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Mary McGlohon, Stephen Bay, Markus G. Anderle, David M. Steier, Christos Faloutsos
2009 Proceedings of the 15th ACM SIGKDD international conference on Knowledge discovery and data mining - KDD '09  
This work builds upon the belief propagation algorithm for use in detecting collusion and other fraud schemes. We propose an algorithm called SNARE (Social Network Analysis for Risk Evaluation).  ...  We also apply SNARE to the task of graph labeling in general on publicly-available datasets.  ...  In addition to their support and feedback, we would like to acknowledge the assistance of our colleagues within the Center for Advanced Research working on the Sherlock system: Jeff DeLisio, Mave Houston  ... 
doi:10.1145/1557019.1557155 dblp:conf/kdd/McGlohonBASF09 fatcat:zl6mwtqbevhitlcvrodc6b5mmi

Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion

M. C. Chicka, Q. Ren, D. Richards, L. M. Hellman, J. Zhang, M. G. Fried, S. W. Whiteheart
2015 Biochemical Journal  
We show that Munc13-4 enhances in vitro SNARE-dependent, proteoliposome fusion in a Ca 2+ -and phosphatidylserine (PS)-dependent manner that was independent of SNARE concentrations.  ...  Analytical ultracentrifugation measurements indicated that, in solution, Munc13-4 was a monomeric prolate ellipsoid with dimensions consistent with a molecule that could bridge two fusing membranes.  ...  This work is supported by NIH grants (HL56652 and HL082193) to S.W.W., a predoctoral fellowship from the Great Rivers Affiliate of the AHA (0615238B) to Q.R., and a postdoctoral fellowship from the Great  ... 
doi:10.1042/bj20151150 pmid:26637270 pmcid:PMC5446777 fatcat:nmp6e3b2vzefnmmawep23gx5xu

The N-Ethylmaleimide-Sensitive Factor and Dysbindin Interact To Modulate Synaptic Plasticity

A. Gokhale, A. P. Mullin, S. A. Zlatic, C. A. Easley, M. E. Merritt, N. Raj, J. Larimore, D. E. Gordon, A. A. Peden, S. Sanyal, V. Faundez
2015 Journal of Neuroscience  
Dysbindin is a schizophrenia susceptibility factor and subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenesis, and in neurons, synaptic  ...  To test the hypothesis that NSF and dysbindin/BLOC-1 participate in a pathway-regulating synaptic function, we examined the role for NSF in dysbindin/BLOC-1-dependent synaptic homeostatic plasticity in  ...  the number of SNAREs identified in content and number (11 SNAREs detected; Fig. 4E ).  ... 
doi:10.1523/jneurosci.4724-14.2015 pmid:25972187 pmcid:PMC4429160 fatcat:p7ocda656jbwbl7mmyxydhcsv4

DP-GCN: Node Classification Based on Both Connectivity and Topology Structure Convolutions for Risky Seller Detection [article]

Chen Zhe, Aixin Sun
2021 arXiv   pre-print
Detecting risky (or bad) sellers on such a payment network is crucial to payment service providers for risk management and legal compliance.  ...  In this research, we formulate this task as a node classification task. Specifically, we aim to predict a label for each seller in a payment network, by analysing its properties and/or interactions.  ...  Snare: a link analytic system for graph labeling and risk detection. [46] Zhedong Zheng, Liang Zheng, Michael Garrett, Yi Yang, Mingliang Xu, and In Proceedings of the 15th ACM SIGKDD international  ... 
arXiv:2112.04757v1 fatcat:w2fozgyeqjfv5bsh7gi4ohg564

Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease

Shyra J. Gardai, Wenxian Mao, Birgitt Schüle, Michael Babcock, Sue Schoebel, Carlos Lorenzana, Jeff Alexander, Sam Kim, Heather Glick, Kathryn Hilton, J. Kent Fitzgerald, Manuel Buttini (+9 others)
2013 PLoS ONE  
Moreover, increased a-synuclein and altered phagocytosis may provide a useful biomarker for human PD.  ...  In summary, this paper provides 1) a new animal model to measure a-synuclein dysfunction; 2) a cellular system to measure synchronized mobilization of a-synuclein and its functional interactions; 3) observations  ...  Acknowledgments We would like to thank all the patients and healthy volunteers for providing skin and blood samples for this study.  ... 
doi:10.1371/journal.pone.0071634 pmid:24058406 pmcid:PMC3751933 fatcat:hs35hwgqcbbc3bojqbomj53mfa

