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Comment on "Tibor Gánti and Robert Rosen" by Athel Cornish-Bowden

Wim Hordijk, Mike Steel
2016 Journal of Theoretical Biology  
Introduction In a recent article published in this journal (Cornish-Bowden, 2015) , a comparison is made between Tibor Gánti's chemoton model and Robert Rosen's (M,R) systems.  ...  In particular, autocatalytic sets are presented as follows (Cornish-Bowden, 2015) : "Autocatalytic sets (Kauffman, 1986) are the most different, because all of the others incorporate, at least implicitly  ... 
doi:10.1016/j.jtbi.2015.11.020 pmid:26640161 fatcat:a2o6dq4vrjb4rni6r7up4hufeq

Cornish, Robert L. "Predictors of College Students' Future Teaching Success." The University of Kansas Bulletin of Education 19: 55-59; February 1965

1965 Journal of Teacher Education  
College The Education Robert L. “Predictors of Students’ Future Teaching University of Kansas Bulletin of 19: 55-59; February 1965.  ...  Cornish, os Success. dil future teaching n selecting and | ] elementary eau persons who had mayor in ersity The rating supervisol i lent Ss po excel iverag ind om | eceivedad a they were tin r tl total  ... 
doi:10.1177/002248716501600319 fatcat:4d4qf4zqbbdshkzaaoi7rhewym

Note on Cholera

W Robert Cornish
1877 The Indian medical gazette  
pmid:28998046 pmcid:PMC5139232 fatcat:uf65ixtc7nbj7bwvo2o2gprl44

On the Pitfalls of Nested Monte Carlo [article]

Tom Rainforth, Robert Cornish, Hongseok Yang, Frank Wood
2016 arXiv   pre-print
There is an increasing interest in estimating expectations outside of the classical inference framework, such as for models expressed as probabilistic programs. Many of these contexts call for some form of nested inference to be applied. In this paper, we analyse the behaviour of nested Monte Carlo (NMC) schemes, for which classical convergence proofs are insufficient. We give conditions under which NMC will converge, establish a rate of convergence, and provide empirical data that suggests
more » ... this rate is observable in practice. Finally, we prove that general-purpose nested inference schemes are inherently biased. Our results serve to warn of the dangers associated with naive composition of inference and models.
arXiv:1612.00951v1 fatcat:52itxlylyrfjdehveh5za2u4lu

Prospects for Antiparasitic Drugs

Robert Eisenthal, Athel Cornish-Bowden
1998 Journal of Biological Chemistry  
Robert Eisenthal and Athel Cornish-Bowden THE CAUSATIVE AGENT OF AFRICAN SLEEPING SICKNESS  ... 
doi:10.1074/jbc.273.10.5500 pmid:9488673 fatcat:y4hmzeofkzarzowk7e66xd7xzi

Recommendations for terminology and databases for biochemical thermodynamics

Robert A. Alberty, Athel Cornish-Bowden, Robert N. Goldberg, Gordon G. Hammes, Keith Tipton, Hans V. Westerhoff
2011 Biophysical Chemistry  
Chemical equations are normally written in terms of specific ionic and elemental species and balance atoms of elements and electric charge. However, in a biochemical context it is usually better to write them with ionic reactants expressed as totals of species in equilibrium with each other. This implies that atoms of elements assumed to be at fixed concentrations, such as hydrogen at a specified pH, should not be balanced in a biochemical equation used for thermodynamic analysis. However, both
more » ... kinds of equations are needed in biochemistry. The apparent equilibrium constant K′ for a biochemical reaction is written in terms of such sums of species and can be used to calculate standard transformed Gibbs energies of reaction ∆ r G′ o . This property for a biochemical reaction can be calculated from the standard transformed Gibbs energies of formation ∆ f G i ′° of reactants, which can be calculated from the standard Gibbs energies of formation of species ∆ f G j° and measured apparent equilibrium constants of enzymecatalyzed reactions. Tables of ∆ r G′ o of reactions and ∆ f G i ′ o of reactants as functions of pH and temperature are available on the web, as are functions for calculating these properties. Biochemical thermodynamics is also important in enzyme kinetics because apparent equilibrium constants K′ can be calculated from experimentally determined kinetic parameters when initial velocities have been determined for both forward and reverse reactions. Specific recommendations are made for reporting experimental results in the literature.
doi:10.1016/j.bpc.2011.03.007 pmid:21501921 fatcat:dovlmmgvzvd6njcsatgwdr5jru

