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New Eurocoin: Tracking Economic Growth in Real Time

Giovanni Furio Veronese, Mario Forni, Marco Lippi, Filippo Altissimo, Riccardo Cristadoro
2007 Social Science Research Network  
Removal of short-run dynamics from a stationary time series to isolate the medium to longrun component can be obtained by a band-pass filter. However, band pass filters are infinite moving averages and can therefore deteriorate at the end of the sample. This is a well-known result in the literature isolating the business cycle in integrated series. We show that the same problem arises with our application to stationary time series. In this paper we develop a method to obtain smoothing of a
more » ... onary time series by using only contemporaneous values of a large dataset, so that no end-of-sample deterioration occurs. Our method is * We gratefully acknowledge encouragement and support from the Bank of Italy and the Centre for Economic Policy Research. We thank Marc Hallin for his suggestions at an early stage of the project, Antonio Bassanetti for his ideas and unique expertise in the realization of the currently published version of Eurocoin indicator and, in particular, Lucrezia Reichlin who started and promoted the Eurocoin project. We also thank those who gave suggestions and comments over the years, among them: Andreas Fisher, Domenico Giannone, James Stock, Mark Watson and two anonymous referees at the Bank of Italy. The views expressed here do not necessarily reflect those of the Bank of Italy, the Brevan Howard Asset Management, or any other institutions with which the authors are affiliated. applied to the construction of New Eurocoin, an indicator of economic activity for the euro area, which is an estimate, in real time, of the medium to long-run component of the GDP growth. As our dataset is monthly and most of the series are updated with a short delay, we are able to produce a monthly, real-time indicator. As an estimate of the medium to long-run GDP growth, Eurocoin performs better than the band-pass filter at the end of the sample, both in terms of fitting and turning-point signaling.
doi:10.2139/ssrn.1005171 fatcat:i2wgeljilrccvkwc3ghjjrj6om

Language-Independent Synthesis of Firewall Policies

Chiara Bodei, Pierpaolo Degano, Letterio Galletta, Riccardo Focardi, Mauro Tempesta, Lorenzo Veronese
2018 2018 IEEE European Symposium on Security and Privacy (EuroS&P)  
Configuring and maintaining a firewall configuration is notoriously hard. Policies are written in low-level, platform-specific languages where firewall rules are inspected and enforced along non trivial control flow paths. Further difficulties arise from Network Address Translation (NAT), since filters must be implemented with addresses translations in mind. In this work, we study the problem of decompiling a real firewall configuration into an abstract specification. This abstract version
more » ... s the low-level details away by exposing the meaning of the configuration, i.e., the allowed connections with possible address translations. The generated specification makes it easier for system administrators to check if: (i) the intended security policy is actually implemented; (ii) two configurations are equivalent; (iii) updates have the desired effect on the firewall behavior. The peculiarity of our approach is that is independent of the specific target firewall system and language. This independence is obtained through a generic intermediate language that provides the typical features of real configuration languages and that separates the specification of the rulesets, determining the destiny of packets, from the specification of the platform-dependent steps needed to elaborate packets. We present a tool that decompiles real firewall configurations from different systems into this intermediate language and uses the Z3 solver to synthesize the abstract specification that succinctly represents the firewall behavior and the NAT. Tests on real configurations show that the tool is effective: it synthesizes complex policies in a matter of minutes and, and it answers to specific queries in just a few seconds. The tool can also point out policy differences before and after configuration updates in a simple, tabular form.
doi:10.1109/eurosp.2018.00015 dblp:conf/eurosp/BodeiDGFTV18 fatcat:krdeuifjjzagzfwhvuopvrndvy

You do not have access to this content Introduction: the theoretical legacy of Augusto Graziani

