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Nora Palomar-Ciria, Patricia Blanco del Valle, Miguel Ángel Hernández-Las Heras, Ricardo Martínez-Gallardo
2020 Psychiatry Research  
Since its outbreak, coronavirus disease 2019 has been producing atypical manifestations aside from fever, coughing and dysnea. One of the most common is delirium, which, however, is highly overlooked. This has consequences in the treatment of patients and also may lead to underdiagnosing the infection. In this work, we present the case of a man diagnosed with schizophrenia, who had been stable for more than 20 years and that presented with an atypical picture of psychotic and confusional symptoms related to COVID-19 infection.
doi:10.1016/j.psychres.2020.113137 pmid:32485483 pmcid:PMC7251413 fatcat:6ho6udo6srf7lanvlmb7r3mc4i

Behavior of populations of floury maize of the Blanco del Cusco variety in the Mantaro valley, Peru
Comportamiento de poblaciones de maíz amiláceo de la variedad Blanco del Cusco en el valle del Mantaro, Perú

Gilberto Gamarra Sánchez, Rubén Munive Cerrón, Yveth Munive Yachachi, Andrés Azabache Leytón, Ricardo Sevilla Panizo, Anghely Lapa Chanca
2020 Agroindustrial science  
RESUMEN Se evaluó cinco poblaciones de la variedad Blanco del Cusco perteneciente a la raza Cuzco Gigante de maíz en el valle del Mantaro -Huancayo -Perú.  ...  Las poblaciones son resultado de procesos de introducción y adaptación de germoplasma al valle del Mantaro. Los experimentos fueron conducidos en tres localidades durante el período 2020.  ...  Conclusiones Las poblaciones de maíz amiláceo Hualhuas, INIA-Blanco Urubamba, Chingas y Blanco Quispicanchi se presentaron como buenos productores de semilla en el valle del Mantaro con un periodo semitardío  ... 
doi:10.17268/agroind.sci.2020.03.09 fatcat:bmcnzxuwuvb4tha42dbfehc3vu

Development of an activity disease score in patients with uveitis (UVEDAI)

Esperanza Pato, Mª Auxiliadora Martin-Martinez, Adela Castelló, Rosalía Méndez-Fernandez, Santiago Muñoz-Fernández, Miguel Cordero-Coma, Lucia Martinez-Costa, Elia Valls, Miguel Reyes, Félix Francisco, Mar Esteban, Alex Fonollosa (+10 others)
2016 Rheumatology International  
included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions,
more » ... ascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were Abstract To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that Electronic supplementary material The online version of this article (
doi:10.1007/s00296-016-3593-1 pmid:27815703 pmcid:PMC5357298 fatcat:mkelspeqqrbvfdtrwjc3bdyseu

Stingray: A Modern Python Library for Spectral Timing

Daniela Huppenkothen, Matteo Bachetti, Abigail L. Stevens, Simone Migliari, Paul Balm, Omar Hammad, Usman Mahmood Khan, Himanshu Mishra, Haroon Rashid, Swapnil Sharma, Evandro Martinez Ribeiro, Ricardo Valles Blanco
2019 Astrophysical Journal  
Stingray Huppenkothen, D.; Bachetti, M.; Stevens, A. L.; Migliari, S.; Balm, P.; Hammad, O.; Khan, U. M.; Mishra, H.; Rashid, H.; Sharma, S. ABSTRACT This paper describes the design and implementation of stingray, a library in Python built to perform time series analysis and related tasks on astronomical light curves. Its core functionality comprises a range of Fourier analysis techniques commonly used in spectral-timing analysis, as well as extensions for analyzing pulsar data, simulating data
more » ... sets, and statistical modeling. Its modular build allows for easy extensions and incorporation of its methods into data analysis workflows and pipelines. We aim for the library to be a platform for the implementation of future spectral-timing techniques. Here, we describe the overall vision and framework, core functionality, extensions, and connections to high-level command-line and graphical interfaces. The code is 2 HUPPENKOTHEN ET AL. well-tested, with a test coverage of currently 95%, and is accompanied by extensive API documentation and a set of step-by-step tutorials.
doi:10.3847/1538-4357/ab258d fatcat:wlnzmemi2zhg7prmi3s3nhhxni

