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Rich Club Organization and Cognitive Performance in Healthy Older Participants

Hugo C. Baggio, Barbara Segura, Carme Junque, Marcel A. de Reus, Roser Sala-Llonch, Martijn P. Van den Heuvel
2015 Journal of Cognitive Neuroscience  
in healthy participants and whether the rich club might be differentially involved in cognitive functions with a heavier dependence on global integration.  ...  With a putative "rich club" of hubs hypothesized to play a central role in global integrative brain functioning, we assessed whether hub and rich club organizations are associated with cognitive performance  ...  Here, we investigated the role of the rich club in cognitive performance in a sample of healthy older participants.  ... 
doi:10.1162/jocn_a_00821 pmid:25941870 fatcat:uo2acd4wfzfvdjbhzymonoyt7i

Rich-Club Connectivity of the Structural Covariance Network Relates to Memory Processes in Mild Cognitive Impairment and Alzheimer's Disease

Gerhard S. Drenthen, Walter H. Backes, Whitney M. Freeze, Heidi I.L. Jacobs, Inge C.M. Verheggen, Martin P.J. van Boxtel, Erik I. Hoff, Frans R. Verhey, Jacobus F.A. Jansen, Juan Zhou
2022 Journal of Alzheimer's Disease  
Objective: To investigate how the cortical brain organization is altered in AD we studied the mutual connectivity of hubs in the SCN, i.e., the rich-club.  ...  Subsequently, rich-club coefficients were calculated from the SCN, and related to memory performance and hippocampal volume using linear regression.  ...  For example, the extent of rich-club configuration in the anatomical network has been associated to cognitive performance in healthy participants using diffusion tensor imaging [21], and more recently  ... 
doi:10.3233/jad-220175 pmid:35871335 fatcat:6lysiacg2vdeth4fwkhtqvvpoi

Longitudinal changes in rich club organization and cognition in cerebral small vessel disease

Esther M.C. van Leijsen, Ingeborg W.M. van Uden, Mayra I. Bergkamp, Helena M. van der Holst, David G. Norris, Jurgen A.H.R. Claassen, Roy P.C. Kessels, Frank-Erik de Leeuw, Anil M. Tuladhar
2019 NeuroImage: Clinical  
Here we examined the progression of disturbances in rich club organization in older adults with SVD and their associations with conventional SVD markers and cognitive decline.  ...  SVD-related disturbances in rich club organization progressed over time, predominantly in participants with severe SVD.  ...  Effects of rich club organization on cognitive performance The results from linear regression analyses on the associations between longitudinal changes in rich club organization and cognitive decline are  ... 
doi:10.1016/j.nicl.2019.102048 pmid:31706220 pmcid:PMC6978216 fatcat:6f2biq2y5bf3rhq6vc2qtb4wr4

Abnormal Rich Club Organization of Structural Network as a Neuroimaging Feature in Relation With the Severity of Primary Insomnia

Yunfan Wu, Zhihua Zhou, Shishun Fu, Shaoqing Zeng, Xiaofen Ma, Jin Fang, Ning Yang, Chao Li, Yi Yin, Kelei Hua, Mengchen Liu, Guomin Li (+2 others)
2020 Frontiers in Psychiatry  
We examined alterations in brain rich-club organization as revealed by diffusion tensor imaging (DTI) and the statistical relationships between abnormalities in rich-club metrics and the clinical features  ...  Aberrant rich-club organization was found mainly in limbic-cortical-basal ganglia circuits and the default-mode network.  ...  Rich Club Organization According by previous studies (9, 11) , rich club organizations were identified in structural networks from WM by averaging-group matrix in all participants of each group with a  ... 
doi:10.3389/fpsyt.2020.00308 pmid:32390883 pmcid:PMC7190795 fatcat:oqr2os6xibcizpguvzcnrzzmfa

Alterations in structural rich-club connectivity of the precuneus are associated with depressive symptoms among individuals with subjective memory complaints

