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Histone deacetylase inhibitors (HDACIs) are currently in clinical trials partly due to their potent antiangiogenic effects. However, the detailed mechanism of their action is unclear. Here, we observed that several HDACIs (TSA, SB, Apicidin, and VPA) dramatically decreased HIF-1· protein level and transcriptional activity of HIF-1 in human and mouse tumor cell lines. Furthermore, class I HDACs, HDAC1 and 3 enhanced HIF-1· stability and HIF-1 transactivation function in hypoxic conditions. Indoi:10.3892/or.17.3.647 fatcat:5pgtvbv33rhmbartuhlvytwq6m
more »... ition, immunoprecipitation and in vitro binding assays revealed that HDAC1 and 3 directly bind to the oxygen-dependent degradation domain of HIF-1·. Collectively, these results suggest that HDAC1 and 3 are considered as a positive regulator of HIF-1· stability via direct interaction and may play an important role in HIF-1-induced tumor angiogenesis.
Hyperechoic lesions of the breast encompass a wide range of conditions that are occasionally encountered during breast ultrasonography. Although typical hyperechoic lesions with a distinct fat component on imaging are well known, some hyperechoic lesions are diagnosed as unexpected pathology, making the radiology-pathology correlation difficult. Therefore, understanding the pathology of these lesions and how it correlates with imaging findings can help radiologists accurately diagnose anddoi:10.14366/usg.21243 pmid:35462528 fatcat:eermftt4mjdn7bwvhssfianyru
more »... ly manage a range of related conditions. This article presents a pictorial review of unexpected hyperechoic benign and malignant breast lesions, with a focus on the pathological conditions that give rise to the hyperechoic pattern.
Seo-Won Ji and Seok-Jae Kang contributed to the execution of the experiments. Seung-Won Jung participated in the discussion about the proposed method and contributed to the analysis of the results. ... (Hwaseong, Korea) Author Contributions: Won-Jae Park contributed to the design and experimental verification of the proposed method as well as the realization of the paper. ... Seo-Won Ji and Seok-Jae Kang contributed to the execution of the experiments. Seung-Won Jung participated in the discussion about the proposed method and contributed to the analysis of the results. ...doi:10.3390/s17071473 pmid:28640235 pmcid:PMC5539793 fatcat:2gei4pb5cve5bcm453a54ahfou
JI HAE SEO 1 , JI-HYEON PARk 1 , EUN JI LEE 1 and kYU-WON kIM 1, 2 1 Cell culture. ...doi:10.3892/ijo.2014.2770 pmid:25421966 fatcat:nrb4kgbk3nbxldcmp3fad4gg3i
The nucleus prepositus hypoglossi (NPH) is known to be a neural integrator of horizontal eye movements. Although the role of the human NPH is not well known, it may also function in postural balance, in view of its anatomic connections with the vestibular nuclei and vestibulocerebellum and of lesion studies in experimental animals. Objective: To show that the human NPH contributes to vestibular function in addition to eye movement control. Design: Case series. Setting: University hospital.doi:10.1001/archneur.61.9.1440 pmid:15364691 fatcat:bmzcsvzsz5fkfevnl5lsmlm5ae
more »... nts: Six patients with small and discrete brain-stem infarctions that predominantly involved the NPH region. Main Outcome Measure: Findings on magnetic resonance images. Results: The NPH was affected at the lower pontine level in 2 patients and at the upper medullary level in 4. In addition to gaze-evoked nystagmus, all patients had vertigo, vomiting, and postural ataxia, suggesting vestibular dysfunction. The patients typically fell contralaterally or bilaterally to the lesion side. Conclusion: The NPH serves a vestibular function in addition to its oculomotor control function.