Investigation of striatal soluble N-ethylmaleimide sensitive factor attachment receptor (SNARE) proteins in schizophrenia

Vilte Elenute Barakauskas
A mass-spectrometry based assay was developed and used to measure SNAP-25 protein isoform levels.  ...  The functional consequences of SNARE alterations were investigated by developing a novel ELISA assay to measure SNARE protein interactions.  ...  Detection of the protein-antibody complex is then achieved directly if the detection antibody is labeled, or indirectly by using a labeled secondary antibody which binds the first one [358] .  ... 
doi:10.14288/1.0071382 fatcat:c3bzmyf4zfb3zdtcc5pyipucni

The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins

Dönem Avci, Nicole S. Malchus, Ronny Heidasch, Holger Lorenz, Karsten Richter, Michelle Neßling, Marius K. Lemberg
2018 Journal of Biological Chemistry  
Inhibition of SPP activity rescues the phenotype without the need for new protein synthesis, and this rescue depends on a pre-existing pool of proteins in the Golgi.  ...  of ER morphogenic proteins, including the SNARE protein syntaxin-18.  ...  Acknowledgments-We thank Anne-Lore Schlaitz and Sara Suna Yücel for critical reading of the manuscript and Bernd Hessling and Thomas Ruppert (ZMBH, MS facility) for MS analysis.  ... 
doi:10.1074/jbc.ra118.005642 pmid:30578301 pmcid:PMC6393608 fatcat:hwl22eg64fg3phpf4whuxjw3xq

Bioanalysis of Eukaryotic Organelles

Chad P. Satori, Michelle M. Henderson, Elyse A. Krautkramer, Vratislav Kostal, Mark M. Distefano, Edgar A. Arriaga
2013 Chemical Reviews  
Vps45 is a SNARE protein essential for organelle fusion.  ...  Another common classification is R-SNARE (v-SNARE) and Q-SNARE (t-SNARE).  ...  Hsc70 NIH3T3, RALA255-10G CFM, TEM Hsc70-positive lysosomes interacted less with autophagosomes; these lysosomes appeared prevalent in CMA; the interaction was also ATP, GTP, temperature, and lysosomal  ... 
doi:10.1021/cr300354g pmid:23570618 pmcid:PMC3676536 fatcat:3xuwqf2lpvcv3kuaoaas42oxje

Possible relationship between common genetic variation and white matter development in a pilot study of preterm infants

Michelle L. Krishnan, Zi Wang, Matt Silver, James P. Boardman, Gareth Ball, Serena J. Counsell, Andrew J. Walley, Giovanni Montana, Anthony David Edwards
2016 Brain and Behavior  
Conclusions: This suggests an important role for lipid pathways in influencing development of white matter in preterm infants, and in particular a significant role for interindividual genetic variation  ...  Common genetic variation may mediate vulnerability to the insult of prematurity and provide opportunities to predict and modify risk.  ...  This study was supported by the NIHR BRCs of Imperial College London and Guy's and St Thomas' NHS Foundation Trust/King's College London, and the MRC through Strategic Grant to ADE and Clinical Training  ... 
doi:10.1002/brb3.434 pmid:27110435 pmcid:PMC4821839 fatcat:vxmuoemh7ndtphg5azp2lo24gi

Protein Interaction Network Biology in Neuroscience

Avik Basu, Peter EA Ash, Benjamin Wolozin, Andrew Emili
2020 Proteomics  
Yet while knowledge of brain PPINs is steadily improving, the complexity and dynamic nature of the heterogeneous central nervous system in normal and disease contexts poses a formidable experimental challenge  ...  Perturbations to the protein-protein interaction networks (PPIN) present in neurons, glia and other cell-types has been linked to multifactorial neurological disorders.  ...  Acknowledgements The authors sincerely thank Sadhna Phanse, Benjamin Blum, and Yusuf Ahmed for their valuable inputs, and members of the Emili and Wolozin groups for helpful discussion and feedback.  ... 
doi:10.1002/pmic.201900311 pmid:33314619 fatcat:euwcnmyetvg7jg4azbgavrnp5e

