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Coffee and health
2014
Integrative Medicine Research
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Most people start their day with a cup of coffee. Many people would also finish their daily work with coffee. As such, coffee drinking is an important part of modern daily life. It has been told that coffee is a driving force for humans to develop science, because it has an alerting effect on the human brain. However, some people report experiencing irregular heartbeat or headaches and are thus reluctant to drink coffee, which suggests individual variation to coffee intolerance. The aim of this
doi:10.1016/j.imr.2014.08.002
pmid:28664096
pmcid:PMC5481750
fatcat:7gsf744d5vamfbuu57potpd5ee
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... review is to briefly summarize the effects of coffee on human health.
Experimental Evaluation for the Mechanism of Acute Ischemic Mitral Regurgitation
1999
Korean Circulation Journal
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and Objectives The ischemic mitral regurgitation MR is known as a clinically important prognostic factor of acute myocardial infarction, and it is important to understand the mechanism of ischemic MR for successful treatment of ischemic MR. However, the mechanism of ischemic MR has not been known clearly. The purposes of this study were to evaluate the role of papillary muscle ischemia and LV dysfunction in the development of ischemic MR and to relate structural and functional changes of LV
doi:10.4070/kcj.1999.29.8.802
fatcat:2ofvrrhuuneqtkehanzt23no64
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... severity of ischemic MR. Methods Left thoracotomy was performed in ten mongrel dogs. In group 1 n 5 , first and second obtuse marginal OM branches were ligated, and in group 2 n 5 , second and third OM branches were ligated. Epicardial echocardiography was performed at baseline, during infusion of esmolol, and during ligation of OM branches to measure end diastolic and end systolic area, fractional area shortening of LV, incomplete leaflet closure distance and area of mitral valve, and jet area of MR. Myocardial contrast echocardiography was performed to evaluate perfusion of papillary muscle and to measure risk area during ligation of OM branches. Results 1 Zligation of OM branches, but the significant MR developed in only one dog during esmolol infusion p NS , and in four dogs during ligation of OM branches p 0.05 . 2 Ischemia of papillary muscle was provoked in none of group 1, but four of five dogs in group 2 p 0.05 . Ischemic MR developed in all four dogs with provocation of papillary muscle ischemia, but in none of six dogs with maintained perfusion of papillary muscle p 0.005 . 3 Only incomplete leaflet closure area was significantly related with the severity of ischemic MR r 0.71, p 0.05 . Conclusions Ischemia of papillary muscle is the important etiologic factor in development of ischemic MR in acute posterior myocardial infarction. It will be useful to assess and restore the perfusion of papillary muscles for the treatment of ischemic MR. Korean Circulation J 1999 ; 29 8 : 802-811 KEY WORDS Ischemic mitral regurgitation·Papillary muscle·Myocardial contrast echocardiography.
Regulation of IGFBP-2 expression during fasting
2015
Biochemical Journal
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Seung-Jae Kim, Yong-Deuk Kim and Young-Kyo Seo contributed to the performance of experiments, analysis and interpretation of data. ...
Jae-Hoon Bae, Goo-Taeg Oh, Dae-Kyu Song and Yong-Ho Ahn contributed to the analysis and interpretation of data and a critical review of the manuscript before submission. ...
doi:10.1042/bj20141248
pmid:25695641
pmcid:PMC4403943
fatcat:t3thdkrjebgmxncac36z2ocjce
Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
2016
BMB Reports
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BMB Reports http://bmbreports.org
Corosolic acid regulates IRAK-1 phosphorylationSeung-Jae Kim, et al. ...
