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The target landscape of clinical kinase drugs

Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter (+36 others)
2017 Science  
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug mechanism of action. Using chemical proteomics, we analyzed the target spectrum of 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on the "druggable" kinome, highlighted (non)kinase off-targets, and suggested potential therapeutic applications. Integration of
more » ... roteomic data refined drug-affected pathways, identified response markers, and strengthened rationale for combination treatments. We exemplify translational value by discovering SIK2 (salt-inducible kinase 2) inhibitors that modulate cytokine production in primary cells, by identifying drugs against the lung cancer survival marker MELK (maternal embryonic leucine zipper kinase), and by repurposing cabozantinib to treat FLT3-ITD-positive acute myeloid leukemia. This resource, available via the ProteomicsDB database, should facilitate basic, clinical, and drug discovery research and aid clinical decision-making.
doi:10.1126/science.aan4368 pmid:29191878 pmcid:PMC6542668 fatcat:ow65j7f2mbblfiwfgbypqjbqja

Page 466 of National Union Catalog Vol. 20, Issue [page]

1958 National Union Catalog  
NN MH Holzer, Rudolf, 1875- Villa Wertheimstein; Haus der Genien und Diimonen.  ...  Aratli iche Rh Rheokardiographie, von Wolfgang Holzer und Kurt Polzer. Wie, w. W, Memdrich, 1948. vi, 141 p. illus.  ... 

S. D. Faust and J. V. Hunter (editors). Principles and Applications of Water Chemistry (Proceedings of the Fourth Rudolfs Conference). Wiley & Sons, New York. xv +643 pp. Price £5

J. M. Bracewell
1968 Clay minerals  
significance in the weathering of primary minerals to clay minerals, namely 'Mineralogical Factors in Natural Water Equilibria' (Bricker & Garrels) and 'Geochemical Control of the Solubility of Aqueous Silica' (Polzer  ... 
doi:10.1180/claymin.1968.007.4.12 fatcat:wjddqc6gmrf3bkqrkstopwzp4m

Page 752 of The Journal of Modern History Vol. 2, Issue 4 [page]

1930 The Journal of Modern History  
Baernreither, Fragmente eines Politischen Tagebuches ; Arthur Graf Polzer-Hoditz, Kaiser Karl. Aus der Geheim- mappe seines Kabinetts-Chefs ; Edmund von Glaise-Horst- enau, Die Katastrophe; Dr.  ...  JAsz1, Oscar, Some Recent Publications Concerning the Dis- solution of the Habsburg Monarchy: Joseph Redlich, Em- peror Francis Joseph of Austria; Oskar Freiherr von Mitis, Das Leben des Kronprinzen Rudolf  ... 

Page 122 of Modern Medicine Vol. 17, Issue 8 [page]

1949 Modern Medicine  
. $2.75 DIE VEGETATIVEN ANFALLE DES HERZENS by Kurt Polzer and Walter Schober. 88 pp. Grune & Stratton, New York City. $2.50 AN ELEMENTARY ATLAS OF CARDIOGRAPHY by H. Wallace-Jones, E.  ...  MATHEMATICAL ANALYSIS OF BINOCULAR vision by Rudolf K. Luneburg. 104 pp., ill. Princeton University Press, Prince- ton, N. J. $2.50 SURGERY OF THE EYE by Meyer Wiener. 2d ed. 426 pp., ill.  ... 

Une Étape du Calvaire Slovaque : le Procès Tuka (1929–1930)

C. A. Macartney
1931 International Affairs  
By Arthur Count Polzer-Hoditz. Tr. D. F. Tait and F. S. Flint. 1930. (London: Putnams. 8vo. xii + 470 pp. 21s.)  ...  NORTH-EASTERN EUROPE 72*, KUsTER, Rudolf: Die polnische Irredenta in West-Oberschlesien. 1931. (Berlin: Hallig-Verlag. 8vo. 178 pp. Rm. 4.) 73*.  ... 
doi:10.2307/3015963 fatcat:4fxpzcdbynfkfhttjdeyw6ypbq

Page 79 of National Union Catalog Vol. 19, Issue [page]

1953 National Union Catalog  
HC267.B2P6 330.9437 53-33550 f Polzer, Wilhelm. Licht iiber Mayerling; Kronprinz Rudolf nennt die Griinde seines Scheidens aus dieser Wi elt.  ...  ., see Palviakaibies (Keb rad , T4.P653 54-33748 Polzer, Robert. Die sudetendeutsche Wirtschaft in der Tschechoslowakei. Kitsingen/Main, Holaner. Verlag 119529, 40 p.  ... 

Page 9 of Rural Sociology Vol. 12, Issue 1 [page]

1947 Rural Sociology  
Polzer-Hoditz, Politische Betrachtungen, ibid., 1920, pp. 15, 45, 52-58, 102-108; Vom Lebenswerk Rudolf Steiner’s, Muenchen, PEASANT CONCEPT 9 such pessimism are the primarily (1) religious pessimism propounded  ... 

