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Land and Conflict in Balovpur Village: The Role of Land Mediation

Mohammad Al-Amin, Rokeya Akter
2022 Zenodo  
Because of changes in some underlying factors, the land is increasingly becoming a source of conflict in rural areas of Bangladesh. One of the greatest issues Bangladesh is currently facing is the resolution of land disputes, which are causing endless difficulty in the lives of a significant percentage of the people. It adds to the already overburdened judiciary's caseload. Resolution of property disputes in Bangladesh is exceedingly difficult, laborious, long, and exorbitant due to a weak
more » ... structure, delay in judiciary land arbitral proceedings, and rampant corruption in land administration. This Study examines the numerous types of land- related conflicts that exist in Boluvpur village in Cumilla district, to highlight the legal concerns and obstacles that arise in their resolution. The research is conducted through primary and secondary data sources and primary data collected by interviews and mixed questionnaires. The author contends that to solve legal concerns in the settlement of land disputes regarding villages, the outdated land-uses planning system would require fundamental revisions and provide more recommendations.
doi:10.5281/zenodo.7104757 fatcat:d7vrr6zmnrczdehipmtsihpjsi

Alternative Medicine: A Recent Overview [chapter]

Salima Akter, Mohammad Nazmul Hasan, Begum Rokeya, Hajara Akhter, Mohammad Shamim Gazi, Farah Sabrin, Sung Soo Kim
2021 Alternative Medicine [Working Title]  
Alternative medicine has renewed its growing public interest in recent times due to inequality of patients and healthcare professionals' ratios with increased workload for the latter, various side effects of modern medicine, lack of complete remission from chronic diseases, high cost of new drugs, and emerging new diseases. Hence, people have become more dependent on treatment systems replying on alternative medicine or herbal medicine from traditional medicinal practitioners. Alternative
more » ... ne has grown substantially over time and encompasses several millennia of therapeutic systems. The significant areas of alternative medicine include mind–body therapies, body manipulation, and the therapies based on biological systems. Natural products based biological treatment is the most popular of them as nature has endowed us with abundance of effective pharmacologically active phytochemicals. These phytochemicals possess numerous specific clinical health benefits including antioxidant, antidiabetic, anti-inflammatory, anticancer, anti-infectious and analgesic effects. In addition, alternative medicine is easily accessible, affordable, most often noninvasive, and provides favorable benefits during terminal periods of some diseases. However, due to the lack of well-designed clinical trials, the safety and effectiveness of many alternative medicines/therapies remains elusive. This chapter will critically discuss major areas, uses, safety and regulation, current challenges & future perspectives of alternative medicine.
doi:10.5772/intechopen.97039 fatcat:yy3sgoqk3rb25ijjzr446sya6a

Socio-demographic, ecological factors and dengue infection trends in Australia

Rokeya Akter, Suchithra Naish, Wenbiao Hu, Shilu Tong, Richard Paul
2017 PLoS ONE  
Dengue has been a major public health concern in Australia. This study has explored the spatio-temporal trends of dengue and potential socio-demographic and ecological determinants in Australia. Data on dengue cases, socio-demographic, climatic and land use types for the period January 1999 to December 2010 were collected from Australian National Notifiable Diseases Surveillance System, Australian Bureau of Statistics, Australian Bureau of Meteorology, and Australian Bureau of Agricultural and
more » ... esource Economics and Sciences, respectively. Descriptive and linear regression analyses were performed to observe the spatio-temporal trends of dengue, socio-demographic and ecological factors in Australia. A total of 5,853 dengue cases (both local and overseas acquired) were recorded across Australia between January 1999 and December 2010. Most the cases (53.0%) were reported from Queensland, followed by New South Wales (16.5%). Dengue outbreak was highest (54.2%) during 2008-2010. A highest percentage of overseas arrivals (29.9%), households having rainwater tanks (33.9%), Indigenous population (27.2%), separate houses (26.5%), terrace house types (26.9%) and economically advantage people (42.8%) were also observed during 2008-2010. Regression analyses demonstrate that there was an increasing trend of dengue incidence, potential socio-ecological factors such as overseas arrivals, number of households having rainwater tanks, housing types and land use types (e.g. intensive uses and production from dryland agriculture). Spatial variation of socio-demographic factors was also observed in this study. In near future, significant increase of temperature was also projected across Australia. The projected increased temperature as well as increased socioecological trend may pose a future threat to the local transmission of dengue in other parts of Australia if Aedes mosquitoes are being established. Therefore, upgraded mosquito and disease surveillance at different ports should be in place to reduce the chance of mosquitoes and dengue cases being imported into all over Australia.
doi:10.1371/journal.pone.0185551 pmid:28968420 pmcid:PMC5624700 fatcat:5r5ay262p5gipfqiimamigzw5e