High-Energy Astrophysics in the 2020s and Beyond [article]

Christopher Reynolds, Robert Petre, Michael Corcoran, Keith Arnaud, Niel Brandt, Laura Brenneman, Neil Cornish, Gabriela Gonzales, Laura Lopez, Kristin Madsen
2019 arXiv   pre-print
The future advent of space-based GW detectors will give exquisitely detailed signals, permitting an unprecedented view of strong gravity at work (Berti, 2019; Berry, 2019; Cornish, 2019; Tinto, 2019)  ...  We stress the very real possibility of there being a profound discovery in this field such as GW echoes from black hole firewalls, strong evidence for non-locality, or "fuzzy" black holes (Cornish, 2019  ... 
arXiv:1903.07760v1 fatcat:7wucx5drajhsvhiwchmqcavwmy

Administrators' Opinions on the Education of Gifted Children

Robert L. Cornish
1964 The gifted child quarterly  
AUTUMN, 1964 ADMINISTRATORS’ OPINIONS ON THE EDUCATION OF GIFTED ROBERT L.  ...  Cornish is Assistant Professor of Education, The University of Kansas, Lawrence this area. | think safe assumption to make.  ... 
doi:10.1177/001698626400800304 fatcat:xz2pypejq5au3c7fgccozgrnzq

Predictors of Poor Outcomes in Critically Ill Adults with Hematologic Malignancy

Marion Cornish, Michael B. Butler, Robert S. Green
2016 Canadian Respiratory Journal  
Background. Patients with hematologic malignancy (HM) often require intensive care unit (ICU) admission due to organ failure through disease progression or treatment-related complications.Objective. To determine mortality and prognostic variables in adult patients with HM who were admitted to ICU.Methods. Structured chart review of all adult patients (age ≥ 18 years) with HM admitted to ICU of a Canadian tertiary care hospital between 2004 and 2014. Outcome measures included mortality (ICU,
more » ... ay, 60-day, and 12-month). Logistic regression was performed to determine predictors of mortality.Results. Overall, there were 206 cases of HM admitted to the ICU during the study (mean age: 51.3 ± 13.6 years; 60% male). Median stay was 3 days, with 14.1% requiring prolonged ICU admission. ICU mortality was 45.6% and increased to 59.2% at 30 days, 62.6% at 60 days, and 74.3% at 12 months. Predictors of increased ICU mortality included mechanical ventilation requirement and vasopressor therapy requirement, while admission to ICU postoperatively and having myeloma were associated with decreased mortality.Conclusions. Patients admitted to ICU with HM have high mortality (45.6%), which increased to 74.3% at 1 year. Analysis of multiple variables identified critical illness, postsurgical admission, and myeloma as predictors of patient outcomes.
doi:10.1155/2016/9431385 pmid:27445571 pmcid:PMC4904527 fatcat:ofuod3chb5hu5pdm52yf4rjkpy

Exome screening to identify loss-of-function mutations in the rhesus macaque for development of preclinical models of human disease