doi:10.5483/bmbrep.2016.49.5.241
pmid:26615974
pmcid:PMC5070707
fatcat:germs4x2dreilmiilgz3jzocuy
Short and Long-term Results of Open Heart Surgery in Aortic Valve Disease
1998
Korean Circulation Journal
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and Objectives This study sought to investigate operative and late mortality in aortic valve surgery and to identify risk factors for operative and late mortality. Materials and Methods We examined operative mode, operative and late mortality, and survival rate of aortic valve surgery performed at Asan Medical Center between June 1989 and December 1996. Results 227 patients 148 men with a mean age 49 15 years underwent aortic valve surgery. Aortic valvular lesions were classified as dominant
doi:10.4070/kcj.1998.28.9.1509
fatcat:nv4eztkpinddrpytpgdengpuj4
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... nosis n 66 , dominant regurgitation n 133 , and balanced stenoinsufficiency n 28 according to the echocardiographic findings. Surgical procedures were aortic valve replacement with mechanical prosthesis in 180 79 and with bioprosthesis in 27 12 and aortic valve repair in 20 9 . The overall operative mortality was 4.8 . Bacterial endocarditis and long bypass time were independent factors associated with high operative mortality p 0.05 . During follow up mean 33 24 months of operative survivors, there were 9 late deaths, 12 redo operations, and 11 clinical events bacterial endocarditis, stroke, major bleeding, and admission for heart failure . There was no single identifiable risk factor for late mortality but age was significantly associated with development of clinical event and late mortality p 0.05 . One-, Three-, and Seven-years survival rate after successful operation were 98 1 , 96 2 , and 92 3 , respectively. Late clinical event-free survival rate was 67 8 at seven years after aortic valve surgery. Conclusions Aortic valve surgery could be done with low operative and late mortality. Complications related with bacterial endocarditis and long-term anticoagulation therapy following valve replacement surgery still remained high, which needs further improvement. Korean Circulation J 1998 ; 28 9 : 1509-1517 KEY WORDS Aortic valve surgery·Mortality·Survival rate.
Prognostic Factors and Characteristics of Pancreatic Neuroendocrine Tumors: Single Center Experience
2012
Yonsei medical journal
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Pancreatic neuroendocrine tumors (PNET) are a rare subgroup of tumors. For PNETs, the predictive factors for survival and prognosis are not well known. The purpose of our study was to evaluate the predictive factors for survival and disease progression in PNETs. We retrospectively analyzed 37 patients who were diagnosed with PNET at Severance Hospital between November 2005 and March 2010. Prognostic factors for survival and disease progression were evaluated using the Kaplan-Meier method. The
doi:10.3349/ymj.2012.53.5.944
pmid:22869477
pmcid:PMC3423842
fatcat:clvyh6uk6zecfiriqmvwniewpy
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... an age of the patients was 50.0±15.0 years. Eight cases (21.6%) were described as functioning tumors and 29 cases (78.4%) as non-functioning tumors. In univariate analysis of clinical factors, patients with liver metastasis (p=0.002), without resection of primary tumors (p=0.002), or American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) stage III/IV (p=0.002) were more likely to demonstrate shorter overall survival (OS). Patients with bile duct or pancreatic duct invasion (p=0.031), sized-lesions larger than 20 mm (p=0.036), liver metastasis (p=0.020), distant metastasis (p=0.005), lymph node metastasis (p=0.009) or without resection of primary tumors (p=0.020) were more likely to demonstrate shorter progression-free survival (PFS). In multivariate analysis of clinical factors, bile duct or pancreatic duct invasion [p=0.010, hazard ratio (HR)=95.046] and tumor location (non-head of pancreas) (p=0.036, HR=7.381) were confirmed as independent factors for predicting shorter PFS. Patients with liver metastasis or without resection of primary tumors were more likely to demonstrate shorter OS. Patients with bile duct or pancreatic duct invasion or tumors located at body or tail of pancreas were more likely to demonstrate shorter PFS.