12-Lipoxygenase in Opioid-Induced Delayed Cardioprotection: Gene Array, Mass Spectrometric, and Pharmacological Analyses

H. H. Patel
2003 Circulation Research  
We characterized the role of 12-LO in an intact rat model of delayed PC induced by a ␦-opioid agonist SNC-121 (SNC). Rats were pretreated with SNC and allowed to recover for 24 hours.  ...  Gene array data showed a significant induction of 12-LO message (PϽ0.05) after opioid pretreatment.  ...  Acknowledgments This work was supported by National Heart, Lung, and Blood Institute grant HL-08311 (G.J.G.), by a Predoctoral Fellowship from the American Heart Association (H.H.P.), and by a Postdoctoral  ... 
doi:10.1161/01.res.0000065167.52922.f6 pmid:12623876 fatcat:mqyaxe2kdngidleb4ev25gjmfy

HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells

Jiaying Yu, Xin He, Aihua Wei, Teng Liu, Qin Zhang, Ying Pan, Zhenhua Hao, Lin Yang, Yefeng Yuan, Zhao Zhang, Chang Zhang, Chanjuan Hao (+2 others)
2020 Frontiers in Immunology  
For some HPS subtypes, such as HPS-1, it is common to have symptoms of HPS-associated inflammatory bowel disease (IBD). However, its underlying mechanism is largely unknown.  ...  HPS1, a BLOC-3 subunit that acts as a guanine nucleotide exchange factor of Rab32/38, may play a role in the removal of VAMP7 during the maturation of large dense core vesicles of Paneth cells.  ...  This establishes a link between the dysfunction of PC LDCVs and the susceptibility of HPS-associated IBD.  ... 
doi:10.3389/fimmu.2020.560110 pmid:33224134 pmcid:PMC7674556 fatcat:iypcc7secrhbtfsbh6hzihmhf4

The electrochemical detection of bioterrorism agents: a review of the detection, diagnostics, and implementation of sensors in biosafety programs for Class A bioweapons

Connor O'Brien, Kathleen Varty, Anna Ignaszak
2021 Microsystems & Nanoengineering  
We therefore present a wide array of electrochemical sensing platforms currently being fabricated, a brief summary of Class A bioweapons, and the potential future of bioweapon detection and biosafety.  ...  It is consequently prudent that easy detection of bioweapons is available to governments for protecting their people.  ...  Author contributions C.O. and K.V. wrote, researched, and structured the manuscript. A.I. provided her expertise on sensing platforms and provided editing.  ... 
doi:10.1038/s41378-021-00242-5 pmid:33585038 pmcid:PMC7872827 fatcat:r62tzecwjvfd7l5452peqomjsm

Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease

Robert Powers, Shulei Lei, Annadurai Anandhan, Darrell Marshall, Bradley Worley, Ronald Cerny, Eric Dodds, Yuting Huang, Mihalis Panayiotidis, Aglaia Pappa, Rodrigo Franco
2017 Metabolites  
Exposure to environmental toxicants including pesticides and metals (e.g., paraquat (PQ) and manganese (Mn)) is also recognized as an important PD risk factor.  ...  Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia  ...  a major risk for human populations.  ... 
doi:10.3390/metabo7020022 pmid:28538683 pmcid:PMC5487993 fatcat:yv3hdnx2obbwvpvyzrklcfdcfu

Proteomic analysis of hippocampus in mice following long-term exposure to low levels of copper

Qian Sun, Ming Ying, Quan Ma, Zhijun Huang, Liangyu Zou, Jianjun Liu, Zhixiong Zhuang, Xifei Yang
2016 Toxicology Research  
A body of evidence indicates that environmental Cu exposure may be a risk factor for Page 3 of 33 Toxicology Research Toxicology Research Accepted Manuscript cognitive impairment 7, 8 .  ...  The graphed results depict the mean ± SEM. *P < 0.05, **P<0.01 for Cu-treated mice vs control mice (n = 8-10 for each group).  ... 
doi:10.1039/c5tx00456j pmid:30090419 pmcid:PMC6060675 fatcat:6kwcl6q2wnhydktgafvfvud5de
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