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Beyond Alcoholism

Laurie M. McCormick, Judith R. Buchanan, Obiora E. Onwuameze, Ronald K. Pierson, Sergio Paradiso
2011 Cognitive and Behavioral Neurology  
Objective-Wernicke encephalopathy and Korsakoff syndrome (the combined disorder is named Wernicke-Korsakoff syndrome [WKS]) are preventable, life-threatening neuropsychiatric syndromes resulting from thiamine deficiency. WKS has historically been associated with alcoholism; more recently, it has been recognized in patients who have anorexia nervosa or have undergone bariatric surgery for obesity. However, patients with nutritional deficiencies of any origin are at risk for WKS. We present
more » ... al histories and neuroimaging data on 2 young adults with underlying psychiatric disorders who became malnourished and developed WKS. Methods-A young woman with bipolar disorder and somatization disorder was hospitalized for intractable vomiting. A young man with chronic paranoid schizophrenia developed delusions that food and water were harmful, and was hospitalized after subsisting for 4 months on soda pop. Results-Acute, life-threatening Wernicke encephalopathy was confirmed in both patients by brain magnetic resonance imaging showing classic thalamic injury. The patients were left with persistent cognitive and physical disabilities that were consistent with Korsakoff syndrome. Conclusions-Failure to suspect a vitamin deficiency led to permanent cognitive and physical disabilities that may necessitate lifelong care for these patients. The neuropsychiatric consequences could have been prevented by prompt recognition of their thiamine deficiency. Wernicke encephalopathy (WE), a life-threatening disorder caused by thiamine (vitamin B1) depletion, has historically been associated with a classic triad of acute neurological symptoms: confusion, ataxia, and ophthalmoplegia. Thiamine deficiency disease can affect primarily the central and peripheral nervous systems (dry beriberi) or the cardiovascular system (wet beriberi). When thiamine deficiency affects the nervous system, ocular findings such as ophthalmoplegia and nystagmus have been described as a hallmark of the disorder, affecting about 85% of patients. 1 However, only 15% to 30% of patients present with the complete WE triad, 1,2 and almost 20% of patients who develop persistent confabulatory
doi:10.1097/wnn.0b013e31823f90c4 pmid:22134191 pmcid:PMC3551444 fatcat:m5byh2xkfvbkdkeil6ni7ifq4e

Alexithymia and Aging

MariaLuisa Onor, Marianna Trevisiol, Mariangela Spano, Eugenio Aguglia, Sergio Paradiso
2010 Journal of Nervous and Mental Disease  
Paradiso was supported by the Edward J. Mallinckrodt Jr. Foundation, the Dana Foundation and an NIH Career development award (5K23AG027837).  ...  Research has shown that in older age, higher alexithymia scores are partly explained by gray matter reduction in the anterior cingulate cortex (Paradiso et al., 2008) , consistent with the role of this  ...  These findings are consistent with lesion (Spalletta et al., 2001) and aging studies (Paradiso et al., 2008) , reporting alterations of right hemisphere structures in association with alexithymia.  ... 
doi:10.1097/nmd.0b013e3181fe743e pmid:21135641 pmcid:PMC3789519 fatcat:jyiqulgdcra7zn5evm3u7ssxze

Cognitive and neurological impairment in mood disorders

Cherie L Marvel, Sergio Paradiso
2004 Psychiatric Clinics of North America  
Paradiso / Psychiatr Clin N Am 27 (2004) [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] There are several adverse cognitive effects related to medications  ... 
doi:10.1016/s0193-953x(03)00106-0 pmid:15062628 pmcid:PMC2570029 fatcat:pa72jrcp4zhubo4yrwpybbaoei

