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Temporal Dynamics of Brain Anatomy

Arthur W. Toga, Paul M. Thompson
2003 Annual Review of Biomedical Engineering  
These dynamic brain maps offer key biological markers for understanding disease progression and testing therapeutic response.  ...  We review a variety of mathematical and computational approaches to detect structural brain change with unprecedented sensitivity, both spatially and temporally.  ...  High-Resolution Random Mesh Algorithms for Creating a Probabilistic 3D Surface Atlas of the Human Brain, NeuroImage 3:19-34.  ... 
doi:10.1146/annurev.bioeng.5.040202.121611 pmid:14527311 fatcat:apd6t7esxjcqxgqkq6sphz7zcu

Impact of Phenylpropanoid Compounds on Heat Stress Tolerance in Carrot Cell Cultures

Mauro Commisso, Ketti Toffali, Pamela Strazzer, Matteo Stocchero, Stefania Ceoldo, Barbara Baldan, Marisa Levi, Flavia Guzzo
2016 Frontiers in Plant Science  
First we characterized the effects of heat stress to identify quantifiable morphological traits as markers of heat stress susceptibility.  ...  We then fed the cultures with precursors to induce the targeted accumulation of specific compounds, and compared the impact of heat stress in these cultures and unfed controls.  ...  ACKNOWLEDGMENTS We would like to thank the whole team working at the TEM Service (http://www.biologia.unipd.it/servizi/microscopiaelettronica/) of the Biology Department of Padua University.  ... 
doi:10.3389/fpls.2016.01439 pmid:27713760 pmcid:PMC5031593 fatcat:xe3b2pg4vjamxhncl2fkhvzqsa

Was theEubrontesTrack Maker Gregarious? Testing the Herding Hypothesis at Powder Hill Dinosaur Park, Middlefield, Connecticut

Patrick R. Getty, Laurel Hardy, Andrew M. Bush
2015 Bulletin of the Peabody Museum of Natural History  
For n<=16, the program also calculates an exact p value based on the T2 statistic evaluated for all possible permutations.  ...  Monte Carlo and exact permutation tests on the F statistic are computed as for the t test above.  ... 
doi:10.3374/014.056.0109 fatcat:uh76azz7dfdtvfm2mthc34ld2a

EMG-based Simultaneous and Proportional Estimation of Wrist Kinematics and its Application in Intuitive Myoelectric Control for Unilateral transradial Amputees

Farina Dario
2011 Frontiers in Computational Neuroscience  
Acknowledgements Center for Neural Science, New York University, USA Prefrontal cortex (PFC) is the hub of a distributed system that coordinates the selection, planning and execution of motor behaviors  ...  Hahne and B. Graimann (Otto Bock HealthCare) for supplying us with data and Armin Biess for fruitful discussions.  ...  Multivariate test statistics (union-intersection test, Wilk's lambda and generalized Hotelling's T2) were then computed separately for several regions of interest (ROIs) as a measure of the overall discriminability  ... 
doi:10.3389/conf.fncom.2011.53.00081 fatcat:nkq5wesfpbcjnikbxqh3v3gtqi

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease [article]

Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr (+24 others)
2020 biorxiv/medrxiv   pre-print
We map the transcriptome of osteocytes at different skeletal sites, across age and sexes in mice to reveal genes and molecular programs that control this complex cell-network.  ...  This reveals the molecular landscape that regulates osteocyte network formation and function, and establishes the importance of osteocytes in human skeletal disease.  ...  The Sanger Institute's Research Support Facility, Mouse Pipelines and Mouse Informatics Group generated mice and collected materials for this manuscript.  ... 
doi:10.1101/2020.04.20.051409 fatcat:k2wdj7sapzaxdagozsqefvm6am

Building the repertoire of neuromusculoskeletal modelling in cerebral palsy... One step at a time [article]

Caroline Alexander
2018
Sensitivity of a Hill-based muscle model to perturbations in model parameters.  ...  Vector field analysis was conducted on the 3D joint vectors and the 2D vector pairs using an SPM Hotelling's T 2 statistic.  ...  I agree that research data gathered from the results of this study may be published, provided that names are not used.  ... 
doi:10.26182/5b85ebc148b11 fatcat:sntcbdtesvheriuppihzkadeny

Book of Abstracts Symposium President Board of Directors Editors

Alberto Leardini, Vincenzo Parenti-Castelli, Ugo Della, Croce, Rita Stagni, Andrea Cutti, Alberto Leardini, Rita Stagni
2012 XII International Symposium on 3D Analysis of Human Movement Technology & Treatment Bologna (Italy)   unpublished
Since there is not a commonly accepted way to define or quantify locomotor stability, the collected data will permit also to apply and evaluate the stability indexes proposed in literature, looking for  ...  Moreover, it will permit to observe when and how the development of pendulum mechanism occurs.  ...  Morel for his help on design of the mechanical simulator and Symbios Orthopdédie SA for providing the prosthesis.  ... 
fatcat:lomluaj4fjgbxminxnq7peolsi

Metabolomics and Metallomics Analyses of Renal Cell Carcinoma and Prostate Cancer [article]