Hypothyroidism and hyperprolactinemia in women with primary and secondary infertility

Shamima Bari, Rokeya Begum, Qazi Shamima Akter
2020 IMC Journal of Medical Science  
and objectives: Infertility is a global health problem including Bangladesh. Altered thyroid and prolactin levels have been implicated as a cause of infertility. The study was undertaken to find out the serum thyroid hormones and prolactin status in women with primary and secondary infertility. Methods: Women with primary and secondary infertility were enrolled. Fertile age-matched women were included as control. The anthropometric details (age, height and weight) were recorded. Overnight
more » ... g blood sample was collected on 2nd day of menstrual cycle of the follicular phase. Serum thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3) and free thyroxine (FT4) were measured by enzyme-linked immunosorbent assay (ELISA). Serum prolactin (PRL) was estimated by radioimmunoassay. Results: A total of 150 women were enrolled in the study. Out of 150 women, 50 had primary and 50 had secondary infertility while 50 women were age-matched fertile women as control. The mean TSH levels of both infertility groups were significantly higher than that of fertile women. Regarding thyroid function, 24% and 28% of women with primary and secondary infertility had hypothyroidism respectively. The serum prolactin level was high in 42.9% and 50% of hypothyroid cases in primary and secondary infertility groups respectively. Conclusion: The study has demonstrated high occurrence of hypothyroidism with raised serum prolactin levels among infertile females emphasizing the importance of estimating both serum TSH and prolactin in infertility. Ibrahim Med. Coll. J. 2020; 14(1): 41-46
doi:10.3329/imcjms.v14i1.47454 fatcat:jreflg3c3jf2lpyvgi4bmkztje

Serum prolactin and gonadotropin levels in women with infertility in Bangladesh

Shamima Bari, Rokeya Begum, Qazi Shamima Akter
2018 IMC Journal of Medical Science  
<p><strong>Background and objectives: </strong>Infertility is a global health problem including Bangladesh. Altered prolactin, follicle (FSH) and luteinizing hormones (LH) levels have been implicated as a cause of infertility. The present study was undertaken to find out the serum prolactin and gonadotropin levels in women with primary and secondary infertility.</p><p><strong>Methods: </strong>The study involved a total of 100 women of which 50 had primary (Group A) and another 50 had secondary
more » ... (Group B) infertility. Fifty fertile age-matched women were included as control (Group C). All the study participants were selected from women attending the infertility unit of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Serum prolactin, FSH and LH hormones were measured by radioimmunoassay with blood collected on the 2nd day of menstrual cycle.</p><p><strong>Results: </strong>The mean serum prolactin level was significantly higher (&lt;p0.01) while the mean serum FSH and LH levels were significantly(p&lt; 0.01) lower in women with primary and secondary infertility compared to fertile women. However, the mean serum prolactin, FSH and LH levels were not significantly different from each other among the women with primary and secondary sterility. High prolactinemia was observed in 16% and 14% women in Group A and B respectively. Compared to women with secondary sterility, significantly (p&lt;0.05%) higher number of cases with primary sterility (30% vs. 54%) had FSH level below the normal range. On the other hand, 28% cases with secondary sterility had LH level below the normal range compared to 10% in primary sterility group (p&lt;0.05).</p><p><strong>Conclusion</strong><strong>: </strong>The study has demonstrated that there was alteration of serum prolactin, FSH and LH levels in women with primary and secondary sterility</p><p>IMC J Med Sci 2018; 12(1): 1-5</p>
doi:10.3329/imcjms.v12i1.35169 fatcat:6me7te4i4fbn3oguxnes6uceou