doi:10.4166/kjg.2012.60.2.119 pmid:22926124 fatcat:4b6ovinjfjg7lixk4wonut566q
doi:10.4166/kjg.2011.58.4.184 pmid:22042418 fatcat:xu7uj3n26jhlpj5xnthf5yggum
Hye Seo, et al. ... of linezolid showed no microorganism, but the size of the aortic arch Surgery or endovascular treatment was recommended to remove the aortic aneurysm, but the patient's family members declined A B Ji ...doi:10.4266/kjccm.2014.29.3.231 fatcat:qucasyedfza63cbv2qgd7r3dji
Reversible posterior leukoencephalopathy syndrome (RPLS) is a distinctive clinicoradiological entity that's characterized by headache, confusion, seizure and frequent visual disturbances. It is associated with certain neuro-radiological findings, and predominantly white matter abnormalities of the parieto-occipital lobes. RPLS has been identified mostly in patients with malignant hypertension, pre-eclampsia and renal insufficiency and in those patients who are using immunosuppressive agents ordoi:10.5045/kjh.2009.44.3.177 fatcat:4vox4qrm6ve7lg5lpdcslrdo3i
more »... ytotoxic drugs. We report here on a case of RPLS in a patient who was undergoing chemotherapy. A 49-year-old woman presented with abrupt mental changes and visual disturbances five days after the administration of a chemotherapeutic agent. MRI showed hyper-intense signals on the magnetic resonance (MR) diffusion images in the bilateral temporal, parietal and occipital lobes. The clinical manifestations completely resolved after one week of treatment that consisted of blood pressure control, a negative intake-output balance and the best supportive care. These radiological changes and the reversible clinical manifestations were consistent with RPLS. (Korean J Hematol 2009;44:177-181.)
Polyurethane pressure-sensitive adhesives (PU-PSAs) with satisfactory tack, cohesion, and removability were newly developed through the synthetic process by reacting methylene diisocyanate, poly(ethylene glycol) (PEG), and a 1,4-butanediol chain extender based on the different HDI/HDI trimer ratios. The sticking properties of PU-PSAs depended on both the HDI/HDI trimer ratio and crosslinking-agent composition in the formulation. The molecular weight (MW) dependence of adhesion in PU-PSA wasdoi:10.3390/ma14092164 pmid:33922818 fatcat:b55635bpjjei3eps7mmvxbrz7e
more »... rved in the range of 1000 < Mn < 3000, suggesting that the increase in MW limits the pressure-sensitive adhesion of these samples. The differences in the crosslinking-density significantly affected the cohesion, adhesion, and tack in PU-PSA. The formulation of 50 wt.% 600PEG and 50 wt.% crosslinking-agent and an HDI/HDI trimer ratio of 1.0 led to the optimal balance between the adhesion and cohesion properties owing to the sufficient tack, high 180-peel strength, and good cohesion.
A case of hemophagocytic syndrome complicated by acute viral hepatitis A infection Hemophagocytic syndrome (HPS) is a rare but serious condition that is histopathologically characterized by activation of macrophage or histiocytes with hemophagocytosis in bone marrow and reticuloendothelial systems. Clinically it presents with high fever, hepatosplenomegaly, pancytopenia, liver dysfunction, and hyperferritinemia. Hepatitis A virus is a very rare cause of secondary HPS. We report a case of adoi:10.3350/kjhep.2010.16.1.79 pmid:20375646 fatcat:vzwtoylxjbh5pb2bjgqpuvyr2i
more »... ar-old woman infected by hepatitis A virus who was consequently complicated with HPS. She presented typical clinical features of acute hepatitis A, and showed clinical and biochemical improvements. However, HPS developed as a complication of acute hepatitis A and the patient died of intraperitoneal bleeding caused by hepatic decompensation and disseminated intravascular coagulation. (Korean J Hepatol 2010;16:79-82)
The mesopores of mesoporous materials prepared with the anionic surfactant N-lauroyl-L-glutamic monosodium salt (AS) were enlarged by adding the cationic surfactant hexadecyltrimethylammonium bromide (CS) to the micelles of AS at pH 9. The f-potential of the micelles in the synthetic mixtures and the physical state of the assembled surfactants in the mesopores were examined by a light scattering spectrophotometer, 1 H 13 C CP-MAS NMR and DSC. The average pore diameters of the mesoporesdoi:10.1016/j.micromeso.2007.10.023 fatcat:mvba4ot2tvgnvikisolvhdsyhe
more »... from 2.8 nm to 6.2 nm with increasing the content of CS. CS molecules inserted to the micelles composed of AS molecules, resulting in the enlargement of mesopores. However, the addition of too much CS interfered with the formation of the micelles. As a result, no mesoporous materials were produced when the ratio of CS to AS was above 80%.
