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., the finite difference operator) that one penalizes using the ℓ p norm, Pol del Aguila Pla is with the CIBM Center for Biomedical Imaging, in Switzerland. ...arXiv:2206.07128v1 fatcat:mlpgocoje5co3gmtf4gbjfbpcm
Supplemental material, sj-pdf-1-pol-10.1177_0263395720975970 for Illiberal democratic attitudes and support for the EU by Wouter van der Brug, Sebastian Adrian Popa, Sara B Hobolt and Hermann Schmitt in ...doi:10.25384/sage.14044171.v1 fatcat:6a3l5irvzrasbbdoyujtjvuqhq
Eukaryotic DNA replication requires the coordinated activity of the multi-subunit DNA polymerases: Pol a, Pol d and Pol e. ... The EM reconstructions of Pol a reveal a bilobal shape with separate catalytic and regulatory modules. ... a, Pol d and Pol e. ...doi:10.1038/emboj.2009.150 pmid:19494830 pmcid:PMC2693882 fatcat:ceajamd6g5hwnenlrk2rwymcu4
Moreover, the ZFP-1/ DOT-1.1 complex contributes to progressive Pol II pausing on essential genes during development and to rapid Pol II pausing during stress response. ... We show that ZFP-1 and its interacting partner DOT-1.1 have a global role in negatively modulating the level of polymerase II (Pol II) transcription on essential widely expressed genes. ... Next, we performed Pol II ChIP-qPCR experiments with the 8WG16 antibody, which recognizes all Pol II isoforms. ...doi:10.1016/j.molcel.2013.06.002 pmid:23806335 pmcid:PMC3784254 fatcat:gztky6ijkndtjipovq6llafmju
Sebastian Seiffert at Johannes Gutenberg University Mainz. ...doi:10.1039/d0sm01371d pmid:33306078 fatcat:e747zjzcmfaoboo73dihiqebza
Supplemental material, sj-pdf-3-pol-10.1177_02633957211008348 for When do parties put Europe in the centre? ... Evidence from the 2019 European Parliament election campaign by Michaela Maier, Carlos Jalali, Jürgen Maier, Alessandro Nai and Sebastian Stier in Politics ... We also researched the Facebook pages of the national political parties and also pages of leaders if the party relies strongly on charismatic leadership, e.g. the ÖVP (Sebastian Kurz) or the Lega (Matteo ...doi:10.25384/sage.14565129.v1 fatcat:cswv55evbbg6lgj2ubkdpon2ce
The duration of a victim's incapacity for work is a factor in sentencing for violent crimes in countries that are heirs to eighteen-century European penal codes. In this article, we consider pitfalls of this criterion. A major issue is the poor correlation between the criminal intent, the criminal act and the outcome of the injury. Furthermore, external factors unrelated to the aggression often contribute to punishment decisions under these systems. As an alternative, we highlight recentdoi:10.1016/j.avb.2020.101390 fatcat:rm7f3gkbuvdo5jk4o4hrjtawca
more »... to the penal code in Spain. The Spanish system has replaced incapacity for work with a different health-related criterion for sentencing in personal injury cases. We argue that this approach places a greater focus on protection of bodily integrity that is more consistent with the ostensible intentions of laws against personal violence.
This sensitivity could be overcome by the addition of exogenous POLη. ... Further interrogation of TLS, using POLη as a representative TLS polymerase, demonstrated that α-HPV16 E6 blocks TLS polymerase induction by degrading p53. ... Acknowledgments: The authors thank Martin Cohn and Simone Sabbioneda (donation of HeLa WT and HeLa POLη), Bert Vogelstein (donation of HCT WT and HCT p53 -/-) and the Les Clow Family (Financial support ...doi:10.3390/cancers13010028 pmid:33374731 fatcat:wpvaz7uxwbc47lv2m3yze5t7jy
The resulting RNA-DNA primers are utilized by Pol d and Pol e for processive elongation on the lagging and leading strands, respectively. ... The catalytic centers of primase and Pol a reside in separate lobes of high relative mobility. ... in the Pol a-B complex (12) . ...doi:10.1093/nar/gkr534 pmid:21715379 pmcid:PMC3185431 fatcat:yy76clynhnfl3lazsga4e5t6aq
., 1989; Bonaparte, 1991; Pol, 2003) . ... ., 2001 Sereno et al., , 2003 Pol and Norell, 2004a) . ...doi:10.1206/0003-0082(2005)490[0001:narfte]2.0.co;2 fatcat:dakw26u2crfqbla43k4akfeiza
Recurrence of breast cancer is a predominant fear for patients who were treated for breast cancer. Acute and late dermatologic effects of radiotherapy are not uncommon and could have similar characteristics to breast cancer recurrence. Thus, it is important to highlight key differences between the clinical and histologic presentations of radiation effects and recurrence. Herein, we present two patients who presented with late dermatologic effects of radiotherapy months to years after treatment,doi:10.1111/iwj.13350 pmid:32227450 fatcat:g3d73zc2rncvjbldbdkqxnk7um
more »... neither of whom had workup consistent with cancer recurrence. We provide clinical and microscopic descriptions of each case and provide a review to differentiate various dermatologic conditions. This report aims to outline potential late dermatologic effects of radiation treatment and emphasise that changes in the breast do not always signal breast cancer recurrence.
PHF3 competes with TFIIS for Pol II binding through its TFIIS-like domain (TLD), thus inhibiting TFIIS-mediated rescue of backtracked Pol II. ... The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. ... To examine their potential co-occupancy, we performed ChIP-seq of PHF3-GFP, Pol II pS2, Pol II pS5 and Pol II pS7. ...doi:10.1101/2020.02.11.943159 fatcat:x5jbqqmkmjhevhklztnp7spg7i
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