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Contact-Lens Biosensors

Ryan Tseng, Ching-Chuen Chen, Sheng-Min Hsu, Han-Sheng Chuang
<span title="2018-08-13">2018</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/taedaf6aozg7vitz5dpgkojane" style="color: black;">Sensors</a> </i> &nbsp;
Rapid diagnosis and screening of diseases have become increasingly important in predictive and preventive medicine as they improve patient treatment strategies and reduce cost as well as burden on our healthcare system. In this regard, wearable devices are emerging as effective and reliable point-of-care diagnostics that can allow users to monitor their health at home. These wrist-worn, head-mounted, smart-textile, or smart-patches devices can offer valuable information on the conditions of
more &raquo; ... ents as a non-invasive form of monitoring. However, they are significantly limited in monitoring physiological signals and biomechanics, and, mostly, rely on the physical attributes. Recently, developed wearable devices utilize body fluids, such as sweat, saliva, or skin interstitial fluid, and electrochemical interactions to allow continuous physiological condition and disease monitoring for users. Among them, tear fluid has been widely utilized in the investigation of ocular diseases, diabetes, and even cancers, because of its easy accessibility, lower complexity, and minimal invasiveness. By determining the concentration change of analytes within the tear fluid, it would be possible to identify disease progression and allow patient-oriented therapies. Considering the emerging trend of tear-based biosensing technology, this review article aims to focus on an overview of the tear fluid as a detection medium for certain diseases, such as ocular disorders, diabetes, and cancer. In addition, the rise and application of minimally invasive detection and monitoring via integrated contact lens biosensors will also be addressed, in regards to their practicality and current developmental progress.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/s18082651">doi:10.3390/s18082651</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30104496">pmid:30104496</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bxmm65nujvhdtb2ytilqgkj4ti">fatcat:bxmm65nujvhdtb2ytilqgkj4ti</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190222204804/http://pdfs.semanticscholar.org/3c65/d435b68680d99b4ef8613a6b0e5715ed6d4d.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3c/65/3c65d435b68680d99b4ef8613a6b0e5715ed6d4d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/s18082651"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

The involvement of neuroimmune cells in adipose innervation

Magdalena Blaszkiewicz, Elizabeth Wood, Sigi Koizar, Jake Willows, Ryan Anderson, Yu-Hua Tseng, James Godwin, Kristy L. Townsend
<span title="2020-12-09">2020</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uwxjca4bdnc5nan6667onkri6q" style="color: black;">Molecular Medicine</a> </i> &nbsp;
Background Innervation of adipose tissue is essential for the proper function of this critical metabolic organ. Numerous surgical and chemical denervation studies have demonstrated how maintenance of brain-adipose communication through both sympathetic efferent and sensory afferent nerves helps regulate adipocyte size, cell number, lipolysis, and 'browning' of white adipose tissue. Neurotrophic factors are growth factors that promote neuron survival, regeneration, and plasticity, including
more &raquo; ... te outgrowth and synapse formation. Peripheral immune cells have been shown to be a source of neurotrophic factors in humans and mice. Although a number of immune cells reside in the adipose stromal vascular fraction (SVF), it has remained unclear what roles they play in adipose innervation. We previously demonstrated that adipose SVF secretes brain derived neurotrophic factor (BDNF). Methods We now show that deletion of this neurotrophic factor from the myeloid lineage of immune cells led to a 'genetic denervation' of inguinal subcutaneous white adipose tissue (scWAT), thereby causing decreased energy expenditure, increased adipose mass, and a blunted UCP1 response to cold stimulation. Results We and others have previously shown that noradrenergic stimulation via cold exposure increases adipose innervation in the inguinal depot. Here we have identified a subset of myeloid cells that home to scWAT upon cold exposure and are Ly6C+ CCR2+ Cx3CR1+ monocytes/macrophages that express noradrenergic receptors and BDNF. This subset of myeloid lineage cells also clearly interacted with peripheral nerves in the scWAT and were therefore considered neuroimmune cells. Conclusions We propose that these myeloid lineage, cold induced neuroimmune cells (CINCs) are key players in maintaining adipose innervation as well as promoting adipose nerve remodeling under noradrenergic stimulation, such as cold exposure.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s10020-020-00254-3">doi:10.1186/s10020-020-00254-3</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33297933">pmid:33297933</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/etflxi52qbciplfz5qjkmngfly">fatcat:etflxi52qbciplfz5qjkmngfly</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201210065428/https://molmed.biomedcentral.com/track/pdf/10.1186/s10020-020-00254-3.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/df/30/df304cef4853a7e7174faecb32bbb443eb6f5847.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s10020-020-00254-3"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