Metabolomics is a powerful tool used to understand comprehensive changes in the metabolic response and to study the phenotype of an organism by instrumental analysis. It most commonly involves mass spectrometry followed by data mining and metabolite assignment. For the last few decades, hair has been used as a valuable analytical sample to investigate retrospective xenobiotic exposure as it provides a wider window of detection than other biological samples such as saliva, plasma, and urine.doi:10.3390/molecules24122195 fatcat:pzenlogskrdjbjbn2czxssy2le
more »... contains functional metabolomes such as amino acids and lipids. Moreover, segmental analysis of hair based on its growth rate can provide information on metabolic changes over time. Therefore, it has great potential as a metabolomics sample to monitor chronic diseases, including drug addiction or abnormal conditions. In the current review, the latest applications of hair metabolomics in animal studies and clinical settings are highlighted. For this purpose, we review and discuss the characteristics of hair as a metabolomics sample, the analytical techniques employed in hair metabolomics and the consequence of hair metabolome alterations in recent studies. Through this, the value of hair as an alternative biological sample in metabolomics is highlighted.
We report the crystal structure and bioinformatic analysis of SF173, a functionally uncharacterized protein from the human enteropathogenic bacteria Shigella flexneri. The structure shows a tightly interlinked dimer formed by adimeric core comprising α2 and α3 helices from both subunits and swapping the N-terminal α1 helix of each monomer. Structural inspection and genomic analysis results suggest that the SF173 might play its putative function by binding to SF172, the partially overlappeddoi:10.3390/cryst8020097 fatcat:osa7wh2ajbchrd6iyy7mtpmfsi
more »... eam product in the operon. As YaeO (an SF172 orthologue) has been identified to be an inhibitor of the bacterial transcription terminator Rho protein, SF173 is suggested to be involved in the regulation of Rho-dependent transcription termination, by inhibiting the Rho protein binding to SF172/YaeO.
There has been recent progress in intraoperative fluid therapy. However, little is known about intraoperative fluid therapy in laparoscopic surgery. The purpose of this study is to determine whether there are differences in the basal fluid requirements during surgery between laparotomy and laparoscopic distal pancreatectomy. This retrospective cohort study analyzed the electronic medical records of 253 patients who underwent distal pancreatectomy via either laparotomy (73 patients) ordoi:10.1097/md.0000000000008763 pmid:29381975 pmcid:PMC5708974 fatcat:fuxei75syffhtauc5adu3gjgra
more »... y (180 patients) between June 2006 and March 2016. The volume of intraoperative fluid administered, postoperative complications, length of hospital stay, and readmission rate were evaluated. The total volume of fluids was calculated as the sum of the volume of crystalloid plus the volume of colloid multiplied by 1.5 or 2.0. Patients who had laparotomy were older and had higher American Society of Anesthesiologists classes. Anesthesia time was longer and estimated blood loss was larger in laparotomy. More colloid (1.8 mL/kg per h vs. 1.2 mL/kg per h, P < .001) and more total calculated fluid (1.5 times: 11.7 mL/kg per h vs. 10.6 mL/kg per h, P = .002; 2.0 times: 12.6 mL/kg per h vs. 11.2 mL/kg per h, P = .001) were infused in laparotomy. Crystalloid (9.0 mL/kg per h vs. 8.9 mL/kg per h, P = .203) did not show significant difference. Postoperative complications were more frequent (63% vs. 45%, P = .008), the hospital stay was longer (18 days vs. 13.4 days, P < .001), and readmission rate was higher (15% vs. 5.6%, P = .02) in laparotomy. By logistic regression analysis, we could find that operation type (laparotomy vs. laparoscopy, odds ratio 1.900, 95% confidence interval 1.072-3.368) and operation time (P = .004) had effect on complications. In patients undergoing distal pancreatectomy, basal fluid requirements were larger in laparotomy compared with laparoscopy. Operation time and estimated blood loss had effects on fluid administration. Postoperative complications were more frequent in laparotomy but we could not find relationships with infused colloid or total calculated fluid volumes. Operation type (laparotomy vs. laparoscopy) and operation time were the only related factors to postoperative complications. Abbreviations: ASA = American Society of Anesthesiologists, EBL = estimated blood loss, Hb = hemoglobin, HES = hydroxyethyl starch, IV = intravenous, r s = Spearman correlation coefficient.
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