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Combined analysis of genome-wide expression and copy number profiles to identify key altered genomic regions in cancer
2012
BMC Genomics
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Analysis of DNA copy number alterations and gene expression changes in human samples have been used to find potential target genes in complex diseases. Recent studies have combined these two types of data using different strategies, but focusing on finding gene-based relationships. However, it has been proposed that these data can be used to identify key genomic regions, which may enclose causal genes under the assumption that disease-associated gene expression changes are caused by genomic
doi:10.1186/1471-2164-13-s5-s5
pmid:23095915
pmcid:PMC3476997
fatcat:nxyqywsg5rdkpfjfdx6p6pevnm
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... rations. Results: Following this proposal, we undertake a new integrative analysis of genome-wide expression and copy number datasets. The analysis is based on the combined location of both types of signals along the genome. Our approach takes into account the genomic location in the copy number (CN) analysis and also in the gene expression (GE) analysis. To achieve this we apply a segmentation algorithm to both types of data using paired samples. Then, we perform a correlation analysis and a frequency analysis of the gene loci in the segmented CN regions and the segmented GE regions; selecting in both cases the statistically significant loci. In this way, we find CN alterations that show strong correspondence with GE changes. We applied our method to a human dataset of 64 Glioblastoma Multiforme samples finding key loci and hotspots that correspond to major alterations previously described for this type of tumors. Conclusions: Identification of key altered genomic loci constitutes a first step to find the genes that drive the alteration in a malignant state. These driver genes can be found in regions that show high correlation in copy number alterations and expression changes.
Identification of expression patterns in the progression of disease stages by integration of transcriptomic data
2016
BMC Bioinformatics
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In the study of complex diseases using genome-wide expression data from clinical samples, a difficult case is the identification and mapping of the gene signatures associated to the stages that occur in the progression of a disease. The stages usually correspond to different subtypes or classes of the disease, and the difficulty to identify them often comes from patient heterogeneity and sample variability that can hide the biomedical relevant changes that characterize each stage, making
doi:10.1186/s12859-016-1290-4
pmid:28185568
pmcid:PMC5133487
fatcat:jm4ouggjbbeujbulhikz5mr4re
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... d differential analysis inadequate or inefficient. Results: We propose a methodology to study diseases or disease stages ordered in a sequential manner (e.g. from early stages with good prognosis to more acute or serious stages associated to poor prognosis). The methodology is applied to diseases that have been studied obtaining genome-wide expression profiling of cohorts of patients at different stages. The approach allows searching for consistent expression patterns along the progression of the disease through two major steps: (i) identifying genes with increasing or decreasing trends in the progression of the disease; (ii) clustering the increasing/decreasing gene expression patterns using an unsupervised approach to reveal whether there are consistent patterns and find genes altered at specific disease stages. The first step is carried out using Gamma rank correlation to identify genes whose expression correlates with a categorical variable that represents the stages of the disease. The second step is done using a Self Organizing Map (SOM) to cluster the genes according to their progressive profiles and identify specific patterns. Both steps are done after normalization of the genomic data to allow the integration of multiple independent datasets. In order to validate the results and evaluate their consistency and biological relevance, the methodology is applied to datasets of three different diseases: myelodysplastic syndrome, colorectal cancer and Alzheimer's disease. A software script written in R, named genediseasePatterns, is provided to allow the use and application of the methodology. (Continued on next page)
Símbolos, significados y prácticas asociados a las finanzas personales en estudiantes universitarios
2018
Suma de Negocios
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La investigación presentada en este artículo fue financiada por la Universidad Santo Tomás de Colombia a través del Acta Nº 17130060 otorgada al primer autor. ...
Queremos agradecer muy especialmente a las estudiantes Mayerli Medina, Michelle Escobar, Dayana Vargas y Juliana Moreno pertenecientes al semillero de Branding de la Facultad de Mercadeo de la Universidad Santo ...
doi:10.14349/sumneg/2018.v9.n19.a2
fatcat:viupmyi6svhanmw25xklty2mii
50 ANOS DE INVESTIGACIÓN ECONÓMICA EN GALICIA, 1967-2017
2018
Revista Galega de Economía
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Directores do período 1992-2018, cuxas teses foron dirixidas por Xosé Manuel Pinho, Joaquín Calors, 2003 Neves Maldonado, Isabel Alexandara, Blanco Dopico, Aibar Guzmán, Beatriz, 1997; Aibar Martínez Hernández ...