Detection of Gearbox lubrication Using PSO-Based WKNN

Chun-Yao Lee, Cheng-Chien Kuo, Ryan Liu, I-Hsiang Tseng, Lu-Chen Chang
<span title="2013-06-01">2013</span> <i title="Walter de Gruyter GmbH"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jx4g6sjrrffvvm3ypedhd7eoyi" style="color: black;">Measurement Science Review</a> </i> &nbsp;
This paper proposes an optimization classification model, which combines particle swarm optimization (PSO) with weighted knearest neighbors (WKNN), namely PWKNN. The model optimizes the weight and k parameter of WKNN to improve the detection accuracy of gearbox lubrication levels. In the experiment, the current signals of the generator are measured, and the relative frequency spectrum of the measured signals is illustrated by using fast Fourier transform (FFT). The features from the spectrum
more &raquo; ... extracted, and then the optimal weight and k parameter of WKNN are obtained by using PSO. The average detection accuracy of gearbox lubrication levels is 96% by using PWKNN, which the result shows that the proposed PWKNN can efficiently detect the lubrication level of gearboxes. The experiment also shows that the performance of the proposed PWKNN by using the current signals of the generator is superior to that by using typical vibration signals of a gearbox. In addition, the accuracy can reach 95.4% even in environments with 20 dB noise interference.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2478/msr-2013-0019">doi:10.2478/msr-2013-0019</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bhxuoz6debbvth7ubdf3ks54ie">fatcat:bhxuoz6debbvth7ubdf3ks54ie</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190426120932/https://content.sciendo.com/downloadpdf/journals/msr/13/3/article-p108.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e6/4e/e64e0773565011ddf49dde87606be12bba0d8e83.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2478/msr-2013-0019"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Managing drug interactions in HIV-infected adults with comorbid illness

Christine A. Hughes, Alice Tseng, Ryan Cooper
<span title="2014-09-15">2014</span> <i title="Joule Inc."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/g2pnuunfpvfhlofd4el4s6p6vi" style="color: black;">CMAJ - Canadian Medical Association Journal</a> </i> &nbsp;
Ryan Cooper was involved in critical revision of the article.  ...  ), Toronto, Ont.; Leslie Dan Faculty of Pharmacy (Tseng), University of Toronto, Toronto, Ont.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1503/cmaj.131626">doi:10.1503/cmaj.131626</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25225224">pmid:25225224</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4284166/">pmcid:PMC4284166</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dvnzsldxlzcatdk3jizmahclcy">fatcat:dvnzsldxlzcatdk3jizmahclcy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719161849/http://www.cmaj.ca/content/cmaj/187/1/36.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ff/56/ff56fb9c502bb7fd5bd5c0b5ccf19a7ab5fad9f7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1503/cmaj.131626"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284166" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Fusion proteins of Arabidopsis cap-binding proteins: Cautionary "tails" of woe

