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Role of Nerve Growth Factor Signaling in Cancer Cell Proliferation and Survival Using a Reachability Analysis Approach [chapter]

Gustavo Santos-García, Carolyn Talcott, Adrián Riesco, Beatriz Santos-Buitrago, Javier De Las Rivas
2016 Advances in Intelligent Systems and Computing  
Nerve growth factor (NGF) is a neuropeptide involved in cellular signaling that binds specific cell surface receptors in order to induce cellular proliferation and survival in different cell types or cell  ...  In this paper we perform a reachability analysis and we compute common elements in all possible solutions in our cases of interest with the help of Pathway Logic, which constitutes a rewriting logic formalism  ...  As a case study, we analyze the role of nerve growth factor receptor signaling in cancer cell proliferation and survival using a reachability analysis approach.  ... 
doi:10.1007/978-3-319-40126-3_18 fatcat:swfwpfnxxfdgno6oce4ofhd7ca

Epidermal Growth Factor Signaling towards Proliferation: Modeling and Logic Inference Using Forward and Backward Search

Adrián Riesco, Beatriz Santos-Buitrago, Javier De Las Rivas, Merrill Knapp, Gustavo Santos-García, Carolyn Talcott
2017 BioMed Research International  
In this work, we use rewriting logic to analyze the cellular signaling of epidermal growth factor (EGF) and its cell surface receptor (EGFR) in order to induce cellular proliferation.  ...  The first one is a standard (forward) search. The second one is a novel approach based onnarrowing, which allows us to trace backwards the causes of a given final state.  ...  Acknowledgments Pathway Logic development has been funded in part by NIH BISTI R21/R33 Grant GM068146-01, NIH/NCI P50 Grant CA112970-01, and NSF Grant IIS-0513857.  ... 
doi:10.1155/2017/1809513 pmid:28191459 pmcid:PMC5278199 fatcat:zrtnzvby25dslorarncmqyn3b4

Menstrual Blood Derived Stem Cells and their Scope in Regenerative Medicine: A Review Article

Sneha Ann John, Dr. Gopinath E, Dr. VineethChandy
2022 Zenodo  
These cells posses all the properties of Stem cells and even have a better rate of cell proliferation and differentiation compared to the other stem cell sources.  ...  The menstrual fluid that is produced due to the endometrial shedding during the menstrual cycle in a women contains the blood cells that plays a major role in cell restoration and repair, these cells constitute  ...  These cells produced large numbers of growth factors, IL-4, HIF-1alpha, MMP3 and MMP10 that exhibited paracrine roles. 2.  ... 
doi:10.5281/zenodo.6571346 fatcat:quacup2osbhfrbtv337nax5rva

Novel management of glioma by molecular therapies, a review article

Amin Alinezhad, Fatemeh Jafari
2019 European Journal of Translational Myology  
Despite the achieved advances in conventional glioma therapy, it proved that a proper medication for glioma is not easily reachable.  ...  cells, incorporate inhibitors of regulators of the immune system with conventional remedial modalities and additionally using tumor cell lysates as sources of antigen for efficient evacuation of particular  ...  Ethical Publication Statement We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.  ... 
doi:10.4081/ejtm.2019.8209 pmid:31579472 pmcid:PMC6767997 fatcat:ytgybu7znjgqvgtxse4ev32ztu

It Takes More than Two to Tango: Complex, Hierarchal, and Membrane-Modulated Interactions in the Regulation of Receptor Tyrosine Kinases

Tamas Kovacs, Florina Zakany, Peter Nagy
2022 Cancers  
In this review, the role of molecular interactions taking place during the activation of receptor tyrosine kinases, with special attention to the epidermal growth factor receptor family, will be discussed  ...  The search for an understanding of how cell fate and motility are regulated is not a purely scientific undertaking, but it can also lead to rationally designed therapies against cancer.  ...  Introduction Receptor tyrosine kinases (RTK) play a central role in regulating the number of cells in tissues that determine the intricate balance between cell proliferation, cell survival, and cell death  ... 
doi:10.3390/cancers14040944 pmid:35205690 pmcid:PMC8869822 fatcat:apxzxbccwfghhbwqatfvcdh54q