Director 1992 -2006 2007 Crespo Domínguez, Miguel Ángel 1983 , UVIGO Martín-Casal García, José Antonio, 1997; Rodríguez Rodríguez, Mª Paz, 2001; Sáez Ocejo, José Luis, 1995 Bandeira, Ana Mª Alves, 2009 Santos ...
doi:10.15304/rge.27.3.5627
fatcat:6pwgpsuzqrhr5jtvszacrqsau4
Acknowledgement to Reviewers of Sustainability in 2019
2020
Sustainability
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Da Silva, Paula
Fabbri, Kristian
Fabbricino, Massimiliano
Faber, Anne
Fabiano, Bruno
Fabregat-Aibar, Laura
Fabrizio, Enrico
Facca Miess, Tina M. ...
Said
Fornacca, Davide
Fornari, Fabrizio
Foroni, Ilaria
Forster, Ian
Förster, Kristian
Forte, Fabiana
Forte, Giovanni
Forthmann, Boris
Fortier, Marie-Odile
Fortmann, Charles
Fortuny Santos ...
doi:10.3390/su12020742
fatcat:sghtijyfcbhcfjbkc42m4yvtgi
La «Valoración de 1607» en la Navarra Media Oriental y central
1995
Cuadernos de Historia Moderna
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La valoración de las casas de Sangliesa (1612) « abunda en estos ejemplos: Joan de Sara, bastero, vive en una casa alquilada de 800 ducs. por la que paga 12 ducs. anuales a su propietario Felipe de Leoz ...
maestros de escuela, obreros de la villa, guardas, justicias, tenientes de justicia, fiscales, sustitutos fiscales, porteros, pregoneros públicos, solicitadores, mudalafes, fieles ejecutores y familiares de Santo ...
doaj:cecd570dae9942c6a42125292e369e42
fatcat:ili4oznmm5gbdildboolsdixce
Aguas milagrosas contra plagas España s. XVII Aguas milagrosas contra plagas en la España del siglo XVII 1 Miraculous waters against rural plagues in the XVII Century Spain
unpublished
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De entre ellos, brilló con luz propia la basílica de San Gregorio Ostiense, donde se custodiaba la cabeza del santo. Palabras clave: aguas milagrosas, agua bendita, reliquias, imágenes, siglo XVII. ...
Para este tema, ver Sara T. NALLE, God in La Mancha. ...
hacer frente, de forma desesperada, a una plaga de langosta: "Dos regidores, cuatro insaculados en el Ayuntamiento y otros cuatro eclesiásticos, todos llevando hachas, salieron a recibirla a la muga de Aibar ...
fatcat:qpqwghzrgrgqrifbqzxshxv6b4
Il ruolo dei vescovi delle diocesi di regio patronato tra Spagna e Italia
[chapter]
2014
Circulations artistiques dans la Couronne d'Aragon
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Joan-Hilari Muñoz i Sebastià
Sara Caredda La actuación artística de los obispos y del cabildo en la catedral de Cagliari : el caso de la capilla de la Merced
L'EXEMPLE DE GÉRONE
Francesc Miralpeix ...
de los sacramentos, aprovechados aquí para lanzar un sutil pero claro ataque contra judíos y moros; y en esas composiciones corales, con am-il. 7 -Pedro Aibar Jiménez (atribución), Traslado procesional ...
doi:10.4000/books.pupvd.7981
fatcat:titg46hefnejtnfsktpeye4j7y
La Ley de Confesiones y Congregaciones Religiosas de 1933 y la fundación de las descalzas reales de Madrid
2012
Hispania Sacra
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-Sara Díaz Orro, natural de la Coruña, dote seis mil pesetas.
