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Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI

Houshang Amiri, Alexandra de Sitter, Kerstin Bendfeldt, Marco Battaglini, Claudia A.M. Gandini Wheeler-Kingshott, Massimiliano Calabrese, Jeroen J.G. Geurts, Maria A. Rocca, Jaume Sastre-Garriga, Christian Enzinger, Nicola de Stefano, Massimo Filippi (+3 others)
2018 NeuroImage: Clinical  
Atrophy of the brain grey matter (GM) is an accepted and important feature of multiple sclerosis (MS).  ...  The focus is on measurements that are obtained in individual patients rather than on group analysis methods, because of their importance in clinical trials and ultimately in clinical care.  ...  Acknowledgements This paper is the outcome of the MAGNIMS workshop "Measuring cortical and deep gray matter atrophy in MS", which was kindly supported by the Multiple Sclerosis International Federation  ... 
doi:10.1016/j.nicl.2018.04.023 pmid:29984155 pmcid:PMC6030805 fatcat:7m5lmrq4i5euxlru5rkgrivwru

Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI

Dominik S. Meier, Charles R.G. Guttmann, Subhash Tummala, Nicola Moscufo, Michele Cavallari, Shahamat Tauhid, Rohit Bakshi, Howard L. Weiner
2017 Journal of Neuroimaging  
and fluid-attenuated inversion-recovery (FLAIR) contrast. 3TM segments white (WM) and gray matter (GM) and cerebrospinal fluid (CSF) to assess atrophy and provides WM lesion (WML) volume.  ...  Scan-rescan yielded coefficients of variation (COVs) of 8% and .4% for WMLs and BPF and COVs of .8%, 1%, and 2% for GM, WM, and CSF volumes.  ...  This automated labeling of cortical and subcortical regions, and initial GM, WM, and CSF tissue classes, is performed via a standard Freesurfer 27 pipeline (version 5.3), based on the T1-and a coregistered  ... 
doi:10.1111/jon.12491 pmid:29235194 pmcid:PMC5814929 fatcat:cxhs7lhkengvpldqtl55a5piam

MRI segmentation analysis in temporal lobe and idiopathic generalized epilepsy

Hila Goldberg, Arie Weinstock, Niels Bergsland, Michael G Dwyer, Osman Farooq, Mona Sazgar, Guy Poloni, Cierra Treu, Bianca Weinstock-Guttman, Murali Ramanathan, Robert Zivadinov
2014 BMC Neurology  
Methods: TLE patients were classified in TLE lesional (L-TLE) or non-lesional (NL-TLE) based on presence or absence of MRI temporal structural abnormalities.  ...  Normal brain volume (NBV), normal grey matter volume (NGMV), normal white matter volume (NWMV), and volumes of subcortical deep grey matter structures were quantified.  ...  FIRST is a model-based automated segmentation/ registration tool.  ... 
doi:10.1186/1471-2377-14-131 pmid:24938118 pmcid:PMC4070342 fatcat:omqhy3e6kvcyfmtw2uputbzt5i

Brain MRI atrophy quantification in MS

Maria A. Rocca, Marco Battaglini, Ralph H.B. Benedict, Nicola De Stefano, Jeroen J.G. Geurts, Roland G. Henry, Mark A. Horsfield, Mark Jenkinson, Elisabetta Pagani, Massimo Filippi
2016 Neurology  
Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying degrees of brain atrophy beyond that of normal aging.  ...  Neurology ® 2017;88:403-413 GLOSSARY BPF 5 brain parenchymal fraction; CIS 5 clinically isolated syndrome; DGM 5 deep gray matter; GM 5 gray matter; ICV 5 intracranial volume; MS 5 multiple sclerosis;  ...  ; GM 5 gray matter; L 5 longitudinal method; MS 5 multiple sclerosis; S 5 automatic lesion segmentation available; SIENA 5 structural image evaluation, using normalization, of atrophy; VBM 5 voxel-based  ... 
doi:10.1212/wnl.0000000000003542 pmid:27986875 pmcid:PMC5272969 fatcat:mujeaqh6kbfi7fc6czfrufd5tq

Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study

Cecilie Jacobsen, Jesper Hagemeier, Kjell-Morten Myhr, Harald Nyland, Kirsten Lode, Niels Bergsland, Deepa P Ramasamy, Turi O Dalaker, Jan Petter Larsen, Elisabeth Farbu, Robert Zivadinov
2014 Journal of Neurology, Neurosurgery and Psychiatry  
T1-lesion and T2-lesion volumes (LVs) were calculated.  ...  Objectives To identify MRI biomarkers associated with long-term disability progression in patients with multiple sclerosis (MS), and to define the rate of evolution of global, tissue-specific and regional  ...  each time point were estimated from inpainted 3D-T1 images with FMRIB's Integrated Registration and Segmentation Tool (FIRST, V.1.2), a model-based segmentation/registration tool. 29 Normalised SDGM  ... 
doi:10.1136/jnnp-2013-306906 pmid:24554101 fatcat:kfp5vkegkfbbbijdtlcclle654

