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Robust Reactions to Potential Day-Zero Worms Through Cooperation and Validation [chapter]

K. Anagnostakis, S. Ioannidis, A. D. Keromytis, M. B. Greenwald
2006 Lecture Notes in Computer Science  
Earlier work has shown that cooperative systems can respond quickly to day-zero worms, while distributed defensive systems allow detectors to be more conservative (i.e. paranoid) about potential attacks  ...  Cooperative defensive systems communicate and cooperate in their response to worm attacks, but determine the presence of a worm attack solely on local information.  ...  Acknowledgements This work was supported in part by the National Science Foundation under grants ITR CNS-0426623, DUE-0417085 and CCR-0331584.  ... 
doi:10.1007/11836810_31 fatcat:7rcpuqt5u5aurhnyzry72ehv3i

COVERAGE: detecting and reacting to worm epidemics using cooperation and validation

Kostas G. Anagnostakis, Michael B. Greenwald, Sotiris Ioannidis, Angelos D. Keromytis
2007 International Journal of Information Security  
Cooperative defensive systems communicate and cooperate in their response to worm attacks, but determine the presence of a worm attack solely on local information.  ...  Earlier work has shown that cooperative systems can respond quickly to dayzero worms, while distributed detection systems allow detectors to be more conservative (i.e. paranoid) about potential attacks  ...  Detection of Zero Day Worms and Viruses Although our algorithm is orthogonal to and agnostic about the method(s) with which new (zero day) viruses are detected, we briefly discuss different techniques  ... 
doi:10.1007/s10207-007-0032-z fatcat:xtybu2v76rdwje2kbhtjxkqwki

Defending against hitlist worms using network address space randomization

S. Antonatos, P. Akritidis, E.P. Markatos, K.G. Anagnostakis
2007 Computer Networks  
NASR slows down hitlist worms, and could even force them to exhibit scanlike features that makes them easier to contain at the perimeter.  ...  Sophisticated worms that use precomputed hitlists of vulnerable targets are especially hard to contain, as they spread at rates where existing defenses may not be able to act in a timely fashion and have  ...  We are indebted to the network administrators at FORTH, UoC and the anonymous ISP for agreeing to tolerate our experiments, and for providing us with detailed information on how their subnets are allocated  ... 
doi:10.1016/j.comnet.2007.02.006 fatcat:aoyh5e65d5bmrm7p5stll2yz34

Defending against hitlist worms using network address space randomization

S. Antonatos, P. Akritidis, E. P. Markatos, K. G. Anagnostakis
2005 Proceedings of the 2005 ACM workshop on Rapid malcode - WORM '05  
NASR slows down hitlist worms, and could even force them to exhibit scanlike features that makes them easier to contain at the perimeter.  ...  Sophisticated worms that use precomputed hitlists of vulnerable targets are especially hard to contain, as they spread at rates where existing defenses may not be able to act in a timely fashion and have  ...  We are indebted to the network administrators at FORTH, UoC and the anonymous ISP for agreeing to tolerate our experiments, and for providing us with detailed information on how their subnets are allocated  ... 
doi:10.1145/1103626.1103633 dblp:conf/worm/AntonatosAMA05 fatcat:lkcsmm53lrgkbghpwuj3gcx67y

SweetBait: Zero-hour worm detection and containment using low- and high-interaction honeypots

Georgios Portokalidis, Herbert Bos
2007 Computer Networks  
Sweet-Bait is deployed on medium sized academic networks across the world and is able to react to zero-day worms within minutes.  ...  By monitoring signature activity and predicting ascending or descending trends in worm virulence, we are able to sort signatures in order of urgency.  ...  Finally, a massive thanks is owed to ICS-FORTH, the University of Pennsylvania and UNINETT for hosting the SweetBait system.  ... 
doi:10.1016/j.comnet.2006.09.005 fatcat:q3r2giwqhjdp7dtquqwydu2wgm