Geon Ha Kim, Jung Yoon Kim, Jieun E. Kim, Jiyoung Ma, Bori R. Kim, Jooyeon Jamie Im, Hyeonseok S. Jeong, Eun Namgung, Suji Lee, Ilhyang Kang, In Kyoon Lyoo, Jaeuk Hwang (+1 others)
2018 Cognitive, Affective, & Behavioral Neuroscience  
Because rich-club organization of the brain plays a key role in the pathophysiology of various neuropsychiatric disorders, the investigation of rich club organization may provide insight regarding the  ...  For all participants, high-resolution, T1-weighted images and diffusion tensor images were obtained, and the network analysis was performed.  ...  rich-club organizations.  ... 
doi:10.3758/s13415-018-0645-x pmid:30298425 fatcat:pg6cno4ihjgmnoly7gjhy56jty

Reorganized Brain Functional Network Topology in Presbycusis

Bing Guan, Yixi Xu, Yu-Chen Chen, Chunhua Xing, Li Xu, Song'an Shang, Jin-Jing Xu, Yuanqing Wu, Qi Yan
2022 Frontiers in Aging Neuroscience  
sex-, and education-matched healthy controls.  ...  Graph theory was applied to analyze the topological properties of brain functional networks including global and nodal metrics, modularity, and rich-club organization.ResultsAt the global level, the brain  ...  FIGURE 4 | 4 FIGURE 4 | The rich-club organization for presbycusis patients with cognitive decline, presbycusis patients without cognitive decline, and healthy controls.  ... 
doi:10.3389/fnagi.2022.905487 pmid:35693344 pmcid:PMC9177949 fatcat:y4ppyke6jzfy7leqhpr25p6e2e

The effect of external stimulation on functional networks in the aging healthy human brain [article]

Anira Escrichs, Yonatan Sanz Perl, Noelia Martinez-Molina, Carles Biarnes, Josep Garre, Jose Manuel Fernandez-Real, Rafel Ramos, Ruth Marti, Reinald Pamplona, Ramon Brugada, Joaquin Serena, Lluis Ramio-Torrenta (+10 others)
2021 bioRxiv   pre-print
We found that the precuneus, a brain area belonging to the default mode network and the rich club, was the best stimulation target.  ...  Then, we fitted the PMS to a whole-brain model and applied in silico stimulations with different intensities in each node to force transitions from the brain states of the older group to the middle-age  ...  Acknowledgments AE, YS and GD were supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship.  ... 
doi:10.1101/2021.11.19.469206 fatcat:e6n36xbohzggxnksl5t6ijbjim

Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease

Peter McColgan, Kiran K. Seunarine, Adeel Razi, James H. Cole, Sarah Gregory, Alexandra Durr, Raymund A. C. Roos, Julie C. Stout, Bernhard Landwehrmeyer, Rachael I. Scahill, Chris A. Clark, Geraint Rees
2015 Brain  
The 'rich club' is a pattern of organization established in healthy human brains, where specific hub 'rich club' brain regions are more highly connected to each other than other brain regions.  ...  Consistent with our hypothesis we found that structural connectivity loss selectively affected rich club brain regions in premanifest and manifest Huntington's disease participants compared with controls  ...  We would also like to thank James Mills for his input in the statistical analysis and Ray Young for his assistance with the figures/tables.  ... 
doi:10.1093/brain/awv259 pmid:26384928 pmcid:PMC4620513 fatcat:otoqxfooanbstn5x5unktkygl4

Trajectory of rich club properties in structural brain networks [article]

Levin Riedel, Martijn P van den Heuvel, Sebastian Markett
2021 bioRxiv   pre-print
Rich club organization has been shown to be highly beneficial for communicability and higher cognition.  ...  A resilient rich club might thus be protective of a functional loss in late adulthood and represent a neural reserve to sustain cognitive functioning in the aging brain.  ...  It has, for instance, been shown that stronger rich club organization in middle and late adulthood relates to better performance in cognitive domains (Baggio et al., 2015) .  ... 
doi:10.1101/2021.11.16.468806 fatcat:ooi6d3zvufggtecpl6qfffmw7y

Weight Rich-Club Analysis in the White Matter Network of Late-Life Depression with Memory Deficits