Riccardo Bellofiore, Marco Veronese Passarella
2016 Review of Keynesian Economics  
doi:10.4337/roke.2016.03.01 fatcat:b3ztb4mjqfgxjoznbseeww3knu

mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer

Giovanni Lanza, Manuela Ferracin, Roberta Gafà, Angelo Veronese, Riccardo Spizzo, Flavia Pichiorri, Chang-gong Liu, George A Calin, Carlo M Croce, Massimo Negrini
2007 Molecular Cancer  
Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results: We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and 16 by high microsatellite instability, MSI-H) for genome-wide expression of microRNA (miRNA) and mRNA. Based on combined miRNA and mRNA gene expression, a molecular signature consisting of twenty seven differentially expressed genes, inclusive of 8 miRNAs,
more » ... could correctly distinguish MSI-H versus MSS colon cancer samples. Among the differentially expressed miRNAs, various members of the oncogenic miR-17-92 family were significantly up-regulated in MSS cancers. The majority of protein coding genes were also up-regulated in MSS cancers. Their functional classification revealed that they were most frequently associated with cell cycle, DNA replication, recombination, repair, gastrointestinal disease and immune response. Conclusion: This is the first report that indicates the existence of differences in miRNA expression between MSS versus MSI-H colorectal cancers. In addition, the work suggests that the combination of mRNA/miRNA expression signatures may represent a general approach for improving bio-molecular classification of human cancer.
doi:10.1186/1476-4598-6-54 pmid:17716371 pmcid:PMC2048978 fatcat:6gvjfpjjn5dbxej2qz3olyki6y

Monetary economics after the global financial crisis: what has happened to the endogenous money theory?

Giuseppe Fontana, Riccardo Realfonzo, Marco Veronese Passarella
2020 European Journal of Economics and Economic Policies: Intervention  
The 2010s have witnessed a new shift in central banking and, partially at least, in monetary economics and macroeconomic modelling. It is a fact that the endogenous money theory has been gradually clawing back popularity at the expense of the classical theory of interest rates, the financial intermediation view of banks, the money-multiplier story and the quantity theory of money. However, the loanable funds theory and the view of banks as pure financial intermediaries (sometimes coupled with
more » ... e money-multiplier story) are still sometimes invoked. In addition, the dynamic process of creation, circulation and destruction of money is usually neglected. The point is that money endogeneity is still regarded by many mainstream economists as a mere empirical fact, not a key feature of capitalist market-based economies to be properly explained by a logically consistent theory. By contrast, dissenting economists have further advanced the endogenous money view through: (a) a generalised theory of the endogenous process of money creation; (b) the increasing popularity of modern monetary theory in the public debate; and (c) the development of aggregative stock–flow consistent models and agent-based stock–flow consistent models as an alternative to dynamic stochastic general equilibrium models.
doi:10.4337/ejeep.2020.0056 fatcat:cmhzxaix5ffrnnezmottyftwoe

Choroidal Rift: A New OCT Finding in Eyes with Central Serous Chorioretinopathy

Marco Battista, Enrico Borrelli, Chiara Veronese, Francesco Gelormini, Riccardo Sacconi, Lea Querques, Francesco Prascina, Giovanna Vella, Antonio P Ciardella, Francesco Bandello, Giuseppe Querques
2020 Journal of Clinical Medicine  
Central serous chorioretinopathy (CSC) is a complex and not entirely understood retinal disease. The aim of our research was to describe a novel optical coherence tomography (OCT) finding named "choroidal rift", which may be identified in the choroid of eyes with CSC. We collected data from 357 patients (488 eyes) with CSC who had structural OCT and OCT angiography (OCTA) scans obtained. Choroidal rifts were identified as polygonal (and not round-shaped) hyporeflective lesions without
more » ... ctive margins. Choroidal rifts had to be characterized by a size superior to that of the largest choroidal vessel. Finally, hyporeflective lesions were graded as choroidal rifts only if these lesions had a main development perpendicular to the retinal pigment epithelium. OCT analysis allowed the identification of choroidal rifts in ten eyes from nine patients, all with chronic CSC, with an estimated prevalence rate of 2.1%. In three out of ten cases with choroidal rifts, these lesions spanned all the choroidal layers. In the remaining cases, choroidal rifts only partially spanned the choroidal thickness. In OCTA, choroidal rifts were characterized by the absence of flow. Combining structural OCT and OCTA information, we hypothesized that choroidal rifts may represent interruptions of the choroidal stroma in correspondence of fragile regions (in between expanded larger-sized choroidal vessels). Choroidal rift represents a novel OCT feature, which may characterize eyes with chronic CSC and may have a role in the development of irreversible chorio-retinal changes.
doi:10.3390/jcm9072260 pmid:32708670 fatcat:x3ub4wbfdzgqlfyhdehq5n5ciy