Oluyemi Seuntitun Falegan, University Of Calgary, Hans J. Vogel, Matthew Eric Hyndman
2019
While prostate cancer screening and diagnosis using serum prostate-specific-antigen is flawed by its low sensitivity and inability to detect indolent disease, the histological diversity of renal cell carcinoma  ...  Briefly, nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry techniques were used to analyze serum and urine samples obtained from renal cell carcinoma patients for isolating  ...  Permutation tests were carried out to confirm the stability and robustness of the supervised OPLS-DA models presented in this study.  ... 
doi:10.11575/prism/37098 fatcat:i66lau7qwze2vift3rkbyh5usu

Fast methods for Magnetic Resonance Angiography (MRA) [article]

Bahareh Vafadar, University Of Canterbury
2014
Magnetic resonance imaging (MRI) is a highly exible and non-invasive medical imaging modality based on the concept of nuclear magnetic resonance (NMR).  ...  The first contribution is the modification of generalized unaliasing using support and sensitivity encoding (GUISE).  ...  It provided a useful vehicle for testing our algorithm.  ... 
doi:10.26021/3036 fatcat:n7go65wmsbeshj6tgrboufsmlu

1H NMR profiling in colorectal cancer

Andrew Smith, Paraskevas Paraskeva, Timothy Allen-Mersh
2014
Colorectal cancer remains a major cause of death and illness in Western society.  ...  This approach involves the investigation of metabolic consequences of disease downstream of the disease process, including the complex interaction between host and environment.  ...  A statistical assessment of outliers can be made using Hotelling's T 2 , which is based on a multivariate Student's t-test.  ... 
doi:10.25560/18085 fatcat:grqkmy56qfhydct5ifyyutbtle

Multivariate Prediction Models for Bio-Analytical Data

Mattias John Rantalainen, Elaine Holmes, Jeremy Nicholson, METAGRAD
2008
Third, a kernel-based method is developed and applied for non-linear multivariate predict [...]  ...  Quantitative bio-analytical techniques that enable parallel measurements of large numbers of biomolecules generate vast amounts of information for studying and characterising biological systems.  ...  The metabonomics performance test mix, used for verification of the LC-MS system (containing theophylline, caffeine, nortriptyline, hippuric acid, and 4-nitrobenzoic acid), was obtained from Waters Corporation  ... 
doi:10.25560/1393 fatcat:hpd6fjbaq5ctjcqyyuido4ojiy

Sensory, cytokine and metabolic profiling of human experimental burn injury pain models

Helen Catherine Laycock, Carsten Bantel, Istvan Nagy, Masao Takata, Elizabeth Want, Wellcome Trust (London, England)
2018
Somatosensory testing and dermal microdialysis were performed.  ...  However the composition of this fluid and its interaction with peripheral nociceptors in incompletely defined, limiting the application of a mechanistic-based approach to burn injury-associated pain management  ...  The ellipse is the Hotelling's T2 that represents the 95% confidence interval of the scores. B: PCA loadings plot.  ... 
doi:10.25560/61633 fatcat:ehbjnjc5r5fqvhpc4epfnoluoq

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Scott E Youlten, John P Kemp, John G Logan, Elena J Ghirardello, Claudio M Sergio, Michael RG Dack, Siobhan E Guilfoyle, Victoria D Leitch, Natalie C Butterfield, Davide Komla-Ebri, Ryan C Chai, Alexander P Corr (+26 others)
2021
We define an osteocyte transcriptome signature of 1239 genes that distinguishes osteocytes from other cells. 77% have no previously known role in the skeleton and are enriched for genes regulating neuronal  ...  Thus, we reveal the molecular landscape that regulates osteocyte network formation and function and establish the importance of osteocytes in human skeletal disease.  ...  The Sanger Institute's Research Support Facility, Mouse Pipelines and Mouse Informatics Group generated mice and collected materials for this manuscript.  ... 
doi:10.17863/cam.70974 fatcat:gqrcbxlsfjhzfjr5i46wmxwfzi

Characterising the bidirectional biomolecular interactions between the intestinal microbiota and host drug metabolism

Marine Patricia Magali Letertre, Jonathan Swann, Ian Wilson, Imperial College London
2021
Despite technical limitations and the need for further development, this work demonstrated the potential utility of this model [...]  ...  Such bidirectional interactions can have implications for host health and the outcomes of treatment strategies and therefore, it is essential that these complex events are further understood.  ...  Acknowledgments First and foremost, I would like to thank my supervisors, Prof Ian Wilson and Dr Jonathan Swann. I found myself  ... 
doi:10.25560/89730 fatcat:45smqs7z4vajzlx6jqxhtp6lj4

Metabolic effects of oncogenic K-Ras in cancer cells

Richmond Takyi Bergner, Hector Keun, Robert Brown
2020
K- Ras mutations are required for cancer initiation in pancreatic cancers, where as in other cancers, such as lung cancer and colorectal cancer, it arises as a form of resistance to therapy.  ...  Overall, using a systems biology approach led to the identification of novel metabolic phenotypes and metabolic dependencies in K-Ras mutant colorectal cancer cells; this can be further exploited for prognostic  ...  This permutation test was significant with p<0.001 for (A) and p<0.009 for (C). (B and D) OPLS-DA loading plot.  ... 
doi:10.25560/82596 fatcat:kkaivkvdtre6xgxbgc2mzvb5nm