Naikeng Mai, Xiaomei Zhong, Ben Chen, Qi Peng, Zhangying Wu, Weiru Zhang, Cong Ouyang, Yuping Ning
2017 Frontiers in Aging Neuroscience  
We found that compared with HC participants, patients with LLD (LLD-MD and LLD-IM) had relatively impaired rich-club organizations and rich-club connectivity.  ...  In conclusion, the disease effects of LLD were prevalent in rich-club organization.  ...  In the current study, positive assortativity was found in all participants. In addition, LLD patients have lower assortativity than HC, which was consistent with our rich-club organization findings.  ... 
doi:10.3389/fnagi.2017.00279 pmid:28878666 pmcid:PMC5572942 fatcat:52sl5yoqtzahda3ynabz2shoci

Brain network analysis reveals affected connectome structure in bipolar I disorder

Guusje Collin, Martijn P. van den Heuvel, Lucija Abramovic, Annabel Vreeker, Marcel A. de Reus, Neeltje E.M. van Haren, Marco P.M. Boks, Roel A. Ophoff, René S. Kahn
2015 Human Brain Mapping  
club' organization.  ...  'rich club' system appears not to be particularly affected.  ...  for Education and Research (UPPER)' for their assistance in recruiting participants.  ... 
doi:10.1002/hbm.23017 pmid:26454006 pmcid:PMC5597048 fatcat:6nh7pm54bzhutckryt23nf36xy

Aberrant Rich Club Organization in Patients with Obsessive-Compulsive Disorder and Their Unaffected First-Degree Relatives

Ziwen Peng, Xinyi Yang, Chuanyong Xu, Xiangshu Wu, Qiong Yang, Zhen Wei, Zihan Zhou, Tom Verguts, Qi Chen
2021 NeuroImage: Clinical  
We examined the structural rich club organization and its interrelationship with functional coupling.  ...  Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD).  ...  Acknowledgment This study was partly supported by National Natural Science Foundation of China (31871113, 31920103009, 32071049, 31900770 and 31671135).  ... 
doi:10.1016/j.nicl.2021.102808 pmid:34500426 pmcid:PMC8430383 fatcat:glhhe3q5yfb4dhyt3du6agtxqu

Rich-Club Analysis of Structural Brain Network Alterations in HIV Positive Patients With Fully Suppressed Plasma Viral Loads

Xire Aili, Wei Wang, Aidong Zhang, Zengxin Jiao, Xing Li, Bo Rao, Ruili Li, Hongjun Li
2022 Frontiers in Neurology  
Rich-club analysis was used to identify hub nodes across groups and abnormal rich-club connections.  ...  alterations and cognitive impairment.  ...  cognitive performance and clinical variables.  ... 
doi:10.3389/fneur.2022.825177 pmid:35812120 pmcid:PMC9263507 fatcat:57hq3ih5hvfc7pkzfexybmoyl4

The Organisation of the Elderly Connectome [article]

Alistair Perry, Wei Wen, Anton Lord, Anbupalam Thalamuthu, Perminder Sachdev, Michael Breakspear
2015 arXiv   pre-print
Here, whole-brain probabilistic tractography was performed on high-angular diffusion-weighted images acquired from 115 healthy elderly subjects, whom were 76 to 94 years old.  ...  These findings provide insights into healthy brain ageing and provide a benchmark for the study of neurodegenerative disorders such as Alzheimers disease and Frontotemporal Dementia.  ...  Structural and functional aspects relating to cost and benefit of rich club organization in the human cerebral cortex. Cereb Cortex 24, 2258-2267.  ... 
arXiv:1502.05772v2 fatcat:rgcl3ufxavdm7iuvok5kanzdqa

Fostering Well-Being in the Elderly: Translating Theories on Positive Aging to Practical Approaches

Liora Bar-Tur
2021 Frontiers in Medicine  
Drawing upon positive psychology and positive aging research and tools, this program is designed to help older adults improve their well-being by acquiring skills and strategies to cope with present and  ...  It can easily be conducted in wide range of adult education programs in community centers, sheltered homes, and primary care clinics.  ...  Interventions in healthy older adults such as physical or dietary changes and enhancing social and cognitive engagement can help diminish the impact of loneliness on the aging process and the emergence  ... 
doi:10.3389/fmed.2021.517226 pmid:33898472 pmcid:PMC8062922 fatcat:hfjyrwn63nhghkb56ln7xvkijq
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