Cancer molecular pathobiology in the clinics: Concluding remarks

Roman-Roman Sergio, Ioana Berindan Neagoe, Angelo Paradiso
2014 Cancer Biomarkers  
This interesting issue in which the Institute of Oncology "Prof. Dr. Ion Chiricuta" of Cluj and the Cancer Institute "G. Paolo II" of Bari approach the problem of cancer biomarkers from different perspectives represents an attempt to provide a novel view of biological, clinical and methodological innovative aspects in this field. In fact, there is a critical need for reliable biomarkers in cancer in order to improve (i) early detection, (ii) accuracy of prognosis, (iii) patient stratification
more » ... r treatments, and (iv) monitoring of tumor response and relapse. Although technological advances in the field of genomics, metabolomics, and proteomics have resulted in the identification of many biomarker candidates, only a few of them have been approved and display a value in clinical practice. This is particularly true for biomarkers suitable for early diagnosis of cancers, despite the considerable efforts devoted to this goal. In the field of diagnosis, one important challenge is getting biomarkers specific enough to avoid false positive conclusions that lead to unnecessarily expensive (imaging) and invasive (biopsies) interventions. Although novel technologies have produced detailed information on the molecular aspects of cancer biology, for the most part, the specificity displayed by single or multiple biomarkers is insufficient to allow the assays to be used in large populations. Very sensitive techniques to address specific hallmarks of cancer and combined approaches (metabolomics and imaging, for instance) need to be improved in the future in order to succeed in this objective. Next-generation sequencing techniques and especially RNAseq provide data about cancer-specific splice variants that can be developed as very useful biomarkers, either by detection of the variants as circulating DNA or by using antibodies when the splice variant results in novel epitopes in transmembrane or soluble proteins. In terms of prognosis and prediction of response, the situation is more favorable because of access to tumor biopsies, which allows the evaluation of different biomarkers at the protein, RNA or DNA levels. A number of signatures are commercialized or under evaluation in large clinical trials and will help clinicians to make therapeutic decisions. In the case of gene profiling in breast cancer, patients who can benefit from adjuvant chemotherapy can be selected based on a high risk of local relapse/ metastasis or to exclude low-risk patients from unnecessary therapeutic intervention. In the era of evidence-based medicine, there is an emergence of biomarkers predicting the response to targeted therapy. These biomarkers allow the selection of the patients who would or would not benefit from a given treatment. Determination of HER2 expression or KRAS mutations are mandatory for selecting patients to be treated with Trastuzumab or Cetuximab in breast or colorectal cancers, respectively. Looking at the expression of immunoregulatory molecules at the surface of tumor cells or immune infiltrates by IHC will be a requisite to treating patients with novel neutralizing immunomodulatory antibodies recognizing these proteins. Obviously, many pharmaceutical companies develop companion diagnostics together with new drugs and invest a great deal of money in identifying pharmacokinetic, toxicological and predictive biomarkers in both preclinical settings and during early and late clinical trials.
doi:10.3233/cbm-130339 pmid:24878821 fatcat:bl3yvnlzfbf4jngkbtf5jfbaci

Suicidal thoughts and emotion competence

Sergio Paradiso, Janelle N. Beadle, Vanessa Raymont, Jordan Grafman
2016 Journal of Clinical and Experimental Neuropsychology  
Paradiso et al. Page 17 Table 1 1 Demographic, cognitive, and clinical variablesNotes. M=Mean, SD=standard deviation. AFQT=Armed Forces Qualification Test.  ...  Paradiso et al. Page 19 Notes. Diagnoses are based on SCID assessment. Chi-square analyses were used to compare the groups. PTSD= Post-traumatic Stress Disorder.  ... 
doi:10.1080/13803395.2016.1172558 pmid:27171549 pmcid:PMC4962605 fatcat:l75gwq6k5vhltbmxalcb7ezsfu

Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering

Janelle N. Beadle, Sergio Paradiso, Daniel Tranel
2018 Frontiers in Neurology  
Copyright © 2018 Beadle, Paradiso and Tranel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fneur.2018.00288 pmid:29887825 pmcid:PMC5981225 fatcat:gdbbpiqqwjb2fkilgu5735zxny

The cerebellum and emotional experience

Beth M. Turner, Sergio Paradiso, Cherie L. Marvel, Ronald Pierson, Laura L. Boles Ponto, Richard D. Hichwa, Robert G. Robinson
2007 Neuropsychologia  
Acknowledgements Beth Turner and Sergio Paradiso contributed equally to this research.  ...  Paradiso is an Edward J. Mallinckrodt Jr. Foundation Scholar and funded by an NIH sponsored Institutional Career Development Award (K12).  ...  Functional neuroimaging studies designed to visually induce emotion (Paradiso et al., 1997; Paradiso, Robinson, Boles Ponto, Watkins, & Hichwa, 2003b; Reiman et al., 1997) or requiring the recognition  ... 
doi:10.1016/j.neuropsychologia.2006.09.023 pmid:17123557 pmcid:PMC1868674 fatcat:wlj6rlkahffddg5xibvvyxhxsy

Recognition of emotion from body language among patients with unipolar depression

Felice Loi, Jatin G. Vaidya, Sergio Paradiso
2013 Psychiatry Research  
When possible, medical records were reviewed in order to confirm information gathered during patient interviews (Paradiso et al., 2011) .  ...  Emotion perception in general and perception of EBL in particular may relate to social adaptation, a critical outcome measure in depression studies (Paradiso et al., 2011) .  ... 
doi:10.1016/j.psychres.2013.03.001 pmid:23608159 pmcid:PMC3935379 fatcat:shca3lo5xbfzxebwtsbkohiahu

Integration Between Cerebral Hemispheres Contributes to Defense Mechanisms

Sergio Paradiso, Warren S. Brown, John H. Porcerelli, Daniel Tranel, Ralph Adolphs, Lynn K. Paul
2020 Frontiers in Psychology  
Copyright © 2020 Paradiso, Brown, Porcerelli, Tranel, Adolphs and Paul. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fpsyg.2020.01534 pmid:32733338 pmcid:PMC7359856 fatcat:jxvjfiawfrhbnb475uyuve7iaa

