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Serotonin modulates learning content-specific neuroplasticity of functional brain networks [article]

Manfred Klöbl, René Seiger, Thomas Vanicek, Patricia Handschuh, Murray Bruce Reed, Benjamin Spurny, Vera Ritter, Godber Mathis Godbersen, Gregor Gryglewski, Christoph Kraus, Andreas Hahn, Rupert Lanzenberger
2021 bioRxiv   pre-print
The directedness of these effects indicates serotonergic modulation of emotional feedback routes.  ...  Assessing the translation of learning effects from animals to humans, 99 healthy subjects underwent six weeks of emotional or semantic learning and subsequent relearning and three resting-state acquisitions  ...  Acknowledgments This research was funded in part, by the Austrian Science Fund (FWF) [KLI 516, PI: Rupert Lanzenberger].  ... 
doi:10.1101/2021.01.15.426779 fatcat:urjlya2edvh3lawrnnuv2da524

Compensatory Relearning Following Stroke: Cellular and Plasticity Mechanisms in Rodents

Gustavo Balbinot, Clarissa Pedrini Schuch
2019 Frontiers in Neuroscience  
Recovery relies on plasticity in the periinfarct and homotopic contralesional regions and involves relearning to perform movements.  ...  von Monakow's theory of diaschisis states the functional 'standstill' of intact brain regions that are remote from a damaged area, often implied in recovery of function.  ...  Numa Dancause for insightful comments and directions in a previous version of this manuscript. We also thank Ph.D. Martín Cammarota and Ph.D. Adriano B.L.  ... 
doi:10.3389/fnins.2018.01023 pmid:30766468 pmcid:PMC6365459 fatcat:454a2uhtqvd5rdvxx5do7oucuu

Page 3430 of Psychological Abstracts Vol. 92, Issue 10 [page]

2005 Psychological Abstracts  
—Recent evidence suggests that a combination of shyness and sociability is associated with distinct behavioral and psychophysiolog- ical correlates at rest and in response to social stress and may be a  ...  (Departmento de Anatomia, Instituto de Ciéncias Biomédicas Universidade de Sao Paulo, Sao Paulo, Brazil) Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic  ... 

Influence of ovarian hormones on value-based decision-making systems: contribution to sexual dimorphisms in mental disorders

Aiste Ambrase, Carolin A. Lewis, Claudia Barth, Birgit Derntl
2020 Frontiers in neuroendocrinology (Print)  
While a significant interaction of neurotransmitter systems and sex hormones has been shown for both sexes, decision-making in women might be particularly affected by variations of ovarian hormones.  ...  We also review previous findings on impaired decision-making in animals and clinical populations with substance use disorder and depression, emphasizing how little we know about the role of ovarian hormones  ...  . (2015) investigated serotonergic modulation of behavioral inhibition in a 'Go/ No-Go' task with reward and punishment conditions (Crockett et al., 2009) in healthy women during the early follicular  ... 
doi:10.1016/j.yfrne.2020.100873 pmid:32987043 fatcat:3kpg2xt6lbey5ee6frqzr5dfpe

The Cerebellar Cognitive Affective/Schmahmann Syndrome: a Task Force Paper

Georgios P. D. Argyropoulos, Kim van Dun, Michael Adamaszek, Maria Leggio, Mario Manto, Marcella Masciullo, Marco Molinari, Catherine J. Stoodley, Frank Van Overwalle, Richard B. Ivry, Jeremy D. Schmahmann
2019 Cerebellum  
The primary objective of this task force paper is thus to stimulate further research in this area.  ...  The CCAS thus offers excellent grounds to investigate the functional topography of the cerebellum, and, ultimately, illustrate the precise mechanisms by which the cerebellum modulates cognition and affect  ...  and Ataxias, and the executive of the American Neuropsychiatric Association; receives royalties from Oxford University Press, Elsevier, and MacKeith Press; and holds the license with the General Hospital  ... 
doi:10.1007/s12311-019-01068-8 pmid:31522332 fatcat:mgscv2qzfjhzxiqa7njsepg3vm

Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and Rehabilitation

Francesca Magrinelli, Alessandro Picelli, Pierluigi Tocco, Angela Federico, Laura Roncari, Nicola Smania, Giampietro Zanette, Stefano Tamburin
2016 Parkinson's Disease  
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and rigidity, which appear in the early stages of the disease and largely depend on dopaminergic nigrostriatal denervation  ...  Nondopaminergic dysfunction results in motor problems, including posture, balance and gait disturbances, and fatigue, and nonmotor problems, encompassing depression, apathy, cognitive impairment, sleep  ...  networks in association with the occurrence of paroxysmal motor arrests [113] .  ... 
doi:10.1155/2016/9832839 pmid:27366343 pmcid:PMC4913065 fatcat:xwcydsyudzeqdd546y6q2ayyeu

Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal

Susan J. Sara, Sebastien Bouret
2012 Neuron  
Central activation of neuromodulatory neurons and peripheral arousal, together, prepare the organism for a reorientation or reset of cortical networks and an adaptive behavioral response.  ...  Noradrenaline, released in forebrain structures, will facilitate sensory processing, enhance cognitive flexibility and executive function in the frontal cortex, and promote offline memory consolidation  ...  ACKNOWLEDGMENTS This review was written while S.J.S. was Visiting Professor at the Institute of Neurosciences, Chinese Academy of Sciences, Shanghai.  ... 
doi:10.1016/j.neuron.2012.09.011 pmid:23040811 fatcat:enfk6simljecncocexixffqjii

Recovery of control of posture and locomotion after a spinal cord injury: solutions staring us in the face [chapter]

