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Post-Translational Regulation of ARF: Perspective in Cancer

Jinho Seo, Daehyeon Seong, Seung Ri Lee, Doo-Byoung Oh, Jaewhan Song
2020 Biomolecules  
(Jaewhan Song) wrote and conceived the manuscript. S.R.L. helped in designing the figures. D.-B.O. revised the manuscript. All authors have read and agreed to the published version of the manuscript.  ... 
doi:10.3390/biom10081143 pmid:32759846 pmcid:PMC7465197 fatcat:yuwl4w4pirb7hnckigax73j6ga

SG-SP1 Suppresses Mast Cell-Mediated Allergic Inflammation via Inhibition of FcεRI Signaling

Min-Jong Kim, In-Gyu Je, Jaeyoung Song, Xiang Fei, Soyoung Lee, Huiseon Yang, Wonku Kang, Yong Hyun Jang, Seung-Yong Seo, Sang-Hyun Kim
2020 Frontiers in Immunology  
Due to the strong inhibitory effect of SG-SP1 on Lyn, the known upstream signaling to FcεRI-dependent pathway, we confirmed the direct binding of SG-SP1 to FcεRI, a high affinity IgE receptor by surface  ...  Conclusions: We determined that SG-SP1 directly interacts with FcεRI and propose SG-SP1 as a therapeutic candidate for mast cell-mediated allergic inflammatory disorders via inhibition of FcεRI signaling  ...  Affinity Analysis of SG-SP1 to FcεRIα To visualize the crosslinking of IgE or SG-SP1 on FcεRIα, SPR experiment was performed. As mentioned above, IgEbinding region is α subunit in FcεRI.  ... 
doi:10.3389/fimmu.2020.00050 pmid:32063904 pmcid:PMC6998798 fatcat:yvx67p7s2vc37foiuvnq5swvqa

Sterilization and quality variation of dried red pepper by atmospheric pressure dielectric barrier discharge plasma

Yoon Seok Song, Yu Ri Park, Seung Min Ryu, Hyeong Won Jeon, Sang Heum Eom, Seung Je Lee
2016 Korean Journal of Food Preservation  
This study was conducted to explore the potential for use of atmospheric pressure dielectric barrier discharge plasma (atmospheric pressure DBD plasma) as a non-thermal sterilization technology for microorganisms in dried red pepper. The effects of key parameters such as power, exposure time and distance on the sterilization efficiency and the quality of red dried pepper by the atmospheric pressure DBD plasma treatment were investigated. The results revealed that the plasma treatment was very
more » ... fective for sterilization of Staphylococcus aureus, with 15 min of treatment at 1.0 kW and 20 mm sterilizing 82.6% of the S. aureus. Increasing the power or exposure time and decreasing the exposure distance led to improved sterilization efficiency. The atmospheric pressure DBD plasma treatment showed no effect on the ASTA (American spice trade association) value or hardness of dried red pepper. Furthermore, no effects of atmospheric pressure DBD plasma treatment were observed on the sensory properties of dried red pepper. To assess the storage stability, the dried red pepper was treated with atmospheric pressure DBD plasma (1.5 kW power, 15 min exposure time and 10 mm exposure distance), then stored for 12 weeks at 25℃. Consequently, the ASTA value, hardness and capsaicin concentration of dried red pepper were maintained.
doi:10.11002/kjfp.2016.23.7.960 fatcat:o6suzzvg7bhllnsd62egpfws6m