Page 16 of European Journal of Physical Medicine & Rehabilitation Vol. 1, Issue 1 [page]

1991 European Journal of Physical Medicine & Rehabilitation  
J Bone Joint Surg 1954;36:820-821. (5) Kaindl F, Polzer K, Schuhfried F: Rheo- graphie. 3. Aufl.  ...  Br J Rheum 1983;22:224-232. (8) Rudolf R, Leyden J, Berger B: Efficacy of physiatric management of linear sclero- derma.  ... 

42. Internationale Mathematik-Olympiade (IMO). Washington D.C., 2001

Hans-Dietrich Gronau
2001 Mitteilungen der DMV  
Polzer 8 Punkte Die Ergebnisse bezüglich der einzelnen Aufgaben Gebiet alle Top 10 deutsches Team Geometrie 53.4% 99.3% 83.3% Ungleichung 22.7% 73.3% 59.5% Kombinatorik 12.8% 31.7% 31.0% Kombinatorik  ...  Die Ergebnisse der deutschen Mannschaft Christian Reiher 32 Punkte Gold Thomas Jäger 26 Punkte Silber Hendrik Lönngren 25 Punkte Silber Michael Tyomkyn 23 Punkte Silber Philipp Lampe 17 Punkte Bronze Rudolf  ... 
doi:10.1515/dmvm-2001-0111 fatcat:3eicngpzhnfydaq44364eg6swu

Goetheanum II: Masterpiece of Organic Architecture by Rudolf Steiner

John Paull
2022 European Journal of Architecture and Urban Planning  
The present building is the second iteration of Dr Rudolf Steiner's ideas of organic architecture for the site on a hill overlooking the Swiss village of Dornach.  ...  Site work began in Rudolf Steiner's lifetime, but he died on 30 March 1925. On 29 September 1928, Goetheanum II was officially opened with plays, lectures and Eurythmy performances.  ...  for anthroposophical work" (Polzer-Hoditz, 1928, p.346) .  ... 
doi:10.24018/ejarch.2022.1.4.9 fatcat:sm7lyalqzzedhgnwdm4ukkvcjy

Page 2362 of Psychological Abstracts Vol. 93, Issue 6 [page]

2006 Psychological Abstracts  
., 16683 Polychronopoulos, Panagiotis, 17329 Polzer, U., 17581 Pomerantz-Zorin, Limor, 16455 Pompili, Maurizio, 17519 Pompilio, Lorena, 15796 Ponce de Leon, Antonio, 16510 Ponds, Rudolf, 17344 Ponsford  ...  18305 Price, Paul C., 16438 Priebe, S., 17451 Priest, Lee, 16235 Prilleltensky, Isaac, 16296 Primm, Annelle, 17871 Prins, Judith B., 17183 Pritchard, Josh, 16918 Privitera, Gregory J., 16496 Probst, Rudolf  ... 

41. Internationale Mathematik-Olympiade (IMO). Taejon, Südkorea, 2000

Hans-Dietrich Gronau
2000 Mitteilungen der DMV  
Die deutsche Mannschaft bestand aus den sechs Schülern Thomas Jäger (Fulda), Jan Christoph Kinne (Hamburg), Hendrik Lönngren (Embsen), Rudolf Polzer (Rodgau), Christian Reiher (Scheyern) und Philipp Schapotschnikov  ... 
doi:10.1515/dmvm-2000-0106 fatcat:rz763mrpfjd27l7kqoaokxjbze

Page 1923 of Psychological Abstracts Vol. 84, Issue 4 [page]

1997 Psychological Abstracts  
., 13150 Pollack, Simcha, 10599 Pollock, Jane, 12487 Polloway, Edward A 12381, 13841 Poltyrev, Tatyana, 10786 Polzer, Jeffrey T., 11656 Pomeroy, Elizabeth C., 13368 Pomuinova, E.  ...  Jefferson, 13075 Prince, Martin, 12661 Prince, Terry, 13742 Printz, Morton P., 11091 Prior, Gabrielle, 11171 Pristach, Cynthia A., 12066 Prizmic, Zvjezdana, 14011 14020, 14025 Probert, L.. 10947 Probst, Rudolf  ... 

Pražské policejní ředitelství, jeho Státní (politická) policie a její informátoři z řad občanstva v převratných dobách Velké války očima očistného Výboru pro prozkoumání policejního archivu v letech 1918-1920

Zdeněk Kárník
2007 Acta Oeconomica Pragensia  
To byl však ji Clam více politickou mrtvolou ne èím jiným, a perspektivním mu em oné doby se stával Artur hrabì Polzer-Hoditz, záhy jmenovaný šéfem císaøova kabinetu.  ...  Rudolf Beran ptal, zda s policií nespolupracoval nìkdo z agrární strany, napø. Šafr, Klíma odpovìdìl, e "také strana agrární vùbec nikdy ve státní policii nikoho nemìla."  ... 
doi:10.18267/j.aop.199 fatcat:tqmgvb63q5b57e4677p4mt2gai
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