Adam S. Cornish, Robert M. Gibbs, Robert B. Norgren
2016 BMC Genomics  
Exome sequencing has been utilized to identify genetic variants associated with disease in humans. Identification of loss-of-function mutations with exome sequencing in rhesus macaques (Macaca mulatta) could lead to valuable animal models of genetic disease. Attempts have been made to identify variants in rhesus macaques by aligning exome data against the rheMac2 draft genome. However, such efforts have been impaired due to the incompleteness and annotation errors associated with rheMac2. We
more » ... hed to determine whether aligning exome reads against our new, improved rhesus genome, MacaM, could be used to identify high impact, loss-of-function mutations in rhesus macaques that would be relevant to human disease. Results: We compared alignments of exome reads from four rhesus macaques, the reference animal and three unrelated animals, against rheMac2 and MacaM. Substantially more reads aligned against MacaM than rheMac2. We followed the Broad Institute's Best Practice guidelines for variant discovery which utilizes the Genome Analysis Toolkit to identify high impact mutations. When rheMac2 was used as the reference genome, a large number of apparent false positives were identified. When MacaM was used as the reference genome, the number of false positives was greatly reduced. After examining the variant analyses conducted with MacaM as reference genome, we identified two putative loss-of-function mutations, in the heterozygous state, in genes related to human health. Sanger sequencing confirmed the presence of these mutations. We followed the transmission of one of these mutations (in the butyrylthiocholine gene) through three generations of rhesus macaques. Further, we demonstrated a functional decrease in butyrylthiocholinesterase activity similar to that observed in human heterozygotes with loss-of-function mutations in the same gene. Conclusions: The new MacaM genome can be effectively utilized to identify loss-of-function mutations in rhesus macaques without generating a high level of false positives. In some cases, heterozygotes may be immediately useful as models of human disease. For diseases where homozygous mutants are needed, directed breeding of loss-of-function heterozygous animals could be used to create rhesus macaque models of human genetic disease. The approach we describe here could be applied to other mammals, but only if their genomes have been improved beyond draft status.
doi:10.1186/s12864-016-2509-5 pmid:26935327 pmcid:PMC4776415 fatcat:pcpmdgnrzzb4fbak6se77ytteu


2012 The Evolution of Language  
Cultural transmission has a key impact on the evolution of linguistic structure (Kirby, Cornish & Smith, 2008) .  ...  Cultural transmission has a key impact on the evolution of linguistic structure (Kirby, Cornish & Smith, 2008) .  ... 
doi:10.1142/9789814401500_0126 fatcat:ky6jikt43nc3jk3drozlgnb3ny

On Nesting Monte Carlo Estimators [article]

Tom Rainforth, Robert Cornish, Hongseok Yang, Andrew Warrington, Frank Wood
2018 arXiv   pre-print
Certain nested estimation problems can be tackled by pseudo-marginal methods (Beaumont, 2003; Andrieu and Roberts, 2009; Andrieu et al., 2010) .  ... 
arXiv:1709.06181v4 fatcat:b4oyiyf7hrblfmj4plvtugcyre

Controlled Collapse of a Bose-Einstein Condensate [chapter]

J. L. Roberts, N. R. Claussen, S.L. Cornish, E. A. Donley, E. A. Cornell, C. E. Wieman
2008 Collected Papers of Carl Wieman  
Cornish) would like to acknowledge the support of the Lindemann Foundation. This work was supported by the ONR and NSF. * FIG. 1. Transition from stable to unstable condensates.  ... 
doi:10.1142/9789812813787_0081 fatcat:raqfxim2mjgwpfpf5ywkuvae6u

Analyzing Array Manipulating Programs by Program Transformation [chapter]

J. Robert M. Cornish, Graeme Gange, Jorge A. Navas, Peter Schachte, Harald Søndergaard, Peter J. Stuckey
2015 Lecture Notes in Computer Science  
We explore a transformational approach to the problem of verifying simple array-manipulating programs. Traditionally, verification of such programs requires intricate analysis machinery to reason with universally quantified statements about symbolic array segments, such as "every data item stored in the segment A[i] to A[j] is equal to the corresponding item stored in the segment B[i] to B[j]." We define a simple abstract machine which allows for set-valued variables and we show how to
more » ... programs with array operations to array-free code for this machine. For the purpose of program analysis, the translated program remains faithful to the semantics of array manipulation. Based on our implementation in LLVM, we evaluate the approach with respect to its ability to extract useful invariants and the cost in terms of code size. Instructions
doi:10.1007/978-3-319-17822-6_1 fatcat:7x2wiaigare4hkjaclqiwmwrb4

Parents', Teachers', and Pupils' Perception of the Gifted Child's Ability

Robert L. Cornish
1968 The gifted child quarterly  
THE GIFTED CHILD QUARTERLY PARENTS', TEACHERS', AND PUPILS' PERCEPTION OF THE GIFTED CHILD'S ABILITY Robert L.  ...  Cornish Parents, teachers, and pupils hold conflicting opinions in regard to a par- ticular student's ability.  ... 
doi:10.1177/001698626801200103 fatcat:wxv2a7vwvfdxjfscoklqjeepgi
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