7T quantitative magnetization transfer (qMT) of cortical gray matter in multiple sclerosis correlates with cognitive impairment

Lydia McKeithan, Bailey D. Lyttle, Bailey A. Box, Kristin P. O'Grady, Richard D. Dortch, Benjamin N. Conrad, Lindsey M. Thompson, Baxter P. Rogers, Paul Newhouse, Siddharama Pawate, Francesca Bagnato, Seth A. Smith
2019 NeuroImage  
at multiple inversion times (TI) at 7T and fit to a two-pool model of magnetization exchange.  ...  Cognitive impairment (CI) is a major manifestation of multiple sclerosis (MS) and is responsible for extensively hindering patient quality of life.  ...  Chris Thompson, and Mr. Dave Pennell. We would also like to acknowledge the funding sources: Department of Defense (W81XWH-13-0073), the National MS Society (RG-1501-02840), the Conrad N.  ... 
doi:10.1016/j.neuroimage.2019.116190 pmid:31525497 pmcid:PMC7549401 fatcat:j6dxvrl36bfmra457zjc5jlxny

A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions

Navid Shiee, Pierre-Louis Bazin, Arzu Ozturk, Daniel S. Reich, Peter A. Calabresi, Dzung L. Pham
2010 NeuroImage  
We describe a new fully automatic method for the segmentation of brain images that contain multiple sclerosis white matter lesions.  ...  Multichannel magnetic resonance images are used to delineate multiple sclerosis lesions while segmenting the brain into its major structures.  ...  MS data were obtained under grant TR3760A3 from the National Multiple Sclerosis Society. We thank Dr. Seth Smith and Ms. Eliza Gordon-Lipkin for their help with data collection.  ... 
doi:10.1016/j.neuroimage.2009.09.005 pmid:19766196 pmcid:PMC2806481 fatcat:5ap6fpm3grd3rhs3632orpoq24

Fibre-specific white matter changes in multiple sclerosis patients with optic neuritis

Sanuji Gajamange, David Raffelt, Thijs Dhollander, Elaine Lui, Anneke van der Walt, Trevor Kilpatrick, Joanne Fielding, Alan Connelly, Scott Kolbe
2018 NeuroImage: Clinical  
A B S T R A C T Long term irreversible disability in multiple sclerosis (MS) is thought to be primarily driven by axonal degeneration.  ...  Unlike standard methods, this novel method involved advanced acquisition and modelling for improved axonal sensitivity and specificity.  ...  Acknowledgements This work was supported by the National Health and Medical Research Council (APP1009757, APP1054147), Multiple Sclerosis Research Australia (Postgraduate Scholarship #14-088, SG), the  ... 
doi:10.1016/j.nicl.2017.09.027 pmid:29527473 pmcid:PMC5842545 fatcat:goavavgh25a47otdzwxs3g7dvq

MR g-ratio-weighted connectome analysis in patients with multiple sclerosis

Koji Kamagata, Andrew Zalesky, Kazumasa Yokoyama, Christina Andica, Akifumi Hagiwara, Keigo Shimoji, Kanako K. Kumamaru, Mariko Y. Takemura, Yasunobu Hoshino, Kouhei Kamiya, Masaaki Hori, Christos Pantelis (+2 others)
2019 Scientific Reports  
Multiple sclerosis (MS) is a brain network disconnection syndrome.  ...  For comparison, probabilistic tractography was also used to map connectomes based on the number of streamlines (NOS).  ...  Program for the Private University Research Branding Project; ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan); and JSPS KAKENHI Grant Number JP16K10327  ... 
doi:10.1038/s41598-019-50025-2 pmid:31534143 pmcid:PMC6751178 fatcat:xls3grueazglhemjrws2jxx2cm

The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

Na-Yeon Jung, Hanna Cho, Yeo Jin Kim, Hee Jin Kim, Jong Min Lee, Seongbeom Park, Sung Tae Kim, Eun-Joo Kim, Jae Seung Kim, Seung Hwan Moon, Jae-Hong Lee, Michael Ewers (+2 others)
2018 Alzheimer's Research & Therapy  
To investigate the correlation of education with cortical thickness, WMH volume, and number of lacunes, multiple linear regression analyses were performed after controlling for covariates, including Mini  ...  We also assessed the volumes of white matter hyperintensities (WMH) and numbers of lacunes as other outcomes.  ...  The surfaces of the inner and outer cortices were automatically extracted using the Constrained Laplacian-Based Automated Segmentation with Proximities (CLASP) algorithm.  ... 
doi:10.1186/s13195-018-0432-5 fatcat:vzskvh2ujvcqvgpno6euz5izke