In Silico Validation of MCID Platform for Monte Carlo-Based Voxel Dosimetry Applied to 90Y-Radioembolization of Liver Malignancies

Alessia Milano, Alex Vergara Gil, Enrico Fabrizi, Marta Cremonesi, Ivan Veronese, Salvatore Gallo, Nico Lanconelli, Riccardo Faccini, Massimiliano Pacilio
2021 Applied Sciences  
The aim was the validation of a platform for internal dosimetry, named MCID, based on patient-specific images and direct Monte Carlo (MC) simulations, for radioembolization of liver tumors with 90Y-labeled microspheres. CT of real patients were used to create voxelized phantoms with different density and activity maps. SPECT acquisitions were simulated by the SIMIND MC code. Input macros for the GATE/Geant4 code were generated by MCID, loading coregistered morphological and functional images
more » ... performing image segmentation. The dosimetric results obtained from the direct MC simulations and from conventional MIRD approach at both organ and voxel level, in condition of homogeneous tissues, were compared, obtaining differences of about 0.3% and within 3%, respectively, whereas differences increased (up to 14%) introducing tissue heterogeneities in phantoms. Mean absorbed dose for spherical regions of different sizes (10 mm ≤ r ≤ 30 mm) from MC code and from OLINDA/EXM were also compared obtaining differences varying in the range 7–69%, which decreased to 2–9% after correcting for partial volume effects (PVEs) from imaging, confirming that differences were mostly due to PVEs, even though a still high difference for the smallest sphere suggested possible source description mismatching. This study validated the MCID platform, which allows the fast implementation of a patient-specific GATE simulation, avoiding complex and time-consuming manual coding. It also points out the relevance of personalized dosimetry, accounting for inhomogeneities, in order to avoid absorbed dose misestimations.
doi:10.3390/app11041939 fatcat:g76vulg57famdlnjmgisf75bni

MicroRNA Gene Expression Deregulation in Human Breast Cancer

Marilena V. Iorio, Manuela Ferracin, Chang-Gong Liu, Angelo Veronese, Riccardo Spizzo, Silvia Sabbioni, Eros Magri, Massimo Pedriali, Muller Fabbri, Manuela Campiglio, Sylvie Ménard, Juan P. Palazzo (+8 others)
2005 Cancer Research  
MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also
more » ... aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index. (Cancer Res 2005; 65(16): 7065-70)
doi:10.1158/0008-5472.can-05-1783 pmid:16103053 fatcat:gz362pwiafcftjrv7bfnjryxda

Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma

Laura Lupini, Felice Pepe, Manuela Ferracin, Chiara Braconi, Elisa Callegari, Sara Pagotto, Riccardo Spizzo, Barbara Zagatti, Paola Lanuti, Francesca Fornari, Reza Ghasemi, Renato Mariani-Costantini (+7 others)
2016 OncoTarget  
The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in HCC cells carrying wild-type TP53 the steady activation of the miR-145 signaling selects clones resistant to apoptosis via up-regulation of the oncogenic miR-483-3p. Expression of the miR-145-5p and of the miR-483-3p correlated negatively in non-neoplastic liver (n=41;
more » ... , P=0.028), but positively in HCCs (n=21; ρ=0.791, P<0.0001), which we hypothesized to be due to impaired glucose metabolism in HCCs versus normal liver. In fact, when liver cancer cells were grown in low glucose, miR-145-5p lowered miR-483-3p expression, allowing apoptosis, whereas when cells were grown in high glucose the levels of miR-483-3p increased, reducing the apoptotic rate. This indicates that depending on glucose availability the miR-145-5p has double effects on the miR-483-3p, either inhibitory or stimulatory. Moreover, resistance to apoptosis in clones overexpressing both miR-145-5p and miR-483-3p was abrogated by silencing the miR-483-3p. Our data highlight a novel mechanism of resistance to apoptosis in liver cancer cells harbouring wild type TP53 and suggest a potential role of miR-145-5p and miR-483-3p as druggable targets in a subset of HCCs.
doi:10.18632/oncotarget.8913 pmid:27120784 pmcid:PMC5058762 fatcat:by7nghsnvbfzfg27iw7kjysvl4

