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Körperunzufriedenheit bei weiblichen und männlichen Jugendlichen: Eine geschlechtervergleichende Betrachtung von Verbreitung, Prädiktoren und Folgen

Sebastian Mohnke, Petra Warschburger
2011 Praxis der Kinderpsychologie und Kinderpsychiatrie  
doi:10.13109/prkk.2011.60.4.285 pmid:21614841 fatcat:e5fhoulgozechcn2lwk7gbibjy

Larger amygdala volume in first-degree relatives of patients with major depression

Nina Romanczuk-Seiferth, Lydia Pöhland, Sebastian Mohnke, Maria Garbusow, Susanne Erk, Leila Haddad, Oliver Grimm, Heike Tost, Andreas Meyer-Lindenberg, Henrik Walter, Torsten Wüstenberg, Andreas Heinz
2014 NeuroImage: Clinical  
Objective: Although a heritable contribution to risk for major depressive disorder (MDD) has been established and neural alterations in patients have been identified through neuroimaging, it is unclear which brain abnormalities are related to genetic risk. Studies on brain structure of high-risk subjectssuch as individuals carrying a familial liability for the development of MDDcan provide information on the potential usefulness of these measures as intermediate phenotypes of MDD. Methods: 63
more » ... althy first-degree relatives of patients with MDD and 63 healthy controls underwent structural magnetic resonance imaging. Regional gray matter volumes were analyzed via voxel-based morphometry (VBM). Results: Whole-brain analysis revealed significantly larger gray matter volume in the bilateral amygdala in firstdegree relatives of patients with MDD. Furthermore, relatives showed significantly larger gray matter volume in anatomical structures found relevant to MDD in previous literature, specifically in the bilateral hippocampus and amygdala as well as the left dorsolateral prefrontal cortex (DLPFC). Bilateral DLPFC volume correlated positively with the experience of negative affect. Conclusions: Larger gray matter volume in healthy relatives of MDD patients point to a possible vulnerability mechanism in MDD etiology and therefore extend knowledge in the field of high-risk approaches in MDD.
doi:10.1016/j.nicl.2014.05.015 pmid:25003028 pmcid:PMC4081974 fatcat:mfvjobg6arczpdcqj6zo7uogve

Decoding Pedophilia: Increased Anterior Insula Response to Infant Animal Pictures

Jorge Ponseti, Daniel Bruhn, Julia Nolting, Hannah Gerwinn, Alexander Pohl, Aglaja Stirn, Oliver Granert, Helmut Laufs, Günther Deuschl, Stephan Wolff, Olav Jansen, Hartwig Siebner (+7 others)
2018 Frontiers in Human Neuroscience  
Previous research found increased brain responses of men with sexual interest in children (i.e., pedophiles) not only to pictures of naked children but also to pictures of child faces. This opens the possibly that pedophilia is linked (in addition to or instead of an aberrant sexual system) to an over-active nurturing system. To test this hypothesis we exposed pedophiles and healthy controls to pictures of infant and adult animals during functional magnetic resonance imaging of the brain. By
more » ... ng pictures of infant animals (instead of human infants), we aimed to elicit nurturing processing without triggering sexual processing. We hypothesized that elevated brain responses to nurturing stimuli will be found -in addition to other brain areas -in the anterior insula of pedophiles because this area was repeatedly found to be activated when adults see pictures of babies. Behavioral ratings confirmed that pictures of infant or adult animals were not perceived as sexually arousing neither by the pedophilic participants nor by the heathy controls. Statistical analysis was applied to the whole brain as well as to the anterior insula as region of interest. Only in pedophiles did infants relative to adult animals increase brain activity in the anterior insula, supplementary motor cortex, and dorsolateral prefrontal areas. Within-group analysis revealed an increased brain response to infant animals in the left anterior insular cortex of the pedophilic participants. Currently, pedophilia is considered the consequence of disturbed sexual or executive brain processing, but details are far from known. The present findings raise the question whether there is also an over-responsive nurturing system in pedophilia.
doi:10.3389/fnhum.2017.00645 pmid:29403367 pmcid:PMC5778266 fatcat:qp5cponoijgcdef3jlervdkxhu

Amygdala functional connectivity in major depression – disentangling markers of pathology, risk and resilience

