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Rhythmic 3–4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures

Mark W. Youngblood, William C. Chen, Asht M. Mishra, Sheila Enamandram, Basavaraju G. Sanganahalli, Joshua E. Motelow, Harrison X. Bai, Flavio Frohlich, Alexandra Gribizis, Alexis Lighten, Fahmeed Hyder, Hal Blumenfeld
2015 NeuroImage  
These findings demonstrate that 3-4 Hz spike-wave discharge in a sulcated animal model does not necessarily produce fMRI decreases, leaving the mechanism for this phenomenon open for further investigation  ...  4 Hz) spike-wave discharges.  ...  Acknowledgments We would like to thank Bei Wang and Xiaoxian Ma for assistance during the animal surgeries.  ... 
doi:10.1016/j.neuroimage.2014.12.066 pmid:25562830 pmcid:PMC4340775 fatcat:kw34nw2nzzfrlpo7ekfubp7y7i

EEG/fMRI contributions to our understanding of genetic generalized epilepsies

Benjamin Kay, Jerzy P. Szaflarski
2014 Epilepsy & Behavior  
computational methods to address the questions regarding the origins of the epileptiform discharge generators in patients with GGEs.  ...  These advances allow studying the electrophysiology of genetic generalized epilepsies (GGEs) in vivo in greater detail than ever.  ...  Acknowledgments Study support: The study was supported in part by T32 GM063483 (BK) and in part by K23 NS052468 (JPS).  ... 
doi:10.1016/j.yebeh.2014.02.030 pmid:24679893 pmcid:PMC4008674 fatcat:pmsicjv3gfhpbdck5uwqwfdomu

Networks underlying paroxysmal fast activity and slow spike and wave in Lennox-Gastaut syndrome

N. Pillay, J. S. Archer, R. A. B. Badawy, D. F. Flanagan, S. F. Berkovic, G. Jackson
2013 Neurology  
Objective: To use EEG-fMRI to determine which structures are critically involved in the generation of paroxysmal fast activity (PFA) and slow spike and wave (SSW) (1.5-2.5 Hz), the characteristic interictal  ...  SSW showed a different pattern of BOLD signal change with many areas of decreased BOLD signal, mostly in primary cortical areas.  ...  ACKNOWLEDGMENT The authors gratefully acknowledge Kate Stone and Shawna Farquharson for assistance in acquiring and collecting data for this study as well as the epileptologists at Austin Health for referral  ... 
doi:10.1212/wnl.0b013e3182a08f6a pmid:23864316 pmcid:PMC3775693 fatcat:n2h42ylfozgdpea6jqmvawxw3q

Neocortical temporal lobe epilepsy [chapter]

A Ebner
2008 Textbook of Epilepsy Surgery  
Various studies have attempted to correctly localize the seizure focus in nTLE as patients with this disorder may benefit from surgery.  ...  Complex partial seizures (CPSs) can present with various semiologies, while mesial temporal lobe epilepsy (mTLE) is a wellrecognized cause of CPS, neocortical temporal lobe epilepsy (nTLE) albeit being  ...  Acknowledgment The authors wish to thank Dr. Jean Gotman, Montreal Neurological Institute, Canada, for the illustration on HFOs (Figure 2 ).  ... 
doi:10.3109/9780203091708-41 fatcat:qrxyyn2f2bfldeql6b4w6oudba

Neocortical Temporal Lobe Epilepsy

Eduard Bercovici, Balagobal Santosh Kumar, Seyed M. Mirsattari
2012 Epilepsy Research and Treatment  
Various studies have attempted to correctly localize the seizure focus in nTLE as patients with this disorder may benefit from surgery.  ...  Complex partial seizures (CPSs) can present with various semiologies, while mesial temporal lobe epilepsy (mTLE) is a well-recognized cause of CPS, neocortical temporal lobe epilepsy (nTLE) albeit being  ...  Acknowledgment The authors wish to thank Dr. Jean Gotman, Montreal Neurological Institute, Canada, for the illustration on HFOs (Figure 2 ).  ... 
doi:10.1155/2012/103160 pmid:22953057 pmcid:PMC3420667 fatcat:oxuuex2m4jgp7llk5mmuzwuc3m

Epilepsy and the Consciousness System: Transient Vegetative State?

