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CMOS Enabled Microfluidic Systems for Healthcare Based Applications

Sherjeel M. Khan, Abdurrahman Gumus, Joanna M. Nassar, Muhammad M. Hussain
2018 Advanced Materials  
Therefore, here, the fundamentals, integration aspects, and applications of CMOS-enabled microfluidic systems for affordable personalized healthcare systems are presented.  ...  Signal acquisition from a large array of sensors to a single system requires a complex integration scheme, but CMOS microfabrication processes enable the integration of analogue multiplexers with biosensors  ...  [53] The potential of merging a complex application-specific integrated circuit (ASIC) with a microfluidic network was shown by Schafer et al.  ... 
doi:10.1002/adma.201705759 pmid:29484725 fatcat:fvsk27zm5bamvd7wziii4u7o7y

Applications of CMOS Devices for the Diagnosis and Control of Infectious Diseases

Saghi Forouhi, Ebrahim Ghafar-Zadeh
2020 Micromachines  
These features as well as low cost, low power and scalability of CMOS technology can pave the way for the development of powerful devices such as point-of-care (PoC) systems, lab-on-chip (LoC) platforms  ...  and symptom screening devices for accurate and timely diagnosis of infectious diseases.  ...  In the third section, different types of CMOS-based electrochemical biosensors reported for these applications are reviewed.  ... 
doi:10.3390/mi11111003 pmid:33202888 fatcat:efncnskflfheba62yfambekaxu

Technical Program

2021 2021 IEEE Latin America Electron Devices Conference (LAEDC)  
and millimeter-wave performance SOI technologies for RF and millimeter-wave integrated circuits Rf cmos SOI technologies for RF and millimeter-wave integrated circuits RF measurements Influence of Calibration  ...  A Simple Method for Seamless Integration of CMOS Chips with Microfluidics CMOS technology Circuit reliability prediction: challenges and solutions for the device time-dependent variability characterization  ... 
doi:10.1109/laedc51812.2021.9437946 fatcat:7j6djeusvzg2jiiem7qibbqsg4

Biosensing microsystem platforms based on the integration of Si Mach-Zehnder interferometer, microfluidics and grating couplers

L. M. Lechuga, K. Zinoviev, L. Fernández, J. Elizalde, O. E. Hidalgo, C. Dominguez, Joel A. Kubby, Graham T. Reed
2009 Silicon Photonics IV  
For the lab-on-a-chip development, the biosensors have been integrated with a 3D microfluidic polymer network.  ...  The optical characterization has shown the excellent compatibility and integration between fabrication technologies of silicon MZI, SU-8 polymer microfluidic network and mountable grating couplers.  ...  Two main factors play a role in the choice of the detection method for LOC application: sensitivity and scalability to smaller dimensions.  ... 
doi:10.1117/12.809166 fatcat:2uxrmwhxzbfddcwpdgpkeu6ucm

Biologically sensitive field-effect transistors: from ISFETs to NanoFETs

V. Pachauri, S. Ingebrandt
2016 Essays in Biochemistry  
The latest examples of highly sensitive label-free detection of deoxyribonucleic acid (DNA) molecules using SiNW FETs and single-cell recordings for drug screening and other applications of ISFETs will  ...  This review will provide a brief overview of the history of ISFET biosensors with general operation concepts and sensing mechanisms.  ...  The resulting recordings in AC mode were explained using a behavioural Personal Simulation Program with Integrated Circuit Emphasis (PSPICE) model for SiNW FET biosensors suitable to simulate frequency  ... 
doi:10.1042/ebc20150009 pmid:27365038 pmcid:PMC4986460 fatcat:ad4m5o5tn5fu5jrpy6ryczilb4

Miniaturization of fluorescence sensing in optofluidic devices

Daniel Măriuţa, Stéphane Colin, Christine Barrot-Lattes, Stéphane Le Calvé, Jan G. Korvink, Lucien Baldas, Jürgen J. Brandner
2020 Microfluidics and Nanofluidics  
Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge.  ...  , CMOS-based fluorescence sensing, and organic electronics.  ...  The work in this article has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant agreement no. 643095.  ... 
doi:10.1007/s10404-020-02371-1 fatcat:62kdzksfj5fbldb7x5kdhcim5a

Design, Fabrication, and Testing of a Hybrid CMOS/PDMS Microsystem for Cell Culture and Incubation

Jennifer Blain Christen, Andreas G. Andreou
2007 IEEE Transactions on Biomedical Circuits and Systems  
The micro-incubator is engineered through the integration of a silicon CMOS die for the heater and temperature sensor, with multilayer silicone (PDMS) structures namely, fluidic channels and a 1.5-mm diameter  ...  We discuss the design, fabrication, and testing of a hybrid microsystem for stand-alone cell culture and incubation.  ...  Jeff Wang for the use of his microscope and cell imaging system. CMOS chip fabrication was provided by MOSIS. The authors also thank Prof. M.  ... 
doi:10.1109/tbcas.2007.893189 pmid:23851516 fatcat:a7duouqdhratndxpj4xkjlmqj4

Overview of Electrochemical DNA Biosensors: New Approaches to Detect the Expression of Life