Carolin Wackerhagen, Ilya M. Veer, Susanne Erk, Sebastian Mohnke, Tristram A. Lett, Torsten Wüstenberg, Nina Y. Romanczuk-Seiferth, Kristina Schwarz, Janina I. Schweiger, Heike Tost, Andreas Meyer-Lindenberg, Andreas Heinz (+1 others)
2019 Psychological Medicine  
AbstractBackgroundLimbic-cortical imbalance is an established model for the neurobiology of major depressive disorder (MDD), but imaging genetics studies have been contradicting regarding potential risk and resilience mechanisms. Here, we re-assessed previously reported limbic-cortical alterations between MDD relatives and controls in combination with a newly acquired sample of MDD patients and controls, to disentangle pathology, risk, and resilience.MethodsWe analyzed functional magnetic
more » ... nce imaging data and negative affectivity (NA) of MDD patients (n = 48), unaffected first-degree relatives of MDD patients (n = 49) and controls (n = 109) who performed a faces matching task. Brain response and task-dependent amygdala functional connectivity (FC) were compared between groups and assessed for associations with NA.ResultsGroups did not differ in task-related brain activation but activation in the superior frontal gyrus (SFG) was inversely correlated with NA in patients and controls. Pathology was associated with task-independent decreases of amygdala FC with regions of the default mode network (DMN) and decreased amygdala FC with the medial frontal gyrus during faces matching, potentially reflecting a task-independent DMN predominance and a limbic-cortical disintegration during faces processing in MDD. Risk was associated with task-independent decreases of amygdala-FC with fronto-parietal regions and reduced faces-associated amygdala-fusiform gyrus FC. Resilience corresponded to task-independent increases in amygdala FC with the perigenual anterior cingulate cortex (pgACC) and increased FC between amygdala, pgACC, and SFG during faces matching.ConclusionOur results encourage a refinement of the limbic-cortical imbalance model of depression. The validity of proposed risk and resilience markers needs to be tested in prospective studies. Further limitations are discussed.
doi:10.1017/s0033291719002885 pmid:31637983 fatcat:eouahgqenfgl5mbgqdk3m6di4m

Influence of Familial Risk for Depression on Cortico-Limbic Connectivity During Implicit Emotional Processing

Carolin Wackerhagen, Torsten Wüstenberg, Sebastian Mohnke, Susanne Erk, Ilya M Veer, Johann D Kruschwitz, Maria Garbusow, Lydia Romund, Kristina Otto, Janina I Schweiger, Heike Tost, Andreas Heinz (+3 others)
2017 Neuropsychopharmacology  
Imbalances in cortico-limbic activity and functional connectivity (FC) supposedly underlie biased emotional processing and present putative intermediate phenotypes (IPs) for major depressive disorder (MDD). To prove the validity of these IPs, we assessed them in familial risk. In 70 healthy first-degree relatives of MDD patients and 70 controls, brain activity and seed-based amygdala FC were assessed during an implicit emotional processing task for fMRI containing angry and fearful faces. Using
more » ... the generalized psychophysiological interaction approach, amygdala FC was assessed (a) across conditions to provide comparable data to previous studies and (b) compared between conditions to elucidate its implications for emotional processing. Associations of amygdala FC with self-reported negative affect were explored post hoc. Groups did not differ in brain activation. In relatives, amygdala FC across conditions was decreased with superior and medial frontal gyrus (SFG, MFG) and increased with subgenual and perigenual anterior cingulate cortex (sgACC, pgACC). NA was inversely correlated with amygdala FC with MFG, pgACC and their interaction in relatives. Relatives showed aberrant condition-dependent modulations of amygdala FC with visual cortex, thalamus and orbitofrontal cortex. Our results do not support imbalanced cortico-limbic activity as IP for MDD. Diminished amygdala-dorsomedial prefrontal FC in relatives might indicate insufficient regulatory capacity, which appears to be compensated by ventromedial prefrontal regions. Differential task-dependent modulations of amygdala FC are discussed as a stronger involvement of automatic instead of voluntary emotional processing pathways. Reliability and etiological implications of these results should be investigated in future studies including longitudinal designs and patient-risk-control comparisons.
doi:10.1038/npp.2017.59 pmid:28294134 pmcid:PMC5518910 fatcat:2rsj36ztrfbudomk7yaasecsyu

Theory of mind network activity is altered in subjects with familial liability for schizophrenia

