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A NOVEL RETROGRADE SIGNALING PATHWAY FROM MITOCHONDRIA

2015 The gerontologist  
, and this likely plays a large role in the species' trait of healthy cardiovascular aging.  ...  Taken together, these data indicate that the NMR heart has a robust glutathione antioxidant capacity to stave off the damaging effects of oxidative stress allowing for the maintenance of cardiac function  ...  This presentation will include an overview and introduction to the NIA, discussion of the NIA Office of Special Populations, and description of health disparities research/training opportunities.  ... 
doi:10.1093/geront/gnv535.06 fatcat:nnbksxjp4jbqbg7irlybocggru

Finding Pathways to More Equitable and Meaningful Public-Scientist Partnerships

2016 Citizen Science: Theory and Practice  
Acknowledgements We thank the participants in the CSA 2015 symposium "Pathways to balance and partnership: advancing equity, inclusion, and local relevance in citizen science" for their enthusiasm and  ...  suggestions that we report here; Patti Iwasaki, our colleague in organizing and conducting the symposium; Jennifer Carrera, Tim Vargo, and Anna Zivian, who volunteered to serve as additional anchor participants  ...  In this essay we provide a brief overview of the problem we were addressing and report the observations and suggestions made by symposium participants in the café. What's the problem?  ... 
doi:10.5334/cstp.46 fatcat:lyjqvfa6i5evhe7o2fdmutkn2u

Synthetic pathways and processes in green chemistry. Introductory overview

Pietro Tundo, Paul Anastas, David StC. Black, Joseph Breen, Terrence J. Collins, Sofia Memoli, Junshi Miyamoto, Martyn Polyakoff, William Tumas
2000 Pure and Applied Chemistry  
and to industry, through education of young and established scientists, the provision of technical tools, governmental engagement, communication to the public and scientific communities, and the pursuit  ...  This plan demonstrates the direct relevance of the mission of IUPAC to green chemistry, and explains why there is growing enthusiasm for the pursuit of this new area as an appropriate activity of a scientific  ...  scientists, the provision of technical tools, governmental engagement, communication to the public and scientific communities, and the pursuit of sustainable development.  ... 
doi:10.1351/pac200072071207 fatcat:csnrx3itmjfwtc2tqylqbq4o2y

An evidence ontology for use in pathway/genome databases

P D Karp, S Paley, C J Krieger, P Zhang
2004 Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing  
We also describe an implementation of the ontology within the Pathway Tools software environment, which is used to query and update Pathway/Genome DBs such as EcoCyc, MetaCyc, and HumanCyc.  ...  An important emerging need in Model Organism Databases (MODs) and other bioinformatics databases (DBs) is that of capturing the scientific evidence that supports the information within a DB.  ...  Acknowledgments Julio Collado-Vides contributed to development of evidence codes related to transcriptional regulation.  ... 
pmid:14992503 fatcat:jrwhlmnn65d65eaayhvbxgyuca

The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway

David A. Stevenson, Lisa Schill, Lisa Schoyer, Brage S. Andresen, Annette Bakker, Pinar Bayrak-Toydemir, Emma Burkitt-Wright, Kathryn Chatfield, Florent Elefteriou, Ype Elgersma, Michael J. Fisher, David Franz (+17 others)
2016 American Journal of Medical Genetics. Part A  
The RASopathies are a group of disorders due to variations of genes associated with the Ras/ MAPK pathway.  ...  This report summarizes the proceedings of the 4th International Symposium on Genetic Disorders of the Ras/MAPK pathway and highlights gaps in the field.  ...  Bruce Gelb received royalties from GeneDx, Prevention Genetics, LabCorp, and Correlegan. Frank McCormick is founder of K-Gen Limited, which will develop prostratin as a therapy.  ... 
doi:10.1002/ajmg.a.37723 pmid:27155140 pmcid:PMC4945362 fatcat:ab243goasndrbe27b3fpnj6xt4

