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SNARE
2009
Proceedings of the 15th ACM SIGKDD international conference on Knowledge discovery and data mining - KDD '09
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This work builds upon the belief propagation algorithm for use in detecting collusion and other fraud schemes. We propose an algorithm called SNARE (Social Network Analysis for Risk Evaluation). ...
We also apply SNARE to the task of graph labeling in general on publicly-available datasets. ...
In addition to their support and feedback, we would like to acknowledge the assistance of our colleagues within the Center for Advanced Research working on the Sherlock system: Jeff DeLisio, Mave Houston ...
doi:10.1145/1557019.1557155
dblp:conf/kdd/McGlohonBASF09
fatcat:zl6mwtqbevhitlcvrodc6b5mmi
Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion
2015
Biochemical Journal
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We show that Munc13-4 enhances in vitro SNARE-dependent, proteoliposome fusion in a Ca 2+ -and phosphatidylserine (PS)-dependent manner that was independent of SNARE concentrations. ...
Analytical ultracentrifugation measurements indicated that, in solution, Munc13-4 was a monomeric prolate ellipsoid with dimensions consistent with a molecule that could bridge two fusing membranes. ...
This work is supported by NIH grants (HL56652 and HL082193) to S.W.W., a predoctoral fellowship from the Great Rivers Affiliate of the AHA (0615238B) to Q.R., and a postdoctoral fellowship from the Great ...
doi:10.1042/bj20151150
pmid:26637270
pmcid:PMC5446777
fatcat:nmp6e3b2vzefnmmawep23gx5xu
The N-Ethylmaleimide-Sensitive Factor and Dysbindin Interact To Modulate Synaptic Plasticity
2015
Journal of Neuroscience
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Dysbindin is a schizophrenia susceptibility factor and subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenesis, and in neurons, synaptic ...
To test the hypothesis that NSF and dysbindin/BLOC-1 participate in a pathway-regulating synaptic function, we examined the role for NSF in dysbindin/BLOC-1-dependent synaptic homeostatic plasticity in ...
the number of SNAREs identified in content and number (11 SNAREs detected; Fig. 4E ). ...
doi:10.1523/jneurosci.4724-14.2015
pmid:25972187
pmcid:PMC4429160
fatcat:p7ocda656jbwbl7mmyxydhcsv4
DP-GCN: Node Classification Based on Both Connectivity and Topology Structure Convolutions for Risky Seller Detection
[article]
2021
arXiv
pre-print
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Detecting risky (or bad) sellers on such a payment network is crucial to payment service providers for risk management and legal compliance. ...
In this research, we formulate this task as a node classification task. Specifically, we aim to predict a label for each seller in a payment network, by analysing its properties and/or interactions. ...
Snare: a link analytic system for graph labeling and risk detection. [46] Zhedong Zheng, Liang Zheng, Michael Garrett, Yi Yang, Mingliang Xu, and
In Proceedings of the 15th ACM SIGKDD international ...
arXiv:2112.04757v1
fatcat:w2fozgyeqjfv5bsh7gi4ohg564
Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease
2013
PLoS ONE
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Moreover, increased a-synuclein and altered phagocytosis may provide a useful biomarker for human PD. ...
In summary, this paper provides 1) a new animal model to measure a-synuclein dysfunction; 2) a cellular system to measure synchronized mobilization of a-synuclein and its functional interactions; 3) observations ...
Acknowledgments We would like to thank all the patients and healthy volunteers for providing skin and blood samples for this study. ...
doi:10.1371/journal.pone.0071634
pmid:24058406
pmcid:PMC3751933
fatcat:hs35hwgqcbbc3bojqbomj53mfa
Investigation of striatal soluble N-ethylmaleimide sensitive factor attachment receptor (SNARE) proteins in schizophrenia
2010
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A mass-spectrometry based assay was developed and used to measure SNAP-25 protein isoform levels. ...
The functional consequences of SNARE alterations were investigated by developing a novel ELISA assay to measure SNARE protein interactions. ...
Detection of the protein-antibody complex is then achieved directly if the detection antibody is labeled, or indirectly by using a labeled secondary antibody which binds the first one [358] . ...
doi:10.14288/1.0071382
fatcat:c3bzmyf4zfb3zdtcc5pyipucni
The intramembrane protease SPP impacts morphology of the endoplasmic reticulum by triggering degradation of morphogenic proteins
2018
Journal of Biological Chemistry
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Inhibition of SPP activity rescues the phenotype without the need for new protein synthesis, and this rescue depends on a pre-existing pool of proteins in the Golgi. ...
of ER morphogenic proteins, including the SNARE protein syntaxin-18. ...
Acknowledgments-We thank Anne-Lore Schlaitz and Sara Suna Yücel for critical reading of the manuscript and Bernd Hessling and Thomas Ruppert (ZMBH, MS facility) for MS analysis. ...
doi:10.1074/jbc.ra118.005642
pmid:30578301
pmcid:PMC6393608
fatcat:hwl22eg64fg3phpf4whuxjw3xq
Bioanalysis of Eukaryotic Organelles
2013
Chemical Reviews
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Vps45 is a SNARE protein essential for organelle fusion. ...
Another common classification is R-SNARE (v-SNARE) and Q-SNARE (t-SNARE). ...