Hal Blumenfeld
2011 Neurologic clinics  
In addition, although there is insufficient time to determine whether sleep-wake cycles are present, patients may exhibit orienting responses or other simple behaviors.  ...  in these seizure types.  ...  Electroencephalography (EEG) during absence seizures shows widespread bilateral 3-to 4-Hz spike-wave discharges ( Fig. 2A) .  ... 
doi:10.1016/j.ncl.2011.07.014 pmid:22032662 pmcid:PMC3432285 fatcat:4lxsfraw5jbbfkcwgyfsm5vqpi

Characterizing the seizure onset zone and epileptic network using EEG-fMRI in a rat seizure model

Junling Wang, Bin Jing, Ru Liu, Donghong Li, Wei Wang, Jiaoyang Wang, Jianfeng Lei, Yue Xing, Jiaqing Yan, Horace H Loh, Guangming Lu, Xiaofeng Yang
2021 NeuroImage  
In this study, we used simultaneous EEG-fMRI recording in a rat model of 4-aminopyridine-induced acute focal seizures to assess the spatial concordance between individual BOLD responses and the SOZ.  ...  This was to determine the optimal use of simultaneous EEG-fMRI recording in the SOZ localization. We observed a high spatial consistency between BOLD responses and the SOZ.  ...  None of the authors has financial interests or potential conflicts of interest to disclose.  ... 
doi:10.1016/j.neuroimage.2021.118133 pmid:33951515 fatcat:yoxj3dmhyzftrjqro3gnn7npii

Consciousness and epilepsy: why are complex-partial seizures complex? [chapter]

Dario J. Englot, Hal Blumenfeld
2009 Progress in Brain Research  
Understanding the contributions of network inhibition to impaired consciousness in TLE is an important goal, as recurrent limbic seizures often result in cortical dysfunction during and between epileptic  ...  Abnormal function of the medial temporal lobe is expected to cause memory loss, but it is unclear why profoundly impaired consciousness is so common in temporal lobe seizures.  ...  Absence seizures are a form of generalized epilepsy in children characterized by rhythmic 3-4 Hz "spike-wave" discharges on electroencephalogram (EEG) produced by pathophysiological corticothalamic interactions  ... 
doi:10.1016/s0079-6123(09)17711-7 pmid:19818900 pmcid:PMC2901990 fatcat:7gylnhrrdnbsjivu3ea4qiejtm

Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat

A. M. Mishra, D. J. Ellens, U. Schridde, J. E. Motelow, M. J. Purcaro, M. N. DeSalvo, M. Enev, B. G. Sanganahalli, F. Hyder, H. Blumenfeld
2011 Journal of Neuroscience  
that fMRI decreases represent neuronal activity decreases.  ...  However, the caudate-putamen showed fMRI, CBV, and CBF decreases despite increases in LFP and MUA signals.  ...  A primary neuronal mechanism is likely to explain BOLD fMRI decreases seen during cortical slow oscillations in limbic seizures, in which cortical neuronal firing, CBF, and CBV all decrease (Englot et  ... 
doi:10.1523/jneurosci.0101-11.2011 pmid:22016539 pmcid:PMC3432284 fatcat:kftv3vqghjabjfoa25hb2o2sme

The hippocampus participates in a pharmacological rat model of absence seizures

Justin Arcaro, Jingyi Ma, Liangwei Chu, MinChing Kuo, Seyed M. Mirsattari, L. Stan Leung
2016 Epilepsy Research  
The thalamocortical network is responsible for the generation of spike-and-wave discharges (SWDs) in absence epilepsy.  ...  Following GBL injection, SWDs of 4 to 6 Hz developed in the spontaneous local field potentials (LFPs) recorded by depth electrodes in the thalamus, neocortex and hippocampus.  ...  Whereas the frequency of the atypical absence seizure is slower than 2.5 Hz, the specific EEG frequency recorded in a patient experiencing a typical absence seizure is 3-4 Hz and is detected in bursts  ... 
doi:10.1016/j.eplepsyres.2015.12.007 pmid:26773250 pmcid:PMC4942264 fatcat:2h3zo4ga6rglvgiey7xzoyujsy

