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A New Interactive Screening Test for Autism Spectrum Disorders in Toddlers

Roula Choueiri, Sheldon Wagner
2015 Journal of Pediatrics  
To develop a clinically valid interactive level 2 screening assessment for autism spectrum disorders (ASD) in toddlers that is brief, easily administered, and scored by clinicians. We describe the development, training, standardization, and validation of the Rapid Interactive Screening Test for Autism in Toddlers (RITA-T) with ASD-specific diagnostic instruments. The RITA-T can be administered and scored in 10 minutes. We studied the validity of the RITA-T to distinguish between toddlers with
more » ... D from toddlers with developmental delay (DD)/non-ASD in an early childhood clinic. We also evaluated the test's performance in toddlers with no developmental concerns. We identified a cutoff score based on sensitivity, specificity, and positive predictive value of the RITA-T that best differentiates between ASD and DD/non-ASD. A total of 61 toddlers were enrolled. RITA-T scores were correlated with ASD-specific diagnostic tools (r = 0.79; P < .01) and ASD clinical diagnoses (r = 0.77; P < .01). Mean scores were significantly different in subjects with ASD, those with DD/non-ASD, and those with no developmental concerns (20.8 vs 13 vs 10.6, respectively; P < .0001). At a cutoff score of >14 , the RITA-T had a sensitivity of 1.00, specificity of 0.84, and positive predictive value of 0.88 for identifying ASD risk in a high-risk group. The RITA-T is a promising new level 2 interactive screening tool for improving the early identification of ASD in toddlers in general pediatric and early intervention settings and allowing access to treatment.
doi:10.1016/j.jpeds.2015.05.029 pmid:26210844 pmcid:PMC7877705 fatcat:54xdwip5sjbpdarfbwgcv3nnrq

Investigating Potential Biomarkers in Autism Spectrum Disorder

Carolyn Bridgemohan, David M. Cochran, Yamini J. Howe, Katherine Pawlowski, Andrew W. Zimmerman, George M. Anderson, Roula Choueiri, Laura Sices, Karen J. Miller, Monica Ultmann, Jessica Helt, Peter W. Forbes (+4 others)
2019 Frontiers in Integrative Neuroscience  
Early identification and treatment of individuals with autism spectrum disorder (ASD) improves outcomes, but specific evidence needed to individualize treatment recommendations is lacking. Biomarkers that could be routinely measured within the clinical setting could potentially transform clinical care for patients with ASD. This demonstration project employed collection of biomarker data during regular autism specialty clinical visits and explored the relationship of biomarkers with clinical
more » ... symptoms. Eighty-three children with ASD, aged 5-10 years, completed a multi-site feasibility study integrating the collection of biochemical (blood serotonin, urine melatonin sulfate excretion) and clinical (head circumference, dysmorphology exam, digit ratio, cognitive and behavioral function) biomarkers during routine ASD clinic visits. Parents completed a demographic survey and the Aberrant Behavior Checklist-Community. Cognitive function was determined by record review. Data analysis utilized Wilcoxon two-sample tests and Spearman correlations. Participants were 82% male, 63% White, 19% Hispanic, with a broad range of functioning. Group means indicated hyperserotonemia. In a single regression analysis adjusting for race and median household income, higher income was associated with higher levels of blood serotonin and urine melatonin sulfate excretion levels (p = 0.004 and p = 0.04, respectively). Melatonin correlated negatively with age (p = 0.048) and reported neurologic problems (p = 0.02). Dysmorphic status correlated with higher reported stereotyped behavior (p = 0.02) and inappropriate speech (p = 0.04). This demonstration project employed collection of multiple biomarkers, allowed for examination of associations between biochemical and clinical measures, and identified several findings that suggest direction for future studies. This clinical research model has promise for integrative biomarker research in individuals with complex, heterogeneous neurodevelopmental disorders such as ASD.
doi:10.3389/fnint.2019.00031 pmid:31427932 pmcid:PMC6687766 fatcat:okvyuxnuofhgpl6bonozqi2rri

Comparing two LEGO Robotics-based interventions for social skills training with children with ASD

Jordi Albo-Canals, Marcel Heerink, Marta Diaz, Vanesa Padillo, Marta Maristany, Alex Barco, Cecilio Angulo, Ariana Riccio, Lauren Brodsky, Simone Dufresne, Samuel Heilbron, Elissa Milto (+3 others)
2013 2013 IEEE RO-MAN  
This paper presents an analysis of two comparable studies with LEGO Robotics-based activities in a social skills training program for children with autism spectrum disorders (ASD). One study has been carried out with a group of 16 children in the Unit of Pediatrics Psychology and Psychiatry in HSJD in Barcelona , Spain and the other with a group of 17 children at the Center for Education and Engineering Outreach (Tufts U.) in Boston, USA. The aim of this comparison is discuss lessons learnt and
more » ... develop empirical based guidelines for intervention design.
doi:10.1109/roman.2013.6628420 dblp:conf/ro-man/Albo-CanalsHDPMBARBDHMCHR13 fatcat:yisvr44qfbhm3dvsdhmxtdzema