A Specificity Map for the PDZ Domain Family

Raffi Tonikian, Yingnan Zhang, Stephen L Sazinsky, Bridget Currell, Jung-Hua Yeh, Boris Reva, Heike A Held, Brent A Appleton, Marie Evangelista, Yan Wu, Xiaofeng Xin, Andrew C Chan (+7 others)
2008 PLoS Biology  
The domains recognize features of the last seven ligand positions, and we find 16 distinct specificity classes conserved from worm to human, significantly extending the canonical two-class system based  ...  Using this approach, we predicted and validated several viral ligands for the PDZ domains of the SCRIB polarity protein.  ...  YZ, BC, J-HY, BAA, ME, YW, ACC, SS, LAL, and SSS are employed by Genentech.  ... 
doi:10.1371/journal.pbio.0060239 pmid:18828675 pmcid:PMC2553845 fatcat:vpqdnxgh6zdovnokuortec6qcq

Neural control of body-plan axis in regenerating planaria

Alexis Pietak, Johanna Bischof, Joshua LaPalme, Junji Morokuma, Michael Levin, David Umulis
2019 PLoS Computational Biology  
The computational model has been developed to predict the fraction of heteromorphoses expected in a population of regenerating planaria fragments subjected to different treatments, and for fragments originating  ...  We constructed and analyzed a comprehensive, multiscale computational model to explain the determination of axial polarity during planarian regeneration.  ...  We gratefully acknowledge help in maintaining the worm colony by Hans Gonzembach and undergraduate students Hannah Stowe, Quynh Anh Phan, Si Kun Wang, Sara E.  ... 
doi:10.1371/journal.pcbi.1006904 fatcat:wivchjvwivdv5kavcw5estav7a

The Synaptonemal Complex Shapes the Crossover Landscape Through Cooperative Assembly, Crossover Promotion and Crossover Inhibition During Caenorhabditis elegans Meiosis

Michiko Hayashi, Susanna Mlynarczyk-Evans, Anne M. Villeneuve
2010 Genetics  
Second, syp-1 RNAi worms exhibit both a strong preference for COs to occur on the left half of the X chromosome and a significant bias for SYP-1 protein to be associated with the left half of the chromosome  ...  The SC has been demonstrated to function both in stabilization of homolog pairing and in promoting the formation of interhomolog crossovers (COs).  ...  This work was supported by a Beckman Senior Research Fellowship to S.M.E. and by NIH grants R01 GM067268 and R01 GM053804 to A.M.V.  ... 
doi:10.1534/genetics.110.115501 pmid:20592266 pmcid:PMC2940310 fatcat:7j6uffnstvhglpuajmcpxc6psm

Synthetic Biology for Terraformation Lessons from Mars, Earth, and the Microbiome

Nuria Conde-Pueyo, Blai Vidiella, Josep Sardanyés, Miguel Berdugo, Fernando T. Maestre, Victor de De Lorenzo, Ricard Solé
2020 Life  
Can it be used to change endangered ecological communities and rescue them to prevent their collapse? What are the best strategies for such ecological engineering paths to succeed?  ...  What is the potential for synthetic biology as a way of engineering, on a large scale, complex ecosystems?  ...  Acknowledgments: The authors thanks all their collaborators for useful, out-of-the-box discussions concerning synthetic biology, drylands, terraformation, climate change and biomathematics.  ... 
doi:10.3390/life10020014 pmid:32050455 pmcid:PMC7175242 fatcat:zc6xexa6b5f2zhxpycktkzv7ze

Removal of benzoylecgonine from water matrices through UV 254 /H 2 O 2 process: Reaction kinetic modeling, ecotoxicity and genotoxicity assessment

D. Spasiano, D. Russo, M. Vaccaro, A. Siciliano, R. Marotta, M. Guida, N.M. Reis, G. Li Puma, R. Andreozzi
2016 Journal of Hazardous Materials  
and COST Action ES1403 for supporting this scientific cooperation.  ...  Acknowledgment The Authors are grateful to ERASMUS-Mobility Student Program, to Patrick Hester (Lamina Dielectrics Ltd) for donating the MCF material, to Ian Belk for allowing access to the STP of Loughborough  ...  In addition to the sample (t 0 ) collected at time zero, two further samples were collected at reaction time of 1.5 min (t f ) corresponding to almost complete BE conversion (Figure 4) and at 3.0 min (  ... 
doi:10.1016/j.jhazmat.2016.07.034 pmid:27450344 fatcat:h623rusqqfenfog62jlyhk7tji