Presurgical diagnosis of epilepsies – concepts and diagnostic tools

Heinz Gregor Wieser
2016 Journal of Epileptology  
Resective epilepsy surgery is a widely accepted and successful therapeutic approach, rendering up to 80% of selected patients seizure free.  ...  The definitions of the various cortical zones have been conceptualized in the presurgical evaluation of candidates for epilepsy surgery: the seizure onset zone versus the epileptogenic zone, the symptomatogenic  ...  Figure 3 . 3 Two frequent ictal scalp EEG patterns in temporal lobe epilepsy. Figure 4 4 Figure 4.  ... 
doi:10.1515/joepi-2016-0014 fatcat:4clma3n6fjbfrnhzm5752rahdm

Neuronal Networks in West Syndrome as Revealed by Source Analysis and Renormalized Partial Directed Coherence

Natia Japaridze, Muthuraman Muthuraman, Friederike Moeller, Rainer Boor, Abdul Rauf Anwar, Günther Deuschl, Urlich Stephani, Jan Raethjen, Michael Siniatchkin
2012 Brain Topography  
In the study of Moeller et al (2011 (in press) ) DICS was applied to different types of generalized epileptiform discharges and showed cortical and thalamic involvement which was in line with the EEG-fMRI  ...  In the fMRI study of Siniatchkin et al. (2007) the lack of association of high-amplitude slow activity with BOLD signal changes in occipital cortex may be attributed to either an insufficient statistical  ... 
doi:10.1007/s10548-012-0245-y pmid:23011408 fatcat:znv3rlfnijgzjm3edrwypyaz3u

Cerebral hemodynamic responses to seizure in the mouse brain: simultaneous near-infrared spectroscopy–electroencephalography study

Seungduk Lee, Mina Lee, Dalkwon Koh, Beop-Min Kim, Jee Hyun Choi
2010 Journal of Biomedical Optics  
seizure is a decrease in deoxyhemolobin; ͑iii͒ the phase shift between oxy-and deoxyhemoglobin reduces in GBL-treated mice but no 4-AP-treated mice; and ͑iv͒ the spatial correlation of hemodynamics increased  ...  ␥-butyrolactone ͑GBL͒ and 4-aminopyridine ͑4-AP͒ were applied to induce absence and tonicclonic seizures, respectively.  ...  One major difference between two drugs is that mostly pyramidal neurons in cortical layers are involved in 4-AP-induced seizure, 17 whereas the whole thalamocortical network is involved in GBL-induced  ... 
doi:10.1117/1.3365952 pmid:20615039 fatcat:j7r6qdudobesfaoojzwrnpyakm

Dynamics of networks during absence seizure's on- and offset in rodents and man

Annika Lüttjohann, Gilles van Luijtelaar
2015 Frontiers in Physiology  
Within the last years, however, improvements in signal analytical techniques, applied to both animal and human fMRI, EEG, MEG, and ECoG data, greatly increased our understanding and challenged several,  ...  The focal onset zone in human data could differ between patients with varying spatial and temporal dynamics; in rats the latter is still poorly investigated.  ...  ACKNOWLEDGMENTS The authors kindly acknowledge to Jan-Mathijs Schoffelen for support and expert discussion regarding signal analysis.  ... 
doi:10.3389/fphys.2015.00016 pmid:25698972 pmcid:PMC4318340 fatcat:dxyjkjtkr5aj3a2yxomjv3uune

From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research

Davide Gobbo, Anja Scheller, Frank Kirchhoff
2021 Frontiers in Neurology  
The electrographic hallmark of childhood absence epilepsy (CAE) and other idiopathic forms of epilepsy are 2.5–4 Hz spike and wave discharges (SWDs) originating from abnormal electrical oscillations of  ...  Hz) oscillations alternating active (Up) and silent (Down) cortical activity and concomitantly occurring during NREM.  ...  ACKNOWLEDGMENTS The authors thank the members of the department for fruitful discussion and Jens Grosche (Effigos AG) for his contribution to  ... 
doi:10.3389/fneur.2021.661408 pmid:34177766 pmcid:PMC8219957 fatcat:d6z3hs6shjh5hegyg4xqvw72nq
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