Elizabeth Levins, Ching-Ying Tseng, Ryan M. Patrick, Laura K. Mayberry, Nicola Cole, Karen S. Browning
<span title="2016-07-02">2016</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4gbi2l2oj5cslkeyx677qw6qga" style="color: black;">Translation</a> </i> &nbsp;
The use of fluorescent proteins fused to other proteins has been very useful in revealing the location and function of many proteins. However, it is very important to show that the fusion of these reporter proteins does not impact the function of the protein of interest. Plants have 2 forms of the cap-binding protein that function in initiation of translation, eIF4E and a plant specific form, eIFiso4E. In an attempt to determine the cellular localization of eIFiso4E, fusions to GFP were made,
more &raquo; ... t were found to not be competent to rescue the lethal phenotype of plants lacking eIF4E and eIFiso4E. This suggested that the GFP fusions at either the N-or C-terminus of eIFiso4E were not functional. Biochemical analysis of the fusions revealed that eIFiso4EGFP fusions were not able to bind to m 7 GTP Sepharose indicating that they were not functional as cap-binding proteins. Analysis of eIF4EGFP fusions, both in yeast and in vitro, showed that the N-terminal fusion may be functional, whereas the C-terminal fusion bound m 7 GTP Sepharose very poorly and functioned poorly in yeast. These results highlight the importance of verification both biochemically and in vivo that reporter fusions of proteins maintain activity and are stable in order to prevent observations that may result in artifacts.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/21690731.2016.1257408">doi:10.1080/21690731.2016.1257408</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28090423">pmid:28090423</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5173309/">pmcid:PMC5173309</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4hl72ossvfcvdew6elftzljfa4">fatcat:4hl72ossvfcvdew6elftzljfa4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208194634/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5173309&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c5/78/c578d5d2c7f583496b769c11f48868b782a025c7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/21690731.2016.1257408"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> tandfonline.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173309" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Treatment sequencing strategy for hepatic epithelioid haemangioendothelioma

Ryan M. Thomas, Thomas A. Aloia, Mark J. Truty, Warren H. Tseng, Eugene A. Choi, Steven A. Curley, Jean N. Vauthey, Eddie K. Abdalla
<span title="">2014</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/koqy5ryzmbfnpafdot2qwos7me" style="color: black;">HPB</a> </i> &nbsp;
The biology of hepatic epithelial haemangioendothelioma (HEHE) is variable, lying intermediate to haemangioma and angiosarcoma. Treatments vary owing to the rarity of the disease and frequent misdiagnosis. Methods: Between 1989 and 2013, patients retrospectively identified with HEHE from a single academic cancer centre were analysed to evaluate clinicopathological factors and initial treatment regimens associated with survival. Results: Fifty patients with confirmed HEHE had a median follow-up
more &raquo; ... f 51 months (range 1-322). There was no difference in 5-year survival between patients presenting with unilateral compared with bilateral hepatic disease (51.4% versus 80.7%, respectively; P = 0.1), localized compared with metastatic disease (69% versus 78.3%, respectively; P = 0.7) or an initial treatment regimen of Surgery, Chemotherapy/ Embolization or Observation alone (83.3% versus 71.3% versus 72.4%, respectively; P = 0.9). However, 5-year survival for patients treated with chemotherapy at any point during their disease course was decreased compared with those who did not receive any chemotherapy (43.6% versus 82.9%, respectively; P = 0.02) and was predictive of a decreased overall survival on univariate analysis [HR 3.1 (CI 0.9-10.7), P = 0.02]. Conclusions: HEHE frequently follows an indolent course, suggesting that immediate treatment may not be the optimal strategy. Initial observation to assess disease behaviour may better stratify treatment options, reserving surgery for those who remain resectable/transplantable. Prospective cooperative trials or registries may confirm this strategy.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/hpb.12202">doi:10.1111/hpb.12202</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24308564">pmid:24308564</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4105907/">pmcid:PMC4105907</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lk6wd2ooanc5bdghtkfscql3iy">fatcat:lk6wd2ooanc5bdghtkfscql3iy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190416065005/https://core.ac.uk/download/pdf/81199693.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fc/1a/fc1a44e7ef129617db1e00111663ecb9377a7d78.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/hpb.12202"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105907" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Highly efficient 7,8,10-triphenylfluoranthene-doped blue organic light-emitting diodes for display application

Ricky J. Tseng, Ryan C. Chiechi, Fred Wudl, Yang Yang
<span title="2006-02-27">2006</span> <i title="AIP Publishing"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gahdfbfwljgajfxqbum465rt4u" style="color: black;">Applied Physics Letters</a> </i> &nbsp;
External quantum efficiency ͑%͒ CIE TPF 2.89 1.75 ͑0.177, 0.24͒ DPF+ 6 % TPF 3.33 2.48 ͑0.164, 0.188͒ DPF+ 1 % TPF 1.29 1.04 ͑0.168, 0.172͒ DPF 0.84 0.72 ͑0.168, 0.157͒ 093512-3 Tseng  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1063/1.2167814">doi:10.1063/1.2167814</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/sy7mlmzel5drjekhatakvxzu6u">fatcat:sy7mlmzel5drjekhatakvxzu6u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719104723/https://pure.rug.nl/ws/files/14465855/2006ApplPhysLettTseng.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c2/b9/c2b97f360b5fec75fa2ffcaeb382110d7e0dbf11.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1063/1.2167814"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Obstructive Sleep Apnea in Elective Spine Surgery: National Prevalence and Inpatient Outcomes