Brain pathways to recovery from alcohol dependence

Changhai Cui, Antonio Noronha, Kenneth R. Warren, George F. Koob, Rajita Sinha, Mahesh Thakkar, John Matochik, Fulton T. Crews, L. Judson Chandler, Adolf Pfefferbaum, Howard C. Becker, David Lovinger (+10 others)
2015 Alcohol  
Kenneth Warren highlighted the recent progress in alcohol neuroscience research, and Dr. Changhai Cui gave an introduction overview on brain pathways to recovery from alcohol dependence.  ...  The purpose of this symposium was to provide an up to date overview of research efforts focusing on understanding brain mechanisms that contribute to recovery from alcohol dependence.  ...  Acknowledgment George Koob would like to thank Michael Arends for assistance with manuscript preparation.  ... 
doi:10.1016/j.alcohol.2015.04.006 pmid:26074423 pmcid:PMC4468789 fatcat:6tqk2hw2m5d2tgry5d6hzf4smi

Pathways Towards a Sustainable Mountain Agriculture for the 21st Century: The Hindu Kush– Himalayan Experience

John Farrington
2000 Mountain Research and Development  
The Federation of Community Forest Groups of Nepal (FECOFUN) uses different media to deliver forestry information to the communities, such as a newsletter in Nepali, meetings and awareness campaigns, a  ...  the introduction.  ... 
doi:10.1659/0276-4741(2000)020[0201:ptasma]2.0.co;2 fatcat:3iatzq74xbbuzigjtqjv4uansa

Process Simulation of Complex Biochemical Pathways in Explicit 3D Space Enabled by Heterogeneous Computing Platform

Jie Li, Amin Salighehdar, Narayan Ganesan
2014 2014 IEEE International Parallel & Distributed Processing Symposium Workshops  
Modeling and simulation of such biological pathways in explicit process space is a computationally intensive due to the size of the system complexity and nature of the interactions.  ...  Besides, the extensible architecture is general enough to be used to study a variety of biological pathways in order to gain deeper insights into biomolecular systems.  ...  ACKNOWLEDGEMENTS The authors would like to thank the Xilinx University Program(XUP) and the NVIDIA-Professor partnership for their generous support and donation helpful in carrying out this research.  ... 
doi:10.1109/ipdpsw.2014.199 dblp:conf/ipps/LiSG14 fatcat:dlhayrnt6fhbla65wfggjxsapa

Advancing research opportunities and promoting pathways in graduate education: a systemic approach to BUILD training at California State University, Long Beach (CSULB)

Guido G. Urizar, Laura Henriques, Chi-Ah Chun, Paul Buonora, Kim-Phuong L. Vu, Gino Galvez, Laura Kingsford
2017 BMC Proceedings  
ability to address the nation's complex health challenges in an interdisciplinary way.  ...  The purpose of this paper is to describe the challenges, lessons learned, and sustainability of implementing a large-scale, multidisciplinary research infrastructure at California State University, Long  ...  faculty mentors, our BUILD team, and students and their families for all of their contributions to make the CSULB BUILD initiative a success.  ... 
doi:10.1186/s12919-017-0088-3 pmid:29375667 pmcid:PMC5773868 fatcat:bbcvzctar5bevdzozeoj27ccsq

Pathways to Success for Multi-Site Clinical Data Research

Deven McGraw, Alice Leiter
2013 eGEMs  
Optimizing this secondary use of clinical data is a key underpinning of many health reform goals and triggers numerous issues related to data stewardship and, more broadly, data governance.  ...  initiatives, as well as a number of resources used by project participants to work through various challenges, are documented and collected here for others wishing to learn from their collective efforts  ...  funder, the Electronic Data Methods (EDM) Forum -and in particular Erin Holve, Alison Rein and Marianne Hamilton-Lopez.  ... 
doi:10.13063/2327-9214.1041 pmid:25848568 pmcid:PMC4371512 fatcat:s2wx6lad3zhgbmypb7wapp4b4u