2008 Onkologie (Basel)  
Introduction: In breast cancer tumor formations there are different cell types. Some cells are able to induce tumor growth.  ...  Methods: We characterised the effects of the selective ET A R antagonist ZD4054 on breast cancer cell gene expression, proliferation, migration, and invasion.  ...  Migration and Çhoming' of these HPCs to sites of tumor growth is directed by chemotactic signaling in which binding of stromal cell-derived factor (SDF)-1 to its receptor CXCR4 plays an important role.  ... 
doi:10.1159/000115424 fatcat:cys7nm3q2naunmmoyjdlrqaxyu

The Second National Festival & International Congress on Stem Cell & Regenerative Medicine - 13-15 July, 2017

2017 Iranian Journal of Biotechnology  
Meanwhile, the field of stem cell sciences and technologies is one of the strategic areas, which has very widespread capacities in different aspects, and now it is directed by a good planning, with the  ...  efforts of my colleagues in the Council for Development of Stem Cell Sciences and Technologies.  ...  astrocytes and neurons using fetal bovine serum (FBS) and nerve growth factor (NGF), respectively.  ... 
doi:10.15171/ijb.2017.s1-334 fatcat:hvotzduiebcg7ppx4q656vljxq

Diabetic Kinome Inhibitors—A New Opportunity for β-Cells Restoration

Barbara Pucelik, Agata Barzowska, Janusz M. Dąbrowski, Anna Czarna
2021 International Journal of Molecular Sciences  
DYRK1A has been characterized as a key regulator of cell growth, differentiation, and signal transduction in various organisms, while further roles and substrates are the subjects of extensive investigation  ...  Increasing evidence for the role of DYRK1A in diabetes progression and β-cell proliferation expands the potential for pharmaceutical applications of DYRK1A inhibitors.  ...  Numerous cell types and signaling pathways in diabetes have been identified (i.e., PI3K-AKT/PKB, ERK/MAPK, growth factor, and hormone signaling pathways) [1] [2] [3] .  ... 
doi:10.3390/ijms22169083 pmid:34445786 pmcid:PMC8396662 fatcat:4pwmr7fq35bv5i2se7lzhfkixi

Identification of Cerebrospinal Fluid MicroRNAs Associated With Leptomeningeal Metastasis From Lung Adenocarcinoma

Zhenyu Pan, Guozi Yang, Hua He, Pengxiang Gao, Tongchao Jiang, Yong Chen, Gang Zhao
2020 Frontiers in Oncology  
The effect of candidate miRNAs on proliferation, invasion, and migration of lung adenocarcinoma cell lines was assessed.  ...  Moreover, 385 targeted genes of miR-7977 were predicted and were involved in various pathways related to cancer metastasis.  ...  Studies have shown that these genes are involved in the growth, invasion, and metastasis of a variety of tumors, and that they play a key role in tumorrelated molecular mechanisms (30) (31) (32) (33)  ... 
doi:10.3389/fonc.2020.00387 pmid:32328453 pmcid:PMC7152668 fatcat:hy37iaumxffqvip527wn7gjopa

Human T Cells Engineered To Express a Programmed Death 1/28 Costimulatory Retargeting Molecule Display Enhanced Antitumor Activity

C. Ankri, K. Shamalov, M. Horovitz-Fried, S. Mauer, C. J. Cohen
2013 Journal of Immunology  
Rachel Levy-Drummer, head of the statistical unit in the Faculty of Life Sciences, Bar-Ilan University, for advice on statistical data processing and presentation.  ...  Goldstein and Dr. Igor Greenberg for expert comments and technical guidance. We thank Dr.  ...  FACS analysis and Abs Fluorophore-labeled anti-human CD8, CD25, CD69, CD107a, CD137, PD1, PDL1, and nerve growth factor receptor (NGFR) were purchased from BioLegend (San Diego, CA).  ... 
doi:10.4049/jimmunol.1203085 pmid:24026081 fatcat:raluhwhnqrdhplnbj74n6qr2la

