoclonus, visual or cerebellar disturbances, extrapyramidal or pyramidal disturbance, and akinetic mutism. However, as an initial manifestation, focal neurologic deficits other than the aforementioned or nonspecific generalized symptoms may lead to a misdiagnosis or a delayed diagnosis. The authors report a case of 66-year-old male patient withdoi:10.1097/md.0000000000002766 pmid:26886621 pmcid:PMC4998621 fatcat:ike4gssvereirl6vqnbim3dapm
more »... adic CJD who had dizziness, gaze-evoked nystagmus (GEN), and other central eye signs (impaired smooth pursuit, saccadic dysmetria) as an initial manifestation without dementia. The central eye signs led us to perform brain magnetic resonance images, which showed abnormal cortical high-signal intensity in both the cerebral and cerebellar hemispheres including the vestibulocerebellum. We reached a presumptive diagnosis of CJD, but the findings did not meet diagnostic criteria for probable CJD at that time. Three weeks after the initial work-ups, the patient presented with typical neurological findings of CJD: rapidly progressive dementia, akinetic mutism, and myoclonus of the left arm. Cerebrospinal fluid was positive for 14-3-3 protein, and electroencephalography showed periodic sharp wave complexes. In this patient, GEN and other central eye signs provided diagnostic clues for CJD. These unusual neurological manifestations may help physicians have a thorough knowledge of early deficits of CJD. (Medicine 95(7):e2766) Abbreviations: CJD = Creutzfeldt -Jakob disease, CSF = cerebrospinal fluid, DWI = diffusion weighted imaging, EEG = electroencephalography, GEN = gaze-evoked nystagmus, MRI = magnetic resonance imaging, PSWC = periodic sharp wave complex. Editor: Li Yong.
Thrombotic thrombocytopenic purpura (TTP) is a rapidly progressive hematological syndrome defined by the pentad of thrombocytopenia, microangiopathic hemolytic anemia, neurologic abnormalities, fever and renal dysfunction. TTP has been associated with major surgical procedures and specific medications. However, there is no known previously reported case in which acute TTP occurred after a percutaneous coronary intervention (PCI). We report a case of TTP after a PCI, that presented with thedoi:10.3904/kjim.2006.21.2.120 pmid:16913442 pmcid:PMC3890734 fatcat:b5t3uihtrjcprfuuhvsgt3x73q
more »... d of symptoms, as well as hepatitis and pancreatitis.
Immediate Zotarolimus-Eluting Stent Fracture http://dx.doi.org/10.4070/kcj.2015.45.1.67 www.e-kcj.org Pil Hyung Lee, et al. http://dx.doi.org/10.4070/kcj.2015.45.1.67 www.e-kcj.org http://dx.doi.org ...doi:10.4070/kcj.2015.45.1.67 pmid:25653706 pmcid:PMC4310982 fatcat:sosz2sbb65fw3chyks4lserfd4
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