Sebastian Mohnke, Susanne Erk, Knut Schnell, Nina Romanczuk-Seiferth, Phöbe Schmierer, Lydia Romund, Maria Garbusow, Carolin Wackerhagen, Stephan Ripke, Oliver Grimm, Leila Haller, Stephanie H. Witt (+5 others)
2015 Social Cognitive and Affective Neuroscience  
Importantly, these findings were recently replicated in an independent sample of 188 HC (Mohnke et al., 2014) .  ...  FHR were compared with a sample of 297 HC described previously (Mohnke et al., 2014) . FHR and HC did not differ in demographic variables (table 1).  ... 
doi:10.1093/scan/nsv111 pmid:26341902 pmcid:PMC4733339 fatcat:cdfnk7hzwvgkzk4fj4vunvy6ci

Altered DLPFC–Hippocampus Connectivity During Working Memory: Independent Replication and Disorder Specificity of a Putative Genetic Risk Phenotype for Schizophrenia

Michael Schneider, Henrik Walter, Carolin Moessnang, Axel Schäfer, Susanne Erk, Sebastian Mohnke, Lydia Romund, Maria Garbusow, Luanna Dixson, Andreas Heinz, Nina Romanczuk-Seiferth, Andreas Meyer-Lindenberg (+1 others)
2017 Schizophrenia Bulletin  
Altered connectivity of dorsolateral prefrontal cortex (DLPFC) and hippocampus during working memory is considered an intermediate phenotype for schizophrenia (SCZ) , but the relevance for other mental disorders with shared genetic background remains unknown. Here we investigated its presence in unaffected first-degree relatives of patients with bipolar disorder (BD) or major depressive disorder (MDD). Furthermore, we aimed to provide an independent replication of this phenotype in first-degree
more » ... relatives of SCZ patients. We acquired functional magnetic resonance imaging (fMRI) data from 309 healthy controls and 218 healthy first-degree relatives of index patients with SCZ (n = 62), BD (n = 66) and MDD (n = 90), who completed the n-back working memory paradigm. We observed a significant group effect on DLPFC-hippocampus coupling (P FWE = .031, all P-values region of interest [ROI] corrected). Post hoc comparisons revealed that this effect was driven by the SCZ relatives, who showed a significant increase in the negative functional connectivity of the DLPFC and right hippocampus compared to controls (P FWE = .001), BD relatives (P FWE = .015) and trend-wise also MDD relatives (P FWE = .082). Comparison of BD and MDD relatives to the controls revealed no difference (P FWEvalues > .451). Supplementary analyses suggested that the SCZ relatives finding is robust to a range of potential confounds, including structural differences. Our data further support altered DLPFC-hippocampus connectivity during working memory as an intermediate phenotype for SCZ. This suggests that this phenotype is relatively specific to SCZ and does not translate to other genetically related disorders in the mood-psychosis spectrum.
doi:10.1093/schbul/sbx001 pmid:28207073 fatcat:iltnsyveerf55ohikayfyzcnia

The 5-HTTLPR Polymorphism Affects Network-Based Functional Connectivity in the Visual-Limbic System in Healthy Adults

Hengyi Cao, Anais Harneit, Henrik Walter, Susanne Erk, Urs Braun, Carolin Moessnang, Lena S Geiger, Zhenxiang Zang, Sebastian Mohnke, Andreas Heinz, Nina Romanczuk-Seiferth, Thomas Mühleisen (+7 others)
2017 Neuropsychopharmacology  
The serotonin transporter-linked polymorphic region 5-HTTLPR is a key genetic regulator of 5-HTT expression in the human brain where the short allele S has been implicated in emotion dysregulation. However, the neural mechanism underlying the association between this variant and emotion processing is still unclear. Earlier studies suggested an effect of 5-HTTLPR on amygdala activation during emotional face processing. However, this association has been questioned in recent studies employing
more » ... er sample sizes and meta-analyses. Here, we examined a sample of 223 healthy subjects with a well-established fMRI emotional face processing task to (1) re-evaluate the association between 5-HTTLPR and amygdala activation, (2) explore potential network-based functional connectivity phenotypes for associations with 5-HTTLPR, and (3) probe the reliability, behavioral significance and potential structural confounds of the identified network phenotype. Our results revealed no significant effect of 5-HTTLPR on amygdala activation (P40.79). However, the number of S alleles was significantly correlated with functional connectivity of a visual-limbic subnetwork (P FWE = 0.03). The subnetwork cluster included brain regions that are pivotal to emotion regulation such as the hippocampus, orbitofrontal cortex, anterior cingulate gyrus, fusiform gyrus, and subcortex. Notably, individuals with lower subnetwork connectivity had significantly higher emotion suppression scores (P = 0.01). Further, the connectivity metrics were test-retest reliable and independent from subnetwork gray matter volume and white matter anisotropy. Our data provide evidence for a functional network-based phenotype linking genetic variation in 5-HTTLPR to emotion regulation, and suggest that further critical evaluations of the association between 5-HTTLPR and amygdala activation are warranted.
doi:10.1038/npp.2017.121 pmid:28589968 fatcat:2trnn577wzggfg6yl3suokyysm

