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Response to transarterial chemoembolization as a biological selection criterion for liver transplantation in hepatocellular carcinoma
2006
Liver transplantation
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Criteria to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT) are based on tumor size and number of nodules rather than on tumor biology. The present study was undertaken to assess the role of transarterial chemoembolization (TACE) in selecting patients with tumors suitable for LT. Ninety-six consecutive patients with HCC were treated by repeatedly performed TACE, 62 of them exceeding the Milan criteria. Patients meeting the Milan criteria were immediately
doi:10.1002/lt.20837
pmid:16826556
fatcat:lu2jhshdgje4hda62sgcrztpoa
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... , and patients beyond the listing criteria were listed upon downstaging of the tumor following successful TACE. Fifty patients were finally transplanted. Of these 50 patients, 34 exceeded the Milan criteria. In these 96 patients, overall 5-year survival was 51.9%. However, it was 80.9% for patients undergoing LT and 0% for patients without transplantation (P Ͻ 0.0001). Tumor recurrence was primarily influenced by the control of the disease through continued TACE during the waiting time. Freedom from recurrence after 5 years was 94.5% in patients (n ϭ 39) with progression-free TACE during the waiting time. Tumor recurrence was significantly higher in patients (n ϭ 11) who after initial response to TACE progressed again before LT (freedom from recurrence 35.4%; P ϭ 0.0017). Progression-free course of TACE during the waiting time (P ϭ 0.006; risk ratio, 8.95), and a limited number of tumor nodules as assessed in the surgical specimen (P ϭ 0.025; risk ratio, 0.116) proved to be significant predictors for freedom from recurrence in the multivariate analysis. Milan criteria were without impact on recurrence. Our data suggest that sustained response to TACE is a better selection criterion for LT than the initial assessment of tumor size or number.
Ein neues Konzept zum gezielten Abtrag von Stahlbetonstrukturen
2011
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CoScience - Gemeinsam forschen und publizieren mit dem Netz
2015
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Schreiben AuTOreN: Sascha Friesike, Martin Fenner kONTrI BuTOreN: Mareike König DOI: 10.2314/coscv1.4 87 Vgl. U.S. ...
Weitere Hinweise finden Sie auch in der englischen Wikipedia.CB Organisieren AuTOreN: Christian Hauschke, Christian Heise kONTrI BuTOreN: Mareike König DOI: 10.2314/coscv1.2 Rittenbruch, Markus; Poschen ...
doi:10.2314/coscv2
fatcat:wkdtukf3lzggfcipzeq5igyacy
Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort
2021
Critical Care
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Background Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU)
doi:10.1186/s13054-021-03580-y
pmid:34034782
fatcat:2obplr62pjcnvp5vtrm5b6xgfa
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... ity rates. Methods Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, according to the respiratory support strategy employed at the day of admission to ICU. Propensity score matching was performed to ensure comparability between groups. Results Initially, 1421 patients were assessed for possible study inclusion. Of these, 351 patients (85 SOT, 87 HFNC, 87 NIV, and 92 IMV) remained eligible for full analysis after propensity score matching. 55% of patients initially receiving noninvasive respiratory support required IMV. The intubation rate was lower in patients initially ventilated with HFNC and NIV compared to those who received SOT (SOT: 64%, HFNC: 52%, NIV: 49%, p = 0.025). Compared to the other respiratory support strategies, NIV was associated with a higher overall ICU mortality (SOT: 18%, HFNC: 20%, NIV: 37%, IMV: 25%, p = 0.016). Conclusion In this cohort of critically ill patients with COVID-19, a trial of HFNC appeared to be the most balanced initial respiratory support strategy, given the reduced intubation rate and comparable ICU mortality rate. Nonetheless, considering the uncertainty and stress associated with the COVID-19 pandemic, SOT and early IMV represented safe initial respiratory support strategies. The presented findings, in agreement with classic ARDS literature, suggest that NIV should be avoided whenever possible due to the elevated ICU mortality risk.
Jahresinhaltsverzeichnis
2012
Bibliotheksdienst
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Heise: ISIL − Ein internationales Kennzeichen für Archive, Bibliotheken und Museen 912 Deutsche Forschungsgemeinschaft: Literaturversorgung und Information / Fachinformationsdienste für die Wissenschaft ...
386
Martin Spangenberg: Vom Aufsatznachweis zum Volltext mit einem Klick -
kontextsensitive Verlinkung im Katalog der Bundestagsbibliothek
Ein Erfahrungsbericht
583
Sascha Szott: Vom Prototypen zum ...
doi:10.1515/bd.2012.46.12.1
fatcat:kunikzqeizbczoubeq5emu7eoi
Open Science Interview Mit Christian Heise
[article]
2014
Zenodo
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For an analysis of the interviews see: Scheliga, Kaja and Sascha Friesike. 2014. "Putting open science into practice: A social dilemma?" First Monday. Volume 19, Number 9. ...
doi:10.5281/zenodo.12341
fatcat:toonybif5rbknj22orytr3v7du
Acknowledgement to Reviewers of Applied Sciences and Announcement of the 2017 Outstanding Reviewer Awards Winners
2018
Applied Sciences
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Sci. 2018, 8, 133 20 of 52 HE, Jianjun He, Jing Selena He, Liming He, Qin He, Suining Hebert, Sylvie Heikkilä, Mikko Hein, Joachim Heinonen-Tanski, Helvi Heise, Bettina Heise, Rainer Heitor, Ana Helfield ...