Relationship of serum fasting insulin with gonadotropins in infertile women

Shamima Bari, Rokeya Begum, Qazi Shamima Akter, Tanvir Alam, Kadeja Begum
2014 Bangladesh Journal of Physiology and Pharmacology  
Infertility has become a global health problem in the world wide affecting 8-10% of couple. It is also a matter of social injustice and inequality. Increase level of insulin has been implicated as a cause of infertility. Objective: To find out the association of fasting serum insulin level with gonadotropins in infertile women. Methods: This cross sectional study was conducted in the department of Physiology, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 150 female
more » ... age ranged from 20 -40 years were included in this study. Out of them100 infertile women were selected as study group (group B). Group B was subdivided into group B 1 and B 2 . Group B 1 consisted of 50 primary infertile women and group B 2 consisted of 50 secondary infertile women. Rest 50 age matched apparently healthy parous women were considered as base line control group A. All the study subjects were selected from out patient department of infertility unit, BSMMU, Dhaka. The control subjects were selected by personal contact. Serum fasting insulin was measured by enzyme-link-immunosorbend assay. Fasting blood glucose and blood glucose two hours after breakfast were measured by glucose oxidase method. The Data were collected in a prescribed data sheet after taking written consent. Statistical analyses were done by unpaired students "t" tests by SPSS program version 12. The level of significance was calculated and p value <0.05 was accepted as level of significance. Results: In this study, the mean fasting serum insulin level were significantly higher in infertile women than those of fertile women (p<0.001). Within the study group serum fasting insulin was higher in primary infertile women than that of secondary infertile women both were statistically not significant. Again, serum FSH and LH levels were significantly lower (P<.0001) in infertile women than those of fertile women. But serum FSH level was lower and LH level was higher in primary infertile women than that of secondary infertile women. In addition, fasting blood glucose level was almost similar but within normal limits in all groups. Blood glucose 2HABF was significantly higher in secondary infertile women than that of fertile women but within in normal limit. Moreover, fasting serum insulin level was negatively correlated with serum FSH and LH in primary infertility but negatively correlated with serum FSH and positive correlation with serum LH in secondary infertility. Conclusion: From the above study it may be concluded that fasting serum insulin level was higher in infertile women than those of healthy fertile women. These alterations may lead to menstrual irregularities, ovulatory dysfunction and infertility.
doi:10.3329/bjpp.v29i1-2.20063 fatcat:jhlqb4wn25akthqgl4b3peoika

Management Strategies and Maternal Outcome of Placenta Accreta

Ferdousi Chowdhury, Mahbuba Akhter, Rokeya Khatoon, Morzina Begum, Mahbuba Siddiqua, Saida Akter, Rahat Afza Chowdhury, Anoara Begum
2016 Bangladesh Journal of Obstetrics & Gynaecology  
<p><strong>Objectives: </strong>To find out the proportion and maternal outcome of placenta accreta.</p><p><strong>Materials and Methods: </strong>Total 10579 deliveries were served during January 2013 to 31st December 2013 in the Department of Obstetrics and Gynecology of Addin Women Medical College Hospital, Dhaka. All patients who needed postpartum or cesarean hysterectomy for postpartum hemorrhage and diagnosed as placenta accreta after postpartum hysterectomy were included for the study.
more » ... ong them who were antentally diagnosed as placenta previa with having other risk factors of placenta accreta, were evaluated by Doppler Sonography. All these cases such as diagnosed, suspected or only had multiple risk factors of placenta accreta were managed by a team approach and proper counseling of the patient's guardian about need of massive transfusion, hysterectomy, Intensive Care Unit (ICU) admission .</p><p><strong>Results: </strong>Among the total 10579 deliveries 22 cases were diagnosed as placenta accreta after postpartum hysterectomy. On histopathology 8 of these cases were placenta percreta, 7 cases were placenta increta and 7 cases were placenta accreta vera. Almost ninety one (90.90%) patient had placenta previa and 90.90% patient had past H/O one or two cesarean section. Placenta percreta cases were more common in patients with H/O two previous C/S or one C /S and dilatation &amp; curettage (D&amp;C). In all preoperatively diagnosed cases, Right lower paramedian incision was given and hysterectomy was done leaving the placenta in situ.</p><p><strong>Conclusion: </strong>Placenta accreta is associated with previous two or more cesarean deliveries, or multigravidae with past H/O repeated D&amp;C or M/R or combined. History of of these operations are diagnosed as having anterior or central placenta previa.</p><p>Bangladesh J Obstet Gynaecol, 2013; Vol. 28(2) : 71-75</p>
doi:10.3329/bjog.v28i2.30093 fatcat:e673ypm6g5ca7hbx7z6t7mccvu