Isotopomer subspaces as indicators of metabolic-pathway structure

Philip W. Kuchel, David J. Philp
2008 Journal of Theoretical Biology  
and the pentose phosphate pathway (PPP).  ...  An example of the glycolysis-PPP system is discussed in the context of a debate that occurred around the F-and L-type PPPs and which one actually operates in the human RBC.  ...  Acknowledgements The work was supported by a grant from the Australian Research Council to PWK and by a grant that supported DJP from the Australian Research Council to Dr. Katie Glass.  ... 
doi:10.1016/j.jtbi.2007.05.039 pmid:17692871 fatcat:wnhbupcpnzfyjlzb2ag5zk7ngy

enRoute: dynamic path extraction from biological pathway maps for exploring heterogeneous experimental datasets

Christian Partl, Alexander Lex, Marc Streit, Denis Kalkofen, Karl Kashofer, Dieter Schmalstieg
2013 BMC Bioinformatics  
To address this we introduce enRoute, a technique that enables analysts to specify a path of interest in a pathway, extract this path into a separate, linked view, and show detailed experimental data associated  ...  Current techniques are either well suited to visualize large amounts of pathway node attributes, or to represent the topology of the pathway well, but do not accomplish both at the same time.  ...  Acknowledgements We would like to thank Hans-Jörg Schulz for his input.  ... 
doi:10.1186/1471-2105-14-s19-s3 pmid:24564375 pmcid:PMC3980897 fatcat:3xcvilj2gncrlkeu7dz4q5sofi

Development of a process-oriented quality improvement strategy for the medicines pathway in nursing homes using the SEIPS model

Goedele Strauven, Kris Vanhaecht, Pauline Anrys, Jan De Lepeleire, Anne Spinewine, Veerle Foulon
2019 Research in Social and Administrative Pharmacy  
A variety of qualitative methods, including observations, semi-structured interviews, the development of a flowchart, an expert meeting and a working symposium, were used to identify processes and work  ...  and policy makers to enhance a safe and efficient medicines pathway.  ...  of a flowchart, semi-structured interviews, an expert meeting and a working symposium (see Fig. 1 ).  ... 
doi:10.1016/j.sapharm.2019.06.003 pmid:31495661 fatcat:lj2ecwwm4vcvndd5bny7d6zj5q

Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways

A. Calderón-Larrañaga, D. L. Vetrano, L. Ferrucci, S. W. Mercer, A. Marengoni, G. Onder, M. Eriksdotter, L. Fratiglioni
2018 Journal of Internal Medicine  
; this review provides an overview of knowledge gaps and future directions.  ...  Furthermore, common pathways seem to underlie multimorbidity, functional impairment and their interplay.  ...  Table 1 provides an overview of the definitions and measurements of multimorbidity and functional impairment encountered in the cited literature.  ... 
doi:10.1111/joim.12843 pmid:30357990 pmcid:PMC6446236 fatcat:q47nexwqmre6del3mfqu3kywqu

enRoute: Dynamic path extraction from biological pathway maps for in-depth experimental data analysis

Christian Partl, Alexander Lex, Marc Streit, Denis Kalkofen, Karl Kashofer, Dieter Schmalstieg
2012 2012 IEEE Symposium on Biological Data Visualization (BioVis)  
ACKNOWLEDGEMENTS We would like to thank Hans-Jörg Schulz for his input.  ...  INTRODUCTION Pathway maps are an important tool for studying biomolecular processes.  ...  However, although KEGG has a very broad focus and is nowadays widely spread in the community, we plan to integrate further pathway resources of different kinds, which often have a special focus on certain  ... 
doi:10.1109/biovis.2012.6378600 dblp:conf/biovis/PartlKLKSS12 fatcat:sf5zkmye65a4zebdsaovotwtei
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