Amplified Spontaneous Emission of GaN Nanorods

Hyeong-Seop Shim, Joo-Hee Seo, Noh-Soo Han, Seung-Min Park, Yu-Ri Sohn, Chin-Kyo Kim, Jae-Kyu Song
2012 Bulletin of the Korean Chemical Society (Print)  
Semiconductor nanowires have been the subject of intense study in recent years. In particular, their ability to confine electrons/holes and photons makes them attractive as potential building blocks of nanoscale electronics and optoelectronic devices. 1-3 For UV/blue light emitting devices, the optical properties of gallium nitride (GaN) nanowires are suitable due to their wide band gap (3.4 eV) and the absence of threading dislocation in the lateral dimensions. 4-7 Therefore, the optical
more » ... ties of GaN nanostructures have been widely investigated, which include stimulated emission processes such as lasing and amplified spontaneous emission (ASE). These can have a positive impact on the optoelectronic devices based on GaN nanowires. In this Note, we examine the stimulated emission process of GaN nanorods using optical excitation of femtosecond laser pulses. The shapes and lengths of the GaN nanostructures were characterized by scanning electron microscopy (SEM), whose result is presented in Figure 1 (a). The diameters of nanorods were in the range of 150-400 nm and the lengths were 500-1000 nm. The as-grown nanorods were excited with a He-Cd laser (325 nm, Kimmon) to obtain a normal photoluminescence spectrum at room temperature ( Figure 1(b) ). In the UV region an emission peak was observed at 368 nm (3.4 eV). As the exciton binding energy in GaN is in the range of 20-25 meV, 4,8 emission of the exciton state was not expected due to the thermal energy at room temperature (26 meV). Therefore, the UV emission is attributed to band edge emission (BGE), which indicates the band gap energy. [4] [5] [6] [7] [8] To measure the nonlinear optical response, GaN nanorods were excited by the second harmonics (355 nm) of a cavitydumped oscillator (Mira/PulseSwitch, Coherent, 1 MHz, 710 nm, 150 fs) using a UV microscope objective. 9,10 The emissions were collected by the same objective, resolved spectrally by a monochromator, and detected by a photomultiplier. The shape of BGE was not changed when a low excitation intensity was used (< 25 µJ/cm 2 ), as shown in Figure 2 (a). The intensity of BGE increased almost linearly in this low excitation intensity regime, which is presented in Figure 2(b) . On the other hand, a superlinear increase in the BGE intensity was observed at an excitation intensity of 30 µJ/cm 2 . In addition, the bandwidth of BGE decreased with increasing excitation intensity above a threshold of 30 µJ/ cm 2 . For example, the full-width at half maximum (FWHM) of the band was found to be 17 nm at an excitation intensity of 10 µJ/cm 2 , which decreased to 15 nm at an excitation intensity of 50 µJ/cm 2 , as seen in the inset of Figure 2 (a). The superlinear increase in the BGE intensity and the narrowing of the bandwidth can be attributed to the waveguiding effect. 4,5 As the diameter of the nanorods is smaller † This paper is to commemorate Professor Kook Joe Shin's honourable retirement. Figure 1. (a) Scanning electron microscopy (SEM) image of GaN nanostructures. Scale bar indicates 2 µm. (b) Photoluminescence spectrum of GaN nanorods at room temperature. The peak wavelength was observed at 368 nm, indicating the band gap energy.
doi:10.5012/bkcs.2012.33.3.1075 fatcat:d6eegcke7bdqvkzatv4ahadmyy

Photofragmentation in selected tautomers of protonated adenine

Nu Ri Cheong, Sang Hwan Nam, Hye Sun Park, Seol Ryu, Jae Kyu Song, Seung Min Park, Marie Pérot, Bruno Lucas, Michel Barat, Jacqueline A. Fayeton, Christophe Jouvet
2011 Physical Chemistry, Chemical Physics - PCCP  
The photofragmentation by UV excitation of selectively prepared 1 + and 3 + tautomers of protonated adenine is studied after excitation at a 266 and 263 nm wavelengths with two different experimental set-ups located in Seoul and Orsay. While the production of 1 + tautomers with an electrospray ion source is now well accepted, calculations were used to ascribe the preparation of 3 + tautomers from cold adenine dimers. The fragmentation patterns are rather similar for both tautomers, suggesting
more » ... milar mechanisms as a statistical fragmentation in the ground electronic state after internal conversion.
doi:10.1039/c000961j pmid:20981363 fatcat:rdfvlkjedfdxtapvccsnuzlzf4