Physical and mechanical properties of (Acacia auriculiformis x A mangium) hybrid Acacia

UK Rokeya, M Akter Hossain, M Rowson Ali, SP Paul
2011 Journal of Bangladesh Academy of Sciences  
The physical and mechanical properties of hybrid Acacia, produced from natural crossing between two introduced timber species (Acacia auriculiformis and Acacia mangium) were studied. The timber hybrid Acacia is of medium dense having specific gravity 0.56 at green condition which is less than that of teak (Tectona grandis). The volumetric shrinkage of hybrid Acacia wood was found greater than that of teak but the specific gravity was found less than that of teak. From the study of physical and
more » ... echanical properties it is evident that the species is moderately strong. The species is suitable for making furniture and other household articles.
doi:10.3329/jbas.v34i2.6864 fatcat:hcihnwpejfc3tf5ohbojkjb5lm

A Prospective Viewpoint on Neurological Diseases and Their Biomarkers

Mehrukh Zehravi, Janisa Kabir, Rokeya Akter, Sumira Malik, Ghulam Md. Ashraf, Priti Tagde, Sarker Ramproshad, Banani Mondal, Md. Habibur Rahman, Aurel George Mohan, Simona Cavalu
2022 Molecules  
Neurodegenerative diseases (NDDs) are disorders that affect both the central and peripheral nervous systems. To name a few causes, NDDs can be caused by ischemia, oxidative and endoplasmic reticulum (ER) cell stress, inflammation, abnormal protein deposition in neural tissue, autoimmune-mediated neuron loss, and viral or prion infections. These conditions include Alzheimer's disease (AD), Lewy body dementia (LBD), and Parkinson's disease (PD). The formation of β-sheet-rich aggregates of intra-
more » ... r extracellular proteins in the CNS hallmarks all neurodegenerative proteinopathies. In systemic lupus erythematosus (SLE), numerous organs, including the central nervous system (CNS), are affected. However, the inflammatory process is linked to several neurodegenerative pathways that are linked to depression because of NDDs. Pro-inflammatory signals activated by aging may increase vulnerability to neuropsychiatric disorders. Viruses may increase macrophages and CCR5+ T cells within the CNS during dementia formation and progression. Unlike medical symptoms, which are just signs of a patient's health as expressed and perceived, biomarkers are reproducible and quantitative. Therefore, this current review will highlight and summarize the neurological disorders and their biomarkers.
doi:10.3390/molecules27113516 pmid:35684455 pmcid:PMC9182418 fatcat:3hmseuv3vfdg3hdw4glptz3kke

Spatial and temporal analysis of dengue infections in Queensland, Australia: Recent trend and perspectives

Rokeya Akter, Suchithra Naish, Michelle Gatton, Hilary Bambrick, Wenbiao Hu, Shilu Tong, Luciano Andrade Moreira
2019 PLoS ONE  
Dengue is a public health concern in northern Queensland, Australia. This study aimed to explore spatial and temporal characteristics of dengue cases in Queensland, and to identify high-risk areas after a 2009 dengue outbreak at fine spatial scale and thereby help in planning resource allocation for dengue control measures. Notifications of dengue cases for Queensland at Statistical Local Area (SLA) level were obtained from Queensland Health for the period 2010 to 2015. Spatial and temporal
more » ... ysis was performed, including plotting of seasonal distribution and decomposition of cases, using regression models and creating choropleth maps of cumulative incidence. Both the space-time scan statistic (SaTScan) and Geographical Information System (GIS) were used to identify and visualise the space-time clusters of dengue cases at SLA level. A total of 1,773 dengue cases with 632 (35.65%) autochthonous cases and 1,141 (64.35%) overseas acquired cases were satisfied for the analysis in Queensland during the study period. Both autochthonous and overseas acquired cases occurred more frequently in autumn and showed a geographically expanding trend over the study period. The most likely cluster of autochthonous cases (Relative Risk, RR = 54.52, p<0.001) contained 50 SLAs in the north-east region of the state around Cairns occurred during 2013-2015. A cluster of overseas cases (RR of 60.81, p<0.001) occurred in a suburb of Brisbane during 2012 to 2013. These results show a clear spatiotemporal trend of recent dengue cases in Queensland, providing evidence in directing future investigations on risk factors of this disease and effective interventions in the high-risk areas.
doi:10.1371/journal.pone.0220134 pmid:31329645 pmcid:PMC6645541 fatcat:5zmrxfbnlrhozp2ip7reu25oiu