Andy J. Fong, Roland R. Roy, Ronaldo M. Ichiyama, Igor Lavrov, Grégoire Courtine, Yury Gerasimenko, Y.C. Tai, Joel Burdick, V. Reggie Edgerton
2009 Progress in Brain Research  
Strategies that seek out the complementary effects of combination treatments and that efficiently integrate relevant technical advances in bioengineering represent an untapped potential and are likely  ...  Advances in multiple areas have provided tools for pursuing effective combination of strategies for recovering stepping and standing after a severe spinal cord injury.  ...  Acknowledgments The work presented in this paper was supported by the National Institutes of Health Grants NS16333 and NS42291, the Russian Foundation for Basic Research -US Civilian Research and Development  ... 
doi:10.1016/s0079-6123(09)17526-x pmid:19660669 pmcid:PMC2904312 fatcat:ecnctdkk75czlachw4qmahpk3e

Changes in neuroplasticity following early-life social adversities: the possible role of brain-derived neurotrophic factor

Christina Miskolczi, József Halász, Éva Mikics
2018 Pediatric Research  
Preclinical and clinical data suggest early-life social adversities (ELSA) might be associated with accelerated maturation of social network circuitry, a possible ontogenic adaptation to the adverse environment  ...  Recent advances in preclinical and clinical research have begun examining neuroplasticity-the nervous system's ability to form adaptive changes in response to new experience-in the context of early-life  ...  In accordance with this, research has suggested that ELSA is associated with altered function involving cognitive tasks, reaction to social or emotional stimuli, reaction to reward, resting states and  ... 
doi:10.1038/s41390-018-0205-7 pmid:30341412 fatcat:zo5zit3re5hblbs2iavtdauzq4

30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts

2021 Journal of Computational Neuroscience  
within the constraints of biological networks.  ...  One of the goals of neuroscience is to understand the computational principles that describe the formation of behaviorally relevant signals in the brain, as well as how these computations are realized  ...  In these preliminary simulations, we also found large effects of the location of the excited MF patch.  ... 
doi:10.1007/s10827-021-00801-9 pmid:34931275 pmcid:PMC8687879 fatcat:evpmmfpaivgpxdqpive5xdgmwu

About Sleep's Role in Memory

Björn Rasch, Jan Born
2013 Physiological Reviews  
While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold  ...  The study took ϳ2 mo during which the participants lived in the laboratory and were tested almost every day and night.  ...  Effects of sleep and wake intervals of different length ACKNOWLEDGMENTS We thank Maren Cordi, Anja Otterbein, Ursula Rasch, Julia Rihm, Thomas Schreiner, Sarah Schoch, and Manuela Steinauer for assistance  ... 
doi:10.1152/physrev.00032.2012 pmid:23589831 pmcid:PMC3768102 fatcat:hwyquoixznaofmhcrp2ipgixie

27th Annual Computational Neuroscience Meeting (CNS*2018): Part One

2018 BMC Neuroscience  
Acknowledgements We acknowledge the Initiative and Networking Fund of the Helmholtz Association, the Helmholtz Association through the Helmholtz Portfolio Theme"Supercomputing and Modeling for the Human  ...  Alliance through the Initiative and Networking Fund of the Helmholtz Association and the Helmholtz Portfolio theme "Supercomputing and Modeling for the Human Brain" and the European Union Seventh Framework  ...  P63 P64 Modeling network connectivity for dopamine-mediated olfactory learning in mosquitos P65 Detection of spatio-temporal spike patterns in motor cortex during a reach-to-grasp task In two recent  ... 
doi:10.1186/s12868-018-0452-x pmid:30373544 pmcid:PMC6205781 fatcat:xv7pgbp76zbdfksl545xof2vzy

Emotion, Cognition, and Mental State Representation in Amygdala and Prefrontal Cortex

C. Daniel Salzman, Stefano Fusi
2010 Annual Review of Neuroscience  
We propose that these mental state parameters are inextricably linked and represented in dynamic neural networks composed of interconnected prefrontal and limbic brain structures.  ...  In this framework, functional interactions between the amygdala and prefrontal cortex mediate emotional influences on cognitive processes such as decision-making, as well as the cognitive regulation of  ...  Lau and S. Morrison for helpful discussion, as well as comments on the manuscript, and H. Cline for invaluable support.  ... 
doi:10.1146/annurev.neuro.051508.135256 pmid:20331363 pmcid:PMC3108339 fatcat:6xop3bxlcfeohpazfewuupy7h4

Motor rehabilitation after stroke, traumatic brain, and spinal cord injury: common denominators within recent clinical trials

Bruce H Dobkin
2009 Current Opinion in Neurology  
This boundary may deter investigators from finding common denominators in the conceptual basis and deployment of rehabilitation interventions, especially across nonprogressive diseases in adults, such  ...  Purpose of review-Experimental studies and clinical trials that aim to improve motor function for use of the upper extremity and walking are traditionally separated by the category of neurological disease  ...  In addition, SCI per se does not affect cortical networks for cognition, but one-third of patients with a SCI have an associated TBI.  ... 
doi:10.1097/wco.0b013e3283314b11 pmid:19724226 pmcid:PMC4077333 fatcat:sx6qs3vvpfdkti3mb2yhhql5qq

A refined model of sleep and the time course of memory formation

Matthew P Walker
2005 Behavioral and Brain Sciences  
These include the upregulation of select plasticity-associated genes, increased protein synthesis, changes in neurotransmitter concentration, and specific electrical events in neuronal networks that modulate  ...  This article begins with an overview of recent studies regarding sleep and learning, predominantly in the procedural memory domain, and is measured against our current understanding of the mechanisms that  ...  This work was supported by the National Science Foundation (BCS-0121953) and the National Institute of Health (MH-48832 and DA11744-01A1).  ... 
pmid:16047457 fatcat:nzcbcc5orjavpl4fwni7kppcs4
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