Microstructural MRI Correlates of Cognitive Impairment in Multiple Sclerosis: The Role of Deep Gray Matter

Marco Pitteri, Ilaria Boscolo Galazzo, Lorenza Brusini, Federica Cruciani, Caterina Dapor, Damiano Marastoni, Gloria Menegaz, Massimiliano Calabrese
2021 Diagnostics  
Although cognitive impairment (CI) is frequently observed in people with multiple sclerosis (pwMS), its pathogenesis is still controversial.  ...  Conversely, reduced anisotropy/restriction values were detected in cortical regions, mostly the pericalcarine cortex and precuneus, combined with reduced thickness of the superior frontal gyrus and insula  ...  multiple sclerosis; SPMS = secondary-progressive multiple sclerosis; * = significant difference.  ... 
doi:10.3390/diagnostics11061103 fatcat:77z2xuwn2rc6vjrl5jkm7yi3ny

Multidimensional associations between cognition and connectome organization in temporal lobe epilepsy

Raúl Rodríguez-Cruces, Boris C. Bernhardt, Luis Concha
2020 NeuroImage  
Cognitive classes presented with an increasing gradient of abnormalities (increasing cortical and subcortical atrophy and less efficient white matter connectome organization in patients with increasing  ...  Our approach was complemented by bootstrap-based hierarchical clustering to derive cognitive subtypes and associated patterns of macroscale connectome anomalies.  ...  Nodes were defined by merging the cortical segmentation of Destrieux Atlas and Volbrain's subcortical segmentation.  ... 
doi:10.1016/j.neuroimage.2020.116706 pmid:32151761 fatcat:zgblj4icazddzaytizfjektbrq

Risk of dementia in MCI: Combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS

K. Kantarci, S. D. Weigand, S. A. Przybelski, M. M. Shiung, J. L. Whitwell, S. Negash, D. S. Knopman, B. F. Boeve, P. C. O'Brien, R. C. Petersen, C. R. Jack
2009 Neurology  
Based on age-and sex-adjusted Kaplan-Meier plots, we estimated that by 3 years, 26% of the MCI patients with normal hippocampal volumes, NAA/Cr ratios Ͼ1 SD, and no cortical infarctions will progress to  ...  The model that best predicted progression to dementia included age, sex, hippocampal volumes, N-acetylaspartate (NAA)/creatine (Cr) on 1 H MRS, and cortical infarctions.  ...  Based on this multivariable model, we estimate that by 3 years from baseline, 26% of MCI patients without cortical infarctions and having the relative protection of hippocampal volumes and NAA/Cr ratio  ... 
doi:10.1212/wnl.0b013e3181a2e864 pmid:19398707 pmcid:PMC2843530 fatcat:ski3unbyxfacbe2kzm5lo3gplu

Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics

René M. H. Besseling, Jacobus F. A. Jansen, Geke M. Overvliet, Maarten J. Vaessen, Hilde M. H. Braakman, Paul A. M. Hofman, Albert P. Aldenkamp, Walter H. Backes, Yong He
2012 PLoS ONE  
Tractography is based on common space seed and target regions and performed for several major white matter tracts.  ...  COV/ICC values of FA, ADC, volume and TDI were 1-4%/0.65-0.94, 2-4%/0.62-0.94, 3-22%/0.53-0.96 and 8-31%/0.48-0.70, respectively, with the lower COV and higher ICC values found in the proximal segmentations  ...  Acknowledgments We would like to thank Donald Tournier, Alexander Leemans and Ben Jeurissen for useful discussions and Kerstin Pannek for her advice on normalization of the whole brain tractograms.  ... 
doi:10.1371/journal.pone.0034125 pmid:22485157 pmcid:PMC3317780 fatcat:l6ahjz2g4bbkjl5mx2fs2w2oq4

Impact of Cognitive Reserve and Structural Connectivity on Cognitive Performance in Multiple Sclerosis

Elisabet Lopez-Soley, Elisabeth Solana, Eloy Martínez-Heras, Magi Andorra, Joaquim Radua, Albert Prats-Uribe, Carmen Montejo, Nuria Sola-Valls, Maria Sepulveda, Irene Pulido-Valdeolivas, Yolanda Blanco, Elena H. Martinez-Lapiscina (+2 others)
2020 Frontiers in Neurology  
Cognitive reserve (CR) could attenuate the impact of the brain burden on the cognition in people with multiple sclerosis (PwMS).  ...  The multiple regression model, adjusted for age, gender, mood, lesion volume, and graph metrics (local and global efficiency, and transitivity), indicated that the CRQ (β = 0.26, 95% CI: 0.17-0.35) was  ...  AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.  ... 
doi:10.3389/fneur.2020.581700 pmid:33193039 pmcid:PMC7662554 fatcat:y4nkwq7t2jaqhayjhvoq55avpy
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