Child sexual offenders show prenatal and epigenetic alterations of the androgen system

Tillmann H. C. Kruger, Christopher Sinke, Jonas Kneer, Gilian Tenbergen, Abdul Qayyum Khan, Alexandra Burkert, Linda Müller-Engling, Harald Engler, Hannah Gerwinn, Nicole von Wurmb-Schwark, Alexander Pohl, Simone Weiß (+12 others)
2019 Translational Psychiatry  
Child sexual offending (CSO) places a serious burden on society and medicine and pedophilia (P) is considered a major risk factor for CSO. The androgen system is closely linked to sexual development and behavior. This study assessed markers of prenatal brain androgenization, genetic parameters of androgen receptor function, epigenetic regulation, and peripheral hormones in a 2 × 2 factorial design comprising the factors Offense (yes/no) and Pedophilia (yes/no) in analyzing blood samples from
more » ... subjects (57 P+CSO, 45 P-CSO, 20 CSO-P, and 72 controls) matched for age and intelligence. Subjects also received a comprehensive clinical screening. Independent of their sexual preference, child sexual offenders showed signs of elevated prenatal androgen exposure compared with non-offending pedophiles and controls. The methylation status of the androgen receptor gene was also higher in child sexual offenders, indicating lower functionality of the testosterone system, accompanied by lower peripheral testosterone levels. In addition, there was an interaction effect on methylation levels between offense status and androgen receptor functionality. Notably, markers of prenatal androgenization and the methylation status of the androgen receptor gene were correlated with the total number of sexual offenses committed. This study demonstrates alterations of the androgen system on a prenatal, epigenetic, and endocrine level. None of the major findings was specific for pedophilia, but they were for CSO. The findings support theories of testosterone-linked abnormalities in early brain development in delinquent behavior and suggest possible interactions of testosterone receptor gene methylation and plasma testosterone with environmental factors.
doi:10.1038/s41398-018-0326-0 pmid:30659171 pmcid:PMC6338724 fatcat:x7oxvybrufftbgcmldyf5tsl2m

Identification of gene ontologies linked to prefrontal–hippocampal functional coupling in the human brain

Luanna Dixson, Henrik Walter, Michael Schneider, Susanne Erk, Axel Schäfer, Leila Haddad, Oliver Grimm, Manuel Mattheisen, Markus M. Nöthen, Sven Cichon, Stephanie H. Witt, Marcella Rietschel (+5 others)
2014 Proceedings of the National Academy of Sciences of the United States of America  
doi:10.1073/pnas.1404082111 pmid:24979789 pmcid:PMC4084419 fatcat:ytcoehqvanfa3g6cqsaucxvl24

Two Sides of One Coin: A Comparison of Clinical and Neurobiological Characteristics of Convicted and Non-Convicted Pedophilic Child Sexual Offenders

Charlotte Gibbels, Christopher Sinke, Jonas Kneer, Till Amelung, Sebastian Mohnke, Klaus Michael Beier, Henrik Walter, Kolja Schiltz, Hannah Gerwinn, Alexander Pohl, Jorge Ponseti, Carina Foedisch (+6 others)
2019 Journal of Clinical Medicine  
High prevalence of child sexual offending stand in contradiction to low conviction rates (one-tenth at most) of child sexual offenders (CSOs). Little is known about possible differences between convicted and non-convicted pedophilic CSOs and why only some become known to the judicial system. This investigation takes a closer look at the two sides of "child sexual offending" by focusing on clinical and neurobiological characteristics of convicted and non-convicted pedophilic CSOs as presented in
more » ... the Neural Mechanisms Underlying Pedophilia and sexual offending against children (NeMUP)*-study. Seventy-nine male pedophilic CSOs were examined, 48 of them convicted. All participants received a thorough clinical examination including the structured clinical interview (SCID), intelligence, empathy, impulsivity, and criminal history. Sixty-one participants (38 convicted) underwent an inhibition performance task (Go/No-go paradigm) combined with functional magnetic resonance imaging (fMRI). Convicted and non-convicted pedophilic CSOs revealed similar clinical characteristics, inhibition performances, and neuronal activation. However, convicted subjects' age preference was lower (i.e., higher interest in prepubescent children) and they had committed a significantly higher number of sexual offenses against children compared to non-convicted subjects. In conclusion, sexual age preference may represent one of the major driving forces for elevated rates of sexual offenses against children in this sample, and careful clinical assessment thereof should be incorporated in every preventive approach.
doi:10.3390/jcm8070947 pmid:31261903 pmcid:PMC6678781 fatcat:luov4hfulvbupg7mn6e6fqlqmm