A Case Report of Patients Diagnosed with ThoracoLumbar Junction Syndrome Treated by Megadose Pharmacopuncture with Korean Medicine Treatment

Kwang Chan Song, Ji Yeon Seo, Seung Bae Song, Won Hyung Ryu, Doo Ri Kim, Yong Hyun Jeon, Hee Young Moon, Gwang Hyun Ryu
2018 Journal of Korean Medicine Rehabilitation  
The purpose of this research is to find out the effect of Megadose pharmacopuncture with Korean Medicine Treatment on patients who were diagnosed as ThoracoLumbar Junction Syndrome. Megadose pharmacopuncture was proceeded on 4 patients who received treatment at OO Korean Medicine Hospital from November, 2016 to Februrary, 2017. In addition, We also kept a record of NRS, ODI, and EQ-5D on the day of admission and discharge to find out the differences between initial and final figures. As a
more » ... , Megadose parmacopuncture showed a significant effect on alleviating pain on patients with ThoracoLumbar Junction Syndrome. There was a significant decrease in NRS, ODI scores. Not only did the scores of NRS and ODI decrease significantly,but also the figures of EQ-5D increased significantly as well. To be specific, the mean of NRS and ODI dcreased from 10 to 1.75 and 61.87 to 12.78 while the mean of EQ-5D increased from 0.258 to 0.850. This research suggests Megadose pharmacopuncture with Korean Medicine Treatment could be a remedy for ThoracoLumbar Junction Syndrome. (J Korean Med Rehabil 2018;28(2): 127-134) 서론»»» 흉요추 연접부 증후군이란 흉요추의 연접부인 T12-L1, 드물게는 T11-T12나 L1-L2분절의 기능장애로 일어나는 단독적이거나 또는 다른 증상과 혼합된 모든 통증을 지칭 하는 말이다 1) . 흉요추 연접부 증후군의 진단은 아직까지 확실한 기준이 없으며 임상 소견에 의존하게 된다. 흉요 추 연접부 증후군의 통증 분포와 진찰시에 나타나는 임상 징후는 T12와 L1의 척수신경 분지들이 지배하는 영역과 일치하는데 이들 신경의 후분지(posterior rami)는 둔부 윗부분과 허리 아랫부분의 피하조직을 지배하며 전분지 (anterior rami)는 아랫배와 사타구니 부위를 지배한다 (Fig. 1) 2) . 추간공을 통해서 척추강에서 나온 제12 흉추신 경의 후분지(posterior rami)는 척추기립근을 뚫고 들어가 송광찬⋅서지연⋅송승배⋅류원형⋅김두리⋅전용현⋅문희영⋅류광현 128
doi:10.18325/jkmr.2018.28.2.127 fatcat:uiihhsnerncxzdvyhfw3ew3gpm

The Effect of Stress Reduction on Color Stimulus Using Healing Bed in Cypress Tree
편백나무로 제작된 힐링 침대에서의 색체 자극이 스트레스 완화에 미치는 효과

