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PLAY: Semantics-Based Event Marketplace [chapter]

Roland Stühmer, Yiannis Verginadis, Iyad Alshabani, Thomas Morsellino, Antonio Aversa
2013 IFIP Advances in Information and Communication Technology  
In this paper we present PLAY Platform, a Web-oriented distributed semantic middleware that serves as an Event Marketplace: the place where heterogeneous events can be integrated and combined. The purpose of the platform is to derive useful information from diverse real-time sources such as collaborative processes. The platform provides technology where instant results are needed or where heterogeneous data must be integrated on the fly or where the data arrive fast enough to require the stream
more » ... processing nature of our approach. The main advantages of the platforms are its scalability (cloud-based nature) and the expressivity of the event combinations that can be defined (using both real-time and historical data). The platform has been applied in a use case about Personal data management. In this paper we present some results from the validation, focusing on smartphone and social media integration.
doi:10.1007/978-3-642-40543-3_73 fatcat:hc4igkkggfbm3lnml7swb27rny

A Rule-Based Language for Complex Event Processing and Reasoning [chapter]

Darko Anicic, Paul Fodor, Sebastian Rudolph, Roland Stühmer, Nenad Stojanovic, Rudi Studer
2010 Lecture Notes in Computer Science  
Complex Event Processing (CEP) is concerned with timely detection of complex events within multiple streams of atomic occurrences. It has useful applications in areas including financial services, mobile and sensor devices, click stream analysis etc. Numerous approaches in CEP have already been proposed in the literature. Event processing systems with a logic-based representation have attracted considerable attention as (among others reasons) they feature formal semantics and offer reasoning
more » ... vice. However logic-based approaches are not optimized for run-time event recognition (as they are mainly query-driven systems). In this paper, we present an expressive logic-based language for specifying and combining complex events. For this language we provide both a syntax as well as a formal declarative semantics. The language enables efficient run time event recognition and supports deductive reasoning. Execution model of the language is based on a compilation strategy into Prolog. We provide an implementation of the language, and present the performance results showing the competitiveness of our approach.
doi:10.1007/978-3-642-15918-3_5 fatcat:2grfdperqvbpfpn3lka3t2rcie

Lifting Events in RDF from Interactions with Annotated Web Pages [chapter]

Roland Stühmer, Darko Anicic, Sinan Sen, Jun Ma, Kay-Uwe Schmidt, Nenad Stojanovic
2009 Lecture Notes in Computer Science  
In this paper we present a method and an implementation for creating and processing semantic events from interaction with Web pages which opens possibilities to build event-driven applications for the (Semantic) Web. Events, simple or complex, are models for things that happen e.g., when a user interacts with a Web page. Events are consumed in some meaningful way e.g., for monitoring reasons or to trigger actions such as responses. In order for receiving parties to understand events e.g.,
more » ... hend what has led to an event, we propose a general event schema using RDFS. In this schema we cover the composition of complex events and event-to-event relationships. These events can then be used to route semantic information about an occurrence to different recipients helping in making the Semantic Web active. Additionally, we present an architecture for detecting and composing events in Web clients. For the contents of events we show a way of how they are enriched with semantic information about the context in which they occurred. The paper is presented in conjunction with the use case of Semantic Advertising, which extends traditional clickstream analysis by introducing semantic short-term profiling, enabling discovery of the current interest of a Web user and therefore supporting advertisement providers in responding with more relevant advertisements.
doi:10.1007/978-3-642-04930-9_56 fatcat:523bqkwf6nhvrbtaveaat47afi

The cross-sectional GRAS sample: A comprehensive phenotypical data collection of schizophrenic patients