Anti-IL-6 Receptor Tocilizumab in Refractory Graves' Orbitopathy: National Multicenter Observational Study of 48 Patients

Lara Sánchez-Bilbao, David Martínez-López, Marcelino Revenga, Ángel López-Vázquez, Elia Valls-Pascual, Belén Atienza-Mateo, Beatriz Valls-Espinosa, Olga Maiz-Alonso, Ana Blanco, Ignacio Torre-Salaberri, Verónica Rodríguez-Méndez, Ángel García-Aparicio (+19 others)
2020 Journal of Clinical Medicine  
Ana Blanco had consultation fees/participation in company sponsored speaker's bureau from AbbVie.  ...  Conflicts of Interest: Disclosures that might be interpreted as constituting of possible conflict(s) of interest for the study: Elia Valls-Pascual received grants/research supports from Roche, Novartis  ... 
doi:10.3390/jcm9092816 pmid:32878150 pmcid:PMC7563792 fatcat:os2zd5jfq5ft7k365wstpcl4ty

Efficacy of Anakinra in Refractory Adult-Onset Still's Disease

Francisco Ortiz-Sanjuán, Ricardo Blanco, Leyre Riancho-Zarrabeitia, Santos Castañeda, Alejandro Olivé, Anne Riveros, María.L. Velloso-Feijoo, Javier Narváez, Inmaculada Jiménez-Moleón, Olga Maiz-Alonso, Carmen Ordóñez, José A. Bernal (+20 others)
2015 Medicine  
Adult-onset Still's disease (AOSD) is often refractory to standard therapy. Anakinra (ANK), an interleukin-1 receptor antagonist, has demonstrated efficacy in single cases and small series of AOSD. We assessed the efficacy of ANK in a series of AOSD patients. Multicenter retrospective open-label study. ANK was used due to lack of efficacy to standard synthetic immunosuppressive drugs and in some cases also to at least 1 biologic agent. Forty-one patients (26 women/15 men) were recruited. They
more » ... d a mean age of 34.4 AE 14 years and a median [interquartile range (IQR)] AOSD duration of 3.5 [2-6] years before ANK onset. At that time the most common clinical features were joint manifestations 87.8%, fever 78%, and cutaneous rash 58.5%. ANK yielded rapid and maintained clinical and laboratory improvement. After 1 year of therapy, the frequency of joint and cutaneous manifestations had decreased to 41.5% and to 7.3% respectively, fever from 78% to 14.6%, anemia from 56.1% to 9.8%, and lymphadenopathy from 26.8% to 4.9%. A dramatic improvement of laboratory parameters was also achieved. The median [IQR] prednisone dose was also reduced from 20 [11.3-47.5] mg/day at ANK onset to 5 [0-10] at 12 months. After a median [IQR] follow-up of 16 [5-50] months, the most important side effects were cutaneous manifestations (n ¼ 8), mild leukopenia (n ¼ 3), myopathy (n ¼ 1), and infections (n ¼ 5). ANK is associated with rapid and maintained clinical and laboratory improvement, even in nonresponders to other biologic agents. However, joint manifestations are more refractory than the systemic manifestations. (Medicine 94(39):e1554) Abbreviations: ACR = American College of Rheumatology, ANK = anakinra, AOSD = adult-onset still disease, CRP = c-reactive protein, DMARD = disease-modifying antirheumatic drugs, ESR = erythrocyte sedimentation rate, FDA = Food and Drug Administration, IFN-g = interferon-g, IL-1 = interleukin 1, IL-6 = interleukin-6, IL-18 = interleukin 18, IQR = interquartile range, NSAIDS = non-steroidal anti-inflammatory drugs, SD = standard deviation, TNF-a = tumor necrosis factor-a. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. Ã In 2 patients from this series ANK was started in combination with disease modifying antirheumatic drugs (DMARDs) (both patients were on treatment with conventional DMARDs before the onset of ANK). In another 2 patients, ANK was initially used as monotherapy and conventional DMARD therapy was added in the follow-up because of persistence of symptoms. þ Some patients received more than 1 TNF inhibitor.
doi:10.1097/md.0000000000001554 pmid:26426623 pmcid:PMC4616841 fatcat:u3id35yclnff7kydnsoocnjd6a

New insights into the genetic component of non-infectious uveitis through an Immunochip strategy

