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Response to transarterial chemoembolization as a biological selection criterion for liver transplantation in hepatocellular carcinoma

Gerd Otto, Sascha Herber, Michael Heise, Ansgar W. Lohse, Christian Mönch, Fernando Bittinger, Maria Hoppe-Lotichius, Marcus Schuchmann, Anja Victor, Michael Pitton
2006 Liver transplantation  
Criteria to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT) are based on tumor size and number of nodules rather than on tumor biology. The present study was undertaken to assess the role of transarterial chemoembolization (TACE) in selecting patients with tumors suitable for LT. Ninety-six consecutive patients with HCC were treated by repeatedly performed TACE, 62 of them exceeding the Milan criteria. Patients meeting the Milan criteria were immediately
more » ... , and patients beyond the listing criteria were listed upon downstaging of the tumor following successful TACE. Fifty patients were finally transplanted. Of these 50 patients, 34 exceeded the Milan criteria. In these 96 patients, overall 5-year survival was 51.9%. However, it was 80.9% for patients undergoing LT and 0% for patients without transplantation (P Ͻ 0.0001). Tumor recurrence was primarily influenced by the control of the disease through continued TACE during the waiting time. Freedom from recurrence after 5 years was 94.5% in patients (n ϭ 39) with progression-free TACE during the waiting time. Tumor recurrence was significantly higher in patients (n ϭ 11) who after initial response to TACE progressed again before LT (freedom from recurrence 35.4%; P ϭ 0.0017). Progression-free course of TACE during the waiting time (P ϭ 0.006; risk ratio, 8.95), and a limited number of tumor nodules as assessed in the surgical specimen (P ϭ 0.025; risk ratio, 0.116) proved to be significant predictors for freedom from recurrence in the multivariate analysis. Milan criteria were without impact on recurrence. Our data suggest that sustained response to TACE is a better selection criterion for LT than the initial assessment of tumor size or number.
doi:10.1002/lt.20837 pmid:16826556 fatcat:lu2jhshdgje4hda62sgcrztpoa

Ein neues Konzept zum gezielten Abtrag von Stahlbetonstrukturen

Steffen Reinhardt, Sascha Gentes, Roman Weidemann, Marcus Geimer, Christoph Heise, Thomas Edelmann
2011
doi:10.5445/ir/1000035099 fatcat:agn627cng5awpbxboamk5srqxu

CoScience - Gemeinsam forschen und publizieren mit dem Netz

Ursula Arning, Margo Bargheer, Ina Blümel, Stefan Dietze, Martin Fenner, Sascha Friesike, Christian Hauschke, Christian Heise, Lambert Heller, Tina Hohmann, Robert Jäschke, Ulrich Kleinwechter (+11 others)
2015
Schreiben AuTOreN: Sascha Friesike, Martin Fenner kONTrI BuTOreN: Mareike König DOI: 10.2314/coscv1.4 87 Vgl. U.S.  ...  Weitere Hinweise finden Sie auch in der englischen Wikipedia.CB Organisieren AuTOreN: Christian Hauschke, Christian Heise kONTrI BuTOreN: Mareike König DOI: 10.2314/coscv1.2 Rittenbruch, Markus; Poschen  ... 
doi:10.2314/coscv2 fatcat:wkdtukf3lzggfcipzeq5igyacy

Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

Pedro D. Wendel Garcia, RISC-19-ICU Investigators, Hernán Aguirre-Bermeo, Philipp K. Buehler, Mario Alfaro-Farias, Bernd Yuen, Sascha David, Thomas Tschoellitsch, Tobias Wengenmayer, Anita Korsos, Alberto Fogagnolo, Gian-Reto Kleger (+53 others)
2021 Critical Care  
Background Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU)
more » ... ity rates. Methods Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, according to the respiratory support strategy employed at the day of admission to ICU. Propensity score matching was performed to ensure comparability between groups. Results Initially, 1421 patients were assessed for possible study inclusion. Of these, 351 patients (85 SOT, 87 HFNC, 87 NIV, and 92 IMV) remained eligible for full analysis after propensity score matching. 55% of patients initially receiving noninvasive respiratory support required IMV. The intubation rate was lower in patients initially ventilated with HFNC and NIV compared to those who received SOT (SOT: 64%, HFNC: 52%, NIV: 49%, p = 0.025). Compared to the other respiratory support strategies, NIV was associated with a higher overall ICU mortality (SOT: 18%, HFNC: 20%, NIV: 37%, IMV: 25%, p = 0.016). Conclusion In this cohort of critically ill patients with COVID-19, a trial of HFNC appeared to be the most balanced initial respiratory support strategy, given the reduced intubation rate and comparable ICU mortality rate. Nonetheless, considering the uncertainty and stress associated with the COVID-19 pandemic, SOT and early IMV represented safe initial respiratory support strategies. The presented findings, in agreement with classic ARDS literature, suggest that NIV should be avoided whenever possible due to the elevated ICU mortality risk.
doi:10.1186/s13054-021-03580-y pmid:34034782 fatcat:2obplr62pjcnvp5vtrm5b6xgfa

