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Current state-of-the-art conditional generative adversarial networks (C-GANs) require strong supervision via labeled datasets in order to generate images with continuously adjustable, disentangled semantics. In this paper we introduce a new formulation of the C-GAN that is able to learn realistic models with continuous, semantically meaningful input parameters and which has the advantage of requiring only the weak supervision of binary attribute labels. We coin the method intra-class variationarXiv:1811.11296v1 fatcat:sa6cwtgucjbmzponaryw3vpiyy
more »... solation (IVI) and the resulting network the IVI-GAN. The method allows continuous control over the attributes in synthesised images where precise labels are not readily available. For example, given only labels found using a simple classifier of ambient / non-ambient lighting in images, IVI has enabled us to learn a generative face-image model with controllable lighting that is disentangled from other factors in the synthesised images, such as the identity. We evaluate IVI-GAN on the CelebA and CelebA-HQ datasets, learning to disentangle attributes such as lighting, pose, expression and age, and provide a quantitative comparison of IVI-GAN with a classical continuous C-GAN.
Influenza is a major global public health threat as a result of its highly pathogenic variants, large zoonotic reservoir, and pandemic potential. Metagenomic viral sequencing offers the potential of a diagnostic test for influenza which also provides insights on transmission, evolution and drug resistance, and simultaneously detects other viruses. We therefore set out to apply Oxford Nanopore Technology to metagenomic sequencing of respiratory samples. We generated influenza reads down to adoi:10.1101/676155 fatcat:5p7mmz6wd5bnngkhfsbvx67hmi
more »... t of detection of 102-103 genome copies/ml in pooled samples, observing a strong relationship between the viral titre and the proportion of influenza reads (p = 4.7x10-5). Applying our methods to clinical throat swabs, we generated influenza reads for 27/27 samples with high-to-mid viral titres (Cycle threshold (Ct) values <30) and 6/13 samples with low viral titres (Ct values 30-40). No false positive reads were generated from 10 influenza-negative samples. Thus Nanopore sequencing operated with 83% sensitivity (95% CI 67-93%) and 100% specificity (95% CI 69-100%) compared to the current diagnostic standard. Coverage of full length virus was dependent on sample composition, being negatively influenced by increased host and bacterial reads. However, at high influenza titres, we were able to reconstruct >99% complete sequence for all eight gene segments. We also detected Human Coronavirus and generated a near complete Human Metapneumovirus genome from clinical samples. While further optimisation is required to improve sensitivity, this approach shows promise for the Nanopore platform to be used in the diagnosis and genetic analysis of influenza and other respiratory viruses.
Marriott et al. ... | www.pnas.org/cgi/doi/10.1073/pnas.1414020111 Marriott et al. | www.pnas.org/cgi/doi/10.1073/pnas.1414020111 Marriott et al. ...doi:10.1073/pnas.1414020111 pmid:25246540 pmcid:PMC4209982 fatcat:pmhrxppvofednmg33bxtjytwpu
Quantitative data (cycle threshold [C T ]) were generated by the GeneXpert assay, and we used the influenza virus C T value to estimate the viral titers in clinical samples. ... At a C T of Ͼ30, 6/13 samples generated influenza virus reads (range, 6 to 92,057 reads) (difference between sensitivity at a C T threshold of 30, P Ͻ 0.0001; Fig. 4 ). ...doi:10.1128/jcm.00963-19 pmid:31666364 pmcid:PMC6935926 fatcat:irk7viehrvhrfpbcnld23qmgxi
To sequence the SNP, nucleotides A, C, T and G were added at this position. The enzyme mix, substrate mix, and the four deoxynucleotides were added to the PSQ 1 96 cartridge (Qiagen 979004). ...doi:10.1371/journal.pone.0138253 pmid:26382066 pmcid:PMC4575197 fatcat:4dokvz5bpbaeje6huy7gnmyazi
To tune T MS E , crude parameter searches were performed in the range [1.5, 12] at intervals of 0.5. This arrived at values of T MS E = 5 for ABW and 7.5 for PERCEPTRON. ... These problems of over-segmentation could potentially be solved by better tuning of the T pro j and T MS E parameters. A coarse hyper-parameter search was performed, however. ...doi:10.1016/j.patrec.2018.03.024 fatcat:hwjhonj4wjgxhl7m3dpvwtvryy
doi:10.1016/s2468-1253(17)30033-x pmid:28404150 fatcat:4txlbu4eirgnzjgqdlcmqbvqfe
National Union Catalog
CaMW NUC65-38761 Marriott, Richard. Woodwork for students. London, Macmillan, 1961. 215 p. CaBVa illus. NUC63-35314 t, Richard A 1963 Kvichak River red salmon smolt studies, by Richard A. Marriott. ... Title, [E98] 970.1 62-14690 t Printed for Card Div. cu Marriott, Alice Lee, 1910- Indian Annie: Kiowa captive ,by, Alice Marriott. New 965. 179 p. 21cm 1. Kiowa Indians—Juvenile fiction. ...