Sun-Hye Shin, Mi Yu, Seung-Yong Oh, Ju-Ri Kim, Eui-Sun Song, Myoung-Chul Moon, Seung-Taek Lim, Hee-Jun Park, Tae-Kyu Kwon
2016 Journal of rehabilitation welfare engineering & assistive technology  
본 연구에서는 삼림욕을 즐기는 것과 같은 편안한 상태의 휴식을 유도하기 위하여 편백나무를 이용하여 힐링 침대 시스템과 색체자극을 위한 LED 감성 모듈을 개발하였고, 8가지 조명과 3가지 색온도의 색체 자극에 따른 휴식이 스트레스 완화에 미치는 효과를 비교·분석하였다. 피험자는 건강한 20대 성인 남여 7명(age 23.3±0.7yr; height 165±;10cm body mass 59±10kg)을 대상으로 하였으며, 8가지 색상(red, orange, yellow, green, blue, indigo, violet, white)과 3가지 색온도(3,000K, 5,000K, 8,000K)에 따른 휴식 시 심박변이도, 피험자의 주관적 인지평가를 진행하였다. 그 결과, 심박변이도의 경우 한색계열인 green, blue, indigo의 조명과 3000K의 낮은 온도 조명이 부 교감신경을 활성화시켜 심리적으로 안정되는 결과를 얻었으며, 피험자가 주관적으로 느끼는 인지시간의 결과 동일
more » ... 을 자극받았을 지라도 green 색상과 3,000K 온도 자극 시 인지 시간이 가장 느렸으며, 감성어휘 평가에서는 orange 색상과 3,000K온도에서 가장 높은 점수를 얻었다. 따라서, 본 연구 결과 3,000K의 낮은 온도자극과 green 색상 자극 시 심리정 안정이 가장 높은 결과를 얻었으며, 추후 연구에서는 작업 환경에 따른 조명 자극 시 피로도 회복과 뇌파 변화를 비교 분석 할 것이다. ABSTRACT The purpose of this study was to verify the emotional response of user to LED light colors in healing bed system in cypress tree. Eight colors of LED light were provided including red, orange, yellow, green, blue, indigo, violet and white. And three illumination color temperature were provided including 3,000K, 5,000K, 8,000K. Seven subjects in their twenties were involved without the medical history of eyes and heart disorders. The subjects were exposed to LED lighting during 5 minutes and their emotional response was evaluated through the following: first, at the physiological effect heart rate variability(HRV) was measured during the stimulation; second, at the emotion level the subjects were asked about lighting color and color temperature through a survey. Results, lower color temperature of 3,000K and green color shows high value on HRV. We have found that there is a difference of physiological and emotion level effect depending on color stimulus. This study could be applied to reference data to analysis of a decrease in fatique and charges of brain waves for color stimulus.
doi:10.21288/resko.2016.10.2.163 fatcat:jkf56vdcnzc4vdmehzeylejlm4

Characterization of Two Novel mAbs Recognizing Different Epitopes on CD43

Soseul Kim, Jeong won Hong, Woon-Dong Cho, Yoo Ri Moon, Sang Soon Yoon, Min-Young Kim, Kwon Pyo Hong, Yong-Moon Lee, Jae Hyuk Yi, Young Jun Ham, Hyung Chul Rah, Seung Ryul Kim (+1 others)
2014 Immune Network  
doi:10.4110/in.2014.14.3.164 pmid:24999313 pmcid:PMC4079823 fatcat:inz67e4pv5chtlfcvzkf43wcxu

Effect of Thyroid-Stimulating Hormone Suppression on Muscle Function After Total Thyroidectomy in Patients With Thyroid Cancer

Jun Choul Lee, Byong-Sop Song, Young Mi Kang, Yu-Ri Kim, Yea Eun Kang, Ju Hee Lee, Minho Shong, Hyon-Seung Yi
2021 Frontiers in Endocrinology  
ContextThyroid-stimulating hormone (TSH) suppression is recommended to reduce tumor recurrence following surgery for differentiated thyroid cancer (DTC). However, prolonged subclinical hyperthyroidism caused by levothyroxine treatment has deleterious effects on various organs.ObjectiveTo evaluate the relationships of TSH concentration with muscle mass, muscle strength, and physical performance related to sarcopenia in patients with DTC undergoing TSH suppression following surgery.MethodsWe
more » ... ed 134 patients of &gt;60 years who were undergoing TSH suppression therapy following surgery for DTC. We evaluated muscle mass and muscle function-related parameters and diagnosed sarcopenia using the threshold for Asian people.ResultsThe participants were 68.3 ± 7.2 years old and 36/134 (26.9%) were diagnosed with sarcopenia. They were allocated to high-TSH and low-TSH groups using a threshold concentration of 0.40 μU/mL, and grip strength was significantly lower in the low-TSH group. The data were further analyzed according to age and sex, and in the low-TSH group, male participants and those of &lt;70 years were found to have significantly lower grip strength.ConclusionsLow-TSH concentrations is associated with low grip strength, and this is most pronounced in individuals of &lt;70 years of age. Therefore, muscle function should be considered an adverse effect of TSH suppression in patients with DTC who undergo TSH suppression therapy, especially in men of &lt;70 years.
doi:10.3389/fendo.2021.769074 pmid:34858341 pmcid:PMC8631429 fatcat:hahgvo2bj5avfaabxt76o2ihte