Nonomura, Kazuteru
Noori, Mohammad
Noori, Navideh
Nord, Michael
Nori, Franco
Norilo, Vesa
Noro, Marco
Noshadi, Amin
Novas, Nuria
Novellino, Alessandro
Novotná, Vladimíra
Nowak, Sascha ...
doi:10.3390/app8010133
fatcat:3ueglkn6hbcxlpqyy5rm7kxn5e
Wolfgang Hilbig - ein Schriftsteller des Samizdat?1
2011
Monatshefte
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Sascha An- derson, Rainer Schedlinski oder Gert Neumann zu. ...
Vgl. dazu Birbel Heising, ,, Briefe voller Zitate aus dem Vergessen™. Intertex tualitdt im Werk Wolfgang Hilbigs. ...
doi:10.1353/mon.2011.0114
fatcat:srn5akd65rebzldso5hcunsari
Page 573 of Monatshefte Vol. 103, Issue 4
[page]
Monatshefte
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Vgl. dazu Birbel Heising, ,, Briefe voller Zitate aus dem Vergessen™. Intertex tualitdt im Werk Wolfgang Hilbigs. ...
Hervorhebungen gemiaf Originaltext
Bibliographie
Anderson, Sascha / Erb, Elke (Hg.), Beriihrung ist nur eine Randerscheinung. Neue Literatur aus der DDR. Koln: Kiepenheuer & Witsch, 1985. ...
Observation of contemporaneous optical radiation from a γ-ray burst
1999
Nature
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Further information about GCN is available at http://gcn.gsfc.nasa.gov/gcn A simple explanation of light emissioninsonoluminescence Sascha Hilgenfeldt*, Siegfried Grossmann² & Detlef Lohse³ * Division ...
doi:10.1038/18837
fatcat:ykvud6yb2bechnrkn673hiads4
Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort
2021
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BACKGROUND Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU)
doi:10.48350/156631
fatcat:o6w3k3q47repvjjkoa4ojxlyka
more »
... ity rates. METHODS Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, according to the respiratory support strategy employed at the day of admission to ICU. Propensity score matching was performed to ensure comparability between groups. RESULTS Initially, 1421 patients were assessed for possible study inclusion. Of these, 351 patients (85 SOT, 87 HFNC, 87 NIV, and 92 IMV) remained eligible for full analysis after propensity score matching. 55% of patients initially receiving noninvasive respiratory support required IMV. The intubation rate was lower in patients initially ventilated with HFNC and NIV compared to those who received SOT (SOT: 64%, HFNC: 52%, NIV: 49%, p = 0.025). Compared to the other respiratory support strategies, NIV was associated with a higher overall ICU mortality (SOT: 18%, HFNC: 20%, NIV: 37%, IMV: 25%, p = 0.016). CONCLUSION In this cohort of critically ill patients with COVID-19, a trial of HFNC appeared to be the most balanced initial respiratory support strategy, given the reduced intubation rate and comparable ICU mortality rate. Nonetheless, considering the uncertainty and stress associated with the COVID-19 pandemic, SOT and early IMV represented safe initial respiratory support strategies. The presented findings, in agreement with classic ARDS literature, suggest tha [...]
Page 905 of American Society of Civil Engineers. Transactions of the American Society of Civil Engineers Vol. 117, Issue
[page]
American Society of Civil Engineers. Transactions of the American Society of Civil Engineers
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<=sssconssenpssiesssonnessssnyp qn srioaslesp heise sascha fut tevedpienasncssiaatedivieletcniticeenectaticion 2 Research Associate, Dept. of Civ. and San. ...
Thank You to Our 2020 Peer Reviewers
2021
Journal of Geophysical Research - Solid Earth
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Susan Brantut, Nicolas Braun, Jean Braunmiller, Jochen Brenguier, Florent Briggs, Richard Brossier, Romain Brown, Larry Brown, Laurie Brown, Maxwell Brown, Robert Browning, John Bruhat, Lucile Brune, Sascha ...
William Hayward, Kathryn He, Chuansong He, Zhen-Yu Heagy, Lindsey Healy, David Heap, Michael Hearn, Elizabeth Heeschen, Katja Heesemann, Martin Heidarzadeh, Mohammad Heimisson, Elias Heinson, Graham Heise ...
doi:10.1029/2021jb021896
fatcat:vwz5k3vuubbfhmbrtdz6valqbi
Utopia 89 – Un projet théâtral et scientifique sur la manifestation du 4 novembre 1989 à Berlin-Est
2020
SYMPOSIUM CULTURE@KULTUR
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Du côté est-allemand, le réalisateur Thomas Heise filme au plus près les oratrices et orateurs, avant le meeting puis, directement, à la tribune 17 . ...
adressées aux auteur.e.s de cet article.11 Le dernier en date est un débat plutôt vif qui a opposé dans la presse, au cours de l'été 2019, plusieurs spécialistes de 1989, en particulierDetlev Pollack et Ilko-Sascha ...
doi:10.2478/sck-2020-0004
fatcat:ogvzihc3mzev5ik56mbplcwe5e
Reviewer Acknowledgement 2012
2013
BMC Genomics
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Headon UK
Edith Heard France
Simon Heath Spain Joshua Heazlewood USA
Julia Heck USA
Jakob Hedegaard Denmark
Mohammad Heidari USA
Jörg Heierhorst Australia
Juergen Heinisch Germany
Mark Heise ...
Thomas Templeton USA
Torstein Tengs Norway Teija Tenhola-Roininen Finland
Paula Tennant Jamaica
Javier Terol Spain Herve Tettelin USA
Rudolf Kurt Thauer Germany
Charles Theillet France
Sascha ...
doi:10.1186/1471-2164-14-231
pmcid:PMC3642022
fatcat:6nglfzwm2jgzvcbt3ywhga4eea
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