Katja Ribbe, Heidi Friedrichs, Martin Begemann, Sabrina Grube, Sergi Papiol, Anne Kästner, Martin F Gerchen, Verena Ackermann, Asieh Tarami, Annika Treitz, Marlene Flögel, Lothar Adler (+30 others)
2010 BMC Psychiatry  
Schizophrenia is the collective term for an exclusively clinically diagnosed, heterogeneous group of mental disorders with still obscure biological roots. Based on the assumption that valuable information about relevant genetic and environmental disease mechanisms can be obtained by association studies on patient cohorts of ≥1000 patients, if performed on detailed clinical datasets and quantifiable biological readouts, we generated a new schizophrenia data base, the GRAS (Göttingen Research
more » ... ciation for Schizophrenia) data collection. GRAS is the necessary ground to study genetic causes of the schizophrenic phenotype in a 'phenotype-based genetic association study' (PGAS). This approach is different from and complementary to the genome-wide association studies (GWAS) on schizophrenia. Methods: For this purpose, 1085 patients were recruited between 2005 and 2010 by an invariable team of traveling investigators in a cross-sectional field study that comprised 23 German psychiatric hospitals. Additionally, chart records and discharge letters of all patients were collected. Results: The corresponding dataset extracted and presented in form of an overview here, comprises biographic information, disease history, medication including side effects, and results of comprehensive cross-sectional psychopathological, neuropsychological, and neurological examinations. With >3000 data points per schizophrenic subject, this data base of living patients, who are also accessible for follow-up studies, provides a wide-ranging and standardized phenotype characterization of as yet unprecedented detail. Conclusions: The GRAS data base will serve as prerequisite for PGAS, a novel approach to better understanding 'the schizophrenias' through exploring the contribution of genetic variation to the schizophrenic phenotypes.
doi:10.1186/1471-244x-10-91 pmid:21067598 pmcid:PMC3002316 fatcat:46skjj3ezbghrfw7efxmrbq4c4

TITOLO TESI An architecture for scaling ontology networks

Presentata Da:, Alessandro Coordinatore, Dottorato Relatore, Gabbrielli Maurizio, Ciancarini, Lora Aroyo, Sean Bechhofer, Gerardo Canfora, Giancarlo Nicoì O Cesa-Bianchi, Irina Bongiovanni, Ugo Coman, Paolo Dal Lago (+31 others)
unpublished
Esame finale anno 2013 Having grown on metal albums, renowned for their overly elaborated thankyou lists, I'm going to have a hard time staying within the mark. My mentor Paolo Ciancarini for trusting this outsider whom he had never met until he first showed up as a candidate for a Ph.D. student position. Aldo Gangemi and Valentina Presutti, without whom I'd be working as a humble system integrator now, if anything. Fellow worker bees in NeOn and IKS/Apache Stanbol all across Europe. We nailed
more » ... em big time. Magistri who mentored me sometime over the years:
fatcat:eepwenoh6jae7jzl4p2lpg2w3y

KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum

N. A. Singh
2003 Brain  
In one family, the phenotype extends beyond neonatal seizures and includes rolandic seizures, and a subset of families has onset of seizures in infancy.  ...  The rolandic seizures remit in adolescence with no impairment of mental function.  ...  Currents were recorded at room temperature (21±23°C) using standard two-microelectrode voltage clamp techniques (Stuhmer, 1992) .  ... 
doi:10.1093/brain/awg286 pmid:14534157 fatcat:nvm6y6feofgwrcjqpcv2bwyzmm

Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family

A. L. George, T. J. Knittle, M. M. Tamkun
1992 Proceedings of the National Academy of Sciences of the United States of America  
Steven Roberds, David Lovinger, Todd Verdoorn, Roland Kallen, and Robert Barchi for advice and critical review of the manuscript.  ...  The functional consequences of replacing arginine residues by glutamine in the S4 segment of domain 1 has been examined by Stuhmer et al. (40) by site-directed mutagenesis of the rat brain II NaCh.  ... 
doi:10.1073/pnas.89.11.4893 pmid:1317577 pmcid:PMC49194 fatcat:gerjg5lyrfanzas4qenh5rmdva

Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel

Maria João Marques-Carvalho, Johannes Oppermann, Eva Muñoz, Andreia S. Fernandes, Guillaume Gabant, Martine Cadene, Stefan H. Heinemann, Roland Schönherr, João Henrique Morais-Cabral
2016 Structure  
., 2003; Pardo and Stuhmer, 2014; Sanguinetti and Tristani-Firouzi, 2006) .  ...  Cell-based FRET experiments have suggested that CaM binds to the EAG1 channel in the absence of Ca 2+ and that this interaction occurs through BDN (Goncalves and Stuhmer, 2010) .  ... 
doi:10.1016/j.str.2016.07.020 pmid:27618660 pmcid:PMC5176025 fatcat:f3uoym3hwrasrldcqvzvtrkyzy

The Na Channel Voltage Sensor Associated with Inactivation Is Localized to the External Charged Residues of Domain IV, S4