C. elegans CEP-1/p53 and BEC-1 Are Involved in DNA Repair

Sandy Hoffman, Daniel Martin, Alicia Meléndez, Jill Bargonetti, Peiwen Fei
2014 PLoS ONE  
These results strongly support cross-talk between BEC-1 and CEP-1 to protect the C. elegans genome.  ...  To examine the influence of wild-type CEP-1 and DNA damage on C. elegans tumors we used glp-1(ar202gf)/Notch germline tumor mutants.  ...  Acknowledgments We thank Joel Meyer, Amanda Bess, Rahul Bhosle and the Meyer Laboratory for excellent technical support with setting up the lesion assay and important conversations and suggestions during  ... 
doi:10.1371/journal.pone.0088828 pmid:24586407 pmcid:PMC3930633 fatcat:tqz5r6neq5gavhkjgs3bvevcum

Isolated cell behavior drives the evolution of antibiotic resistance

T. Artemova, Y. Gerardin, C. Dudley, N. M. Vega, J. Gore
2015 Molecular Systems Biology  
Unlike the MIC, we find that the scMIC predicts the direction of selection and also specifies the antibiotic concentration at which selection begins to favor new mutants.  ...  Understanding the cooperative nature of bacterial growth in antibiotics is therefore essential in predicting the evolution of antibiotic resistance.  ...  The error bars are the maximum of the two Poissonian errors for zero antibiotic concentration and the standard error of the mean for all non-zero antibiotic points.  ... 
doi:10.15252/msb.20145888 pmid:26227664 pmcid:PMC4547850 fatcat:2du6njq2nngrxg4xwmvj3uk4zi

Illuminating Cancer Systems with Genetically Engineered Mouse Models and Coupled Luciferase Reporters In Vivo

Brandon Kocher, David Piwnica-Worms
2013 Cancer Discovery  
processing, protein-protein interactions, transformation, and oncogene addiction in live cells and animals.  ...  Luciferase-coupled GEMMs ultimately serve as a noninvasive, repetitive, longitudinal, and physiologic means by which cancer systems and therapeutic responses can be investigated accurately within the autochthonous  ...  to Brandon Kocher (T32 CA113275).  ... 
doi:10.1158/2159-8290.cd-12-0503 pmid:23585416 pmcid:PMC3679270 fatcat:pqveimo5k5cc5mf63cdm6dqoha

Growth and Scaling during Development and Regeneration [article]

Steffen Werner
2016 arXiv   pre-print
This allows us to identify generic principles of scalable body plan patterning and growth control in flatworms.  ...  In multi-cellular organisms, a multitude of cells interact to form and maintain highly complex body plans of well-defined size.  ...  It remains to validate this result with additional experiments and to investigate whether it could be linked to potential lipid stores.  ... 
arXiv:1608.06918v1 fatcat:4gpf3gskuvhxpf7p7nmdohlsxa

DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans

Daniel R. McHugh, Elena Koumis, Paul Jacob, Jennifer Goldfarb, Michelle Schlaubitz-Garcia, Safae Bennani, Paul Regan, Prem Patel, Matthew J. Youngman
2020 G3: Genes, Genomes, Genetics  
Accordingly, DAF-16 has little to no role in larval immunity, but functions specifically during adulthood to confer resistance to bacterial pathogens.  ...  The dynamic activity of regulatory modules that control immunity appears to underlie age-dependent modifications to the immune system.  ...  ACKNOWLEDGMENTS We thank Dennis Kim and members of his laboratory for their generous gifts of resources, reagents, and advice. Portions of this work were funded by a grant to MJY from the Charles E.  ... 
doi:10.1534/g3.120.401166 pmid:32161087 pmcid:PMC7202018 fatcat:7egmxr2zn5at3cm7jpkdywr7zq
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