Long-term outcomes of percutaneous mitral balloon valvuloplasty versus open cardiac surgery
2010
Journal of Thoracic and Cardiovascular Surgery
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Objectives: We sought to compare long-term outcomes between percutaneous mitral valvuloplasty and open heart surgery. Methods: The study evaluated 402 patients who underwent percutaneous mitral valvuloplasty and 159 patients who underwent open heart surgery between January 1, 1995, and December 31, 2000. The rates of cardiovascular death or repeated intervention (redo percutaneous mitral valvuloplasty or open heart surgery) were determined over a median follow-up of 109 months (mean AE SD, 106
doi:10.1016/j.jtcvs.2009.04.022
pmid:19660411
fatcat:zybqz5vpofezjd2zstk2wzmo3y
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... E 27). The therapeutic effects on adverse outcomes were estimated by the Cox proportional hazards model adjusting differences in the severity of illness before intervention. The effects of the cardiac rhythm and echocardiographic score were also tested. Results: The observed (unadjusted) event-free survival was similar for both groups, and the hazard ratio for the clinical events after percutaneous mitral valvuloplasty as compared with after open heart surgery was 1.510 (95% confidence interval, 0.914-2.496; P ¼ .1079). However, the adjusted hazard ratio was 3.729 (95% confidence interval, 1.963-7.082; P < .0001), showing a higher event-free survival in the open heart surgery group. The adjusted hazard ratio after percutaneous mitral valvuloplasty as compared with after open heart surgery in patients with echocardiographic scores of 8 or more and atrial fibrillation were 5.348 (95% confidence interval, 2.504-11.422; P<.001) and 3.440 (95% confidence interval, 1.805-6.555; P ¼ .0002), respectively, whereas the hazard ratio in patients with echocardiographic scores less than 8 and normal sinus rhythm did not show differences. Conclusions: Open heart surgery was associated with a higher adjusted rate of long-term event-free survival than percutaneous mitral valvuloplasty. Patients with high echocardiographic scores or atrial fibrillation showed better outcomes after open heart surgery. (J Thorac Cardiovasc Surg 2010;139:103-10) From the Divisions of Cardiology,
Clinical characteristics of second primary pancreatic cancer
2017
PLoS ONE
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Purpose Several studies reported the increased risk of second primary pancreatic ductal adenocarcinoma (2nd PDAC) in cancer survivors. However, data on the characteristics of 2nd PDAC are insufficient. Methods This retrospective cohort study included 1759 patients with PDAC. They were classified as having 2nd PDAC or first primary PDAC (1st PDAC) according to a prior diagnosed cancer of different origin, at least 6 months before PDAC diagnosis. Results There were 110 patients (6.4%) with 2nd
doi:10.1371/journal.pone.0179784
pmid:28650984
pmcid:PMC5484482
fatcat:pvdmlkmvpngjxftq2yanuetfii
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... C and 1606 (93.6%) patients with 1st PDAC. Patients with 2nd PDAC presented with older age (66.5 vs. 62.2 years, p < 0.001) and higher rate of resectability (26.4% vs. 15.9%, p = 0.004) at diagnosis than those with 1st PDAC. Multivariate analysis without considering resectable status showed that 2nd PDAC (hazard ratio [HR] 0.73, 95% confidence interval [CI] 0.56-0.94, p = 0.016) was associated with better overall survival. After adjusting for resectable status, however, 2nd PDAC (HR 0.85, 95% CI 0.66-1.09, p = 0.198) was no longer associated with overall survival. When subgroups were separately analyzed according to initial treatment modality, the effectiveness of surgery and chemotherapy were similar between 2nd and 1st PDAC (33.1 vs. 28.5 months, p = 0.860 and 10.8 vs. 10.7 months, p = 0.952). Conclusions The proportion of resectable cases was significantly higher in 2nd PDAC. When surgery with curative aim was possible, the overall survival was increased even in patients with 2nd PDAC. These results suggest the importance of screening for second primary cancer in cancer survivors.
Recent Trends and Outcome of Mitral Valve Surgery
1998
Korean Circulation Journal
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and Objectives:Recently, in mitral valve surgery, valvuloplasty or valve repair was successfully introduced to improve postoperative left ventricular function and to decrease operative mortality. However, the real impact of this technique on daily practice in Korea was not systematically assessed. Materials and Method:The operative methods, postoperative death, follow-up results and their contributing factors were analysed among patients who underwent mitral valve surgery at our institution.
doi:10.4070/kcj.1998.28.7.1059
fatcat:k22d5iyonnad3ffw6brb4tq5eu
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... ults:1) From June 1989 to December 1996, 416 patients (186 males, mean age 48±13 years) underwent mitral valve surgery. Dominant mitral stenosis (MS) was the main pathology in 167 patients;dominant mitral regurgitation (MR) and balanced mitral stenoinsufficiency (MSR) in 197 and 52 respectively. 2) In MS, valve replacement was performed in 91% whereas commissurotomy in 9%. However, in MR, the rates of valve repair surgery has increased up to 60% of the total surgical procedures for the past three years. 3) The overall operative mortality was 4% (18/416). It was significantly lower in valve repair compaired with valve replacement (0% vs. 6%;p=0.003). In MS, factors associated with high mortality were longer cardiopulmonary bypass and aortic cross clamp time. In MR, high mortality was associated with diabetes, endocarditis, valve replacement and longer cardiopulmonary bypass time. 4) The 7-year late survival among operative survivors was 95±2% in MS, which was singnificantly higher than that in MR (80±6%, p=0.04). 5) In MR, the 4-year cardiac event-free survival among operative survivors (absence of cardiac death, reoperation, bleeding, endocarditis, thromboembolism, or development of heart failure) was significantly higher in valve repair group than in valve replacement (84±7 vs. 76±5%;p=0.03). Conclusion:The overall outcomes of recent mitral valve surgery were satisfactory. In MR, valve repair surgery seemed to be an established method to decrease operative mortality and long-term complications. ( ( ( (Korean Circulation J 1998 ; 28( ( ( (7) ) ) ) : 1059-1068) ) ) ) KEY WORDS:Mitral valve surgery•Mortality•Survival.