The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

Yeha Kim, Soyeon Lim, Taejeong Ha, You-Hyang Song, Young-In Sohn, Dae-Jin Park, Sun-Sook Paik, Joo-ri Kim-Kaneyama, Mi-Ryoung Song, Amanda Leung, Edward M Levine, In-Beom Kim (+4 others)
2017 eLife  
The visual responses of vertebrates are sensitive to the overall composition of retinal interneurons including amacrine cells, which tune the activity of the retinal circuitry. The expression of Paired-homeobox 6 (PAX6) is regulated by multiple cis-DNA elements including the intronic α-enhancer, which is active in GABAergic amacrine cell subsets. Here, we report that the transforming growth factor ß1-induced transcript 1 protein (Tgfb1i1) interacts with the LIM domain transcription factors Lhx3
more » ... and Isl1 to inhibit the α-enhancer in the post-natal mouse retina. Tgfb1i1-/- mice show elevated α-enhancer activity leading to overproduction of Pax6ΔPD isoform that supports the GABAergic amacrine cell fate maintenance. Consequently, the Tgfb1i1-/- mouse retinas show a sustained light response, which becomes more transient in mice with the auto-stimulation-defective Pax6ΔPBS/ΔPBS mutation. Together, we show the antagonistic regulation of the α-enhancer activity by Pax6 and the LIM protein complex is necessary for the establishment of an inner retinal circuitry, which controls visual adaptation.
doi:10.7554/elife.21303 pmid:28139974 pmcid:PMC5308899 fatcat:xgni2k755jhkbl5b4dnn6ygeei

Case of Renal Microaneurysms and Multiple Renal Infarctions in a Patient with Systemic Lupus Erythematosus

Jong Wan Kang, Eun Song Lee, Jung Su Eun, Na Ri Kim, Seung Woo Han, Sang Jin Lee, Young Mo Kang, Man Hoon Han, Eon Jeong Nam
2018 Journal of Rheumatic Diseases  
Systemic lupus erythematosus (SLE) is a chronic inflammatory, heterogeneous autoimmune disease characterized by autoantibody production and the potential involvement of almost every organ system. Although vasculitis usually confined to small vessels is a fairly common feature of SLE, ischemic vasculitis with an aneurysm is an uncommon feature. In particular, renal arterial microaneurysms and multiple renal infarctions are very rarely reported in patients with SLE. Furthermore, to the best of
more » ... authors' knowledge, there is no report on renal arterial microaneurysms associated with SLE in Korea. Here, this paper presents a case of renal microaneurysms and multiple renal infarctions in a 41-year-old woman with SLE. (J Rheum Dis 2018;25:296-301)
doi:10.4078/jrd.2018.25.4.296 fatcat:gl6oc6llzzdshhwr4y4fz526c4

Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex

Jinho Seo, Daehyeon Seong, Young Woo Nam, Chi Hyun Hwang, Seung Ri Lee, Choong-Sil Lee, Young Jin, Han-Woong Lee, Doo-Byoung Oh, Peter Vandenabeele, Jaewhan Song
2020 Cell Death and Differentiation  
Recently, Song et al. demonstrated the autophagy-independent role of Beclin 1 in ferroptosis [33] .  ... 
doi:10.1038/s41418-020-0561-9 pmid:32457484 pmcid:PMC7560833 fatcat:xpuu34vcgzh3xehm7z5pe5z2aq