Jahresinhaltsverzeichnis

2012 Bibliotheksdienst  
Heise: ISIL − Ein internationales Kennzeichen für Archive, Bibliotheken und Museen 912 Deutsche Forschungsgemeinschaft: Literaturversorgung und Information / Fachinformationsdienste für die Wissenschaft  ...  386 Martin Spangenberg: Vom Aufsatznachweis zum Volltext mit einem Klick - kontextsensitive Verlinkung im Katalog der Bundestagsbibliothek Ein Erfahrungsbericht 583 Sascha Szott: Vom Prototypen zum  ... 
doi:10.1515/bd.2012.46.12.1 fatcat:kunikzqeizbczoubeq5emu7eoi

Open Science Interview Mit Christian Heise [article]

Kaja Scheliga
2014 Zenodo  
For an analysis of the interviews see: Scheliga, Kaja and Sascha Friesike. 2014. "Putting open science into practice: A social dilemma?" First Monday. Volume 19, Number 9.  ... 
doi:10.5281/zenodo.12341 fatcat:toonybif5rbknj22orytr3v7du

Acknowledgement to Reviewers of Applied Sciences and Announcement of the 2017 Outstanding Reviewer Awards Winners

2018 Applied Sciences  
Sci. 2018, 8, 133 20 of 52 HE, Jianjun He, Jing Selena He, Liming He, Qin He, Suining Hebert, Sylvie Heikkilä, Mikko Hein, Joachim Heinonen-Tanski, Helvi Heise, Bettina Heise, Rainer Heitor, Ana Helfield  ...  Nonomura, Kazuteru Noori, Mohammad Noori, Navideh Nord, Michael Nori, Franco Norilo, Vesa Noro, Marco Noshadi, Amin Novas, Nuria Novellino, Alessandro Novotná, Vladimíra Nowak, Sascha  ... 
doi:10.3390/app8010133 fatcat:3ueglkn6hbcxlpqyy5rm7kxn5e

Wolfgang Hilbig - ein Schriftsteller des Samizdat?1

A. Steiner
2011 Monatshefte  
Sascha An- derson, Rainer Schedlinski oder Gert Neumann zu.  ...  Vgl. dazu Birbel Heising, ,, Briefe voller Zitate aus dem Vergessen™. Intertex tualitdt im Werk Wolfgang Hilbigs.  ... 
doi:10.1353/mon.2011.0114 fatcat:srn5akd65rebzldso5hcunsari

Page 573 of Monatshefte Vol. 103, Issue 4 [page]

Monatshefte  
Vgl. dazu Birbel Heising, ,, Briefe voller Zitate aus dem Vergessen™. Intertex tualitdt im Werk Wolfgang Hilbigs.  ...  Hervorhebungen gemiaf Originaltext Bibliographie Anderson, Sascha / Erb, Elke (Hg.), Beriihrung ist nur eine Randerscheinung. Neue Literatur aus der DDR. Koln: Kiepenheuer & Witsch, 1985.  ... 

Observation of contemporaneous optical radiation from a γ-ray burst

C. Akerlof, R. Balsano, S. Barthelmy, J. Bloch, P. Butterworth, D. Casperson, T. Cline, S. Fletcher, F. Frontera, G. Gisler, J. Heise, J. Hills (+9 others)
1999 Nature  
Further information about GCN is available at http://gcn.gsfc.nasa.gov/gcn A simple explanation of light emissioninsonoluminescence Sascha Hilgenfeldt*, Siegfried Grossmann² & Detlef Lohse³ * Division  ... 
doi:10.1038/18837 fatcat:ykvud6yb2bechnrkn673hiads4

Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort

Pedro D Wendel Garcia, Hernán Aguirre-Bermeo, Philipp K Buehler, Mario Alfaro-Farias, Bernd Yuen, Sascha David, Thomas Tschoellitsch, Tobias Wengenmayer, Anita Korsos, Alberto Fogagnolo, Gian-Reto Kleger, Maddalena A Wu (+52 others)
2021
BACKGROUND Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU)
more » ... ity rates. METHODS Subanalysis of a prospective, multinational registry of critically ill COVID-19 patients. Patients were subclassified into standard oxygen therapy ≥10 L/min (SOT), high-flow oxygen therapy (HFNC), noninvasive positive-pressure ventilation (NIV), and early IMV, according to the respiratory support strategy employed at the day of admission to ICU. Propensity score matching was performed to ensure comparability between groups. RESULTS Initially, 1421 patients were assessed for possible study inclusion. Of these, 351 patients (85 SOT, 87 HFNC, 87 NIV, and 92 IMV) remained eligible for full analysis after propensity score matching. 55% of patients initially receiving noninvasive respiratory support required IMV. The intubation rate was lower in patients initially ventilated with HFNC and NIV compared to those who received SOT (SOT: 64%, HFNC: 52%, NIV: 49%, p = 0.025). Compared to the other respiratory support strategies, NIV was associated with a higher overall ICU mortality (SOT: 18%, HFNC: 20%, NIV: 37%, IMV: 25%, p = 0.016). CONCLUSION In this cohort of critically ill patients with COVID-19, a trial of HFNC appeared to be the most balanced initial respiratory support strategy, given the reduced intubation rate and comparable ICU mortality rate. Nonetheless, considering the uncertainty and stress associated with the COVID-19 pandemic, SOT and early IMV represented safe initial respiratory support strategies. The presented findings, in agreement with classic ARDS literature, suggest tha [...]
doi:10.48350/156631 fatcat:o6w3k3q47repvjjkoa4ojxlyka

Page 905 of American Society of Civil Engineers. Transactions of the American Society of Civil Engineers Vol. 117, Issue [page]

American Society of Civil Engineers. Transactions of the American Society of Civil Engineers  
<=sssconssenpssiesssonnessssnyp qn srioaslesp heise sascha fut tevedpienasncssiaatedivieletcniticeenectaticion 2 Research Associate, Dept. of Civ. and San.  ... 

Thank You to Our 2020 Peer Reviewers

Isabelle Manighetti, Rachel Abercrombie, Yehuda Ben‐Zion, Yves Bernabé, Michael Bostock, Mark Dekkers, Stephen W. Parman, Douglas Schmitt, Paul Tregoning
2021 Journal of Geophysical Research - Solid Earth  
Susan Brantut, Nicolas Braun, Jean Braunmiller, Jochen Brenguier, Florent Briggs, Richard Brossier, Romain Brown, Larry Brown, Laurie Brown, Maxwell Brown, Robert Browning, John Bruhat, Lucile Brune, Sascha  ...  William Hayward, Kathryn He, Chuansong He, Zhen-Yu Heagy, Lindsey Healy, David Heap, Michael Hearn, Elizabeth Heeschen, Katja Heesemann, Martin Heidarzadeh, Mohammad Heimisson, Elias Heinson, Graham Heise  ... 
doi:10.1029/2021jb021896 fatcat:vwz5k3vuubbfhmbrtdz6valqbi

Utopia 89 – Un projet théâtral et scientifique sur la manifestation du 4 novembre 1989 à Berlin-Est

Caroline Moine, Guillaume Mouralis, Laure de Verdalle
2020 SYMPOSIUM CULTURE@KULTUR  
Du côté est-allemand, le réalisateur Thomas Heise filme au plus près les oratrices et orateurs, avant le meeting puis, directement, à la tribune 17 .  ...  adressées aux auteur.e.s de cet article.11 Le dernier en date est un débat plutôt vif qui a opposé dans la presse, au cours de l'été 2019, plusieurs spécialistes de 1989, en particulierDetlev Pollack et Ilko-Sascha  ... 
doi:10.2478/sck-2020-0004 fatcat:ogvzihc3mzev5ik56mbplcwe5e

Reviewer Acknowledgement 2012

Catherine M Rice
2013 BMC Genomics  
Headon UK Edith Heard France Simon Heath Spain Joshua Heazlewood USA Julia Heck USA Jakob Hedegaard Denmark Mohammad Heidari USA Jörg Heierhorst Australia Juergen Heinisch Germany Mark Heise  ...  Thomas Templeton USA Torstein Tengs Norway Teija Tenhola-Roininen Finland Paula Tennant Jamaica Javier Terol Spain Herve Tettelin USA Rudolf Kurt Thauer Germany Charles Theillet France Sascha  ... 
doi:10.1186/1471-2164-14-231 pmcid:PMC3642022 fatcat:6nglfzwm2jgzvcbt3ywhga4eea
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