Clinical Characteristics of Surgically Corrected Mitral Regurgitation Due to Myxomatous Degeneration in Korea
2001
Korean Circulation Journal
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and Objectives Although the clinical significance of mitral regurgitation MR due to prolapse or chordae rupture with myxomatous degeneration MD is increasing significantly, the clinical features of patients with MD in Korea have not been characterized. Materials and Method A retrospective analysis was performed of the clinical data of 90 patients who underwent surgical correction of significant MR due to MD. Lesion sites of MD were confirmed during surgery anterior A and posterior P mitral
doi:10.4070/kcj.2001.31.10.1042
fatcat:x6dvu74tfveipejgurqjcbucly
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... ets were divided into lateral A1 P1 , middle A2 P2 , and medial segments A3 P3 . Results The mean age was 51 14 years and the male/female ratio was 1 age distribution showed a typical bimodal pattern with two peaks at the mid-thirties and the mid-fifties each. MD was confined to P leaflet in 36 40% , A leaflet in 20 22% , and both leaflets in 34 patients 38% . Forty-six patients 51% showed MD in a single segment, and 37 41% in 2 segments 7 patients 8% showed MD in more than 2 segments. In 90 patients, pathologic MD was confirmed in 139 mitral segments among these, P3 was the most commonly involved segment 30% , followed by A3 17% , P2 14% , A2 14% , A1 14% , and P1 12% . Chordae rupture was observed in 71 patients 79% , and was associated with hypertension HT . Younger patients age 45 years, N 31 showed a lower prevalence of HT and a higher incidence of MD involving multiple segments. Conclusion MD develops preferentially in the medial part of the mitral valve, and patterns of clinical presentation can change according to the age and existence of HT in selected patients with significant MR. Korean Circulation J 2001 ; 31 10 : 1042-1048 KEY WORDS Mitral valve prolapse Chordae tendineae rupture Mitral valve insufficiency. Cardiol 1986 58 762-7. 2) Hickey AJ, Wilcken DE, Wright JS, Warren BA. Primary chordal rupture Relation to myxomatous valve disease and mitral valve prolapse. J Am Coll Cardiol 1985 5 1341-6. 3) Kim SY, Kim KS, Kwon TK, Lee YS, Cho GK, Son BJ, Kang MS, Nam MH, Kim YN, Kim KB. The change of cardiac function and morphology after mitral valve repair surgery in mitral valve prolapse with mitral regurgitation. J Kor Soc Echocardiogr 2000 8 182-90. 4) Eisenmann B, Charpentier A, Popescu S, Epailly E, Billaud P, Jirari A. Is a prosthetic ring required for mitral repair of mitral insufficiency due to leaflet prolapse? Eur J Cardiothorac Surg 1998 14 584-9. 5) Fukuda N, Oki T, Iunchi A, Tabata T, Manabe K, Kageji Y, Sasaki M, Yamada H, Ito S. Predisposing factors for severe mitral regurgitation in idiopathic mitral valve prolapse. Am J Cardiol 1995 76 503-7. 6) Totaro P, Tulumello E, Fellini P, Rambaldini M, La Canna G, Coletti G, Zogno M, Lorusso R. Mitral valve repair for isolated prolapse of anterior leaflet An 11-year follow-up. Eur J Cardiothorac Surg 1999 15 119-26. 7) Freed LA, Levy D, Levine RA, Larson MG, Evans JC, Fuller DL, Lehman B, Benjamin EJ. Prevalence and clinical outcome of mitral valve prolapse. N Engl J Med 1999 341 1-7. 8) Foster GP, Isselbacher EM. Rose GA, Torchiana DF, Akins CW, Picard MH. Accurate localization of mitral regurgitant defects using multiplane transesophageal echocardiography. Ann Thorac Surg 1998 65 1025-31. 9) Roberts WC. Mitral valve prolapse and systemic hypertension. Am J Cardiol 1985 56 703. 10) Roberts WC. Morphologic features of the normal and abnormal mitral valve. Am J Cardiol 1983 51 1005-28. 11) Singh RG, Cappucci R, Kramer-Fox R, Roman MJ, Kligfield P, Borer JS, Hochreiter C, Isom OW, Devereux RB. Severe mitral regurgitation due to mitral valve prolapse Risk factors for development progression and need for mitral valve surgery. Am J Cardiol 2000 85 193-8.