Andrew S. Chung, Ryan DiGiovanni, Steve Tseng, Joshua W. Hustedt, Norman Chutkan
<span title="2017-11-16">2017</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/eyrt4i6difai5f5enim36kqwky" style="color: black;">Global Spine Journal</a> </i> &nbsp;
Study Design: Retrospective cohort study. Objectives: Epidemiologic studies suggest that the prevalence of moderate to severe obstructive sleep apnea (OSA) is increasing. OSA has been linked to increased rates of postoperative complications following surgery. Large studies, however, regarding surgical outcomes in this patient population, particularly in the spine literature, are limited. Consequently, the purpose of this study was to assess the prevalence of and postoperative risks conferred by
more &raquo; ... OSA in the elective spine population. Methods: Using data from the National Inpatient Sample from 2008 to 2012, an estimated 56 372 (5.1%) patients with OSA undergoing elective cervical and thoracolumbar spine surgery were selected and compared to 1 052 837 patients without OSA undergoing the same procedures. Our primary outcome measures included postoperative complication rates, inpatient mortality, length of stay, and total hospital charges. Results: Patients with OSA were, on average 2.6 years older than those without OSA (P < .001) and had a higher comorbidity burden. The prevalence of OSA increased between 2008 and 2012 from 3.5% to 6.8%; P < .001. OSA was associated with a 3-fold increase in major complications (P < .001) and was confirmed as an independent risk factor for major complications based on multivariate analysis (odds ratio [OR] ¼ 2.82; 95% CI ¼ 2.59-2.79; P < .001). Rates of deep venous thrombosis were doubled in patients with OSA. OSA was determined to be an independent predictor of pulmonary complications (OR ¼ 2.69; 95% CI ¼ 2.59-2.79; P < .001). OSA did not increase the risk of postoperative mortality. Conclusions: Patients with OSA often have multiple concomitant comorbidities and consequently are at increased risk of experiencing a more difficult postoperative course following elective spine surgery. Specifically, increased risks of pulmonary complications and deep venous thrombosis should be anticipated.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/2192568217740898">doi:10.1177/2192568217740898</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30202707">pmid:30202707</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6125927/">pmcid:PMC6125927</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zdykfxwrnjhuxnbj75whjhu6bq">fatcat:zdykfxwrnjhuxnbj75whjhu6bq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223012642/http://pdfs.semanticscholar.org/3d6b/aa071264e3802a80ab47f1a593a5c8ef0749.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3d/6b/3d6baa071264e3802a80ab47f1a593a5c8ef0749.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/2192568217740898"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> sagepub.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125927" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia

Marianne L. Seney, Kelly Cahill, John F. Enwright, Ryan W. Logan, Zhiguang Huo, Wei Zong, George Tseng, Colleen A. McClung
<span title="2019-08-09">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a4wan6l5o5dfzn767kyz7jqevi" style="color: black;">Nature Communications</a> </i> &nbsp;
Schizophrenia is associated with disrupted cognitive control and sleep-wake cycles. Here we identify diurnal rhythms in gene expression in the human dorsolateral prefrontal cortex (dlPFC), in schizophrenia and control subjects. We find significant diurnal (24 h) rhythms in control subjects, however, most of these transcripts are not rhythmic in subjects with schizophrenia. Instead, subjects with schizophrenia have a different set of rhythmic transcripts. The top pathways identified in
more &raquo; ... s rhythmic only in subjects with schizophrenia are associated with mitochondrial function. Importantly, these rhythms drive differential expression patterns of these and several other genes that have long been implicated in schizophrenia (including BDNF and GABAergic-related transcripts). Indeed, differential expression of these transcripts is only seen in subjects that died during the night, with no change in subjects that died during the day. These data provide insights into a potential mechanism that underlies changes in gene expression in the dlPFC with schizophrenia.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-019-11335-1">doi:10.1038/s41467-019-11335-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31399567">pmid:31399567</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6689017/">pmcid:PMC6689017</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/si3vx6dlibdvhnm7f2kmhs6laq">fatcat:si3vx6dlibdvhnm7f2kmhs6laq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191115024751/https://www.nature.com/articles/s41467-019-11335-1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/30/46/30468d0b4ddd9be57d75e7d9f6bf2c08956a359f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-019-11335-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> nature.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689017" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Opposite Molecular Signatures of Depression in Men and Women