Safety of Fertility-Sparing Surgery in Primary Mucinous Carcinoma of the Ovary

Jung-Yun Lee, Yu Ri Jo, Tae Hun Kim, Hee Seung Kim, Min A Kim, Jae Weon Kim, Noh Hyun Park, Yong-Sang Song
2014 Cancer research and treatment : official journal of Korean Cancer Association  
Safety of Fertility-Sparing Surgery in Primary Mucinous Carcinoma of the Ovary Purpose The aim of this study is to evaluate the safety of fertility-sparing surgery as the treatment for patients with primary mucinous epithelial ovarian cancer. Materials and Methods A retrospective study of patients with mucinous ovarian cancer between 1991 and 2010 was performed. The demographics and survival outcomes were compared between patients who underwent fertility-sparing surgery and those who underwent
more » ... adical surgery. Results A total of 110 patients underwent primary surgery. At the time of surgery, tumors appeared to be grossly confined to the ovaries in 90 patients, and evidence of metastasis was definite in 20 patients. Of the 90 patients with tumors that appeared to be grossly confined to the ovaries at surgical exploration, 35 (38.9%) underwent fertility-sparing surgery. The Kaplan-Meier curve and the log rank test showed no difference in either recurrence-free survival (p=0.792) or disease-specific survival (p=0.706) between the two groups. Furthermore, there was no significant difference in recurrence-free survival (p=0.126) or disease-specific survival (p=0.377) between the two groups, even when the analysis was limited to women below the age of 40. In a multivariate Cox model, fertility-sparing surgery had no effect on either recurrence-free survival (recurrence hazard ratio [HR], 1.20; 95% confidence interval [CI], 0.25 to 5.71) or disease-specific survival (death HR, 0.88; 95% CI, 0.17 to 4.60). Conclusion Fertility-sparing surgery in primary mucinous cancer grossly confined to the ovaries may be a safe option and one not associated with an increase in recurrence or mortality.
doi:10.4143/crt.2014.004 pmid:25287480 pmcid:PMC4398117 fatcat:22sllxhbtvgbbif5btvryye234

A Study on the Environmental Impact Assessment for Passive Apartment based on Life Cycle Assessment
LCA에 기초한 패시브 공동주택의 친환경성 평가에 관한 연구

Yu-Ri Gong, Sung-Ho Tae, Suwon Song, Seung-Jun Roh
2014 Journal of the Korea Institute of Building Construction  
As environmental matters such as Green House Effect rise, many construction industries are putting an effort on minimizing environmental impact in terms of building life cycle throughout the world. However, in South Korea, evaluating the eco-friendly building based on life cycle assessment has been facing an academic ostracism while the most studies are focusing on assessing the 6 environmental impact assessments of passive apartment based on life cycle assessment. The theoretical consideration
more » ... of the life cycle assessment and environmental impact category were performed and the direction of the study was set up. Also, existing apartment and passive apartment, which had same structure and same type were chosen and building materials per unit area were compared to find out the difference environmental impact for building life cycle. As a result, passive apartment was rated as low level among the 6 environmental impacts. Also, effect of building material on passive apartment was more important than its operational stage.
doi:10.5345/jkibc.2014.14.6.537 fatcat:ua75dsekafdbbi4bysk2oepzom

A Survey on Acute Traffic Injury Patient's Perception on Korean Herbal Medicine

Soo-yeon Kim, Seung-ju Oh, Kyu-hyun Hwang, Eun-seok Jin, Sun-Kyu Yeom, Dong-woo Kim, Seok-woo Kim, So-ri Jin, Mu-Jin Park, Eun-song Kim, Hyun-seok Lee
2020 Journal of Korean Medicine Rehabilitation  
doi:10.18325/jkmr.2020.30.4.165 fatcat:4utpludfanb5rmlptkjbw36kuq
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