Social Adaptive Functioning, Apathy, and Nondysphoric Depression among Nursing Home-Dwelling Very Old Adults

Obiora E. Onwuameze, Sergio Paradiso
2014 Psychopathology  
Paradiso was supported in part by the Edward J. Mallinckrodt Jr. Foundation, the Dana Foundation, and an NIH Career Development Award (5K23AG027837).  ...  Paradiso et al. [8] reported significant rates of selfdepreciation/worthlessness among stroke victims with NDD.  ...  The lower likelihood of anxiety in NDD found in the present study is similar to the result of an earlier study by Paradiso et al.  ... 
doi:10.1159/000360823 pmid:25171652 pmcid:PMC4194145 fatcat:6ihsydrra5h6jegbzcuoxvixhy

Cognition and nondysphoric depression among adoptees at high risk for psychopathology

Sergio Paradiso, Kristin Caspers, Daniel Tranel, William Coryell
2011 Comprehensive Psychiatry  
Paradiso was supported by the Edward J. Mallinckrodt Jr. Foundation, the Dana Foundation and an NIH Career development award (5K23AG027837). Dr.  ...  Nonetheless, because by definition persons with NDD do not frequent mental health services (and only sparsely medical clinics -Paradiso unpublished data), large numbers of community-dwelling volunteers  ... 
doi:10.1016/j.comppsych.2010.10.007 pmid:21195396 pmcid:PMC3348660 fatcat:orvtcc2lljgn5eaoohxwxdqene

Mirror neuron function, psychosis, and empathy in schizophrenia

Laurie M. McCormick, Michael C. Brumm, Janelle N. Beadle, Sergio Paradiso, Thoru Yamada, Nancy Andreasen
2012 Psychiatry Research : Neuroimaging  
., 2007; Paradiso et al., 2003; Crespo Facorro et al., 2001 ) that often appear before the onset of florid psychotic symptoms (Edwards et al., 2001; Brüne, 2005; Bertrand et al., 2008) and that affect  ... 
doi:10.1016/j.pscychresns.2012.01.004 pmid:22510432 pmcid:PMC3545445 fatcat:lna6uder3bhllo6nm5nbprr74e

Complete Genome Sequence of a Myoviridae Bacteriophage Infecting Salmonella enterica Serovar Typhimurium

Rubina Paradiso, Massimiliano Orsini, Sergio Bolletti Censi, Giorgia Borriello, Giorgio Galiero
2016 Genome Announcements  
The bacteriophage 118970_sal3 was isolated from water buffalo feces in southern Italy, exhibiting lytic activity against Salmonella enterica serovar Typhimurium. This bacteriophage belongs to the Myoviridae family and has a 39,464-bp double-stranded DNA (ds-DNA) genome containing 53 coding sequences (CDSs).
doi:10.1128/genomea.00940-16 pmid:27688333 pmcid:PMC5043551 fatcat:2wltxih5rndg5ccjggrqy7wi7u

Alexithymia in oncologic disease: association with cancer invasion and hemoglobin levels

Antonino Messina, Anna Maria Fogliani, Sergio Paradiso
2011 Annals of Clinical Psychiatry  
Paradiso was supported by the Edward J. Mallinckrodt, Jr. Foundation Grant Program, the Dana Foundation, and a National Institutes of Health Career Development Award (5K23AG027837).  ... 
pmid:21547273 pmcid:PMC3789518 fatcat:cfiynd2cozghlnxbwv7uwqio4a

Alexithymia, emotional empathy, and self-regulation in anorexia nervosa

Janelle N Beadle, Sergio Paradiso, Alexandria Salerno, Laurie M McCormick
2013 Annals of Clinical Psychiatry  
Individuals with anorexia nervosa (AN) who are starved have poor awareness (alexithymia), reduced understanding of others' mental states (cognitive empathy), and difficulty regulating personal emotions (self-regulation). Despite its important role in social interaction, sympathy for others (emotional empathy) has not been measured in AN. Furthermore, it is unknown how restoring weight affects the relationship among alexithymia, empathy, and self-regulation in AN. Women with AN were tested
more » ... udinally during their starvation period (N = 26) and after weight was restored (N = 20) and compared with 16 age-matched healthy women. Alexithymia, empathy, and self-regulation were assessed with the Toronto Alexithymia Scale, the Interpersonal Reactivity Index, and items measuring self-regulation from the Minnesota Multiphasic Personality Inventory-2, respectively. Relative to comparison participants, individuals with AN during both starvation and weight restoration reported greater alexithymia and emotional empathy in one domain, personal distress (vicarious negative arousal to others' suffering). Among AN participants, personal distress was positively correlated with alexithymia and negatively correlated with self-regulation, when accounting for depression. High levels of alexithymia and personal distress may be persistent features of AN because they do not resolve upon weight restoration. Greater personal distress in AN may be a function of poor emotional awareness and regulation.
pmid:23638441 pmcid:PMC3880788 fatcat:qgi5f7ee3vgylgkfceyg6ctj5m
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