Ana Márquez, Miguel Cordero-Coma, José Manuel Martín-Villa, Marina Begoña Gorroño-Echebarría, Ricardo Blanco, David Díaz Valle, María José del Rio, Ana Blanco, Jose Luis Olea, Yolanda Cordero, María José Capella, Manuel Díaz-Llopis (+12 others)
2016 Journal of Medical Genetics  
General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: ABSTRACT Background. Large-scale genetic studies have reported several loci associated with specific disorders involving uveitis. Our aim was to identify genetic risk factors that might predispose to uveitis per se, independent of the clinical diagnosis, by performing a dense genotyping of immune-related loci.
more » ... hods. 613 cases and 3,693 unaffected controls from three European case/control sets were genotyped using the Immunochip array. Only patients with non-infectious non-anterior uveitis and without systemic features were selected. To perform a more comprehensive analysis of the human leucocyte antigen (HLA) region, singlenucleotide polymorphisms (SNPs), classical alleles and polymorphic amino acid variants were obtained via imputation. A meta-analysis combining the three case/control sets was conducted by the inverse variance method. Results . The highest peak belonged to the HLA region. A more detailed analysis of this signal evidenced a strong association between the classical allele HLA-A*2902 and birdshot chorioretinopathy (p=3.21E-35, OR=50.95). An omnibus test yielded HLA-A 62 and 63 as relevant amino acid positions for this disease. In patients with intermediate and posterior uveitis, the strongest associations belonged to the rs7197 polymorphism, within HLA-DRA (p=2.07E-11, OR=1.99), and the HLA-DR15 haplotype (DRB1*1501: p=1.16E-10, OR=2.08; DQA1*0102: p=4.37E-09, OR=1.77; DQB1*0602: p=7.26E-10, OR=2.02). Outside the HLA region, the MAP4K4/IL1R2 locus reached statistical significance (rs7608679: p=8.38E-07, OR=1.42). Suggestive associations were found at five other loci. Conclusions. We have further interrogated the association between the HLA region and non-infectious non-anterior uveitis. In addition, we have identified a new non-HLA susceptibility factor and proposed additional risk loci with putative roles in this complex condition. KEYWORDS: non-infectious uveitis, non-anterior uveitis, human leukocyte antigen, meta-analysis, Immunochip.
doi:10.1136/jmedgenet-2016-104144 pmid:27609017 fatcat:fy6vwygqwvdn5l3q6eb2zsom3q

No Evidence of Association between Common Autoimmunity STAT4 and IL23R Risk Polymorphisms and Non-Anterior Uveitis

María Carmen Cénit, Ana Márquez, Miguel Cordero-Coma, Marina Begoña Gorroño-Echebarría, Alejandro Fonollosa, Alfredo Adán, Agustín Martínez-Berriotxoa, David Díaz Valle, Esperanza Pato, Ricardo Blanco, Joaquín Cañal, Manuel Díaz-Llopis (+8 others)
2013 PLoS ONE  
Objective: STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity. We decided to investigate for the first time the possible role of different STAT4/IL23R autoimmune disease-associated polymorphisms on the susceptibility to develop non-anterior uveitis and its main clinical phenotypes. Methods: Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026,
more » ... rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain. Results: No statistically significant differences were found when allele and genotype distributions were compared between non-anterior uveitis patients and controls for any STAT4 ( rs3821236: P=0.39, OR=1.12, CI 95%=0.87-1.43; rs7574865: P=0.59 OR=1.07, CI 95%=0.84-1.37; rs7574070: P=0.26, OR=0.89, CI 95%=0.72-1.10; rs897200: P=0.22, OR=0.88, CI 95%=0.71-1.08;) or IL23R polymorphisms (rs7517847: P=0.49, OR=1.08, CI 95%=0.87-1.33; rs11209026: P=0.26, OR=0.78, CI 95%=0.51-1.21; rs1495965: P=0.51, OR=0.93, CI 95%=0.76-1.15). Conclusion: Our results do not support a relevant role, similar to that described for other autoimmune diseases, of IL23R and STAT4 polymorphisms in the non-anterior uveitis genetic predisposition. Further studies are needed to discard a possible weak effect of the studied variant.
doi:10.1371/journal.pone.0072892 pmid:24312163 pmcid:PMC3843656 fatcat:smupoyheznc4nnfh6vxesszlom

Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition

María Carmen Cénit, Ana Márquez, Miguel Cordero-Coma, Alejandro Fonollosa, Alfredo Adán, Agustín Martínez-Berriotxoa, Victor Llorenç, David Díaz Valle, Ricardo Blanco, Joaquín Cañal, Manuel Díaz-Llopis, José Luis García Serrano (+6 others)
2013 BMC Medical Genetics  
Recently, different genetic variants located within the IL2/IL21 genetic region as well as within both IL2RA and IL2RB loci have been associated to multiple autoimmune disorders. We aimed to investigate for the first time the potential influence of the IL2/IL21, IL2RA and IL2RB most associated polymorphisms with autoimmunity on the endogenous non-anterior uveitis genetic predisposition. Methods: A total of 196 patients with endogenous non-anterior uveitis and 760 healthy controls, all of them
more » ... om Caucasian population, were included in the current study. The IL2/IL21 (rs2069762, rs6822844 and rs907715), IL2RA (2104286, rs11594656 and rs12722495) and IL2RB (rs743777) genetic variants were genotyped using TaqMan® allelic discrimination assays. Results: A statistically significant difference was found for the rs6822844 (IL2/IL21 region) minor allele frequency in the group of uveitis patients compared with controls (Pvalue =0.02, OR=0.64 CI 95%=0.43-0.94) although the significance was lost after multiple testing correction. Furthermore, no evidence of association with uveitis was detected for the analyzed genetic variants of the IL2RA or IL2RB loci. Conclusion: Our results indicate that analyzed IL2/IL21, IL2RA and IL2RB polymorphisms do not seem to play a significant role on the non-anterior uveitis genetic predisposition although further studies are needed in order to clear up the influence of these loci on the non-anterior uveitis susceptibility.
doi:10.1186/1471-2350-14-52 pmid:23676143 pmcid:PMC3658927 fatcat:m76pwvwjgrh2djshmtbo7r4y6i

Two Functional Variants of IRF5 Influence the Development of Macular Edema in Patients with Non-Anterior Uveitis

Ana Márquez, María Carmen Cénit, Miguel Cordero-Coma, Norberto Ortego-Centeno, Alfredo Adán, Alejandro Fonollosa, David Díaz Valle, Esperanza Pato, Ricardo Blanco, Joaquín Cañal, Manuel Díaz-Llopis, Enrique de Ramón (+8 others)
2013 PLoS ONE  
Objective: Interferon (IFN) signaling plays a crucial role in autoimmunity. Genetic variation in interferon regulatory factor 5 (IRF5), a major regulator of the type I interferon induction, has been associated with risk of developing several autoimmune diseases. In the current study we aimed to evaluate whether three sets of correlated IRF5 genetic variants, independently associated with SLE and with different functional roles, are involved in uveitis susceptibility and its clinical
more » ... s. Methods: Three IRF5 polymorphisms, rs2004640, rs2070197 and rs10954213, representative of each group, were genotyped using TaqMan® allelic discrimination assays in a total of 263 non-anterior uveitis patients and 724 healthy controls of Spanish origin. Results: A clear association between two of the three analyzed genetic variants, rs2004640 and rs10954213, and the absence of macular edema was observed in the case/control analysis (P FDR =5.07E-03, OR=1.48, CI 95%=1.14-1.92 and P FDR =3.37E-03, OR=1.54, CI 95%=1.19-2.01, respectively). Consistently, the subphenotype analysis accordingly with the presence/absence of this clinical condition also reached statistical significance (rs2004640: P=0.037, OR=0.69, CI 95%=0.48-0.98; rs10954213: P=0.030, OR=0.67, CI 95%=0.47-0.96), thus suggesting that both IRF5 genetic variants are specifically associated with the lack of macular edema in uveitis patients. Conclusion: Our results clearly showed for the first time that two functional genetic variants of IRF5 may play a role in the development of macular edema in non-anterior uveitis patients. Identifying genetic markers for macular edema could lead to the possibility of developing novel treatments or preventive therapies.
doi:10.1371/journal.pone.0076777 pmid:24116155 pmcid:PMC3792064 fatcat:ehggqfc6n5hmdpxnzibfh6k7kq