Marianne L. Seney, Zhiguang Huo, Kelly Cahill, Leon French, Rachel Puralewski, Joyce Zhang, Ryan W. Logan, George Tseng, David A. Lewis, Etienne Sibille
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z5ukx73avrb57kufzzr36timya" style="color: black;">Biological Psychiatry</a> </i> &nbsp;
Background-Major depressive disorder (MDD) affects women approximately twice as often as men. Women are three times as likely to have atypical depression, with hypersomnia and weight gain. This suggests that the molecular mechanisms of MDD may differ by sex. Methods-To test this hypothesis, we performed a large-scale gene expression meta-analysis across three corticolimbic brain regions, the dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, and basolateral amygdala (N=26 men,
more &raquo; ... 24 women with MDD and sex-matched § controls). Results were further analyzed using a threshold-free approach, gene ontology, and cell type-specific analyses. A separate dataset was used for independent validation [N=13 MDD subjects/sex; 22 controls (13 males, 9 females)]. Results-Of the 706 genes differentially expressed in men with MDD and 882 genes differentially expressed in women with MDD, only 21 were changed in the same direction in both sexes. Notably, 52 genes displayed expression changes in opposite directions between men and women with MDD. Similar results were obtained using a threshold-free approach, where the overall transcriptional profile of MDD was opposite in men and women. Gene ontology indicated that men with MDD had decreases in synapse-related genes, whereas women with MDD exhibited transcriptional increases in this pathway. Cell type-specific analysis indicated that men with MDD exhibited increases in oligodendrocyte-and microglia-related genes, while women with MDD had decreases in markers of these cell types. Conclusions-The brain transcriptional profile of MDD differs greatly by sex, with multiple transcriptional changes in opposite directions between men and women with MDD.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2018.01.017">doi:10.1016/j.biopsych.2018.01.017</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29548746">pmid:29548746</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6014892/">pmcid:PMC6014892</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ixdezr6n75ggpdoxktcqqcztuq">fatcat:ixdezr6n75ggpdoxktcqqcztuq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191017095606/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6014892&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/00/05/0005c6ff2cb5ac2882b8c1893082a18db363714c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2018.01.017"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014892" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A mid-Cretaceous enantiornithine (Aves) hatchling preserved in Burmese amber with unusual plumage

Lida Xing, Jingmai K. O'Connor, Ryan C. McKellar, Luis M. Chiappe, Kuowei Tseng, Gang Li, Ming Bai
<span title="">2017</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5wtset45dnfcfl2v2654hehaoa" style="color: black;">Gondwana Research</a> </i> &nbsp;
Burmese amber has recently provided some detailed glimpses of plumage, soft tissues, and osteology of juvenile enantiornithine birds, but these insights have been restricted to isolated wing apices. Here we describe nearly half of a hatchling individual, based on osteological and soft tissue data obtained from the skull, neck, feet, and wing, and identified as a member of the extinct avian clade Enantiornithes. Preserved soft tissue provides the unique opportunity to observe the external
more &raquo; ... of the ear, the eyelid, and fine details of tarsal scutellation. The new amber specimen yields the most complete view of hatchling plumage and integument yet to be recovered from the Cretaceous, including details of pterylosis, feather microstructure, and pigmentation patterns. The hatchling was encapsulated during the earliest stages of its feather production, providing a point for comparisons to other forms of body fossils, as well as isolated feathers found in Cretaceous ambers. The plumage preserves an unusual combination of precocial and altricial features unlike any living hatchling bird, having functional remiges combined with sparse body feathers. Unusual feather morphotypes on the legs, feet, and tail suggest that first generation feathers in the Enantiornithes may have been much more like contour feathers than the natal down observed in many modern birds. However, these regions also preserve filamentous feathers that appear comparable to the protofeathers observed in more primitive theropods. Overall, the new specimen brings a new level of detail to our understanding of the anatomy of the juvenile stages of the most species-rich clade of pre-modern birds and contributes to mounting data that enantiornithine development drastically differed from that of Neornithes.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.gr.2017.06.001">doi:10.1016/j.gr.2017.06.001</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5nlc4r7bk5htzjum6q3hxn6sei">fatcat:5nlc4r7bk5htzjum6q3hxn6sei</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190214061700/https://terratreasures.com/amber/research/publications/XING%20+%202017%20Enantiornithine%20hatchling%20in%20Burmese%20amber_%20ACCEPTED%20VERSION.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/28/2f/282f0b51e20360cb652aca1a9b94aa0abd4826d1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.gr.2017.06.001"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Is single incision midurethral sling effective in patients with low maximal urethral closure pressure?