Clinical analysis on infections after cardiac transplantation
2001
Korean Circulation Journal
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MG, Seo DM, Lee JW, Kim JJ, Park SW, Song JK, Park KY, Kim HC, Oh MH, Hong SK, Jung IS, Park JW, EB, Remington JS. ...
virus
15
Onychomycosis
6
Otitis media
2
Sinusisitis
1
No. of infections per patient
1 episode
22
2 episodes
10
3 episodes
2
6 episodes
1
Table 3 . 3 The summary of mortality Song ...
doi:10.4070/kcj.2001.31.8.815
fatcat:pfq77xozj5a33fl5mzcwjpvvjm
Late intravascular ultrasound findings of patients treated with brachytherapy for diffuse in-stent restenosis
2004
Catheterization and cardiovascular interventions
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This study aimed at evaluating long-term (24-month) effects of -irradiation ( 188 Re-MAG 3 -filled balloon) using intravascular ultrasound (IVUS) in patients with in-stent restenosis (ISR). Long-term effects of -irradiation on intimal hyperplasia (IH) within the stented segment and vessel and lumen dimensions of nonstented adjacent segments in patients with ISR have not been sufficiently evaluated. Two-year follow-up IVUS was performed in 30 patients with patent ISR segments at 6-month
doi:10.1002/ccd.20118
pmid:15390251
fatcat:xnzpunmwjzh6njkejopckx35ea
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... up angiography. Serial IVUS images were acquired at five equidistant intrastent sites and at three different reference segment sites. IH burden (%) was defined as 100 ؋ (IH/stent area). Mean intrastent IH area and IH burden significantly increased between 6 and 24 months, from 2.1 ؎ 1.1 to 2.6 ؎ 1.4 mm 2 (P < 0.001) and from 26% ؎ 10% to 33% ؎ 14% (P < 0.001), respectively. There was a significant decrease of mean external elastic membrane (from 10.1 ؎ 3.9 to 9.7 ؎ 3.9 mm 2 ; P ؍ 0.015) and lumen area (from 5.6 ؎ 2.3 to 5.1 ؎ 2.3 mm 2 ; P ؍ 0.021) within distal reference segments between 6 and 24 months. Target lesion revascularization (TLR) was performed in six patients (20%) between 6 and 24 months after -irradiation therapy. There were no significant differences between TLR and non-TLR groups except for a smaller minimum lumen area at 24 months in the TLR group. Because of a small amount of late loss between 6 and 24 months, most irradiated ISR vessel segments remained stable for up to 2 years. However, quantitative evidence of late catch-up was evident in most patients and was significantly associated with 24-month TLR in some patients.
Bivariate Beta-LSTM
[article]
2019
arXiv
pre-print
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Long Short-Term Memory (LSTM) infers the long term dependency through a cell state maintained by the input and the forget gate structures, which models a gate output as a value in [0,1] through a sigmoid function. However, due to the graduality of the sigmoid function, the sigmoid gate is not flexible in representing multi-modality or skewness. Besides, the previous models lack modeling on the correlation between the gates, which would be a new method to adopt inductive bias for a relationship
arXiv:1905.10521v3
fatcat:c46jtnn6cnhc5hhfkf6pidjety
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... etween previous and current input. This paper proposes a new gate structure with the bivariate Beta distribution. The proposed gate structure enables probabilistic modeling on the gates within the LSTM cell so that the modelers can customize the cell state flow with priors and distributions. Moreover, we theoretically show the higher upper bound of the gradient compared to the sigmoid function, and we empirically observed that the bivariate Beta distribution gate structure provides higher gradient values in training. We demonstrate the effectiveness of bivariate Beta gate structure on the sentence classification, image classification, polyphonic music modeling, and image caption generation.
Clinical Characteristics of Constrictive Pericarditis Diagnosed by Echo-Doppler Technique in Korea
2001
Journal of Korean medical science
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Clinical Characteristics of Patients with Cardiac Involvement in Behcet's Disease
2005
Korean Circulation Journal
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