Stefano Cagnin, Marcelo Caraballo, Carlotta Guiducci, Paolo Martini, Marty Ross, Mark SantaAna, David Danley, Todd West, Gerolamo Lanfranchi
2009 Sensors  
They are having a strong impact in medical diagnostics for cancer, toxicology and infectious disease applications.  ...  DNA microarrays are an important tool with a variety of applications in gene expression studies, genotyping, pharmacogenomics, pathogen classification, drug discovery, sequencing and molecular diagnostics  ...  Veneto Nanotech, Venice, Italy to G.L. are acknowledged for funding the development of DNA biosensors for the environment and food monitoring.  ... 
doi:10.3390/s90403122 pmid:22574066 pmcid:PMC3348825 fatcat:ekfkmpigzrakxil2pfb5jgo27m

2020 Index IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems Vol. 39

2020 IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems  
., +, TCAD Nov. 2020 4252-4265 CMOS digital integrated circuits A Macromodeling Approach for Analog Behavior of Digital Integrated Circuits.  ...  ., +, TCAD Dec. 2020 4375-4384 CMOS logic circuits A Macromodeling Approach for Analog Behavior of Digital Integrated Circuits.  ...  Entropy-Directed Scheduling for FPGA High-Level Synthesis. Shen, M., +, TCAD Oct. 2020 2588 -2601 FLASH: Fast, Parallel, and Accurate Simulator for HLS.  ... 
doi:10.1109/tcad.2021.3054536 fatcat:wsw3olpxzbeclenhex3f73qlw4

Lab-on-Chip for Everyone: Introducing an Electronic-Photonic Platform for Multiparametric Biosensing Using Standard CMOS Processes

Christos Adamopoulos, Panagiotis Zarkos, Sidney Buchbinder, Pavan Bhargava, Ali Niknejad, Mekhail Anwar, Vladimir Stojanovic
2021 IEEE Open Journal of Solid-State Circuits  
Leveraging co-integration of 10µm micro-ring resonators (MRRs) with on-chip electronics, we address the current needs of scalability, power and area by providing nanophotonic sensing and readout processing  ...  This work presents a solution based on a first of its kind fully integrated electronic-photonic platform in a zero-change high volume CMOS-SOI process, tailored towards molecular and ultrasound sensing  ...  FULLY INTEGRATED BIOSENSING EPSOCs Deep integration of nanophotonic sensing with on-die electronics solves key problems in the arena of nanophotonic biosensors targeting PoC applications.  ... 
doi:10.1109/ojsscs.2021.3118336 fatcat:vs63yhngbbfkpevxlkvamtctve

Live Cell Analysis: When Electric Detection Interfaces Microfluidics

Nathalie Picollet- D'hahan
2011 Journal of Biochips & Tissue Chips  
Microfluidics and 3D aspects Miniaturized biosensors are necessary for many applications that need portable integrated systems.  ...  This is in fact one of the first applications of integrated systems in cellomics.  ... 
doi:10.4172/2153-0777.s1-001 fatcat:6qxjmqgvzjcbjbu53s2ov6vz2a

Personalised physical exercise regime for chronic patients through a wearable ICT platform

Pantelis A. Angelidis
2010 International Journal of Electronic Healthcare  
In particular, it will look into wearable electronics embedded in textile capable of performing regular or exceptional measurements of vital physiological parameters and communicating them to an application  ...  and advanced processing of vital signs information.  ...  and Sophia-Anna Ioannidou and Eleftheria Velidou for assisting with editing the text.  ... 
doi:10.1504/ijeh.2010.036207 pmid:21041175 fatcat:7hxn2jisxrck7nkxu5swicc5oi

Microfluidic Biosensing Systems Using Magnetic Nanoparticles

Ioanna Giouroudi, Franz Keplinger
2013 International Journal of Molecular Sciences  
Microfluidic systems for biomedical analysis usually consist of a set of units, which guarantees the manipulation, detection and recognition of bioanalytes in a reliable and flexible manner.  ...  The impressive and rapid progress in micro-and nanotechnology as well as in biotechnology enables the integration of a variety of analytical functions in a single chip.  ...  Conflicts of Interest The authors declare no conflict of interest.  ... 
doi:10.3390/ijms140918535 pmid:24022689 pmcid:PMC3794794 fatcat:utvdu5wmqfh5flyptlhehs5rfq

Hybrid Silicon Nanowire Devices and Their Functional Diversity

Larysa Baraban, Bergoi Ibarlucea, Eunhye Baek, Gianaurelio Cuniberti
2019 Advanced Science  
Their application areas span from miniaturized elements of devices and circuits to ultrasensitive biosensors for diagnostics.  ...  In this Review, the current trends in the developments of silicon nanowire-based devices are summarized, and their functionalities, novel architectures, and applications are discussed from the point of  ...  [189] presented a fully integrated polysilicon nanowire-based biosensor with wireless acquisition circuit in CMOS technology.  ... 
doi:10.1002/advs.201900522 pmid:31406669 pmcid:PMC6685480 fatcat:lzjyp3mpuzbxvonrsxgqufjgae

Point-of-care biosensor system

Arvind Sai Sarathi Vasan
2013 Frontiers in bioscience (Scholar edition)  
and clinical judgment (217). support scalable data rates ranging from 1 kbps to hundreds POC wireless systems require the integration of current lab- of Mbps over a distance of 2–5m with a network  ...  IEEE Trans Biomed the 5th Workshop on Applications and Services in Wireless Circuits Syst 1 (3), 203-216 (2007) Networks, 147-152 (2005) 197.  ... 
doi:10.2741/s357 pmid:23277036 fatcat:kymehvonrfg33f26vd6nwef2dy
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