388 Hits in 8.3 sec

Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis

Robert A. Brown, Sridar Narayanan, Douglas L. Arnold
2014 NeuroImage: Clinical  
We use a recently proposed technique to examine magnetization transfer ratio (MTR) timecourses in lesions segmented from MTR images in patients with relapsing-remitting MS (RRMS) and secondary progressive  ...  Multiple sclerosis (MS) is characterized by the formation of demyelinating lesions in the white matter (WM).  ...  Acknowledgments This work was supported by grants from the Multiple Sclerosis Society of Canada (MSSC) and the Canadian Institutes of Health Research (CIHR).  ... 
doi:10.1016/j.nicl.2014.06.009 pmid:25610760 pmcid:PMC4299955 fatcat:kcro54fztjcrncyy4r7cq63swy

Measuring Demyelination and Remyelination in Acute Multiple Sclerosis Lesion Voxels

Paul S. Giacomini, Ives R. Levesque, Luciana Ribeiro, Sridar Narayanan, Simon J. Francis, G. Bruce Pike, Douglas L. Arnold
2009 Archives of Neurology  
Objective: To validate the use of the magnetization transfer ratio (MTR) as a practical imaging marker of demyelination and remyelination in acute multiple sclerosis lesions. Design: Case study.  ...  Patients: Six patients with relapsing-remitting multiple sclerosis and acute gadolinium-enhancing lesions were studied serially using a quantitative magnetization transfer examination.  ...  Changes in the magnetization transfer ratio (MTR) of white matter have been shown to be a reliable marker of myelin content in chronic demyelinated lesions and normalappearing white matter (NAWM) based  ... 
doi:10.1001/archneurol.2008.578 pmid:19273757 fatcat:z723ummykbdh3e3lkhunoormnu

Magnetisation transfer imaging in multiple sclerosis

M Filippi, M Rovaris
2000 Journal of Neurovirology  
sclerosis (MS) lesions.  ...  Magnetisation transfer imaging (MTI) is a magnetic resonance imaging (MRI) technique that has a higher specificity than conventional T2-weighted scans to the heterogeneous pathological substrates of multiple  ...  Magnetization transfer ratios of contrast-enhancing and nonenhancing lesions in multiple sclerosis.Neuroradiology 38: 115 ± 119.  ... 
pmid:10871798 fatcat:qasi7ioakna35i3m4f3uoxo5ky

Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume

F. Yu, Q. Fan, Q. Tian, C. Ngamsombat, N. Machado, J.D. Bireley, A.W. Russo, A. Nummenmaa, T. Witzel, L.L. Wald, E.C. Klawiter, S.Y. Huang
2019 American Journal of Neuroradiology  
Remyelination represents an area of great therapeutic interest in multiple sclerosis but currently lacks a robust imaging marker.  ...  The imaging g-ratio may serve as a biomarker for the relative degree of axonal and myelin loss in MS.  ...  M ultiple sclerosis is a disease of the CNS characterized by inflammatory demyelination and axonal loss.  ... 
doi:10.3174/ajnr.a6283 pmid:31694819 pmcid:PMC6975105 fatcat:iftzxgovtvdj3ltsli5boesty4

Longitudinal microstructural MRI markers of demyelination and neurodegeneration in early relapsing-remitting multiple sclerosis: magnetization transfer, water diffusion and g-ratio [article]

Elizabeth N. York, Rozanna Meijboom, Michael J. Thrippleton, Mark E. Bastin, Agniete Kampaite, Nicole White, Siddharthan Chandran, Adam D. Waldman, Future-MS Consortium
2022 medRxiv   pre-print
Imaging (NODDI), and the derived aggregate g-ratio, may provide more specific markers of white matter integrity than conventional MRI for early patient stratification in relapsing-remitting multiple sclerosis  ...  The aim of this study is to determine the sensitivity of such markers to longitudinal pathological change within cerebral white matter lesions (WML) and normal-appearing white matter (NAWM) in recently  ...  Acknowledgements With special thanks to all participants in FutureMS, the radiographers at the RIE Edinburgh, and Dr. Daisy Mollison.  ... 
doi:10.1101/2022.06.08.22276139 fatcat:yuuzrddhrvg57irc6vehacupxy

Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques

Maria Petracca, Monica Margoni, Giulia Bommarito, Matilde Inglese
2018 Neurology and Therapy  
Imaging markers for monitoring disease progression in progressive multiple sclerosis (PMS) are scarce, thereby limiting the possibility to monitor disease evolution and to test effective treatments in  ...  magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques.  ...  Advanced MRI Techniques Magnetization Transfer Ratio Magnetization transfer ratio abnormalities in the pial and subpial regions of the spinal cord are more marked in patients with PMS compared to the early  ... 
doi:10.1007/s40120-018-0103-2 pmid:29956263 fatcat:5atggmvtjredddx237lqlkwejq

Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients

Robert A. Brown, Sridar Narayanan, Brenda Banwell, Douglas L. Arnold
2014 NeuroImage: Clinical  
Magnetization transfer ratio (MTR) MRI can be used to quantify changes in myelin in MS.  ...  We used serial MTR imaging and longitudinal random effects analysis to quantify recovery of MTR in acute lesions and to evaluate MTR changes in normal-appearing tissue in 19 adolescent MS patients.  ...  transfer ratio (MTR), which is a semi-quantitative measurement of magnetization exchange between free and bound proton pools.  ... 
doi:10.1016/j.nicl.2014.09.003 pmid:25379436 pmcid:PMC4215523 fatcat:y4cwc6qizzg7he7q5ngtmm7uzq

Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosis

N. De Stefano
2006 Brain  
Acknowledgements The study was supported in part by a grant of the Associazione Italiana Sclerosi Multipla (AISM).  ...  The authors are grateful to Arlene Cohen for revising the manuscript language and to all the subjects who agreed to participate in the study.  ...  Multifocal brain multiple sclerosis lesions are usually associated with various degrees of demyelination and remyelination. Demyelination leads to axonal injury and disability.  ... 
doi:10.1093/brain/awl152 pmid:16815879 fatcat:cfz32dd42nct5g47xjsamuqgka

In Vivo MRI of Endogenous Remyelination in a Nonhuman Primate Model of Multiple Sclerosis [article]

Nathanael J. Lee, Pascal Sati, Seung-Kwon Ha, Nicholas J. Luciano, Snehashis Roy, Benjamin Ineichen, Emily C. Leibovitch, Cecil C. Yen, Dzung L. Pham, Afonso C. Silva, Mac Johnson, Steven Jacobson (+1 others)
2021 bioRxiv   pre-print
ABSTRACTRemyelination is crucial for recovery from inflammatory demyelination in multiple sclerosis (MS).  ...  Remyelination occurred in 5 of 6 marmosets and 51% of lesions. Radiological-pathological comparison showed high sensitivity (88%) and specificity (90%) for detecting remyelination by in vivo MRI.  ...  Prior studies demonstrated that certain signal changes in MRI, such as magnetization transfer ratio (MTR), correlate with remyelination in MS lesions (15) (16) (17) (18) (19) .  ... 
doi:10.1101/2021.10.27.466044 fatcat:h5la4kdua5eunibrh4uswyjayu

MTR recovery in brain lesions in the BECOME study of glatiramer acetate vs interferon β-1b

Robert A. Brown, Sridar Narayanan, Nikola Stikov, Stuart Cook, Diego Cadavid, Leo Wolansky, Douglas L. Arnold
2016 Neurology  
Objective: To compare magnetization transfer changes in new brain MRI lesions identified during monthly imaging in patients with multiple sclerosis (MS) randomized to treatment with 250 mg subcutaneous  ...  5 interferon-b-1b; LFB 5 Luxol fast blue; MS 5 multiple sclerosis; MTR 5 magnetization transfer ratio; NAWM 5 normal-appearing white matter; PD 5 proton density.  ...  We have proposed a method to quantify demyelination and remyelination using longitudinal analysis of MTR images. 7, 8 We applied this procedure to measure the change in FSMTR between stable postlesion  ... 
doi:10.1212/wnl.0000000000003043 pmid:27473139 pmcid:PMC5035157 fatcat:tvdvhlpn2vcajk2j5we2yqcoky