Hsc70 NIH3T3, RALA255-10G CFM, TEM Hsc70-positive lysosomes interacted less with autophagosomes; these lysosomes appeared prevalent in CMA; the interaction was also ATP, GTP, temperature, and lysosomal ...
doi:10.1021/cr300354g
pmid:23570618
pmcid:PMC3676536
fatcat:3xuwqf2lpvcv3kuaoaas42oxje
Possible relationship between common genetic variation and white matter development in a pilot study of preterm infants
2016
Brain and Behavior
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Conclusions: This suggests an important role for lipid pathways in influencing development of white matter in preterm infants, and in particular a significant role for interindividual genetic variation ...
Common genetic variation may mediate vulnerability to the insult of prematurity and provide opportunities to predict and modify risk. ...
This study was supported by the NIHR BRCs of Imperial College London and Guy's and St Thomas' NHS Foundation Trust/King's College London, and the MRC through Strategic Grant to ADE and Clinical Training ...
doi:10.1002/brb3.434
pmid:27110435
pmcid:PMC4821839
fatcat:vxmuoemh7ndtphg5azp2lo24gi
Protein Interaction Network Biology in Neuroscience
2020
Proteomics
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Yet while knowledge of brain PPINs is steadily improving, the complexity and dynamic nature of the heterogeneous central nervous system in normal and disease contexts poses a formidable experimental challenge ...
Perturbations to the protein-protein interaction networks (PPIN) present in neurons, glia and other cell-types has been linked to multifactorial neurological disorders. ...
Acknowledgements The authors sincerely thank Sadhna Phanse, Benjamin Blum, and Yusuf Ahmed for their valuable inputs, and members of the Emili and Wolozin groups for helpful discussion and feedback. ...
doi:10.1002/pmic.201900311
pmid:33314619
fatcat:euwcnmyetvg7jg4azbgavrnp5e
12-Lipoxygenase in Opioid-Induced Delayed Cardioprotection: Gene Array, Mass Spectrometric, and Pharmacological Analyses
2003
Circulation Research
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We characterized the role of 12-LO in an intact rat model of delayed PC induced by a ␦-opioid agonist SNC-121 (SNC). Rats were pretreated with SNC and allowed to recover for 24 hours. ...
Gene array data showed a significant induction of 12-LO message (PϽ0.05) after opioid pretreatment. ...
Acknowledgments This work was supported by National Heart, Lung, and Blood Institute grant HL-08311 (G.J.G.), by a Predoctoral Fellowship from the American Heart Association (H.H.P.), and by a Postdoctoral ...
doi:10.1161/01.res.0000065167.52922.f6
pmid:12623876
fatcat:mqyaxe2kdngidleb4ev25gjmfy
HPS1 Regulates the Maturation of Large Dense Core Vesicles and Lysozyme Secretion in Paneth Cells
2020
Frontiers in Immunology
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For some HPS subtypes, such as HPS-1, it is common to have symptoms of HPS-associated inflammatory bowel disease (IBD). However, its underlying mechanism is largely unknown. ...
HPS1, a BLOC-3 subunit that acts as a guanine nucleotide exchange factor of Rab32/38, may play a role in the removal of VAMP7 during the maturation of large dense core vesicles of Paneth cells. ...
This establishes a link between the dysfunction of PC LDCVs and the susceptibility of HPS-associated IBD. ...
doi:10.3389/fimmu.2020.560110
pmid:33224134
pmcid:PMC7674556
fatcat:iypcc7secrhbtfsbh6hzihmhf4
The electrochemical detection of bioterrorism agents: a review of the detection, diagnostics, and implementation of sensors in biosafety programs for Class A bioweapons
2021
Microsystems & Nanoengineering
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We therefore present a wide array of electrochemical sensing platforms currently being fabricated, a brief summary of Class A bioweapons, and the potential future of bioweapon detection and biosafety. ...
It is consequently prudent that easy detection of bioweapons is available to governments for protecting their people. ...
Author contributions C.O. and K.V. wrote, researched, and structured the manuscript. A.I. provided her expertise on sensing platforms and provided editing. ...
doi:10.1038/s41378-021-00242-5
pmid:33585038
pmcid:PMC7872827
fatcat:r62tzecwjvfd7l5452peqomjsm
Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease
2017
Metabolites
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Exposure to environmental toxicants including pesticides and metals (e.g., paraquat (PQ) and manganese (Mn)) is also recognized as an important PD risk factor. ...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia ...
a major risk for human populations. ...
doi:10.3390/metabo7020022
pmid:28538683
pmcid:PMC5487993
fatcat:yv3hdnx2obbwvpvyzrklcfdcfu
Proteomic analysis of hippocampus in mice following long-term exposure to low levels of copper
2016
Toxicology Research
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A body of evidence indicates that environmental Cu exposure may be a risk factor for
Page 3 of 33 Toxicology Research Toxicology Research Accepted Manuscript cognitive impairment 7, 8 . ...
The graphed results depict the mean ± SEM. *P < 0.05, **P<0.01 for Cu-treated mice vs control mice (n = 8-10 for each group). ...
doi:10.1039/c5tx00456j
pmid:30090419
pmcid:PMC6060675
fatcat:6kwcl6q2wnhydktgafvfvud5de
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