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Novel Therapies in BCMA-exposed Relapsed/Refractory Multiple Myeloma: The Anti-BCMA Therapy-refractory Patient

Emma Golden, Sara Ingram, Henning Schade, Jeffrey Matous, Tara K Gregory, Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA
2022 Oncology & Haematology  
Multiple myeloma (MM) is a haematologic malignancy resulting from the malignant overgrowth of monoclonal plasma cells in the bone marrow. Nearly 35,000 new cases are expected in the USA each year. In the last two decades there have been many clinical advances with the approvals of many new drugs and their combinations, which have improved survival statistics. Despite this, MM remains incurable, and patients with relapsed/refractory MM remain vulnerable. The development of chimeric antigen
more » ... or T-cell (CAR-T) therapy has shown promising results utilizing several target antigens; of note, B-cell maturation antigen (BCMA) is most prominent, due to its universal expression on the surface of malignant plasma cells. While anti-BCMA CAR-T therapies are inspiring, most patients eventually relapse and require further treatment. With these patients progressing through standard-of-care therapies, and more recently through novel anti-BCMA CAR-T therapies, we are faced with exploring novel treatment regimens to challenge their diseases. In this review, we discuss the different mechanisms of resistance to anti-BCMA therapies, effective retreatment with anti-BCMA-targeted therapies in MM, and advances in therapies utilizing other novel targets for patients who have progressed through anti-BCMA treatment.
doi:10.17925/ohr.2022.18.1.59 fatcat:taotxtmatnejzezxyccunu7iwu

SARAH FRANCES WHITING

A. J. Cannon
1927 Science  
CANNON HARVARD COLLEGE OBSERVATORY NovEMBE THE | THE t of New Worcest Clark U Massack and the Perry, were D1 and Pre neva. ( “Aubur changes trusions offered morphi: curious Crosby stone” was she On § or  ...  Arrer a life characterized by devotion to high ideals and filled with unusual activities, Sarah Frances Whiting, professor emeritus of physics and astronomy at Wellesley College, died on September 12,  ... 
doi:10.1126/science.66.1714.417 pmid:17756237 fatcat:d2d5jv6jgrfgdgaj6a7qcyzcxi

Latest Developments in Cellular Therapy for Multiple Myeloma

Tara K Gregory, Henning Schade, Jesús G Berdeja, Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Sarah Cannon Research Institute at the Colorado Blood Cancer Institute, Denver, CO, USA, Sarah Cannon Research Institute, Nashville, TN, USA
2021 Oncology & Hematology Review (US)  
doi:10.17925/ohr.2021.16.2.111 fatcat:7murrebcvngopco422qmbzqzzu

Lenalidomide in combination with gemcitabine as first-line treatment for patients with metastatic carcinoma of the pancreas: A Sarah Cannon Research Institute phase II trial

Jeffrey Infante, Hendrik-Tobias Arkenau, Johanna Bendell, Mark Rubin, David Waterhouse, George Jones, David Spigel, Cassie Lane, John Hainsworth, Howard Burris, III
2013 Cancer Biology & Therapy  
Patient and Methods This multicenter phase II study was initiated in May 2009 and was performed across 11 sites of the Sarah Cannon Oncology Research Consortium (see Appendix).  ... 
doi:10.4161/cbt.23625 pmid:23358470 pmcid:PMC3667874 fatcat:eccpwwowv5bdvprls5efufsj5m

Hidden Mobile Guards in Simple Polygons [article]

Sarah Cannon, Diane L. Souvaine, Andrew Winslow
2012 arXiv   pre-print
We consider guarding classes of simple polygons using mobile guards (polygon edges and diagonals) under the constraint that no two guards may see each other. In contrast to most other art gallery problems, existence is the primary question: does a specific type of polygon admit some guard set? Types include simple polygons and the subclasses of orthogonal, monotone, and starshaped polygons. Additionally, guards may either exclude or include the endpoints (so-called open and closed guards). We
more » ... ovide a nearly complete set of answers to existence questions of open and closed edge, diagonal, and mobile guards in simple, orthogonal, monotone, and starshaped polygons, with some surprising results. For instance, every monotone or starshaped polygon can be guarded using hidden open mobile (edge or diagonal) guards, but not necessarily with hidden open edge or hidden open diagonal guards.
arXiv:1206.1803v1 fatcat:6kkb2nalajaprhnmy3265dhopy

Paclitaxel/carboplatin with or without sorafenib in the first-line treatment of patients with stage III/IV epithelial ovarian cancer: a randomized phase II study of the Sarah Cannon Research Institute