Maternal and Fetal Outcome of Preterm Prelabor Rupture of the Membranes in a Tertiary Care Hospital

Mst Rokeya Khatun, Nasrin Akter, Md Nowshad Ali
2020 TAJ Journal of Teachers Association  
Objective: To describe the clinical presentation and feto-maternal outcome of preterm prelabor rupture of the membrane of patients admitted in a tertiary care hospital of Bangladesh. Methods and Material: This is a cross-sectional observational type study carried out in Rajshahi Medical College Hospital, Rajshahi, Bangladesh during the year 2019 in the Department of Obstetrics and Gynecology. Sixty pregnant women with preterm prelabor rupture of the membrane (gestational age 28 to 37 weeks)
more » ... included in this study. Results: The mean age of the women was 27.03±6.13 years. Forty (66.7%) of them were from rural area. Majority were studied up to primary school (33.30%). Sixty five percent were house wife. Thirty seven (61.7%) women were multi gravid. Mean gestational age of the patient was 34.43±2.75 weeks. Antenatal care of the women was low. Most of the women have associated one or more diseases like anemia (35%), Urinary tract infection (28.33%), Pregnancy induced hypertension (20%), Lower genital infection (13.33 %,), gestational diabetes mellitus (10%) and heart disease (3.33%). The mean time interval between membrane rupture and delivery was 29±9 hours. Thirty one patients (51.7%) were delivered by caesarian section. Twenty eight (46.7%) women did not experience any complication and other suffered from wound infection (20%), PPH (10%), puerperal sepsis (8.33%) and chorioamnionitis (11.7%). Mean birth weight of the newborns was 2.16±0.42 Kg. Thirty eight (63.33%) newborn suffered from complications like neonatal asphyxia (30%), respiratory distress syndrome (13.3%), neonatal jaundice (11.7%) and neonatal sepsis (3.3%). Neonatal death was noticed in three (5%) cases. Fetal outcome was found significantly (p< 0.001) associated with low gestational age. Conclusion: Women with low education, associated co-morbidity, long latency and neonate with low birth weight have unfavorable outcome. Antenatal care is an important tool to prevent preterm prelabor rupture of the membrane by identifying the risk factors and its management. Optimum obstetric and medical care is essential for the reduction of these devastating complications. TAJ 2020; 33(2): 1-9
doi:10.3329/taj.v33i2.51306 fatcat:d7gygyssxncdridmw55ww7fycu

Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives

Rokeya Akter, Agnieszka Najda, Md. Habibur Rahman, Muddaser Shah, Sylwia Wesołowska, Syed Shams ul Hassan, Sidra Mubin, Parveen Bibi, Saeeda Saeeda
2021 Molecules  
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy (RT) are the common cancer treatments. In addition to these limitations, the development of adverse effects from chemotherapy and RT reduces the quality of life for cancer patients. Cellular radiosensitivity, or the ability to resist and overcome cell damage caused by ionizing radiation (IR), is directly related to cancer cells' response to RT. Therefore, radiobiological research is emphasizing chemical
more » ... unds 'radiosensitization of cancer cells so that they are more reactive in the IR spectrum. Recent years researchers have seen an increase in interest in natural products that have antitumor effects with minimal side effects. Natural products, on the other hand, are easy to recover and therefore less expensive. There have been several scientific studies done based on these compounds that have tested their ability in vitro and in vivo to induce tumor radiosensitization. The role of natural products in RT, as well as their usefulness and potential applications, is the goal of this current review.
doi:10.3390/molecules26195997 pmid:34641542 pmcid:PMC8512367 fatcat:b3ez4vugu5c7lgxsd6q5m4fema