Lack of association between the protein tyrosine phosphatase non-receptor type 22 R263Q and R620W functional genetic variants and endogenous non-anterior uveitis

María Carmen Cénit, Ana Márquez, Miguel Cordero-Coma, Alejandro Fonollosa, Victor Llorenç, Joseba Artaraz, David Díaz Valle, Ricardo Blanco, Joaquín Cañal, David Salom, José Luis García Serrano, Enrique de Ramón (+6 others)
2013 Molecular Vision  
Endogenous uveitis is a major cause of visual loss mediated by the immune system. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes a lymphoid-specific phosphatase that plays a key role in T-cell receptor (TCR) signaling. Two independent functional missense single nucleotide polymorphisms (SNPs) located within the PTPN22 gene (R263Q and R620W) have been associated with different autoimmune disorders. We aimed to analyze for the first time the influence of these PTPN22
more » ... enetic variants on endogenous non-anterior uveitis susceptibility. We performed a case-control study of 217 patients with endogenous non-anterior uveitis and 718 healthy controls from a Spanish population. The PTPN22 polymorphisms (rs33996649 and rs2476601) were genotyped using TaqMan allelic discrimination assays. The allele, genotype, carriers, and allelic combination frequencies were compared between cases and controls with χ(2) analysis or Fisher's exact test. Our results showed no influence of the studied SNPs in the global susceptibility analysis (rs33996649: allelic P- value=0.92, odds ratio=0.97, 95% confidence interval=0.54-1.75; rs2476601: allelic P- value=0.86, odds ratio=1.04, 95% confidence interval=0.68-1.59). Similarly, the allelic combination analysis did not provide additional information. Our results suggest that the studied polymorphisms of the PTPN22 gene do not play an important role in the pathophysiology of endogenous non-anterior uveitis.
pmid:23559857 pmcid:PMC3611931 fatcat:nz2jfzqhmzg6vdjeg2eplrzzjy

Revisores del Volumen 10 (2013)

2014 Revista Iberoamericana de Automática e Informática Industrial RIAI  
Vallés Miquel, Marina Vargas, Hector Vassallo, Raquel Frizera Vázquez, Francisco Vega Cruz, Pastora Vélez, Jose Verde, Cristina Vidal, Antonio M.  ...  Vinagre Jara, Blas M.Vivas, CarlosYznaga Blanco, Ivonne Zamora Parra, Blas Tarazaga, Pablo Tornero i Montserrat, Josep Torres, Fernando Torres, Roque Trujillo Rasúa, Rafael A.  ... 
doi:10.1016/j.riai.2014.03.003 fatcat:j7rp2yt7xfhl3ibsiwq5x5cvcu

Los autores como actores en el teatro experimental español de los años veinte

María Jesús Fraga Fernández-Cuevas
2010 Revista de Literatura  
Los hermanos Baroja actuaron en la compañía 'El Mirlo Blanco': la participación de D. Pío fue entusiasta pero breve; de su hermano Ricardo se recuerda con mayor interés su labor de escenógrafo.  ...  The Baroja's acted in the company 'El Mirlo Blanco'; D. Pío participation was enthusiastic although brief, while his brother Ricardo was better recognized for his work as stage designer.  ...  Tanto en 'El Mirlo Blanco' como en las siguientes experiencias teatrales Valle-Inclán no participaría como actor.  ... 
doi:10.3989/revliteratura.2010.v72.i143.207 fatcat:c7zsja4dqbc63aybl3toqi4y2q

Page 204 of Hispania Vol. 6, Issue 4 [page]

1923 Hispania  
Material from the pens of Ramon del Valle Inclan, Ricardo Leén, Azorin, Salvador Rueda, Blanco- Belmonte, the Quinteros, Benavente, and others is in- cluded.  ... 

Page 281 of Journal of European Studies Vol. 23, Issue 91 [page]

1993 Journal of European Studies  
Zahareas (New York: Las Americas, 1968), 131-50 (146); Ricardo Gullon, — en Tirano Banderas’, in Zahareas, ae (744, my translation); C.  ...  Aranda, 215; Miguel de Unamuno, ‘La literatura y el cine’, La Nacién (Buenos Aires), 29 April 1923, in Obras completas, Volume XI, edited by Manuel Garcia Blanco (Madrid: Aguado, 1958), 534; Sergei Eisenstein  ... 
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