John D. Hainsworth, Dana S. Thompson, John A. Bismayer, Victor G. Gian, William M. Merritt, Robert C. Whorf, Lindsey H. Finney, B. Stephens Dudley
2014 Cancer Medicine  
Fourteen sites in the Sarah Cannon Oncology Research Consortium participated in the trial.  ... 
doi:10.1002/cam4.376 pmid:25556916 pmcid:PMC4430260 fatcat:og6fpj5b2jg2vk4br6sns5e4dm

Phase Transitions in Random Dyadic Tilings and Rectangular Dissections

Sarah Cannon, Sarah Miracle, Dana Randall
2018 SIAM Journal on Discrete Mathematics  
We study rectangular dissections of an n × n lattice region into rectangles of area n, where n = 2 k for an even integer k. We show that there is a natural edgeflipping Markov chain that connects the state space. A similar edge-flipping chain is also known to connect the state space when restricted to dyadic tilings, where each rectangle is required to have the form where s, t, u and v are nonnegative integers. The mixing time of these chains is open. We consider a weighted version of these
more » ... ov chains where, given a parameter λ > 0, we would like to generate each rectangular dissection (or dyadic tiling) σ with probability proportional to λ |σ| , where |σ| is the total edge length. We show there is a phase transition in the dyadic setting: when λ < 1, the edge-flipping chain mixes in time O(n 2 log n), and when λ > 1, the mixing time is exp(Ω(n 2 )). Simulations suggest that the chain converges quickly when λ = 1, but this case remains open. The behavior for general rectangular dissections is more subtle, and even establishing ergodicity of the chain requires a careful inductive argument. As in the dyadic case, we show that the edge-flipping Markov chain for rectangular dissections requires exponential time when λ > 1. Surprisingly, the chain also requires exponential time when λ < 1, which we show using a different argument. Simulations suggest that the chain converges quickly at the isolated point λ = 1.
doi:10.1137/17m1157118 fatcat:trdh4oa6vren3j4c6xzgcxlicq

Two Hands Are Better Than One (up to constant factors) [article]

Sarah Cannon, Erik D. Demaine, Martin L. Demaine, Sarah Eisenstat, Matthew J. Patitz, Robert Schweller, Scott M. Summers, Andrew Winslow
2012 arXiv   pre-print
We study the difference between the standard seeded model of tile self-assembly, and the "seedless" two-handed model of tile self-assembly. Most of our results suggest that the two-handed model is more powerful. In particular, we show how to simulate any seeded system with a two-handed system that is essentially just a constant factor larger. We exhibit finite shapes with a busy-beaver separation in the number of distinct tiles required by seeded versus two-handed, and exhibit an infinite shape
more » ... that can be constructed two-handed but not seeded. Finally, we show that verifying whether a given system uniquely assembles a desired supertile is co-NP-complete in the two-handed model, while it was known to be polynomially solvable in the seeded model.
arXiv:1201.1650v1 fatcat:vch7gbktajbsdbjxa5lbzutiwi

Chronic kidney disease in cats

Martha Cannon, Sarah Caney
2016 In practice (London. 1979)  
In the first article in this In Practice Focus, Martha Cannon sets out how to diagnose chronic kidney disease and identify the different stages.  ...  Martha Cannon is an RCVS Specialist in Feline Medicine and co-director of the Oxford Cat Clinic, a first-opinion and referral cat-only veterinary practice.  ... 
doi:10.1136/inp.i4918 fatcat:qtol5t454bckdnmvuxsdcp27bu

Phase Transitions in Random Dyadic Tilings and Rectangular Dissections [chapter]

Sarah Cannon, Sarah Miracle, Dana Randall
2014 Proceedings of the Twenty-Sixth Annual ACM-SIAM Symposium on Discrete Algorithms  
We study rectangular dissections of an n × n lattice region into rectangles of area n, where n = 2 k for an even integer k. We show that there is a natural edgeflipping Markov chain that connects the state space. A similar edge-flipping chain is also known to connect the state space when restricted to dyadic tilings, where each rectangle is required to have the form where s, t, u and v are nonnegative integers. The mixing time of these chains is open. We consider a weighted version of these
more » ... ov chains where, given a parameter λ > 0, we would like to generate each rectangular dissection (or dyadic tiling) σ with probability proportional to λ |σ| , where |σ| is the total edge length. We show there is a phase transition in the dyadic setting: when λ < 1, the edge-flipping chain mixes in time O(n 2 log n), and when λ > 1, the mixing time is exp(Ω(n 2 )). Simulations suggest that the chain converges quickly when λ = 1, but this case remains open. The behavior for general rectangular dissections is more subtle, and even establishing ergodicity of the chain requires a careful inductive argument. As in the dyadic case, we show that the edge-flipping Markov chain for rectangular dissections requires exponential time when λ > 1. Surprisingly, the chain also requires exponential time when λ < 1, which we show using a different argument. Simulations suggest that the chain converges quickly at the isolated point λ = 1.
doi:10.1137/1.9781611973730.104 dblp:conf/soda/CannonMR15 fatcat:f2v4kgjh4vhgjnmtrhjqv3neba