Role of Phytonutrients in Nutrigenetics and Nutrigenomic Perspective in Curing Breast Cancer

Tanima Bhattacharya, Soumam Dutta, Rokeya Akter, Md. Habibur Rahman, Chenmala Karthika, Hechanur Puttappa Nagaswarupa, Hanabe Chowdappa Ananda Murthy, Ovidiu Fratila, Roxana Brata, Simona Bungau
2021 Biomolecules  
Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence that certain phytonutrients are able to modulate gene expression at transcriptional and post-transcriptional levels. Such phytonutrients may also be beneficial to prevent and treat BC. In this review,
more » ... e will focus on the nutrigenomic effects of various phytochemicals including polyphenols, phytosterols, terpenoids, alkaloids, and other compounds from different sources. Overall, these phytonutrients are found to inhibit BC cell proliferation, differentiation, invasion, metastasis, angiogenesis, and induce apoptotic cell death by targeting various molecular pathways. They also alter epigenetic mechanisms and enhance the chemosensitivity and radiosensitivity of cancer cells. Such phytochemicals may be used for the effective management of BC patients in the clinical setting in the future. The present article aims to summarize the specific molecular pathways involved in the genetic effects of phytochemicals in BC.
doi:10.3390/biom11081176 pmid:34439842 pmcid:PMC8394348 fatcat:eodt6khskbh5zbibgijksop5k4

Chemo-Preventive Action of Resveratrol: Suppression of p53—A Molecular Targeting Approach

Rokeya Akter, Md. Habibur Rahman, Deepak Kaushik, Vineet Mittal, Diana Uivarosan, Aurelia Cristina Nechifor, Tapan Behl, Chenmala Karthika, Manuela Stoicescu, Mihai Alexandru Munteanu, Cristiana Bustea, Simona Bungau
2021 Molecules  
Extensive experimental, clinical, and epidemiological evidence has explained and proven that products of natural origin are significantly important in preventing and/or ameliorating various disorders, including different types of cancer that researchers are extremely focused on. Among these studies on natural active substances, one can distinguish the emphasis on resveratrol and its properties, especially the potential anticancer role. Resveratrol is a natural product proven for its therapeutic
more » ... activity, with remarkable anti-inflammatory properties. Various other benefits/actions have also been reported, such as cardioprotective, anti-ageing, antioxidant, etc. and its rapid digestion/absorption as well. This review aims to collect and present the latest published studies on resveratrol and its impact on cancer prevention, molecular signals (especially p53 protein participation), and its therapeutic prospects. The most recent information regarding the healing action of resveratrol is presented and concentrated to create an updated database focused on this topic presented above.
doi:10.3390/molecules26175325 pmid:34500758 pmcid:PMC8433711 fatcat:6miexemuubdmhga46g2ysmn6je

Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein

Chenmala Karthika, Raman Sureshkumar, Mehrukh Zehravi, Rokeya Akter, Faraat Ali, Sarker Ramproshad, Banani Mondal, Priti Tagde, Zubair Ahmed, Farhat S. Khan, Md. Habibur Rahman, Simona Cavalu
2022 Life  
P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells. P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer medicines and confers resistance. Due to its wide specificity, several attempts have been made to block the action of P-gp to restore the efficacy of anticancer drugs. The major goal has been to create molecules that either compete with anticancer medicines for transport or function as a direct P-gp inhibitor.
more » ... te significant in vitro success, there are presently no drugs available in the clinic that can "block" P-gp–mediated resistance. Toxicity, unfavourable pharmacological interactions, and a variety of pharmacokinetic difficulties might all be the reason for the failure. On the other hand, P-gp has a significant effect in the body. It protects the vital organs from the entry of foreign bodies and other toxic chemicals. Hence, the inhibitors of P-gp should not hinder its action in the normal cells. To develop an effective inhibitor of P-gp, thorough background knowledge is needed in this field. The main aim of this review article was to set forth the merits and demerits of the action of P-gp on cancer cells as well as on normal cells. The influence of P-gp on cancer drug delivery and the contribution of P-gp to activating drug resistance were also mentioned.
doi:10.3390/life12060897 pmid:35743927 pmcid:PMC9227591 fatcat:xdzhbaevmne7bagpnwq4vzrj4e
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