Mou-Jong Sun, Ryan Sun, Shiuan-Hui Tseng
<span title="">2016</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/t57oilzfcrcxtklzih6sjq6vam" style="color: black;">Taiwanese Journal of Obstetrics &amp; Gynecology</a> </i> &nbsp;
Keywords: comparison efficacy low maximal urethral closure pressure MiniArc single incision sling a b s t r a c t Objective: To ascertain whether low preoperational maximal urethral closure pressure (MUCP) affects the outcomes of single incision sling (SIS) procedures and changes MUCP values postsurgery. Material and methods: There were 112 (MUCP 40 cmH 2 O, n ¼ 88; MUCP < 40 cmH 2 O, n ¼ 24) consecutive women with urodynamic stress incontinence who had undergone SIS (MiniArc) procedures
more &raquo; ... d in this study. The threshold of 40 cmH 2 O was used since it has been shown to be a significant risk factor for failed incontinence surgery. Clinical outcomes were assessed by the cough stress test, the 1-hour pad test, the Incontinence Impact Questionnaire-Short Form, the Urogenital Distress Inventory six-item questionnaire, the Sexual Questionnaire-SF, and postoperative changes in the urodynamic parameters. A comparison of the 1-year follow-up data is presented. Results: Three months postsurgery, a significant decrease was observed in the 1-hour pad test, from 20.6 g preoperatively to 0.73 g postoperatively (p < 0.001). The objective cure rate was 82.1% without any significant differences between the two groups (p ¼ 0.202). At 3 months and 1 year after surgery, significantly decreasing Urogenital Distress Inventory six-item questionnaire and Incontinence Impact Questionnaire-Short Form, and increasing Sexual Questionnaire-SF scores were observed in both groups, without any significant differences between the two groups. No statistically significant difference in the subjective cured rate was noted between the two groups at the 3-month and 18.4 month follow-ups. The postoperative MUCP was significantly decreased in the MUCP 40 group (p < 0.05) while significantly increased in the MUCP < 40 group (p ¼ 0.006). Conclusions: These results suggest that SIS is a safe and highly effective treatment for urodynamic stress incontinence even in women with low MUCP at a mean follow-up of 18.4 months. Evaluation of the outcomes with more subjects after a longer follow-up period is necessary.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.tjog.2014.09.013">doi:10.1016/j.tjog.2014.09.013</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26927242">pmid:26927242</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gknw57bdkng43o3iqb2oaw5f44">fatcat:gknw57bdkng43o3iqb2oaw5f44</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171003091941/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/c8a/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMTAyODQ1NTkxNTAwMjgzMQ%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a7/5d/a75d4c16b2b357fd9878c076b1151918aa5d66ec.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.tjog.2014.09.013"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a>

Cascadable Current-Mode First-Order and Second-Order Multifunction Filters Employing Grounded Capacitors