Current developments in MRI for assessing rodent models of multiple sclerosis

Othman I Alomair, Maree T Smith, Ian M Brereton, Graham J Galloway, Nyoman D Kurniawan
2014 Future Neurology  
MRI is a key radiological imaging technique that plays an important role in the diagnosis and characterization of heterogeneous multiple sclerosis (MS) lesions.  ...  to determine the severity of MS pathology, including demyelination/remyelination and brain connectivity impairment from axonal loss.  ...  • axonal loss • demyelination • diffusion-weighted imaging • experimental autoimmune encephalomyelitis • inflammation • magnetic resonance imaging • magnetization transfer imaging • multiple sclerosis  ... 
doi:10.2217/fnl.14.33 fatcat:byc5bkk565dnpkiqum3sp4sxva

Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab

T. Button, D. Altmann, D. Tozer, C. Dalton, K. Hunter, A. Compston, A. Coles, D. Miller
2012 Multiple Sclerosis  
Mean magnetization transfer ratio fell in 18 untreated patients with multiple sclerosis both in normal appearing grey (-0.25 pu/ year, p < 0.001) and white matter (-0.12 pu/year, p = 0.004).  ...  The magnetization transfer ratio reflects the integrity of tissue structure, including myelination and axonal density.  ...  Funding Study CAMMS223 was supported by Genzyme Corporation and Bayer Schering Pharma.  ... 
doi:10.1177/1352458512444915 pmid:22492133 fatcat:w4pu24jfzncgdmpxyonnrc4iai

Quantitative 7-Tesla Imaging of Cortical Myelin Changes in Early Multiple Sclerosis

Valeria Barletta, Elena Herranz, Constantina A. Treaba, Ambica Mehndiratta, Russell Ouellette, Gabriel Mangeat, Tobias Granberg, Jacob A. Sloane, Eric C. Klawiter, Julien Cohen-Adad, Caterina Mainero
2021 Frontiers in Neurology  
Cortical demyelination occurs early in multiple sclerosis (MS) and relates to disease outcome. The brain cortex has endogenous propensity for remyelination as proven from histopathology study.  ...  In conclusion, CME allows detection of cortical microstructural changes related to coexisting demyelination and remyelination since the early phases of MS, and shows to be more sensitive than NODDI and  ...  FUNDING This work was supported partly by the National Multiple Sclerosis Society (NMSS RG-1802-30468) and the National Institute of Health (NIH R01NS078832201 A1).  ... 
doi:10.3389/fneur.2021.714820 pmid:34539559 pmcid:PMC8446537 fatcat:rz64p7lzkjawzeactgl3unxjme

Dirty-appearing white matter in multiple sclerosis: volumetric MR imaging and magnetization transfer ratio histogram analysis

Yulin Ge, Robert I Grossman, James S Babb, Juan He, Lois J Mannon
2003 American Journal of Neuroradiology  
Our study was designed to determine the volumetric and magnetization transfer ratio (MTR) features of DAWM in patients with MS.  ...  In contrast to "normal-appearing" white matter (NAWM) in patients with multiple sclerosis (MS), there are subtle, abnormal and diffuse signal intensity changes often seen on T2-weighted MR images, which  ...  Multiple sclerosis (MS) is a demyelinating, inflammatory disease that is most often associated with multifocal lesions in the central nervous system.  ... 
pmid:14625213 pmcid:PMC8148922 fatcat:vyk7bsyiavhs5mlqcds7zwptxe

Imaging outcome measures of neuroprotection and repair in MS

Jiwon Oh, Daniel Ontaneda, Christina Azevedo, Eric C. Klawiter, Martina Absinta, Douglas L. Arnold, Rohit Bakshi, Peter A. Calabresi, Ciprian Crainiceanu, Blake Dewey, Leorah Freeman, Susan Gauthier (+23 others)
2019 Neurology  
To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each  ...  technique in clinical trial settings.  ...  Nelson has received research grant funding from Alkermes, Novartis, and the NMSS, as well as personal compensation for speaking or consulting from Acorda, Bayer, Consortium of Multiple Sclerosis Centers  ... 
doi:10.1212/wnl.0000000000007099 pmid:30787160 pmcid:PMC6511106 fatcat:btpd5d5crzgkhowxxmoob6eiyy
« Previous Showing results 1 — 15 out of 388 results