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

Richard J. Orton, Oliver E. Sturm, Vladislav Vyshemirsky, Muffy Calder, David R. Gilbert, Walter Kolch
2005 Biochemical Journal  
It is at the heart of a molecular-signalling network that governs the growth, proliferation, differentiation and survival of many, if not all, cell types.  ...  In the present review we give an overview of the processes involved in modelling a biological system using the popular approach of ordinary differential equations.  ...  We acknowledge support through the Department of Trade and Industry Beacons Project 'BPS: Biochemical Pathway Simulator'.  ... 
doi:10.1042/bj20050908 pmid:16293107 pmcid:PMC1316260 fatcat:vvefrohebvdhba76nly57wce7m

Animal Models of Angiogenesis and Lymphangiogenesis [chapter]

L. D., J. Honek, K. Hosaka, P. Rouhi, S. Lim, H. Ji, Z. Cao, E. M., J. Zhang, Y. Cao
2012 Biomedical Science, Engineering and Technology  
These factors interact to regulate the survival, proliferation and differentiation of pre-adipocytes to adipocytes.  ...  In addition to signals produced by the tumor cells themselves, inflammatory cells such as macrophages are recruited to tumors by a wide range of tumor cell-derived cytokines and growth factors.  ...  rate variability analysis of diabetic neuropathy, and EEG analysis in brain function assessment.  ... 
doi:10.5772/20211 fatcat:phyowsyfuraj3mjlso7e5zlxhu

The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration

Chih-Chiang Chen, Maksim V. Plikus, Pin-Chi Tang, Randall B. Widelitz, Cheng Ming Chuong
2016 Journal of Molecular Biology  
in healthy individuals and (4) regeneration is also induced in response to injury.  ...  Given that stem cells are hard to manipulate, focusing translational therapeutic applications at the environments appears to be a more practical approach.  ...  By using a transwell-based co-culture system, Bassino et al. identified that human follicle dermal papilla cells (FDPC) can promote survival, proliferation and tubulogenesis of human microvascular endothelial  ... 
doi:10.1016/j.jmb.2015.07.009 pmid:26196442 pmcid:PMC4716892 fatcat:v6qu54db4zgd3jnq25oqyn4tzm

Knowledge-based analysis of proteomics data

Marina Bessarabova, Alexander Ishkin, Lellean JeBailey, Tatiana Nikolskaya, Yuri Nikolsky
2012 BMC Bioinformatics  
Knowledge-based approach deals with this complexity by creating a structured database of protein interactions, pathways and protein-disease associations from experimental literature and a set of statistical  ...  Here we describe the main methods of ontology enrichment, interactome topology and network analysis applied on a comprehensive, manually curated and semantically consistent knowledge source MetaBase and  ...  The full contents of the supplement are available online at http://www.  ... 
doi:10.1186/1471-2105-13-s16-s13 pmid:23176192 pmcid:PMC3489533 fatcat:nembromr5nfkhln2pjsnz5mc3a

1st Annual Meeting: The Canadian Association for Neuroscience / Association canadienne de neuroscience

2007 Canadian Journal of Neurological Sciences  
, Montreal Nerve growth factor (NGF) is a neurotrophic factor important for the survival, growth and function of cholinergic basal forebrain neurons.  ...  Individual AdNSCs and ENSCs proliferate to generate clonally derived colonies of cells termed "neurospheres" in the presence of growth factors.  ... 
doi:10.1017/s0317167100017066 fatcat:aupmr4ntyjd6xes4gp5epa2epm
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