Jiun-Wei Horng, Chun-Li Hou, Ching-Yao Tseng, Ryan Chang, Dun-Yih Yang
<span title="">2012</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/teahpug7pzaopcw3sqpxql3hhm" style="color: black;">Active and Passive Electronic Components</a> </i> &nbsp;
A configuration for realizing low input and high output impedances current-mode multifunction filters using multiple output second-generation current conveyors (MOCCIIs) is presented. From the proposed circuit configuration, first-order allpass, highpass, lowpass and second-order allpass, notch, bandpass filters can be obtained. The simulation results confirm the theoretical analysis.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2012/261075">doi:10.1155/2012/261075</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hiprk2f4xbhknixkaygt4534om">fatcat:hiprk2f4xbhknixkaygt4534om</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200216135902/http://downloads.hindawi.com/journals/apec/2012/261075.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/66/55/66559592626af099f00f51eaf7b458040245efa8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2012/261075"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a>

A flattened enantiornithine in mid-Cretaceous Burmese amber: morphology and preservation

Lida Xing, Jingmai K. O'Connor, Ryan C. McKellar, Luis M. Chiappe, Ming Bai, Kuowei Tseng, Jie Zhang, Haidong Yang, Jun Fang, Gang Li
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dn6dcjz2unefzj5uifc57sz55a" style="color: black;">Science Bulletin</a> </i> &nbsp;
Cretaceous amber from Myanmar ($99 Ma Burmese amber) has become a valuable supplement to the traditional skeletal record of small theropod dinosaurs preserved in sedimentary rocks, particularly for coelurosaurs and enantiornithines. The specimens recovered from this deposit preserve skeletal material and soft tissues in unmatched detail. This provides opportunities to study three-dimensional preservation of soft tissues, microstructure, and pigmentation patterns that are seldom available
more &raquo; ... re in the fossil record. Ultimately, this line of research provides insights into life stages that are difficult to preserve, the ecology and appearance of the groups involved, and the evolutionarydevelopment of structures such as feathers. Here we describe the most recent discovery from Burmese amber, an articulated skeleton of an enantiornithine bird. This individual has been sectioned along the coronal plane, providing a unique view inside multiple body regions. Osteological observations and plumage patterns support placement within the Enantiornithes, and suggest that the animal may have been a juvenile at the time of death. The specimen has a complex taphonomic history that includes exposure at the surface of a resin flow prior to encapsulation, and may include scavenging by some of the insects trapped within the same amber piece. The chemical composition observed along surface exposures and shallowly buried regions of the body indicate that the specimen has not undergone significant exchange with its surroundings. High iron concentrations are present in regions that preserve soft tissues as carbon films, and calcium distribution corresponds to regions where bones breach the surface of the amber.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.scib.2018.01.019">doi:10.1016/j.scib.2018.01.019</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/d2m2hhvmnvgulo2nj42q3nvbji">fatcat:d2m2hhvmnvgulo2nj42q3nvbji</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210803231347/https://www.sciengine.com/doi/pdf/dc1862b8b35448d6903a743dec2a3920" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c0/36/c036c5a25a70cd0161d87e88808555de55fa28f0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.scib.2018.01.019"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Loosely-coupled wireless power transfer: Physics, circuits, standards

Kamil A. Grajski, Ryan Tseng, Chuck Wheatley
<span title="">2012</span> <i title="IEEE"> 2012 IEEE MTT-S International Microwave Workshop Series on Innovative Wireless Power Transmission: Technologies, Systems, and Applications </i> &nbsp;
Loosely-coupled (LC) wireless power transfer (WPT) offers unique, next-generation improvements in user experience, and product design and innovation towards the vision of ubiquitous power, and infinite stand-by time for a wide range of consumer electronic devices. We outline the vision as it relates to today's mobile, battery-powered, hand-held, consumer electronics devices, and consider the unique capabilities of loosely-coupled (LC) WPT. We then describe the physics of the magnetically
more &raquo; ... resonant coil subsystem, which lies at the heart of LC WPT, discuss approaches and challenges in implementing WPT electronic circuits, and review industry progress towards timely, high-quality WPT technical standards.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/imws.2012.6215828">doi:10.1109/imws.2012.6215828</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nbfcwuxgvbgmlbrzcl2n2y77su">fatcat:nbfcwuxgvbgmlbrzcl2n2y77su</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180514005320/https://www.qualcomm.com/media/documents/files/loosely-coupled-wireless-power-transfer-physics-circuits-standards.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fb/b2/fbb2e457964e30736e1cd4b2463455d427881d95.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/imws.2012.6215828"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>
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