Conflict-free graph orientations with parity constraints [article]

Sarah Cannon, Mashhood Ishaque, Csaba Tóth
2012 arXiv   pre-print
It is known that every multigraph with an even number of edges has an even orientation (i.e., all indegrees are even). We study parity constrained graph orientations under additional constraints. We consider two types of constraints for a multigraph G=(V,E): (1) an exact conflict constraint is an edge set C in E and a vertex v in V such that C should not equal the set of incoming edges at v; (2) a subset conflict constraint is an edge set C in E and a vertex v in V such that C should not be a
more » ... bset of incoming edges at v. We show that it is NP-complete to decide whether G has an even orientation with exact or subset conflicts, for all conflict sets of size two or higher. We present efficient algorithms for computing parity constrained orientations with disjoint exact or subset conflict pairs.
arXiv:1203.3256v2 fatcat:6pfhqqutxfgp3evxthiplkcr3q

Polynomial mixing of the edge-flip Markov chain for unbiased dyadic tilings [article]

Sarah Cannon, David Levin, Alexandre Stauffer
2016 arXiv   pre-print
Cannon, Miracle, and Randall considered the mixing time of the edge-flip Markov chain for a weighted version of dyadic tilings [2] .  ... 
arXiv:1611.03636v1 fatcat:gssfcjs5lrhadobw7tjngdlqwm

Recommendations to clarify NASA open source requirements [article]

John D. Haiducek, Thom R. Edwards, Wade Duvall, Sarah R. Cannon, Kai Germaschewski, Jason E. Kooi
2021 arXiv   pre-print
The software community has specific definitions for terms such as "open source software," "free software," and "permissive license," but scientists proposing software development efforts to NASA are not always knowledgeable about these definitions. Misunderstandings about the meaning of these terms can result in problems of fairness with solicitations, because scientists who interpret the terms differently than NASA intends may either needlessly limit the scope of their proposed work, or
more » ... ngly propose work that does not comply with software licensing requirements. It is therefore recommended that NASA adopt definitions of the above terms that are in line with software community usage, that these definitions be communicated as part of solicitations to ensure a common understanding, and that proposals be required to identify what software licenses the proposers expect to use.
arXiv:2111.02550v1 fatcat:wfa3upcf7zbt5pwtk53c7vjkgi

Conflict-Free Graph Orientations with Parity Constraints [chapter]

Sarah Cannon, Mashhood Ishaque, Csaba D. Tóth
2012 Lecture Notes in Computer Science  
It is known that every multigraph with an even number of edges has an even orientation (i.e., all indegrees are even). We study parity constrained graph orientations under additional constraints. We consider two types of constraints for a multigraph G = (V, E): (1) an exact conflict constraint is an edge set C ⊆ E and a vertex v ∈ V such that C should not equal the set of incoming edges at v; (2) a subset conflict constraint is an edge set C ⊆ E and a vertex v ∈ V such that C should not be a
more » ... set of incoming edges at v. We show that it is NP-complete to decide whether G has an even orientation with exact or subset conflicts, for all conflict sets of size two or higher. We present efficient algorithms for computing parity constrained orientations with disjoint exact or subset conflict pairs.
doi:10.1007/978-3-642-30347-0_9 fatcat:qzl54ploc5gwdetts52womve6u

Math Is in the Title

Kayla D. Myers, Susan O. Cannon, Sarah Bridges-Rhoads
2017 International review of Qualitative Research  
Kayla and Susan needed publications, and Sarah needed to show her university that she was writing with doctoral students.  ...  Others have experimented with writing conventions (e.g., , including ourselves (Bridges-Rhoads, 2015; Cannon & Holbrook, in press; Van Cleave & Bridges-Rhoads, in press), searching for ways conventions  ...  called ''Parental Motivation and Nature Schools,'' which would produce research Sarah promised to share with a local nature-based elementary school.  ... 
doi:10.1525/irqr.2017.10.3.309 fatcat:6fnxirfbtjgondcxeroqlrzno4
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