Further Evidence for the Impact of a Genome-Wide-Supported Psychosis Risk Variant in ZNF804A on the Theory of Mind Network

Sebastian Mohnke, Susanne Erk, Knut Schnell, Claudia Schütz, Nina Romanczuk-Seiferth, Oliver Grimm, Leila Haddad, Lydia Pöhland, Maria Garbusow, Mike M Schmitgen, Peter Kirsch, Christine Esslinger (+12 others)
2013 Neuropsychopharmacology  
Impact of ZNF804A on the theory of mind network S Mohnke et al Behavioral Results As in our earlier study, we found condition but no genotype effects on task performance measures.  ...  However, Impact of ZNF804A on the theory of mind network S Mohnke et al although this effect was observable in the discovery and replication samples, it could not be detected in the joint sample.  ... 
doi:10.1038/npp.2013.321 pmid:24247043 pmcid:PMC3957114 fatcat:kwi52wjjcne4nmters4n3xulfa

Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function

Urs Braun, Axel Schäfer, Danielle S. Bassett, Franziska Rausch, Janina I. Schweiger, Edda Bilek, Susanne Erk, Nina Romanczuk-Seiferth, Oliver Grimm, Lena S. Geiger, Leila Haddad, Kristina Otto (+7 others)
2016 Proceedings of the National Academy of Sciences of the United States of America  
Significance Converging evidence points to a role for glutamate and altered brain network dynamics in schizophrenia, but the molecular and genetic contributions are poorly understood. Here, we applied dynamic network neuroscience methods to neuroimaging working memory data to identify potential alterations in brain network flexibility related to schizophrenia genetic risk and N-methyl-Daspartate (NMDA) receptor hypofunction. Consistent with altered network dynamics, we detected significant
more » ... ases in brain network flexibility in patients with schizophrenia, healthy firstdegree relatives, and healthy subjects receiving a single dose of an NMDA receptor antagonist. Our data identify a potential dynamic network intermediate phenotype related to the genetic risk for schizophrenia and point to a critical role for glutamate in the temporal coordination of neural networks and the pathophysiology of schizophrenia.
doi:10.1073/pnas.1608819113 pmid:27791105 pmcid:PMC5098640 fatcat:qftg6ln4tvcttotamcmxmyirau

Theory of Mind – Neurogenetische Grundlagen und klinische Relevanz [article]

Sebastian Mohnke, Universitätsbibliothek Der FU Berlin, Universitätsbibliothek Der FU Berlin
2016
Publikationsliste│90 Eidesstattliche Versicherung Anteilserklärung an den erfolgten Publikationen Publikation 1 Publikation 2 Publikation 3 Komplette Publikationsliste "Ich, Sebastian Mohnke, versichere  ...  an Eides statt durch meine eigenhändige Unterschrift, dass Sebastian Mohnke hatte folgenden Anteil an den folgenden Publikationen: Einschränkend ist ferner zu erwähnen, dass Konnektivitätseffekte ausschließlich  ... 
doi:10.17169/refubium-13868 fatcat:rrrghvtfzzc3tdthuekvx25wki

Neural correlates of theory of mind and empathy in schizophrenia: An activation likelihood estimation meta-analysis

Ksenija Vucurovic, Stéphanie Caillies, Arthur Kaladjian
2019 Journal of Psychiatric Research  
., 2013; Frith and Corcoran, 1996) and predict impaired social functioning in patients (Mohnke et al., 2015; van Os et al., 2010) .  ...  Cognitive empathy relies on the affective perspective taking that enables us to understand other people's emotional states (Sebastian et al., 2012) .  ... 
doi:10.1016/j.jpsychires.2019.10.018 pmid:31689587 fatcat:tlgvjltwzngrxesk7unqs437te
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