The emergence of loss of efficacy during antidepressant drug treatment for major depressive disorder: An integrative review of evidence, mechanisms, and clinical implications

Michele Fornaro, Annalisa Anastasia, Stefano Novello, Andrea Fusco, Riccardo Pariano, Domenico De Berardis, Marco Solmi, Nicola Veronese, Brendon Stubbs, Eduard Vieta, Michael Berk, Andrea de Bartolomeis (+1 others)
2019 Pharmacological Research  
The re-emergence (i.e. 'breakthrough') of depressive symptoms despite maintenance treatment of depression with antidepressant drugs is a complex clinical phenomenon referred to as tolerance. Herein we critically appraise evidence from both pre-clinical and clinical studies, focusing on putative mechanisms as well as clinical correlates and implications of the emergence tolerance during antidepressant treatment for major depressive disorder (MDD). It is firstly unclear to what extent this
more » ... pe reflects a pharmacological effect of an antidepressant, is driven by non-adherence, is a marker of latent bipolarity or another comorbidity, a marker of neuroprogression of the underlying disorder or the intrusion of the impact of psychosocial variables into the clinical course. The operational definitions of tolerance and its related phenomena have also been largely inconsistent. Several protective clinical indicators have been proposed, including a rapid-cycling course and comorbid chronic anxiety, whilst poor treatment adherence, proneness to emotional blunting and sub-threshold bipolarity have been identified as possible correlates of tolerance to antidepressant treatment in MDD. Putative neurobiological underpinnings include adaptations in the hypothalamic-pituitary-adrenal (HPA) axis and the serotonergic system. Due to the clinical and diagnostic challenges imposed by the emergence of tolerance to antidepressants, there is an urgent need for upcoming international guidelines to reach a consensus on operational definitions for this complex clinical phenomenon, thus enabling a more precise appreciation of the incidence and correlates of tolerance to antidepressants. Taken together, the present review underscores the need to cautiously weight benefits and risks prior to considering long-term antidepressant treatment for patients with MDD as tolerance may emerge in a subset of patients.
doi:10.1016/j.phrs.2018.10.025 pmid:30385364 fatcat:jswwztdusnb75foxhi4ylsgvvy

Studi Veronesi Miscellanea di studi sul territorio veronese II Verona 2017

Studi Veronesi, Comitato Editoriale, Riccardo Bertolazzi, Claudio Bismara, Andrea Brugnoli, Pierpaolo Brugnoli, Valeria Chilese, Marianna Cipriani, Evelina De Rossi, Emanuele Luciani, Davide Mantovanelli, Fausta Piccoli (+1 others)
Divinità maschili nel Veronese.  ...  Miscellanea di studi sul territorio veronese.  ...  Divinità maschili nel Veronese.  ... 

Title page, colophon and table of context

Comitato editoriale Studi Veronesi
2019 Studi veronesi  
Miscellanea di studi sul territorio veronese, IV, Verona 2019  ...  Miscellanea di studi sul territorio veronese.  ...  Veronesi : Miscellanea di studi sul territorio veronese : 4. / a cura di Andrea Brugnoli e Pierpaolo Brugnoli ; collaborazione redazionale di Valeria Chilese, Marianna Cipriani, Alessia Marchiori e Riccardo  ... 
doaj:39ad5649afa14bcea16307b2452bbc7a fatcat:tdbmgubag5bcbi4fxdirsusuni

Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience

Andrea Sartore-Bianchi, Alessio Amatu, Erica Bonazzina, Stefano Stabile, Laura Giannetta, Giulio Cerea, Ilaria Schiavetto, Katia Bencardino, Chiara Funaioli, Riccardo Ricotta, Tiziana Cipani, Michele Schirru (+18 others)
2017 Targeted oncology  
Patients with metastatic colorectal cancer (mCRC) refractory to standard therapies have a poor prognosis. In this setting, recruitment into clinical trials is warranted, and studies driven by selection according to individual tumor molecular characteristics are expected to provide added value. Objective We retrospectively analyzed data from patients with mCRC refractory to or following failure of standard therapies who were enrolled into phase I/II clinical studies at the Niguarda Cancer Center
more » ... based on the presence of a specific molecular profile expected to represent the target of susceptibility to the experimental drug(s). patients with mCRC underwent molecular screening. Eighty patients (3.9%) were enrolled in ad hoc studies; the median age was 60 years (range 36-86) and the median number of previous treatment lines was five (range 2-8). Molecular char-acteristics exploited within these studies were MGMT promoter hypermethylation (48.7%), HER2 amplification (28.8%), BRAF V600E mutation (20%), and novel gene fusions involving ALK or NTRK (2.5%). Results One patient (1%) had RECIST (Response Evaluation Criteria In Solid Tumors) complete response (CR), 13 patients (16.5%) experienced a partial response (PR), and 28 (35%) stable disease (SD). Median progression-free survival (PFS) was 2.8 months (range 2.63-3.83), with 24% of patients displaying PFS >5 months. Median growth modulation index (GMI) was 0.85 (range 0-15.61) and 32.5% of patients had GMI >1.33. KRAS exon 2 mutations were found in 38.5% of patients, and among the 78 patients with known KRAS status, those with wildtype tumors had longer PFS than those with mutated tumors (3.80 [95% CI 2.80-5.03] vs. 2.13 months [95% CI 1.77-2.87], respectively, p = 0.001). Median overall survival (OS) was 7.83 months (range 7.17-9.33) for all patients, and patients with KRAS wild-type tumors had longer OS than those with mutated tumors (7.83 [95% CI 7.33-10.80] vs. 7.18 months [95% CI 5.63-9.33], respectively, p = 0.06). Conclusions This single-institution retrospective study indicates that in a heavily pretreated population approximately 4% of mCRC tumors display a potential actionable molecular context suitable for therapeutic intervention. Application of molecular selection is challenging but improves clinical outcome even in later lines of treatment.
doi:10.1007/s11523-017-0505-6 pmid:28669023 pmcid:PMC5524857 fatcat:4hauuzmrhvcovmorsrf5nqwmha

Title page, colophon and table of context

Comitato editoriale Studi Veronesi
2016 Studi veronesi  
Miscellanea di studi sul territorio veronese, I, Verona 2016  ...  La società veronese del XVI secolo di fronte alla novella di Giulietta e Romeo 11 FAUSTA PICCOLI Giochi di specchi.  ...  VIII di Gian Giacomo Dionisi (1806) Comitato editoriale Elisa Anti, Riccardo Bertolazzi, Claudio Bismara, Andrea Brugnoli, Pierpaolo Brugnoli, Valeria Chilese, Marianna Cipriani, Evelina De Rossi, Emanuele  ... 
doaj:8b736ddd1d39423bbda66d3d9f07a958 fatcat:qyub3ciiuzbe5eodiuvqqfwxf4

Page 579 of Nuova Antologia, Revista Di Lettere, Scienze Ed Arti Vol. 130, Issue [page]

1893 Nuova Antologia, Revista Di Lettere, Scienze Ed Arti  
Della pretesa sua di discendere dalla dinastia veronese degli Scali- geri fa testimonianza un altro luogo di questa lettera, dove egli chiede al collega che gli raccolga monete loro, le quali egli avrà  ...  Riccardo e Olga si amano; cioè, Olga ama Riccardo e, con l’aiuto di Malvina, riesce a farsene riamare.  ... 
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