-Carmen García Pomareda, natural de Madrid, dote seis mil pesetas. ...
comunicada la misma en 20 de febrero de 1935. 49 En el año de la solicitud la abadesa era Dª María Paz Gaullés Chocarro, su composición era: Religiosas Profesas: -María Paz Gallués Chocarros, natural de Aibar ...
doi:10.3989/hs.2012.029
fatcat:gimmq73teza2lgsmt4owwrmqgm
Estación Experimental de Aula Dei. Memoria / Annual Report 2008
[article]
2011
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AGROFORESTRY SYSTEMS
2008
72
173
186
Nhan, NC; Zazubovich, V; Reppert, M;
Neupane, B; Picorel, R; Seibert, M;
Jankowiak, R
JOURNAL OF PHYSICAL
CHEMISTRY B
2008
112
9921
9934
Palacio, Sara ...
protegido bajo la denominación de
origen "melocotón de Calanda"
Libro de Resumenes del IX Simposio Nacional y VI Ibérico sobre
Maduración y Postcosecha
2008
39
40
Zapata, N.,
Burguete, J., Santos ...
doi:10.20350/digitalcsic/10208
fatcat:7zdkf4na6zhn5mmogflyyydbke
Euskal toponymia eta dialektologia
unpublished
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Ataunen hurrengokook ditugu: 50 Aiznabardi, "afio 1707 Monte Aiznabardi",
(55) Santos A. Garcia Larraguera, EI gran Priorado de Navarra de la Orden de Sanjuan deJerusalen, siglos XII-XIII,
t. ...
Se Haman: Vizcaya, montes de Aibar, Roncal y Atondo, un barranco de Guetadar, un arroyo que es afluente del do Aragon, parajes de Garde (Roncal) y Echarri-Aranaz, todos ellos en Navarra, y un barrio de ...
fatcat:pngu3jm5e5dezhqpt4lducualm
Dossier Chile A la sombra de la catástrofe. Nuevas miradas sobre el testimonio chileno
2019
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Nuevas miradas sobre el testimonio chileno Coordinado por José Santos Herceg Introducción, Carolina Pizarro Cortés El campo testimonial chileno: una mirada de conjunto, Carolina Pizarro Cortés y José Santos ...
En esta línea está la representación de santos y revolucionarios que ha tenido un soporte también en la historieta o cómic. ...
Por ejemplo, el mismo Quinteros refiere el suicidio de Sanguinetti (38); Cozzi, el de un ex GAP (Estadio 50-1); Benavente (22) e Ibar Aibar (217 y siguientes), el de Oscar Vega. ...
doi:10.13130/2035-7680/11732
fatcat:opatyqsikjd3jmqbupdoha5b4y
ANÁLISIS DE COMPORTAMIENTOS RELACIONADOS CON LA SALUD: EFECTOS DE UN PROGRAMA DE INTERVENCIÓN MULTICOMPONENTE EN ADOLESCENTES DE LA CIUDAD DE HUESCA
2018
Zenodo
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Alberto Aibar y D. Luis García, por haber aceptado el reto de tutorizar una tesis doctoral a una mente tan inquieta. ...
Nota: Este estudio está publicado.Sevil, J., García-González, L., Abós, A., Generelo, E., & Aibar, A. (2018). ...
doi:10.5281/zenodo.3354013
fatcat:mg4ii4o3irhq5pbgvvpmsm5nr4
(re) DISEÑO DESOBEDIENTE
2018
INMATERIAL. Diseño, Arte y Sociedad
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The map-as-entanglement is representation and orientation in permanent tension (de Sousa Santos, 1995, p.472). 14 Boaventura De Sousa Santos points out that "the map distorts reality through […] scale, ...
claim that the map is an "unofficial, and, likely, incomplete record" (Suárez Val, n.d.; my translation) materialises an(other state) absence: the lack of official statistics on feminicide. 18 De Sousa Santos ...
Los grandes trazados urbanos, que tienen como ejemplo la reforma de París emprendida por Haussmann o la Barcelona del Plan Cerdá (Aibar y Bijker, 1997) , dieron origen al nacimiento del urbanismo moderno ...
doi:10.46516/inmaterial.v3.73
fatcat:aqujywiaczfujoko3lmz6q4jqi
Schuhmacher-Seto, 1993a y b, 1994a y b; Silnitski
1970
unpublished
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-"El vascuence en Gallipienzo y la Val de Aibar", FLV, XXIV, 60 (1992b), pp. 271-275. -"El vascuence en Aoiz (Siglos XVIII-XIX)", FLV, XXIV, 61 (1992c), pp. 457-480. -"El P. ...
A caballo entre los siglos XVII y XVIII se encuentra la obra de Etxeberri de Sara, perteneciente a la escuela de esta localidad labortana liderada por Axular, y cuya influencia es innegable en Etxeberri ...
fatcat:fv4d7o5xnfhthkm3w567a2atva
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