Michael F. Sheets, John W. Kyle, Roland G. Kallen, Dorothy A. Hanck
1999 Biophysical Journal  
., 1996) and Na channels (Stuhmer et al., 1989; Yang and Horn, 1995; Yang et al., 1996) .  ...  Previous studies of Na channels have, in fact, suggested that the putative voltage sensor formed by S4 in domain IV (DIV) may have a unique role in channel inactivation (Stuhmer et al., 1989; Krafte et  ... 
doi:10.1016/s0006-3495(99)76929-8 pmid:10423423 pmcid:PMC1300369 fatcat:a6f6wtoa4nc3nedlgimnftjqky

Novel conopeptides of the I-superfamily occur in several clades of cone snails

Silke Kauferstein, Isabelle Huys, Ulrich Kuch, Christian Melaun, Jan Tytgat, Dietrich Mebs
2004 Toxicon  
The hH1 clone was kindly provided by Roland G. Kallen. Isabelle Huys is a Research Assistant of the Flemish Fund for Scientific Research (F.W.O.-Vlaanderen).  ...  Oocytes from Xenopus laevis were prepared as described (Stühmer, 1992) . Stage V-VI X. laevis oocytes were isolated by partial ovariectomy.  ... 
doi:10.1016/j.toxicon.2004.07.006 pmid:15450929 fatcat:ynic36hcijalrcukxmejhqgnsy

Satellite-Tracked Cumulus Velocities

T. Theodore Fujita, Edward W. Fearl, William E. Shenk
1975 Journal of Applied Meteorology  
Yaw Corrections for Accurate Gridding of Nimbus HRIR Data -Roland A. Madden. 78.  ...  Proposed Mechanism of Hook Echo Formation -Tetsuya Fujita with a Preliminary Mesosynoptic Analysis of Tornado Cyclone Case of May 26, 1963 -Tetsuya Fujita and Robbi Stuhmer 28.  ... 
doi:10.1175/1520-0450(1975)014<0407:stcv>2.0.co;2 fatcat:7ixhigo7uzgylloulrdwau3b5m

A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

Franziska Hartung, Thomas Krüwel, Xiaoyi Shi, Klaus Pfizenmaier, Roland Kontermann, Patrick Chames, Frauke Alves, Luis A. Pardo
2020 Frontiers in Pharmacology  
design of a nanobody-based affinity protein targeting the tumor-associated antigen Kv10.1, a voltage-gated potassium channel overexpressed in different tumor tissues and many cancer cell lines (Pardo and Stühmer  ... 
doi:10.3389/fphar.2020.00686 pmid:32528281 pmcid:PMC7246340 fatcat:qsyapaernzbe3kdtl5roffbdeq

Interventional Assays for the Latent Space of Autoencoders [article]

Felix Leeb, Stefan Bauer, Bernhard Schölkopf
2021 arXiv   pre-print
[71] Jan Stühmer, Richard Turner, and Sebastian Nowozin. Independent subspace analysis for unsupervised learning of disentangled representations.  ...  [67] Han Xiao, Kashif Rasul, and Roland Vollgraf. Fashion-mnist: a novel image dataset for benchmarking machine learning algorithms. arXiv preprint arXiv:1708.07747, 2017.  ... 
arXiv:2106.16091v1 fatcat:m2maxgrtivczhlprewua7s7ysm

Effects of Channel Cytoplasmic Regions on the Activation Mechanisms of Cardiac versus Skeletal Muscle Na + Channels

Eric S. Bennett
1999 Biophysical Journal  
., Stuhmer et al., 1989; Ukomadu et al., 1992; West et al., 1992) .  ...  Roland G. Kallen and Hali Hartmann for the generous gifts of the human heart sodium channel 1 cDNA and the hH1Q3 cDNA, respectively. The author is also grateful to Dr.  ... 
doi:10.1016/s0006-3495(99)77131-6 pmid:10585922 pmcid:PMC1300571 fatcat:swxk5pwhgrhw3d5c3c5qmymlr4

Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors [article]

Sandra Burgstaller, Teresa R. Wagner, Helmut Bischof, Sarah Bueckle, Aman Padamsey, Desiree I. Frecot, Philipp D. Kaiser, David Skrabak, Roland Malli, Robert Lukowski, Ulrich Rothbauer
2022 bioRxiv   pre-print
., 2019c; Pardo and Stühmer, 2014; Steudel et al., 2017) .  ... 
doi:10.1101/2022.04.12.488002 fatcat:yimm4xfk5rfmrj54ukcryiax6y
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