Improving Early Identification and Access to Diagnosis of Autism Spectrum Disorder in Toddlers in a Culturally Diverse Community with the Rapid Interactive screening Test for Autism in Toddlers

Roula Choueiri, Asher Lindenbaum, Manasa Ravi, William Robsky, Julie Flahive, William Garrison
2021 Journal of Autism and Developmental Disorders  
Choueiri receives no royalties from the RITA-T.  ...  The initial paper by Choueiri and Wagner (2015) included a third group of toddlers with no developmental concerns.  ... 
doi:10.1007/s10803-020-04851-3 pmid:33423215 pmcid:PMC8510911 fatcat:n5mmn3x7fzdixjxhummu5gdrum

Role of sexual reproduction in the aggressiveness of Didymella rabiei affecting chickpea

Basem Attar, International Center for Agricultural Research in The Dry Areas (ICARDA), Terbol Station, Beqa'a valley, Zahle, Lebanon, Seid Ahmad, Mukaddes Kayim, Elia Choueiri, Hend A. Ghannam, Aladdin Hamwieh, ICARDA, Rabat, Morocco, Department of Plant Protection, Faculty of Agriculture, University of Çukurova, Balcali 01330 Adana, Turkey, Department of Plant Protection, Lebanese Agricultural Research Institute, Tal Amara, Zahlé, Lebanon;, Department of Food Legumes Research, Field Crop Research Institute, Cairo, Egypt;, ICARDA, Cairo, Egypt.
2020 Arab Journal Of Plant Protection  
Choueiri, H.A. Ghannam, A. Hamwieh. 2020. Role of sexual reproduction in the aggressiveness of Didymella rabiei affecting chickpea. Arab Journal of Plant Protection, 38(1): 17-24.  ...  The assistance of Ahmad Albitar, Fouad Jreijiri, Roula Al Amil and Joseph Kahwaji at LARI is also acknowledged.  ... 
doi:10.22268/ajpp-038.1.017024 fatcat:53csoopizvah3j2vqt62tpokfy

Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas

Alcides Chaux, Luciana Schultz, Roula Albadine, Jessica Hicks, Jenny J. Kim, Mohamad E. Allaf, Michael A. Carducci, Ronald Rodriguez, Hans-Joerg Hammers, Pedram Argani, Victor E. Reuter, George J. Netto
2012 Human Pathology  
Low response rates (5%) were also reported by Choueiri et al [23] in a series of 41 patients with metastatic papillary RCC treated with either sunitinib or sorafenib.  ... 
doi:10.1016/j.humpath.2012.01.009 pmid:22542128 pmcid:PMC4029100 fatcat:lotvke5xjbd6nfrq23dep5dtry

Validation of Rapid Interactive Screening Test for Autism in Toddlers Using Autism Diagnostic Observation Schedule™ Second Edition in Children at High-Risk for Autism Spectrum Disorder

Xue-Jun Kong, Hannah Tayla Sherman, Ruiyi Tian, Madelyn Koh, Siyu Liu, Alice Chukun Li, William S. Stone
2021 Frontiers in Psychiatry  
Roula Choueiri for her kind instruction of RITA-T and comments about the manuscript. We would like to thank Dr. Yiqing Song and Mr.  ... 
doi:10.3389/fpsyt.2021.737890 pmid:34658971 pmcid:PMC8517472 fatcat:ztazspcz5ffidgrm2tjgquriku

Developmental regression and mitochondrial function in children with autism

Kanwaljit Singh, Indrapal N. Singh, Eileen Diggins, Susan L. Connors, Mohammad A. Karim, David Lee, Andrew W. Zimmerman, Richard E. Frye
2020 Annals of Clinical and Translational Neurology  
Patients were referred to the study by Roula Choueiri, JoAnn Carson, Stephanie Blenner and others in the Department of Pediatrics at UMass Memorial Children's Medical Center.  ... 
doi:10.1002/acn3.51034 pmid:32343046 fatcat:dmj75wx7sjawleyrrdxfvcgvby

Grapevine leaf stripe disease symptoms (esca complex) are reduced by a nutrients and seaweed mixture

Francesco CALZARANO, Stefano DI MARCO, Vincenzo D'AGOSTINO, Silvia SCHIFF, Laura MUGNAI
2014 Phytopathologia Mediterranea  
Choueiri, F. Jreijiri, Roula Phaeomoniella chlamydospora and esca proper infected vines El Amil and M. Fermaud, 2012. New insights into esca of under greenhouse and field conditions.  ... 
doi:10.14601/phytopathol_mediterr-15253 doaj:b69414be992d4bf9b159aa20f6ec1276 fatcat:c2fjp352rncs7hbtifsjfxgdvi