National Union Catalog
Pugsley, Richard Marriotte, 1866-1918. ... Title. 19-14203 Library of Congress VKi4S.P9 1918 — Copy 2 Copyright ASI7iL 3, Pugsley, Richard Marriotte, 1866-1918. ...
Notes and Queries
Benjamin Marriott, of the King’s Remembrancer’g Office, 1723. Richard Marriott, 1725. Can he be identified with Richard Marriott of the Ordnance Office, who died in 1738 (London Magazine, p. 309) ? ... John Marriott, 1728. He was a benefactor to the library of St. Paul’s School in 1690. Was he a_ brother of Benjamin and Richard Marriott ? Thomas Norris, 1707. Gabriel Neve, 1712. ...
Notes and Queries
. — MARRIOTT FAMILY OF UGHILL, YORKS, AND DERBYSHIRE. —In view of the ‘admirable ‘ History of Under- bank Chapel, Stannington,’ by Dr. F. T. ... She married first, in 1786, a Colonel Richard St. ...doi:10.1093/nq/187.8.168a fatcat:vfrphyoxxjbfxcpmhh4bgrxdoe
American Ceramic Society Bulletin
5th floor near Marquette Room ACerS Member Welcome Center 1:00-3:30 p.m., Marriott Greco MS&6°T’07 Conference Registration 2:00-7:00 p.m., Cobo Center Pub Ceramographic Exhibit 2:00-7:00 p.m., Cobo Center ... p.m., Cobo Center Ceramographic Exhibit 7:00 a.m.—6:00 p.m., Cobo Center The Profound Influence of Tony Evans on Engineering Use of Structural Materials Morning session begins at 7:55 a.m., Cobo M2-29 Richard ...
Bioehen Z Richards, T. W . MeCaffrey Arts and Se., 1901, xxxvi. \MeCrudder H., J. Bio Stolte, K., Bioehe Z., (M11 ... Marriott, W. MecK., J. Biol. Chem.. 1916. XXIV, p. xvill. Howland, J.. Haessler, F. H., and Marriott. W. Meck., J. Biol. Chem., 1916. XXIV, p. Xvill. Marriott, W. Mek ind Howland, J., J. ...
National Union Catalog
Stationery Of, 1956 Marriott, Richard, Engineering drawing for students, Methuen (1960, 80 p, diagrs. 1, Mechanical drawing. NNC London, L Title, Marriott, Richard. ... Baltimore, Wil- Tocardiography. t. Title. RCOSS: 25M3 1962 616.1075 62-14618 Marriott, James William, 1884- comp. see The Best one-act plays. 1931- London, G. G. Harrap. ...
M* Emanuel Marriott, at his Father’s, Mt Joseph Marriott, M™ Caleb Davis, at M* Philip Hammond’s. And Mr’ Richard Green, Sub-Sheriff. In all 11. Of 300£ and upwards, Col. ... Robert Swan, M’ Brice T. B. Worthington, M® James Maccubbin, M* William Roberts, M? ...
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